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 Allergy Advisor Digest - August 2014
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Read Wheat allergy in children - new tools for diagnostics.
Read Hypersensitivity from intravenous iron products.
Read Place of excipients in systemic drug allergy.
Read Antiviral drug allergy.
Read Vaccine allergy.
Read Anaphylaxis in adults treated in a Canadian emergency department.
Read Allergen analysis of sea urchin roe using sera from five patients.
Read A hospital-based survey on food allergy in the population of Kolkata, India.
Read Oleaceae pollen allergy and its cross-reactivity in the mediterranean area in the context of globalization.
Read Component-Resolved Diagnosis (CRD): is it worth it? frequency and differentiation in rhinitis patients with mite reactivity.
Read Four-food group elimination diet for adult eosinophilic esophagitis
Read Food allergy: A practice parameter update-2014.
Read Decreased bone mineral density in young adult IgE-mediated cow's milk-allergic patients.
Read Recombinant allergens rarely allow identification of Hymenoptera venom-allergic patients with negative specific IgE to whole venom preparations.
Read Exclusive breastfeeding is associated with reduced cow's milk sensitization in early childhood.
Read Effects of reforestation on tree pollen sensitization in inhabitants of Nuevo Leon, Mexico.
Read Prevalence of pollinosis in patients with allergic asthma, rhinitis and conjunctivitis in the South of Mexico City
Read Profilin as a severe food allergen in allergic patients overexposed to grass pollen.
Read High resolution crystal structure and IgE recognition of the major grass pollen allergen Phl p 3.
Read Prevalence of common food allergies in Europe: a systematic review and meta-analysis.
Read The diagnostic accuracy of specific IgE to Ara h 6 in adults is as good as Ara h 2.
Read Wheat - dependent exercise-induced anaphylaxis occurred with a delayed onset of 10 to 24 hours after wheat ingestion: a case report.
Read Identification of the main allergen sensitizers in an Iran asthmatic population by molecular diagnosis.
Read Risk of sensitization and allergy in Ragweed workers - a pilot study.
Read Anaphylaxis caused by linseed included in baked bread

Abstracts shared in August 2014 Advisor Digest Newsletter

Allergy and Intolerance Abstracts
Wheat allergy in children - new tools for diagnostics.
The detection of wheat-specific IgE in children often leads to a suspicion of wheat allergy, but little information is available on the most reliable wheat allergens for predicting clinical reactivity. This study evaluated the role of allergenic components of wheat in wheat allergy diagnostics. 108 children (median age 1.5 years; range 0.6-17.3 years) with suspected wheat allergy underwent open or double-blinded, placebo-controlled oral wheat challenges. Responsiveness to different allergenic components of wheat was studied by skin prick tests and by determination of serum IgE antibodies using a semi-quantitative microarray assay. 30 (28%) children reacted with immediate symptoms, and 27 (25%) with delayed symptoms to ingested wheat, whereas 51 (47%) children exhibited no reactions in oral wheat challenges. Positive IgE responses to any of the 12 allergenic components of wheat was seen in 93%, 41%, and 43% of those with immediate, delayed, or no reactions to ingested wheat, respectively. Positive IgE responses to >/=5 different allergenic components improved significantly the diagnostic accuracy. Alpha-amylase inhibitors (AAI), in particular dimeric AAI 0.19 (LR+ 6.12), alpha-, beta-, and gamma-gliadins (LR+ from 3.57 to 4.53), and high-molecular-weight (HMW) glutenin subunits (LR+ 4.37) were the single allergenic components of wheat differentiating most effectively those with immediate symptoms from those who did not exhibit any reactions.

Wheat allergy in children - new tools for diagnostics.  
Makela MJ, Eriksson C, Kotaniemi-Syrjanen A, Palosuo K, Marsh J, Borres M, Kuitunen M, Pelkonen AS.
Clin Exp Allergy 2014 Aug 21;

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Allergy and Intolerance Abstracts
Hypersensitivity from intravenous iron products.
In the last several years, intravenous therapy with iron products has been more widely used. Although it has been a standard procedure in dialysis-associated anemia since the early 1990s, its use is expanding to a host of conditions associated with iron deficiency, especially young women with heavy uterine bleeding and pregnancy. Free iron is associated with unacceptable high toxicity inducing severe, hemodynamically significant symptoms. Subsequently, formulations that contain the iron as an iron carbohydrate nanoparticle have been designed. With newer formulations, including low-molecular-weight iron dextran, iron sucrose, ferric gluconate, ferumoxytol, iron isomaltoside, and ferric carboxymaltose, serious adverse events are rare

