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 Allergy Advisor Digest - November 2017
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Snippets NOT posted in the November 2017 Advisor Digest Newsletter

Read Better recognition, diagnosis and management of non-IgE-mediated cow's milk allergy in infancy: iMAP-an international interpretation of the MAP (Milk Allergy in Primary Care) guideline.
Read Non-IgE-mediated Adverse Food Reactions.
Read Mite-Induced Asthma and IgE Levels to Shrimp, Mite, Tropomyosin, Arginine Kinase, and Der p 10 Are the Most Relevant Risk Factors for Challenge-Proven Shrimp Allergy.
Read Cocaine allergy in drug-dependent patients and allergic people.
Read Food Allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention and management.
Read Early life innate immune signatures of persistent food allergy.
Read Allergy terminology: towards a common language and shared understanding.
Read The allergen-specificity of early peanut consumption and the impact on the development of allergic disease in the LEAP Study Cohort.
Read ImmunoCAP assays: Pros and cons in allergology.
Read Salsola kali cross-reacts extensively with Salsola imbricata.
Read Food allergy in EAACI journals (2016).
Read Early-life sensitization to hen's egg predicts asthma and rhinoconjunctivitis at 14 years of age.
Read Allergy-like immediate reactions with herbal medicines in children:A retrospective study using data from VigiBase((R)).
Read Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future.
Read Gluten sensitivities and the allergist: Threshing the grain from the husks.
Read Strong and frequent T-cell responses to the minor allergen Phl p 12 in Spanish patients IgE-sensitized to Profilins.
Read Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules.
Read Food protein-induced enterocolitis syndrome by fish: Not necessarily a restricted diet.
Read Children with atopic dermatitis and frequent emollient use have increased urinary levels of low-molecular-weight phthalate metabolites and parabens.
Read Prevalence of type I sensitization to alpha-gal in forest service employees and hunters.
Read Occupational respiratory allergy in peach crop workers.
Read Delayed-type hypersensitivity reactions induced by proton pump inhibitors
Read Poaceae pollen as the leading aeroallergen worldwide: A review.
Read Der f 35: An MD-2-like house dust mite allergen that cross-reacts with Der f 2 and Pso o 2.
Read Are food allergic consumers ready for informative precautionary allergen labelling?
Read Optimal cutoff values of allergen-specific immunoglobulin E to house dust mites and animal dander based on skin-prick test results: Analysis in 16,209 patients with allergic rhinitis.
Read Concomitant sensitization to legumin, Fag e 2 and Fag e 5 predicts buckwheat allergy.

Snippets posted in the November 2017 Advisor Digest Newsletter

Read A comprehensive review on mustard-induced allergy and implications for human health.
Read Reduced risk of peanut sensitization following exposure through breast-feeding and early peanut introduction.
Read Profilin, a change in the paradigm.
Read Surfing as a risk factor for sensitization to poly(gamma-glutamic acid) in fermented soybeans, natto, allergy.
Read Identification of alpha-gal sensitivity in patients with a diagnosis of idiopathic anaphylaxis.
Read Pigeon tick bite: A neglected cause of idiopathic nocturnal anaphylaxis.
Read Cockroach is a major cross-reactive allergen source in shrimp-sensitized rural children in southern China.
Read Component-resolved diagnosis and beyond: Multivariable regression models to predict severity of hazelnut allergy.
Read Recurrent anaphylaxis in patient allergic to eggplant - a case study.
Read The clinical relevance of lipid transfer protein.
Read High frequency of IgE sensitization towards kiwi seed storage proteins among peanut allergic individuals also reporting allergy to kiwi.

Allergy and Intolerance Abstracts
Better recognition, diagnosis and management of non-IgE-mediated cow's milk allergy in infancy: iMAP-an international interpretation of the MAP (Milk Allergy in Primary Care) guideline.
Cow's milk allergy (CMA) is one of the most common presentations of food allergy seen in early childhood. It is also one of the most complex food allergies, being implicated in IgE-mediated food allergy as well as diverse manifestations of non-IgE-mediated food allergy. For example, gastrointestinal CMA may present as food protein induced enteropathy, enterocolitis or proctocolitis. Concerns regarding the early and timely diagnosis of CMA have been highlighted over the years. In response to these, guideline papers from the United Kingdom (UK), Australia, Europe, the Americas and the World Allergy Organisation have been published. The UK guideline, 'Diagnosis and management of non-IgE-mediated cow's milk allergy in infancy-a UK primary care practical guide' was published in this journal in 2013. This Milk Allergy in Primary Care (MAP) guideline outlines in simple algorithmic form, both the varying presentations of cow's milk allergy and also focuses on the practical management of the most common presentation, namely mild-to-moderate non-IgE-mediated allergy. Based on the international uptake of the MAP guideline, it became clear that there was a need for practical guidance beyond the UK. Consequently, this paper presents an international interpretation of the MAP guideline to help practitioners in primary care settings around the world. It incorporates further published UK guidance, feedback from UK healthcare professionals and affected families and, importantly, also international guidance and expertise.

Better recognition, diagnosis and management of non-IgE-mediated cow's milk allergy in infancy: iMAP-an international interpretation of the MAP (Milk Allergy in Primary Care) guideline.  
Venter C, Brown T, Meyer R, Walsh J, Shah N, Nowak-Wegrzyn A(6), Chen TX(7), Fleischer DM(1), Heine RG(8), Levin M(9), Vieira MC(10), Fox AT(11)(12).
Clin Transl Allergy 2017 Aug 23;7:26.

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Allergy and Intolerance Abstracts
Non-IgE-mediated Adverse Food Reactions.
Purpose of Review: The purpose of this review is to update what is currently known about the major non-IgE-mediated food allergies: food protein-induced enterocolitis syndrome (FPIES), food protein-induced allergic proctocolitis (FPIAP), and food protein-induced enteropathy (FPE). These conditions are similar in that symptoms are regulated to the gastrointestinal tract; therefore understanding their specific features is important for diagnosis and management.

Non-IgE-mediated Adverse Food Reactions.  
Leonard SA.
Curr Allergy Asthma Rep 2017 Nov 14;17(12):84

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Allergy and Intolerance Abstracts
Mite-Induced Asthma and IgE Levels to Shrimp, Mite, Tropomyosin, Arginine Kinase, and Der p 10 Are the Most Relevant Risk Factors for Challenge-Proven Shrimp Allergy.
Shrimp sensitization is common in the general population, but the presence of symptoms is only moderately related to sensitization. A point still at issue is which in vivo and/or in vitro tests (food challenge, component-resolved diagnosis, house dust mite [HDM] sensitization) can help in distinguishing shrimp-allergic subjects from subjects that are sensitized but tolerant. The aim of this study was to evaluate the role of IgE to the different shrimp and mite allergens in distinguishing shrimp challenge-positive from challenge-negative patients. In total, 13 out of 51 (25.5%) patients with reported reactions to shrimp were truly shrimp allergic (7 DBPCFC positive and 6 with documented severe reactions). The study concludes that food challenge tests are mandatory for the diagnosis of shrimp allergy. Tropomyosin is associated with clinical reactivity. HDM-induced asthma and anti-mite IgE are risk factors for shrimp allergy

Mite-Induced Asthma and IgE Levels to Shrimp, Mite, Tropomyosin, Arginine Kinase, and Der p 10 Are the Most Relevant Risk Factors for Challenge-Proven Shrimp Allergy.  
Farioli L, Losappio LM, Giuffrida MG, Pravettoni V, Micarelli G, Nichelatti M, Scibilia J, Mirone C, Cavallarin L, Lamberti C, Balossi LG, Pastorello EA.
Int Arch Allergy Immunol 2017 Nov 24;174(3-4):

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Allergy and Intolerance Abstracts
Cocaine allergy in drug-dependent patients and allergic people.
Cocaine may be an important allergen. Drug abusers and patients sensitized to local anesthesia and tobacco are at risk. Both prick tests and specific IgE against coca leaf extract detected sensitization to cocaine. The highest levels were related to severe clinical profiles