Hypersensitivity from intravenous iron products.  
Bircher AJ, Auerbach M.
Immunol Allergy Clin North Am 2014 Aug;34(3):707-7xi

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Allergy and Intolerance Abstracts
Place of excipients in systemic drug allergy.
Hypersensitivity reactions to excipients contained in drugs are rare but can be severe or confusing. With regard to generic versus brand drug, often the ingredients are different; for each DHR, we recommend that the physician exercises caution in considering which brand drug or generic was administered and in listing all medicine components and not only the active drug

Place of excipients in systemic drug allergy.  
Barbaud A.
Immunol Allergy Clin North Am 2014 Aug;34(3):671-9, x

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Allergy and Intolerance Abstracts
Antiviral drug allergy.
Antiviral drugs used to treat HIV and hepatitis C are common causes of delayed drug hypersensitivities for which many of the more severe reactions have been recently shown to be immunogenetically mediated such as abacavir hypersensitivity where HLA-B( *)57:01 is now used routinely as a screening test to exclude patients carrying this allele from abacavir prescription. Most antiviral drug allergies consist of mild to moderate delayed rash without other serious features (eg, fever, mucosal involvement, blistering rash, organ impairment.

Antiviral drug allergy.  
Milpied-Homsi B, Moran EM, Phillips EJ.
Immunol Allergy Clin North Am 2014 Aug;34(3):645-62, ix

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Allergy and Intolerance Abstracts
Vaccine allergy.
Overdiagnosis of vaccine allergy is considered a major public health problem. This article discusses the different types of allergic reactions after immunization based on the timing (immediate vs nonimmediate) and the extent of the reaction (local vs systemic). The vaccine components potentially responsible for an allergic reaction are discussed, as well as the management of patients with a history of reaction to a specific vaccine and those with a history of allergy to one of the vaccine components

Vaccine allergy.  
Caubet JC, Ponvert C.
Immunol Allergy Clin North Am 2014 Aug;34(3):597-613, ix

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Allergy and Intolerance Abstracts
Anaphylaxis in adults treated in a Canadian emergency department.
Data from an urban adult tertiary care emergency department (ED) in Montreal, Canada is reported. Among 37,730 ED visits, 0.26% fulfilled the definition of anaphylaxis. Food was the suspected trigger in almost 60% of cases. Reaction to shellfish was associated with more severe reactions.

Rate, triggers, severity and management of anaphylaxis in adults treated in a Canadian emergency department.  
Asai Y, Yanishevsky Y, Clarke A, La VS, Delaney JS, Alizadehfar R, Joseph L, Mill C, Morris J, Ben-Shoshan M.
Int Arch Allergy Immunol 2014 Aug 26;164(3):246-252

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Allergy and Intolerance Abstracts
Allergen analysis of sea urchin roe using sera from five patients.
Sea urchin roe can cause anaphylactic reactions the first time they are consumed. This study attempted to identify sea urchin allergens using sera from 5 patients with sea urchin allergies. Ten protein bands ranging from 18 to 170 kDa were detected in more than 2 patients' sera. In immunoblotting, the protein band for the 170-kDa major yolk protein was recognized by 4 of the 5 sera. The reaction between IgE and the protein band for egg cortical vesicle protein (18 kDa) was inhibited by the addition of salmon roe extract. Therefore Major yolk protein was confirmed to be one of the main allergens in sea urchin roe. In addition, egg cortical vesicle protein (18 kDa) was demonstrated to be an important protein for cross-reactivity with salmon roe.

Allergen analysis of sea urchin roe using sera from five patients.  
Tanaka K, Kondo Y, Inuo C, Nakajima Y, Tsuge I, Doi S, Yanagihara S, Yoshikawa T, Urisu A.
Int Arch Allergy Immunol 2014 Aug 16;164(3):222-227

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Allergy and Intolerance Abstracts
A hospital-based survey on food allergy in the population of Kolkata, India.
The prevalence of food allergy was investigated among patients reporting to a clinic in Kolkata, India. Of the 5,161 patients tested, 4,160 showed a positive response to one or more food items. Banana (32%), brinjal (29%), wheat (22%), and egg (23%) were found to be dominant allergens. Sixty-three percent of patients with a family history of allergy showed either a sudden or an insidious mode of onset, whereas the remaining 37% suffered insidious allergic symptoms. Patients in the age group of 15-40 years were the most susceptible.