Cocaine allergy in drug-dependent patients and allergic people.  
Armentia A, Martin-Armentia B, Martin-Armentia S, Ruiz-Munoz P, Quesada JM, Postigo I, Conde R, Gonzalez-Sagrado M, Pineda F, Castillo M, Palacios R, Tejedor J.
J Allergy Clin Immunol Pract 2017 Aug 29;

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Allergy and Intolerance Abstracts
Food Allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention and management.
This review provides general information to serve as a primer for those embarking on understanding food allergy and also details advances and updates in epidemiology, pathogenesis, diagnosis and treatment that have occurred over the four years since our last comprehensive review. Although firm prevalence data are lacking, there is a strong impression that food allergy has increased, and rates as high as approximately 10% have been documented. Genetic, epigenetic and environmental risk factors are being increasingly elucidated, opening the potential for improved prevention and treatment strategies targeted to those at risk. Insights on pathophysiology are revealing a complex interplay of epithelial barrier, mucosal and systemic immune response, route of exposure and microbiome among other influences resulting in allergy or tolerance. The diagnosis of food allergy is largely reliant on the medical history, tests for sensitization, and oral food challenges, but emerging use of component resolved diagnostics are improving diagnostic accuracy. Additional novel diagnostics such as basophil activation tests, determination of epitope binding, DNA methylation signatures and bioinformatics approaches will further change the landscape. A number of prevention strategies are under investigation, but early introduction of peanut has been advised as a public health measure based on existing data. Management remains largely based on allergen avoidance, but a panoply of promising treatment strategies are in phase 2 and 3 studies, giving immense hope that better treatment will be imminently and widely available, while numerous additional promising treatments are in the preclinical and clinical pipeline

Food Allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention and management.  
Sicherer SH, Sampson HA.
J Allergy Clin Immunol 2017 Nov 17;

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Allergy and Intolerance Abstracts
Early life innate immune signatures of persistent food allergy.
We show that infants with persistent egg allergy exhibit a unique innate immune signature, characterised by increased numbers of circulating monocytes and dendritic cells that produce more inflammatory cytokines both at baseline and following endotoxin exposure when compared to infants with transient egg allergy.

Early life innate immune signatures of persistent food allergy.  
Neeland MR, Koplin JJ, Dang TD, Dharmage SC, Tang ML, Prescott SL, Saffery R, Martino DJ, Allen KJ.
J Allergy Clin Immunol 2017 Nov 14;

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Allergy and Intolerance Abstracts
Allergy terminology: towards a common language and shared understanding.
Terminology that is used in an inconsistent and ambiguous way by allergists includes the term 'cross reactivity' and the use of the word 'positive' when referring to allergy tests. This may have serious potential for miscommunication and adversely affect patient care.

Allergy terminology: towards a common language and shared understanding.  
Levin M.
J Allergy Clin Immunol 2017 Nov 10;

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Allergy and Intolerance Abstracts
The allergen-specificity of early peanut consumption and the impact on the development of allergic disease in the LEAP Study Cohort.
Early consumption of peanut in infants at high risk of peanut allergy is allergen-specific and does not prevent the development of other allergic disease, sensitization to other foods and aeroallergens, or reported allergic reactions to tree nuts and sesame. Furthermore, peanut consumption does not hasten the resolution of eczema or egg allergy

The allergen-specificity of early peanut consumption and the impact on the development of allergic disease in the LEAP Study Cohort.  
du Toit G, Sayre PH, Roberts G, Lawson K, Sever ML, Bahnson HT, Fisher HR, Feeney M, Radulovic S, Basting M, Plaut M, Lack G.
J Allergy Clin Immunol 2017 Oct 30;

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Allergy and Intolerance Abstracts
ImmunoCAP assays: Pros and cons in allergology.
Allergen-specific IgE measurements and the clinical history are the cornerstones of allergy diagnosis. During the past decades, both characterization and standardization of allergen extracts and assay technology have improved. Here we discuss the uses, advantages, misinterpretations, and limitations of ImmunoCAP IgE assays (Thermo Fisher Scientific/Phadia, Uppsala, Sweden) in the field of allergology. They can be performed as singleplex (ImmunoCAP) and, for the last decade, as multiplex (Immuno Solid-phase Allergen Chip [ISAC]). The major benefit of ImmunoCAP is the obtained quantified allergen-specific IgE antibody level and the lack of interference from allergen-specific IgG antibodies. However, ImmunoCAP allergen extracts are limited to the composition of the extract. The introduction of allergen molecules has had a major effect on analytic specificity and allergy diagnosis. They are used in both singleplex ImmunoCAP and multiplex ImmunoCAP ISAC assays. The major advantage of ISAC is the comprehensive IgE pattern obtained with a minute amount of serum. The shortcomings are its semiquantitative measurements, lower linear range, and cost per assay. With respect to assay performance, ImmunoCAP allergen extracts are good screening tools, but allergen molecules dissect the IgE response on a molecular level and put allergy research on the map of precision medicine.

ImmunoCAP assays: Pros and cons in allergology.  
van Hage M, Hamsten C, Valenta R.
J Allergy Clin Immunol 2017 Oct;140(4):974-977

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Allergy and Intolerance Abstracts
Salsola kali cross-reacts extensively with Salsola imbricata.
Salsola kali and Salsola imbricata present strong cross-reactivity as observed in ELISA inhibition and this might be clinically relevant for the efficacy of allergen specific immunotherapy. We described, for the first time, the allergenic profile for Salsola imbricata and possible common allergenic proteins for Salsola kali and Salsola imbricata

Salsola kali cross-reacts extensively with Salsola imbricata.  
Al-Ahmad M, Rodriguez-Bouza T, Fakim N, Pineda F.
J Investig Allergol Clin Immunol 2017 Sep 29;0

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Allergy and Intolerance Abstracts
Food allergy in EAACI journals (2016).
Over the last years we have observed considerable progress in the area of food allergy, particularly in children. This review article focusses on important contributions which have lately been published in the three journals of the European Academy of Allergy and Clinical Immunology. A better understanding of allergens as well as the mechanisms of sensitization and tolerance induction may hopefully lead to a more targeted management of food allergy in the near future

Food allergy in EAACI journals (2016).  
Wahn U, Matricardi PM, Bieber T, Bousquet J, Grattan C, Simon HU, Muraro A, Agache I.
Pediatr Allergy Immunol 2017 Oct 25;

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Allergy and Intolerance Abstracts
Early-life sensitization to hen's egg predicts asthma and rhinoconjunctivitis at 14 years of age.
Early transient and persistent IgE sensitization to hen's egg was associated with asthma and RC at 14 years. Furthermore, sensitization to HDM was associated with asthma at 14 years.

Early-life sensitization to hen's egg predicts asthma and rhinoconjunctivitis at 14 years of age.  
Christiansen ES, Kjaer HF, Eller E, Bindslev-Jensen C, Host A, Mortz CG, Halken S.
Pediatr Allergy Immunol 2017 Oct 5;

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Allergy and Intolerance Abstracts
Allergy-like immediate reactions with herbal medicines in children:A retrospective study using data from VigiBase((R)).
VigiBase® contained 2646 ICSRs with 14 860 distinct adverse reactions reported in association with herbal medicine in children. Among those, 79 cases with 107 allergy-like reactions met our inclusion criteria. The most commonly reported WHO-ART terms were urticaria or rash/rash erythematous (59.8%), and allergic reaction (8.4%). The most frequently reported suspected herbal medicines were mixed herbal products (51.4%), Hedera helix (15.0%), and Echinacea purpurea (5.6%). Most frequent routes of administration were oral (75.9%), topical (8.9%), and rectal (3.8%). Over 30% of cases were reported in the age group from 7 to 12 years. The majority of reports were received from Germany (29.1%), Thailand (21.5%), and Australia (11.4%).

Allergy-like immediate reactions with herbal medicines in children:A retrospective study using data from VigiBase((R)).  
Meincke R, Pokladnikova J, Straznicka J, Meyboom RHB, Niedrig D, Russmann S, Jahodar L.
Pediatr Allergy Immunol 2017 Nov;28(7):668-674

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Allergy and Intolerance Abstracts
Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future.
In today's clinical practice patients' skin is used as screening organ for diagnosing type 1 allergy. According to European guidelines skin prick testing with a panel of 18 allergen extracts is recommended, in the US between 10 to 50 allergens are used. The specificity and sensitivity of skin testing is individually highly variable depending on age, body mass, and skin barrier status. In atopic inflammation skin testing gives more false positive results. Smaller skin area and strain limits prick testing in small children. Although the risk for systemic reactions in skin prick testing is very small, emergency medications must be available. Considering the fact that IgE is the only reliable biomarker for type I allergy, upfront IgE screening with ISAC, followed by fewer skin tests to approve positive sensitizations, is proposed. It is time to arrive in the age of molecular allergy diagnosis in daily patient care

Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future.  
Jensen-Jarolim E, Jensen AN, Canonica GW.
World Allergy Organ J 2017;10(1):33

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Allergy and Intolerance Abstracts
Gluten sensitivities and the allergist: Threshing the grain from the husks.
'Gluten sensitivity' has become commonplace among the public. Wheat allergy (WA) and celiac disease (CD) are well-defined entities, but are becoming a fraction of individuals following a gluten-free diet. WA has a prevalence of <0.5%. Wheat, specifically its omega-5 gliadin fraction, is the most common allergen implicated in food-dependent, exercise-induced anaphylaxis. CD is a non-IgE hypersensitivity to certain cereal proteins: gluten in wheat, secalin in rye, hordein in barley, and to a lesser extent avenin in oat. It is a rare disease, with an estimated prevalence that varied widely geographically, being higher in Northern Europe and the African Saharawi region than in Southeast Asia. In addition to suggestive symptoms, serologic testing has high diagnostic reliability and biopsy is a confirmatory procedure. CD patients have extra-intestinal autoimmune comorbid conditions more frequently than expected. A third entity is non-celiac gluten sensitivity, which has been created because of the increasing number of subjects who claim a better quality of life or improvement of their variety of symptoms on switching to a gluten-free diet.

Gluten sensitivities and the allergist: Threshing the grain from the husks.  
Burkhardt JG, Chapa-Rodriguez A, Bahna SL.
Allergy 2017 Nov 13;

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Allergy and Intolerance Abstracts
Strong and frequent T-cell responses to the minor allergen Phl p 12 in Spanish patients IgE-sensitized to Profilins.
The strength, prevalence and cross reactivity of T-cell responses towards Phl p 12 is comparable to the major allergen Phl p 1, which supports the hypothesis that T-cells to Phl p 12 can play an important role in development of allergic symptoms, such as those associated with the pollen-food syndrome.

Strong and frequent T-cell responses to the minor allergen Phl p 12 in Spanish patients IgE-sensitized to Profilins.  
Lund G, Brand S, Ramos T, Jimeno L, Boissy P, Vega F, Arina M, Christensen LH, Hoof I, Meno KH, Barber D, Blanco C, Wurtzen PA, Andersen PS.
Allergy 2017 Nov 9;

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Allergy and Intolerance Abstracts
Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules.
n a large pediatric population, the complexity of IgE sensitization profiles against Phleum pratense molecules is related to high atopic features although useless for predicting the clinical severity. The detection of serum IgE to Phl p 1, Phl p 7 and Phl p 12 can be used as clinical biomarkers of SARg and comorbidities. Further studies in different areas are required to test the impact of different IgE molecular profiles on AIT response.

Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules.  
Cipriani F, Mastrorilli C, Tripodi S, Ricci G, Perna S, Panetta V, Asero R, Dondi A, Bianchi A, Maiello N, Miraglia Del GM, Frediani T, Macri F, Lucarelli S, Dello I, Patria MF, Varin E, Pe.
Allergy 2017 Oct 20;

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Allergy and Intolerance Abstracts
Food protein-induced enterocolitis syndrome by fish: Not necessarily a restricted diet.
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food hypersensitivity usually due to cow's milk or soy. Recent researches show that fish is 1 of the most important triggers of FPIES in the Mediterranean countries. Due to the risk of multiple-food FPIES, avoiding foods in the same category or that often occur together may be reasonable. The aim of this study was to evaluate the evolution and follow-up of FPIES related to fish over a period of 20 years. We describe the clinical features of our population, discuss different approaches to oral food challenges, and analyze the possibility of introducing the culprit fish or other nonrelated fish to avoid unnecessary restricted diets

Food protein-induced enterocolitis syndrome by fish: Not necessarily a restricted diet.  
Infante S, Marco-Martin G, Sanchez-Dominguez M, Rodriguez-Fernandez A, Fuentes-Aparicio V, varez-Perea A, Cabrera-Freitag P, Morales-Cabeza C, Zubeldia JM, Zapatero L.
Allergy 2017 Oct 20;

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Allergy and Intolerance Abstracts
Children with atopic dermatitis and frequent emollient use have increased urinary levels of low-molecular-weight phthalate metabolites and parabens.
Emollient use and atopic dermatitis were associated with modestly increased internal LMW phthalate and paraben exposure in 4-9 year old children. It is unknown whether the difference is explained by increased use of the specific emollients that are used to treat pruritic and inflamed skin, and/or whether the impaired skin barrier allows chemicals to penetrate more easily. Moreover, the putative toxicological burden is unknown

Children with atopic dermatitis and frequent emollient use have increased urinary levels of low-molecular-weight phthalate metabolites and parabens.  
Overgaard LEK, Main KM, Frederiksen H, Stender S, Szecsi PB, Williams HC, Thyssen JP.
Allergy 2017 Nov;72(11):1768-1777

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Allergy and Intolerance Abstracts
Prevalence of type I sensitization to alpha-gal in forest service employees and hunters.
Forest service employees and hunters compose a population with a high prevalence of alpha-gal-sIgE positivity and carry a considerable risk of red meat allergy

In the study population, the prevalence of alpha-gal-sIgE-positive (>/=0.10 kUA /L) individuals was 35.0%, whereas the prevalence of individuals with alpha-gal-sIgE levels >/=0.35 kUA /L was 19.3%. Alpha-gal-sIgE positivity was associated with total IgE levels and recent tick bites. Mammalian meat-induced delayed anaphylaxis was found in 8.6% of the participants with alpha-gal-sIgE levels >/=0.35 kUA /L. For forest service employees and hunters, the odds ratio for alpha-gal-sIgE positivity was 2.48 compared to the residential population. The prevalence of alpha-gal-sIgE positivity in the current and historic cohort was comparable.

Prevalence of type I sensitization to alpha-gal in forest service employees and hunters.  
Fischer J, Lupberger E, Hebsaker J, Blumenstock G, Aichinger E, Yazdi AS, Reick D, Oehme R, Biedermann T.
Allergy 2017 Oct;72(10):1540-1547

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Allergy and Intolerance Abstracts
Occupational respiratory allergy in peach crop workers.
Occupational respiratory diseases in workers of peach tree crops have been reported punctually and have been associated with sensitization to proteins present in both pollen and leaf tree. We report the study of 37 workers with respiratory symptoms related to occupational exposure to peach trees. Most patients suffered symptoms when peach trees had leaves, specifically during thinning and harvesting fruit (rhinoconjunctivitis: 100% and asthma: 67.5%). Sensitization to leaf extract was demonstrated in 86% of patients. IgE-immunoblotting with peach leaf extract revealed in six patient sera a pair of bands of 10 and 16 kDa, and in nine a 16-kDa band. Those bands could be two isoforms of peach leaf lipid transfer proteins( LTP), so the recognition frequency of some LTP isoform by our patient sera was 42%. 33% of the sera recognized a doubled band of about 14.5 kDa and this recognition was inhibited by nPho d 2. The SBCT with peach leaf extract was positive in the asthmatic sensitized patients tested.