A hospital-based survey on food allergy in the population of Kolkata, India.  
Dey D, Ghosh N, Pandey N, Gupta BS.
Int Arch Allergy Immunol 2014 Aug 16;164(3):218-221

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Allergy and Intolerance Abstracts
Oleaceae pollen allergy and its cross-reactivity in the mediterranean area in the context of globalization.
Opening frontiers has led in the last two decades to a massive migration of Romanians to Spain and Italy, two countries known to have large areas planted with olives. Romania owns large areas planted with ash forests. Because of cross-reactivity between these two trees belonging to the Oleaceae family and the big allergenic potential of olive pollens, after a number of years of residence in these countries, many Romanians will present allergic respiratory symptoms of rhinitis and asthma, both in the season of olive pollination and ash pollination

Oleaceae pollen allergy and its cross-reactivity in the mediterranean area in the context of globalization.  
Berghi NO.
Iran J Allergy Asthma Immunol 2014 Aug;13(4):290-295

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Allergy and Intolerance Abstracts
Component-Resolved Diagnosis (CRD): is it worth it? frequency and differentiation in rhinitis patients with mite reactivity.
The aim of this study was to compare performance of this allergen microarray to those of an established extract-based skin prick testing (SPT).45 patients with allergic rhinitis were studied. SPT to Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis extracts and allergen microarray ImmunoCAP ISAC were carried out for all patients. Forty out of 45 patients demonstrated positive SPT to all mite extracts tested. The remaining 5 patients with negative SPT to any mite extracts were classified as non-mite allergic. Comparatively, based on the microarray results, only 34 mite-allergic patients had detectable serum IgE to at least one of the mite allergen components tested whereas 6 patients with positive SPT to mite extracts showed no detectable IgE reactivity to any of the components tested. One non-mite allergic patient had a positive test- Blo t 5. Der p 10-positive patients also reacted to other cross-reactive tropomyosin from anisakis (Ani s 3) (25%), cockroach (Bla g 7) (50%) and shrimp (Pen m 1) (75%). The study concludes that CRD is a reliable tool for the diagnosis of allergy to mites. Der p 10 might be a useful indicator to identify a subset of mite-allergic patient that have additional sensitization due to cross-reactivity and thus allows selection of patients for immunotherapy.

Component-Resolved Diagnosis (CRD): is it worth it? frequency and differentiation in rhinitis patients with mite reactivity.  
Mohamad Yadzir ZH, Misnan R, Abdullah N, Bakhtiar F, Leecyous B, Murad S.
Iran J Allergy Asthma Immunol 2014 Aug;13(4):240-246

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Allergy and Intolerance Abstracts
Four-food group elimination diet for adult eosinophilic esophagitis
Eosinophilic esophagitis (EoE) is an esophageal disorder predominantly triggered by food antigens. This study evaluated the efficacy of a four-food group elimination diet (FFGED) (dairy products, wheat, egg, and legumes) for adult patients with EoE. A total of 52 adult patients were included, of whom 12 patients (23%) had previous failure to topical steroid therapy. Twenty-eight of the 52 patients (54%) achieved clinicopathologic remission on the FFGED and 6 of the 19 (31%) nonresponders to the FFGED were successfully rescued with the SFGED. Milk was identified as an EoE trigger in 11 patients (50%), egg in 8 (36%), wheat in 7 (31%), and legumes in 4 (18%). All patients had just 1 or 2 food triggers, with milk being the only causative food in 27% of the patients.

Four-food group elimination diet for adult eosinophilic esophagitis: A prospective multicenter study.  
Molina-Infante J, Arias A, Barrio J, Rodriguez-Sanchez J, Sanchez-Cazalilla M, Lucendo AJ.
J Allergy Clin Immunol 2014 Aug 27;

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Allergy and Intolerance Abstracts
Food allergy: A practice parameter update-2014.
This parameter was developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology (AAAAI); the American College of Allergy, Asthma & Immunology (ACAAI); and the Joint Council of Allergy, Asthma & Immunology (JCAAI). The AAAAI and the ACAAI have jointly accepted responsibility for establishing 'Food Allergy: A practice parameter update-2014.' This is a complete and comprehensive document at the current time. The medical environment is a changing one, and not all recommendations will be appropriate for all patients. Because this document incorporated the efforts of many participants, no single individual, including those who served on the Joint Task Force, is authorized to provide an official AAAAI or ACAAI interpretation of these practice parameters. Any request for information about or an interpretation of these practice parameters by the AAAAI or ACAAI should be directed to the Executive Offices of the AAAAI, ACAAI, and JCAAI. These parameters are not designed for use by pharmaceutical companies in drug promotion