Occupational respiratory allergy in peach crop workers.  
Perez-Calderon R, Gonzalo-Garijo MA, Rodriguez-Velasco FJ, Sanchez-Vega S, Bartolome-Zavala B.
Allergy 2017 Oct;72(10):1556-1564

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Allergy and Intolerance Abstracts
Delayed-type hypersensitivity reactions induced by proton pump inhibitors
There were 69 cases of PPI-related DHR, including SJS/TEN (n=27) and DRESS (n=10). The LAT by measuring granulysin showed a sensitivity of 59.3% and specificity of 96.4%. Esomeprazole was the most commonly involved in Proton pump inhibitors (PPIs) -related delayed-type hypersensitivity reactions (DHR) (51%). Thirteen patients allergic to one kind of PPI could tolerate other structurally different PPI without cross-hypersensitivity reactions, whereas three patients developed cross-hypersensitivity reactions to alternative structurally similar PPI. The cross-reactivity to structurally similar PPI was also observed in LAT assay. PPIs have the potential to induce life-threatening DHR. In patients when PPI is necessary for treatment, switching to structurally different alternatives should be considered

Delayed-type hypersensitivity reactions induced by proton pump inhibitors: A clinical and in vitro T-cell reactivity study.  
Lin CY, Wang CW, Hui CR, Chang YC, Yang CH, Cheng CY, Chen WW, Ke WM, Chung WH.
Allergy 2017 Jun 28;

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Allergy and Intolerance Abstracts
Poaceae pollen as the leading aeroallergen worldwide: A review.
The Poaceae family comprises over 12 000 wind-pollinated species, which release large amounts of pollen into the atmosphere. Poaceae pollen is currently regarded as the leading airborne biological pollutant and the chief cause of pollen allergy worldwide. Sensitization rates vary by country, and those variations are reviewed here. Grass pollen allergens are grouped according to their protein structure and function. In Poaceae, although species belonging to different subfamilies are characterized by distinct allergen subsets, there is a considerable degree of cross-reactivity between many species. Cross-reactivity between grass pollen protein and fresh fruit pan-allergens is associated with the appearance of food allergies. The additional influence of urban pollution may prompt a more severe immunological response. The timing and the intensity of the pollen season are governed by species genetics, but plant phenology is also influenced by climate; as a result, climate changes may affect airborne pollen concentrations. This article reviews the findings of worldwide research which has highlighted the major impact of climate change on plant phenology and also on the prevalence and severity of allergic disease

Poaceae pollen as the leading aeroallergen worldwide: A review.  
Garcia-Mozo H.
Allergy 2017 Dec;72(12):1849-1858

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Allergy and Intolerance Abstracts
Der f 35: An MD-2-like house dust mite allergen that cross-reacts with Der f 2 and Pso o 2.
Der f 35: An MD-2-like house dust mite allergen that cross-reacts with Der f 2 and Pso o 2. Der f 35 is a candidate major allergen from D. farinae, which is more similar to group 2 allergens from sheep scab mite and storage mites. Der f 35 could be responsible for the cross-reactivity among group 2 mite allergens

Der f 35: An MD-2-like house dust mite allergen that cross-reacts with Der f 2 and Pso o 2.  
Fujimura T, Aki T, Isobe T, Matsuoka A, Hayashi T, Ono K, Kawamoto S.
Allergy 2017 Nov;72(11):1728-1736

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Allergy and Intolerance Abstracts
Are food allergic consumers ready for informative precautionary allergen labelling?
Precautionary allergen labelling (PAL) has resulted in consumer confusion. Previous research has shown that interpretive labels (using graphics, symbols, or colours) are better understood than the traditional forms of labels. In this study, we aimed to understand if consumers would use interpretive labels (symbol, mobile phone application and a toll-free number) with or without medical advice that was advocated by the food industry rather than the normal PAL. This is relevant information for industry and clinicians as it provides an insight into the food allergic perception regarding PAL

Are food allergic consumers ready for informative precautionary allergen labelling?  
Zurzolo GA, Peters RL, Koplin JJ, de Court, Mathai ML, Allen KJ.
Allergy Asthma Clin Immunol 2017;1342

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Allergy and Intolerance Abstracts
Optimal cutoff values of allergen-specific immunoglobulin E to house dust mites and animal dander based on skin-prick test results: Analysis in 16,209 patients with allergic rhinitis.
A total of 16,209 patients with more than one allergic rhinitis symptom who underwent both SPT and serum sIgE testing were retrospectively evaluated between March 2008 and May 2012. There were 9374 male (57.8%) and 6835 female (42.2%) patients. Cutoff values of sIgE for Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, and dog were 0.69, 1.16, 0.13, and 0.45 kU/L, respectively. The cutoff value of sIgE changed according to age for D. pteronyssinus and D. farinae but not for cat and dog allergens. When categorizingaccording to age group, the cutoff values of sIgE for D. pteronyssinus and D. farinae had a tendency to decrease with age. There was no significant difference in cutoff value according to gender.

Optimal cutoff values of allergen-specific immunoglobulin E to house dust mites and animal dander based on skin-prick test results: Analysis in 16,209 patients with allergic rhinitis.  

Am J Rhinol Allergy 2017 Oct 25;

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Allergy and Intolerance Abstracts
Concomitant sensitization to legumin, Fag e 2 and Fag e 5 predicts buckwheat allergy.
Concomitant sensitization to legumin, Fag e 2 and Fag e 5 predicts buckwheat allergy. Patients with clinical symptoms clearly show a distinct allergen recognition pattern. We characterized a buckwheat vicilin-like protein as a new relevant marker allergen, designated Fag e 5. Additionally, another new allergen, Fag e 4, potentially important for cross-reactivity to latex was added to the allergen panel of buckwheat. Further, our data show that the full-length legumin comprising both, large and small subunit should be applied for component resolved diagnosis. Our data indicate that concomitant sensitization to legumin, Fag e 2 and Fag e 5 predicts buckwheat allergy.

Concomitant sensitization to legumin, Fag e 2 and Fag e 5 predicts buckwheat allergy.  
Geiselhart S, Nagl C, Dubiela P, Pedersen AC, Bublin M, Radauer C, Bindslev-Jensen C, Hoffmann-Sommergruber K, Mortz CG.
Clin Exp Allergy 2017 Nov 24;

Click to view abstract

Index

Allergen-, Food allergy-, Intolerance-related articles

Better recognition, diagnosis and management of non-IgE-mediated cow's milk allergy in infancy: iMAP-an international interpretation of the MAP (Milk Allergy in Primary Care) guideline.  
Venter C, Brown T, Meyer R, Walsh J, Shah N, Nowak-Wegrzyn A(6), Chen TX(7), Fleischer DM(1), Heine RG(8), Levin M(9), Vieira MC(10), Fox AT(11)(12).
Clin Transl Allergy 2017 Aug 23;7:26.

National clinical practice guidelines for food allergy and anaphylaxis: an international assessment.  
Sheikh A et al
Clin Transl Allergy 2017 Jul 25;7:23.

A comprehensive review on mustard-induced allergy and implications for human health.  
Sharma A, Verma AK, Gupta RK, Neelabh, Dwivedi PD.
Clin Rev Allergy Immunol 2017 Nov 20;
Click to view abstract

Non-IgE-mediated Adverse Food Reactions.  
Leonard SA.
Curr Allergy Asthma Rep 2017 Nov 14;17(12):84
Click to view abstract

Prevalence and clinical characteristics of local allergic rhinitis to house dust mites.  
Shin YS, Jung CG, Park HS.
Curr Opin Allergy Clin Immunol 2017 Nov 14;
Click to view abstract

Drug-induced anaphylaxis: is it an epidemic?  
Giavina-Bianchi P, Aun MV, Kalil J.
Curr Opin Allergy Clin Immunol 2017 Nov 11;
Click to view abstract

Diagnosis of Food Allergy.  
Gupta M, Cox A, Nowak-Wegrzyn A, Wang J.
Immunol Allergy Clin North Am 2018 Feb;38(1):39-52

Diagnosis and Management of Eosinophilic Esophagitis.  
Wilson JM, McGowan EC.
Immunol Allergy Clin North Am 2018 Feb;38(1):125-139

Prevention of Food Allergies.  
Koplin JJ, Peters RL, Allen KJ.
Immunol Allergy Clin North Am 2018 Feb;38(1):1-11

Drug Hypersensitivity: Broadening Horizons.  
Tilles SA.
Immunol Allergy Clin North Am 2017 Nov;37(4):xv-xvi

Severe Delayed Drug Reactions: Role of Genetics and Viral Infections.  
Pavlos R, White KD, Wanjalla C, Mallal SA, Phillips EJ.
Immunol Allergy Clin North Am 2017 Nov;37(4):785-815
Click to view abstract

Progestogen Hypersensitivity: An Evidence-Based Approach to Diagnosis and Management in Clinical Practice.  
Foer D, Buchheit KM.
Immunol Allergy Clin North Am 2017 Nov;37(4):773-784
Click to view abstract

Management of Children with Hypersensitivity to Antibiotics and Monoclonal Antibodies.  
Norton AE, Broyles AD.
Immunol Allergy Clin North Am 2017 Nov;37(4):713-725
Click to view abstract

Management of Hypersensitivity Reactions to Taxanes.  
Picard M.
Immunol Allergy Clin North Am 2017 Nov;37(4):679-693
Click to view abstract

Platinum Chemotherapy Hypersensitivity: Prevalence and Management.  
Otani IM, Wong J, Banerji A.
Immunol Allergy Clin North Am 2017 Nov;37(4):663-677
Click to view abstract

Drug-Induced Anaphylaxis.  
Aun MV, Kalil J, Giavina-Bianchi P.
Immunol Allergy Clin North Am 2017 Nov;37(4):629-641
Click to view abstract

Mite-Induced Asthma and IgE Levels to Shrimp, Mite, Tropomyosin, Arginine Kinase, and Der p 10 Are the Most Relevant Risk Factors for Challenge-Proven Shrimp Allergy.  
Farioli L, Losappio LM, Giuffrida MG, Pravettoni V, Micarelli G, Nichelatti M, Scibilia J, Mirone C, Cavallarin L, Lamberti C, Balossi LG, Pastorello EA.
Int Arch Allergy Immunol 2017 Nov 24;174(3-4):
Click to view abstract

Evaluation of Nickel Release from Endobronchial Valves as a Possible Cause of Hypersensitivity Pneumonitis in a Patient Treated with Bronchoscopic Lung Volume Reduction.  
Franzen DP, Lang C, Agorastos N, Freitag L, Kohler M, Schmid-Grendelmeier P.
Int Arch Allergy Immunol 2017 Nov 15;
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Prevalence and Clinical Characteristics of Local Allergic Rhinitis in Children Sensitized to House Dust Mites.  
Ha EK, Na MS, Lee S, Baek H, Lee SJ, Sheen YH, Jung YH, Lee KS, Kim MA, Jee HM, Han MY.
Int Arch Allergy Immunol 2017 Nov 10;
Click to view abstract

The Implications of DNA Methylation on Food Allergy.  
Lee KH, Song Y, O'Sullivan M, Pereira G, Loh R, Zhang GB.
Int Arch Allergy Immunol 2017;173(4):183-192
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A Case of Severe Anaphylaxis to Polyhexanide: Cross-Reactivity between Biguanide Antiseptics.  
Schunter JA, Stocker B, Brehler R.
Int Arch Allergy Immunol 2017;173(4):233-236
Click to view abstract

Eight Aeroallergen Skin Extracts May Be the Optimal Panel for Allergic Rhinitis Patients in Central China.  
Wang J, Wu Y, Li J, Huang X, Zhu R.
Int Arch Allergy Immunol 2017;173(4):193-198
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Natural History of Benign Nonimmediate Allergy to Beta-Lactams in Children: A Prospective Study in Retreated Patients After a Positive and a Negative Provocation Test.  
Tonson la TA, Michelet M, Eigenmann PA, Caubet JC.
J Allergy Clin Immunol Pract 2017 Nov 23;
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Serum IgE as an immunological marker to predict response to omalizumab treatment in symptomatic chronic urticaria.  
Straesser MD, Oliver E, Palacios T, Kyin T, Patrie J, Borish L, Saini SS, Lawrence MG.
J Allergy Clin Immunol Pract 2017 Nov 23;

Food allergy is an important risk factor for childhood asthma, irrespective of whether it resolves.  
Vermeulen EM, Koplin JJ, Dharmage SC, Gurrin LC, Peters RL, McWilliam V, Ponsonby AL, Dwyer T, Lowe AJ, Tang MLK, Allen KJ.
J Allergy Clin Immunol Pract 2017 Nov 15;
Click to view abstract

Anti-IgE or Anti-IL5: That Is the Question.  
Israel E, Panettieri RA.
J Allergy Clin Immunol Pract 2017 Nov 14;

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome successfully treated with mepolizumab.  
Ange N, Alley S, Fernando SL, Coyle L, Yun J.
J Allergy Clin Immunol Pract 2017 Nov 10;

When Should Infants with Cow's Milk Protein Allergy Use an Amino Acid Formula? A Practical Guide.  
Meyer R, Groetch M, Venter C.
J Allergy Clin Immunol Pract 2017 Nov 3;
Click to view abstract

The Combined Utility of Ex vivo IFN-gamma Release Enzyme-Linked ImmunoSpot Assay and In vivo Skin Testing in Patients With Antibiotic-Associated Severe Cutaneous Adverse Reactions.  
Trubiano JA, Strautins K, Redwood AJ, Pavlos R, Konvinse KC, Aung AK, Slavin MA, Thursky KA, Grayson ML, Phillips EJ.
J Allergy Clin Immunol Pract 2017 Oct 31;
Click to view abstract

Food allergen component proteins are not detected in early-childhood vaccines.  
Hoyt AEW, Chapman MD, King EM, Platts-Mills TAE, Steinke JW.
J Allergy Clin Immunol Pract 2017 Oct 31;

A case of flagellate dermatitis after ingestion of shiitake mushrooms.  
Santos N, Silva PM, Sao Braz MA.
J Allergy Clin Immunol Pract 2017 Sep 29;

Safety and allergic reaction profiles of children undergoing baked milk and egg challenges: a 6-year experience from a pediatric tertiary referral center.  
Al EM, Lack G, Fox AT, Anagnostou K.
J Allergy Clin Immunol Pract 2017 Sep 29;

Skin testing or sige testing is necessary before early introduction of peanut for prevention of peanut allergy: pro-con debate.  
Tang MLK, Koplin JJ, Sampson HA.
J Allergy Clin Immunol Pract 2017 Sep 26;

Development of IgE-mediated immediate hypersensitivity to a previously tolerated food following its avoidance for eosinophilic gastrointestinal diseases.  
Ho HE, Chehade M.
J Allergy Clin Immunol Pract 2017 Sep 22;

Delayed-type allergy to articaine with cross-reactivity to other local anesthetics from the amide group.  
De Pasquale TMA, Buonomo A, Pucci S.
J Allergy Clin Immunol Pract 2017 Sep 22;

Are Cephalosporins Safe for Use in Penicillin Allergy Without Prior Allergy Evaluation?  
Macy E, Blumenthal KG.
J Allergy Clin Immunol Pract 2017 Sep 22;

The associations between eczema and food and inhalant allergen-specific IgE vary between black and white children.  
Wegienka G, Sitarik A, Bassirpour G, Zoratti EM, Ownby D, Johnson CC, Havstad S.
J Allergy Clin Immunol Pract 2017 Sep 22;

A survey of drug allergy training opportunities in the United States.  
Derrick MI, Williams KB, Shade LMP, Phillips EJ.
J Allergy Clin Immunol Pract 2017 Sep 22;

Sweet syndrome caused by sensitization to gabapentin.  
Rojas-Perez-Ezquerra P, Noguerado-Mellado B, Saenz de Santamaria GM, Roa-Medellin D, Hernandez-Aragues I, Zubeldia Ortuno JM.
J Allergy Clin Immunol Pract 2017 Sep 22;

The Cost of Penicillin Allergy Evaluation.  
Blumenthal KG, Li Y, Banerji A, Yun BJ, Long AA, Walensky RP.
J Allergy Clin Immunol Pract 2017 Sep 22;
Click to view abstract

Cocaine allergy in drug-dependent patients and allergic people.  
Armentia A, Martin-Armentia B, Martin-Armentia S, Ruiz-Munoz P, Quesada JM, Postigo I, Conde R, Gonzalez-Sagrado M, Pineda F, Castillo M, Palacios R, Tejedor J.
J Allergy Clin Immunol Pract 2017 Aug 29;
Click to view abstract

A case of lichenoid and pigmented drug eruption to acetazolamide confirmed by a lichenoid patch test.  
Dequidt L, Milpied B, Chauvel A, Seneschal J, Taieb A, Darrigade AS.
J Allergy Clin Immunol Pract 2017 Aug 25;

A three-level stepwise oral food challenge for egg, milk, and wheat allergy.  
Yanagida N, Minoura T, Kitaoka S, Ebisawa M.
J Allergy Clin Immunol Pract 2017 Aug 25;

Skin testing in gadolinium allergy: 2 case reports.  
Sellaturay P, Nasser S, Ewan P.
J Allergy Clin Immunol Pract 2017 Jun 29;

Outcomes of 84 consecutive open food challenges to extensively heated (baked) milk in the allergy office.  
Agyemang A, Feuille E, Tang J, Steinwandtner I, Sampson H, Nowak-Wegrzyn A.
J Allergy Clin Immunol Pract 2017 Jun 29;

Food Allergy in the developing world.  
Leung AS, Wong GW, Tang ML.
J Allergy Clin Immunol 2017 Nov 22;

Self-reported adverse food reactions and anaphylaxis in the SchoolNuts study: A population-based study of adolescents.  
McWilliam VL, Koplin JJ, Field MJ, Sasaki M, Dharmage SC, Tang MLK, Sawyer SM, Peters RL, Allen KJ.
J Allergy Clin Immunol 2017 Nov 10;
Click to view abstract

Endolysosomal protease susceptibility of Amb a 1 as a determinant of allergenicity.  
Wolf M, Aglas L, Twaroch TE, Steiner M, Huber S, Hauser M, Parigiani MA, Hofer H, Ebner C, Bohle B, Briza P, Neubauer A, Stolz F, Wallner M, Ferreira F.
J Allergy Clin Immunol 2017 Nov 17;
Click to view abstract

Food Allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention and management.  
Sicherer SH, Sampson HA.
J Allergy Clin Immunol 2017 Nov 17;
Click to view abstract

Drug hypersensitivity: we need to do more.  
Pichler WJ, Yerly D.
J Allergy Clin Immunol 2017 Nov 16;

Early life innate immune signatures of persistent food allergy.  
Neeland MR, Koplin JJ, Dang TD, Dharmage SC, Tang ML, Prescott SL, Saffery R, Martino DJ, Allen KJ.
J Allergy Clin Immunol 2017 Nov 14;
Click to view abstract

Timing of regular egg intake for prevention of egg allergy.  
Jiang WH, Deng L, Ye QJ, Cai JR, Cai XR, Li X.
J Allergy Clin Immunol 2017 Nov 14;

Allergy terminology: towards a common language and shared understanding.  
Levin M.
J Allergy Clin Immunol 2017 Nov 10;
Click to view abstract

EoE genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci.  
Martin LJ, He H, Collins MH, Abonia JP, Biagini Myers JM, Eby M, Johansson HE, Kottyan LC, Khurana Hershey GK, Rothenberg ME.
J Allergy Clin Immunol 2017 Nov 9;
Click to view abstract

Home freezers kill house dust mites.  
Feichtner CR, Arlian LG, Morgan MS, Vyszenski-Moher DL.
J Allergy Clin Immunol 2017 Oct 27;

Cat ownership, cat allergen exposure, and trajectories of sensitization and asthma throughout childhood.  
Ihuoma H, Belgrave DC, Murray CS, Foden P, Simpson A, Custovic A.
J Allergy Clin Immunol 2017 Oct 28;

Cat exposure in early life decreases asthma risk from the 17q21 high-risk variant.  
Stokholm J, Chawes BL, Vissing N, Bonnelykke K, Bisgaard H.
J Allergy Clin Immunol 2017 Oct 14;
Click to view abstract

The allergen-specificity of early peanut consumption and the impact on the development of allergic disease in the LEAP Study Cohort.  
du Toit G, Sayre PH, Roberts G, Lawson K, Sever ML, Bahnson HT, Fisher HR, Feeney M, Radulovic S, Basting M, Plaut M, Lack G.
J Allergy Clin Immunol 2017 Oct 30;
Click to view abstract

Advances in Environmental and Occupational Disorders 2016.  
Sheehan WJ, Gaffin JM, Peden DB, Bush RK, Phipatanakul W.
J Allergy Clin Immunol 2017 Oct 25;
Click to view abstract

Clinical relevance of sensitization to hydrolyzed wheat protein in wheat-sensitized subjects.  
Christensen MJ, Stahl SP, Poulsen LK, Bindslev-Jensen C, Mortz CG.
J Allergy Clin Immunol 2017 Oct 13;

Reduced risk of peanut sensitization following exposure through breast-feeding and early peanut introduction.  
Pitt TJ, Becker AB, Chan-Yeung M, Chan ES, Watson WTA, Chooniedass R, Azad MB.
J Allergy Clin Immunol 2017 Aug 22;
Click to view abstract

ImmunoCAP assays: Pros and cons in allergology.  
van Hage M, Hamsten C, Valenta R.
J Allergy Clin Immunol 2017 Oct;140(4):974-977
Click to view abstract

Molecular diagnostics and lack of clinical allergy in helminth-endemic areas in Indonesia.  
Hamid F, Versteeg SA, Wiria AE, Wammes LJ, Wahyuni S, Supali T, Sartono E, van RR, Yazdanbakhsh M.
J Allergy Clin Immunol 2017 Oct;140(4):1196-1199

Profilin, a change in the paradigm.  
Rodriguez Del RP, az-Perales A, Sanchez-Garcia S, Escudero C, Ibanez MD, Mendez-Brea P, Barber D.
J Investig Allergol Clin Immunol 2017 Aug 1;0
Click to view abstract

Salsola kali cross-reacts extensively with Salsola imbricata.  
Al-Ahmad M, Rodriguez-Bouza T, Fakim N, Pineda F.
J Investig Allergol Clin Immunol 2017 Sep 29;0
Click to view abstract

Latest insights on Food Protein-Induced Enterocolitis Syndrome: an emerging medical condition.  
Vila SL.
J Investig Allergol Clin Immunol 2017 Aug 29;0
Click to view abstract

Early introduction of allergenic foods for the prevention of food allergy from an Asian perspective-An Asia Pacific Association of Pediatric Allergy, Respirology & Immunology (APAPARI) consensus statement.  
Tham EH, Shek LP, Van Bever HP, Vichyanond P, Ebisawa M, Wong GW, Lee BW.
Pediatr Allergy Immunol 2017 Oct 25;
Click to view abstract

Food allergy in EAACI journals (2016).  
Wahn U, Matricardi PM, Bieber T, Bousquet J, Grattan C, Simon HU, Muraro A, Agache I.
Pediatr Allergy Immunol 2017 Oct 25;
Click to view abstract

Fatal anaphylaxis in children in France: analysis of national data.  
Pouessel G, Tanno LK, Claverie C, Lejeune S, Labreuche J, Dorkenoo A, Renaudin JM, Eb M, Leteurtre S, Deschildre A.
Pediatr Allergy Immunol 2017 Oct 19;
Click to view abstract

Non-immediate-reading skin tests and prolonged challenges in non-immediate hypersensitivity to beta-lactams in children.  
Lezmi G, Alrowaishdi F, Bados-Albiero A, Scheinmann P, de BJ, Ponvert C.
Pediatr Allergy Immunol 2017 Oct 19;
Click to view abstract

Multifocal Fixed Drug Eruption to ceftazidime in a child with cystic fibrosis.  
Ben MA, Bellon N, Frassati-Biaggi A, Sermet-Gaudelus I, Ponvert C, de BJ, Lezmi G.
Pediatr Allergy Immunol 2017 Oct 19;
Click to view abstract

Early-life sensitization to hen's egg predicts asthma and rhinoconjunctivitis at 14 years of age.  
Christiansen ES, Kjaer HF, Eller E, Bindslev-Jensen C, Host A, Mortz CG, Halken S.
Pediatr Allergy Immunol 2017 Oct 5;
Click to view abstract

Allergy-like immediate reactions with herbal medicines in children:A retrospective study using data from VigiBase((R)).  
Meincke R, Pokladnikova J, Straznicka J, Meyboom RHB, Niedrig D, Russmann S, Jahodar L.
Pediatr Allergy Immunol 2017 Nov;28(7):668-674
Click to view abstract

A pediatric case of selective fixed drug eruption to amoxicillin.  
Labrosse R, Graham F, Begin P, Samaan K, Paradis L, Des RA, Lacombe-Barrios J.
Pediatr Allergy Immunol 2017 Aug 28;

Frequency of skin reactivity to food allergens in allergic patients. [Spanish]  
Camero-Martinez H, Lopez-Garcia AI, Rivero-Yeverino D, Caballero-Lopez CG, rana-Munoz O, Papaqui-Tapia S, Rojas-Mendez IC, Vazquez-Rojas E.
Rev Alerg Mex 2017 Jul;64(3):291-297
Click to view abstract

Determination of a new cow's milk-based formula allergenic capacity in 7 infants. [Spanish]  
Lopez-Marin BE, Rojano B, Carvajal-de Pabon LM.
Rev Alerg Mex 2017 Jul;64(3):250-259
Click to view abstract

Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future.  
Jensen-Jarolim E, Jensen AN, Canonica GW.
World Allergy Organ J 2017;10(1):33
Click to view abstract

Requirements of a new allergen regulation.  
Rivas-Juesas C, Tomas BJ, Purroy Tabar AM.
Allergol Immunopathol (Madr ) 2017 Dec;45 Suppl 115-16

Surfing as a risk factor for sensitization to poly(gamma-glutamic acid) in fermented soybeans, natto, allergy.  
Inomata N, Miyakawa M, Aihara M.
Allergol Int 2017 Nov 24;

How important is allergic sensitization as a cause of atopic asthma?  
Kanazawa J, Masuko H, Yamada H, Yatagai Y, Sakamoto T, Kitazawa H, Iijima H, Naito T, Hirota T, Tamari M, Hizawa N.
Allergol Int 2017 Nov 2;

Successful treatment of refractory alopecia universalis by persuading a patient not to sleep with her dog.  
Arita T, Nomiyama T, Asai J, Katoh N.
Allergol Int 2017 Oct 30;

Occupational allergy to Triticum spelta flour.  
Mencia G, El-Qutob D, Pineda F, Castillo M.
Allergol Int 2017 Jul 29;

Urticaria by thiamine (vitamin B1).  
Rodriguez-Fernandez A, Sanchez-Dominguez M, Noguerado-Mellado B, Rojas-Perez-Ezquerra P.
Allergol Int 2017 Aug 23;

Pustular allergic contact dermatitis caused by Disperse Yellow 3 in a dark blue dress.  
Hotta E, Tamagawa-Mineoka R, Masuda K, Katoh N.
Allergol Int 2017 Oct;66(4):629-631

Characterization of epitope specificities of reference antibodies used for the quantification of the birch pollen allergen Bet v 1.  
Brier S, Le MM, Jain K, Lebrun C, Peurois F, Kellenberger C, Bordas-Le F, Mascarell L, Nony E, Moingeon P.
Allergy 2017 Nov 24;
Click to view abstract

Identification of alpha-gal sensitivity in patients with a diagnosis of idiopathic anaphylaxis.  
Carter MC, Ruiz-Esteves KN, Workman L, Lieberman P, Platts-Mills TAE, Metcalfe DD.
Allergy 2017 Nov 21;
Click to view abstract

Gluten sensitivities and the allergist: Threshing the grain from the husks.  
Burkhardt JG, Chapa-Rodriguez A, Bahna SL.
Allergy 2017 Nov 13;
Click to view abstract

Strong and frequent T-cell responses to the minor allergen Phl p 12 in Spanish patients IgE-sensitized to Profilins.  
Lund G, Brand S, Ramos T, Jimeno L, Boissy P, Vega F, Arina M, Christensen LH, Hoof I, Meno KH, Barber D, Blanco C, Wurtzen PA, Andersen PS.
Allergy 2017 Nov 9;
Click to view abstract

What can we learn in drug allergy management from World Health Organization's international classifications?  
Tanno LK, Torres MJ, Castells M, Demoly P.
Allergy 2017 Nov 6;
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Pigeon tick bite: A neglected cause of idiopathic nocturnal anaphylaxis.  
Rolla G, Heffler E, Boita M, Doyen V, Mairesse M, Cvackova M, Debarbieux S, Kleine-Tebbe J, Ollert M, Raulf M, Bircher AJ, Hilger C.
Allergy 2017 Oct 30;
Click to view abstract

Cockroach is a major cross-reactive allergen source in shrimp-sensitized rural children in southern China.  
Yang Z, Zhao J, Wei N, Feng M, Xian M, Shi X, Zheng Z, Su Q, Wong GWK, Li J.
Allergy 2017 Oct 26;
Click to view abstract

Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules.  
Cipriani F, Mastrorilli C, Tripodi S, Ricci G, Perna S, Panetta V, Asero R, Dondi A, Bianchi A, Maiello N, Miraglia Del GM, Frediani T, Macri F, Lucarelli S, Dello I, Patria MF, Varin E, Pe.
Allergy 2017 Oct 20;
Click to view abstract

Food protein-induced enterocolitis syndrome by fish: Not necessarily a restricted diet.  
Infante S, Marco-Martin G, Sanchez-Dominguez M, Rodriguez-Fernandez A, Fuentes-Aparicio V, varez-Perea A, Cabrera-Freitag P, Morales-Cabeza C, Zubeldia JM, Zapatero L.
Allergy 2017 Oct 20;
Click to view abstract

Children with atopic dermatitis and frequent emollient use have increased urinary levels of low-molecular-weight phthalate metabolites and parabens.  
Overgaard LEK, Main KM, Frederiksen H, Stender S, Szecsi PB, Williams HC, Thyssen JP.
Allergy 2017 Nov;72(11):1768-1777
Click to view abstract

Prevalence of type I sensitization to alpha-gal in forest service employees and hunters.  
Fischer J, Lupberger E, Hebsaker J, Blumenstock G, Aichinger E, Yazdi AS, Reick D, Oehme R, Biedermann T.
Allergy 2017 Oct;72(10):1540-1547

Component-resolved diagnosis and beyond: Multivariable regression models to predict severity of hazelnut allergy.  
Datema MR, van RR, Asero R, Barreales L, Belohlavkova S, de BF, Clausen M, Dubakiene R, Fernandez-Perez C, Fritsche P, Gislason D, Hoffmann-Sommergruber K, Jedrzejczak-Czechowicz M, Jon.
Allergy 2017 Oct 7;
Click to view abstract

Distinct epitope structures of defensin-like proteins linked to proline-rich regions give rise to differences in their allergenic activity.  
Pablos I, Eichhorn S, Machado Y, Briza P, Neunkirchner A, Jahn-Schmid B, Wildner S, Soh WT, Ebner C, Park JW, Pickl WF, Arora N, Vieths S, Ferreira F, Gadermaier G.
Allergy 2017 Sep 27;
Click to view abstract

Altered miR-193a-5p expression in children with cow's milk allergy.  
D'Argenio V, Del M, Paparo L, De Palma FDE, Nocerino R, D'Alessio F, Visconte F, Discepolo V, Del VL, Salvatore F, Berni CR.
Allergy 2017 Aug 30;
Click to view abstract

Possible effect of landscape design on IgE recognition profiles of two generations revealed with micro-arrayed allergens.  
Garib V, Wollmann E, Djambekova G, Lemell P, Kmenta M, Berger U, Zieglmayer P, Valenta R.
Allergy 2017 Oct;72(10):1579-1582
Click to view abstract

Delayed-type hypersensitivity reactions induced by proton pump inhibitors: A clinical and in vitro T-cell reactivity study.  
Lin CY, Wang CW, Hui CR, Chang YC, Yang CH, Cheng CY, Chen WW, Ke WM, Chung WH.
Allergy 2017 Jun 28;
Click to view abstract

Immediate moxifloxacin hypersensitivity: Is there more than currently meets the eye?  
Van Gasse AL, Sabato V, Uyttebroek AP, Elst J, Faber MA, Hagendorens MM, Mertens C, Bridts CH, De Clerck LS, Ebo DG.
Allergy 2017 Dec;72(12):2039-2043
Click to view abstract

Poaceae pollen as the leading aeroallergen worldwide: A review.  
Garcia-Mozo H.
Allergy 2017 Dec;72(12):1849-1858
Click to view abstract

Patterns of anaphylaxis after diagnostic workup: A follow-up study of 226 patients with suspected anaphylaxis.  
Oropeza AR, Bindslev-Jensen C, Broesby-Olsen S, Kristensen T, Moller MB, Vestergaard H, Kjaer HF, Halken S, Lassen A, Mortz CG.
Allergy 2017 Dec;72(12):1944-1952
Click to view abstract

Identification of a polygalacturonase (Cup s 2) as the major CCD-bearing allergen in Cupressus sempervirens pollen.  
Shahali Y, Sutra JP, Hilger C, Swiontek K, Haddad I, Vinh J, Guilloux L, Charpin D, Senechal H, Poncet P.
Allergy 2017 Nov;72(11):1806-1810
Click to view abstract

Effect of anti-IgE in occupational asthma caused by exposure to low molecular weight agents.  
Olle-Monge M, Cruz MJ, Gomez-Olles S, Ojanguren I, Vanoirbeek J, Munoz X.
Allergy 2017 Nov;72(11):1720-1727
Click to view abstract

Der f 35: An MD-2-like house dust mite allergen that cross-reacts with Der f 2 and Pso o 2.  
Fujimura T, Aki T, Isobe T, Matsuoka A, Hayashi T, Ono K, Kawamoto S.
Allergy 2017 Nov;72(11):1728-1736
Click to view abstract

Management of adverse reactions to biologic agents.  
Isabwe GAC, de L, Castells M.
Allergy Asthma Proc 2017 Nov 1;38(6):409-418
Click to view abstract

A Retrospective Study of Korean Adults With Food Allergy: Differences in Phenotypes and Causes.  
Lee SH, Ban GY, Jeong K, Shin YS, Park HS, Lee S, Ye YM.
Allergy Asthma Immunol Res 2017 Nov;9(6):534-539
Click to view abstract

Patterns of Inhalant Allergen Sensitization and Geographical Variation in Korean Adults: A Multicenter Retrospective Study.  
Kang MG, Kim MY, Song WJ, Kim S, Jo EJ, Lee SE, Kwon JW, Lee SM, Park CS, Park HK, Park HW, Chang YS, Lee J, Lee YM, Jee YK, Lee JM, Choi IS, Cho SH.
Allergy Asthma Immunol Res 2017 Nov;9(6):499-508
Click to view abstract

Are food allergic consumers ready for informative precautionary allergen labelling?  
Zurzolo GA, Peters RL, Koplin JJ, de Court, Mathai ML, Allen KJ.
Allergy Asthma Clin Immunol 2017;1342
Click to view abstract

Optimal cutoff values of allergen-specific immunoglobulin E to house dust mites and animal dander based on skin-prick test results: Analysis in 16,209 patients with allergic rhinitis.  

Am J Rhinol Allergy 2017 Oct 25;
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Cockroach hypersensitivity is associated with greater severity of chronic rhinosinusitis.  
Yamasaki A, Hoehle LP, Phillips KM, Campbell AP, Caradonna DS, Gray ST, Sedaghat AR.
Ann Allergy Asthma Immunol 2017 Nov;119(5):469-470

Diagnosis and treatment of food allergic reactions in pediatric emergency settings.  
Brooks C, Coffman A, Erwin E, Mikhail I.
Ann Allergy Asthma Immunol 2017 Nov;119(5):467-468

Shiitake mushroom-induced flagellate dermatitis.  
Fang S, Bajoghli A, Bajoghli M.
Ann Allergy Asthma Immunol 2017 Nov;119(5):462-463

Sensitization to Staphylococcus aureus enterotoxins in smokers with asthma.  
Nagasaki T, Matsumoto H, Oguma T, Ito I, Inoue H, Iwata T, Tajiri T, Kanemitsu Y, Izuhara Y, Morimoto C, Ishiyama Y, Sunadome H, Niimi A, Hirai T.
Ann Allergy Asthma Immunol 2017 Nov;119(5):408-414
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Bee moth (Galleria mellonella) allergy: New insight from a case of monosensitization.  
Antico A, Vegro M, Rasio G, Pasini G, Curioni A.
Ann Allergy Asthma Immunol 2017 Oct 26;

Immediate reactions to iodinated contrast media.  
Morales-Cabeza C, Roa-Medellin D, Torrado I, De BM, Fernandez-Alvarez C, Montes-Acenero JF, De LR, Prieto-Garcia A.
Ann Allergy Asthma Immunol 2017 Oct 7;
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Evaluation of periprocedural hypersensitivity reactions.  
Iammatteo M, Keskin T, Jerschow E.
Ann Allergy Asthma Immunol 2017 Oct;119(4):349-355
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Absence of esophageal eosinophilia in a toddler with severe eosinophilic esophagitis.  
Loh W, Wright KM, Chiou FK.
Asia Pac Allergy 2017 Oct;7(4):243-246
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Evaluation of the results of oral food challenges conducted in specialized and general hospitals.  
Sakai K, Sasaki K, Furuta T, Sugiura S, Watanabe Y, Kobayashi T, Kawabe T, Morishita M, Nakanishi K, Ito K.
Asia Pac Allergy 2017 Oct;7(4):234-242
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Autumn leaves: about aging and allergy.  
Chang YS.
Asia Pac Allergy 2017 Oct;7(4):183-184

De novo food allergy in pediatric liver transplantation recipients.  
Sinitkul R, Manuyakorn W, Kamchaisatian W, Vilaiyuk S, Benjaponpitak S, Lertudompholwanit C, Treepongkaruna S.
Asian Pac J Allergy Immunol 2017 Nov 22;
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Great flood and aeroallergen sensitization in children with asthma and/or allergic rhinitis.  
Visitsunthorn N, Chaimongkol W, Visitsunthorn K, Pacharn P, Jirapongsananuruk O.
Asian Pac J Allergy Immunol 2017 Nov 22;
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Recurrent anaphylaxis in patient allergic to eggplant - a case study.  
Ukleja-Sokolowska N, Gawronska-Ukleja E, Zbikowska-Gotz M, Sokolowski L, Bartuzi Z.
Asian Pac J Allergy Immunol 2017 Nov 22;
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Concomitant sensitization to legumin, Fag e 2 and Fag e 5 predicts buckwheat allergy.  
Geiselhart S, Nagl C, Dubiela P, Pedersen AC, Bublin M, Radauer C, Bindslev-Jensen C, Hoffmann-Sommergruber K, Mortz CG.
Clin Exp Allergy 2017 Nov 24;
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Coincidence of pollen season with the first fetal trimester together with early pet exposure is associated with sensitisation to cat and dog allergens in early childhood: a Finnish population-based study.  
Pyrhonen K, Kulmala P, Nayha S.
Clin Exp Allergy 2017 Nov 24;
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The clinical relevance of lipid transfer protein.  
Asero R, Piantanida M, Pinter E, Pravettoni V.
Clin Exp Allergy 2017 Nov 3;
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Enhancing antibiotic stewardship by tackling 'spurious' penicillin allergy.  
Krishna MT, Huissoon AP, Li M, Richter A, Pillay DG, Sambanthan D, Raman SC, Nasser S, Misbah SA.
Clin Exp Allergy 2017 Nov;47(11):1362-1373
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BSACI guideline for the diagnosis and management of peanut and tree nut allergy.  
Stiefel G, Anagnostou K, Boyle RJ, Brathwaite N, Ewan P, Fox AT, Huber P, Luyt D, Till SJ, Venter C, Clark AT.
Clin Exp Allergy 2017 Jun;47(6):719-739
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