Food allergy: A practice parameter update-2014.  
Sampson HA, Aceves S, Bock SA, James J, Jones S, Lang D, Nadeau K, Nowak-Wegrzyn A, Oppenheimer J, Perry TT, Randolph C, Sicherer SH, Simon RA, Vickery BP, Wood R, Sampson HA, Randolph C, Bern.
J Allergy Clin Immunol 2014 Aug 28;

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Allergy and Intolerance Abstracts
Decreased bone mineral density in young adult IgE-mediated cow's milk-allergic patients.
This study sought to determine the effects of dairy restriction on BMD in young adult IgE-mediated cow's milk-allergic (IgE-CMA) patients. Densitometric measurements of the hip, femoral neck, and lumbar spine of IgE-CMA patients were significantly lower than of those in the control group (P < .0001). A T score below -2.5 SD, identifying a risk for osteoporosis, was found in 27% of IgE-CMA patients but in none of the controls (P = .0071). Calcium intake was severely reduced in allergic patients than in controls (P < .0001). BMD measurements in group III were significantly greater than in group I (P < .0001) and unchanged from the control group.

Decreased bone mineral density in young adult IgE-mediated cow's milk-allergic patients.  
Nachshon L, Goldberg MR, Schwartz N, Sinai T, mitzur-Levy R, Elizur A, Eisenberg E, Katz Y.
J Allergy Clin Immunol 2014 Aug 1;

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Allergy and Intolerance Abstracts
Recombinant allergens rarely allow identification of Hymenoptera venom-allergic patients with negative specific IgE to whole venom preparations.
This letter argues that, in the authors experience, while recombinant Hymenoptera venom allergens play an important role in the differentiation between genuine sensitization to and cross-reactivity between honeybee and vespid venoms,5-7 they provide no significant improvement over current venom extract tests in their ability to detect Hymenoptera venom┬ľallergic patients.

Recombinant allergens rarely allow identification of Hymenoptera venom-allergic patients with negative specific IgE to whole venom preparations.  
Rafei-Shamsabadi D, Muller S, Pfutzner W, Spillner E, Rueff F, Jakob T.
J Allergy Clin Immunol 2014 Aug;134(2):493-494

Index
Allergy and Intolerance Abstracts
Exclusive breastfeeding is associated with reduced cow's milk sensitization in early childhood.
Results of this study suggest that exclusive breastfeeding is associated with a reduced risk of cow's milk protein sensitization during early childhood

Exclusive breastfeeding is associated with reduced cow's milk sensitization in early childhood.  
Liao SL, Lai SH, Yeh KW, Huang YL, Yao TC, Tsai MH, Hua MC, Huang JL.
Pediatr Allergy Immunol 2014 Aug;25(5):456-461

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Allergy and Intolerance Abstracts
Effects of reforestation on tree pollen sensitization in inhabitants of Nuevo Leon, Mexico.
Reforestation contributes to some extent to the change in the pattern of positive skin tests and may result in more frequent exacerbations of respiratory diseases. It is an activity that should always be regulated and assisted by experts in the according field

Effects of reforestation on tree pollen sensitization in inhabitants of Nuevo Leon, Mexico. [Spanish]  
Palma-Gomez S, Gonzalez-Diaz SN, rias-Cruz A, ias-Weinmann A, maro-Vivian LE, Perez-Vanzzini R, Gutierrez-Mujica JJ, Yong-Rodriguez A.
Rev Alerg Mex 2014 Jul;61(3):162-167

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Allergy and Intolerance Abstracts
Prevalence of pollinosis in patients with allergic asthma, rhinitis and conjunctivitis in the South of Mexico City
Sensitization to weeds is the first cause of respiratory pollinosis in the south of Mexico City, Amaranthus was the most prevalent pollen in this area. Sensitization to trees is the second cause, with a predominance of trees form Betulaceae, Fagaceae and Oleacea families. Sensitization to grass is the third cause of respiratory pollinosis. The most common are from Pooideae (Lolium perenne), Chloroideae and Cynodon/Dactylon family.

Prevalence of pollinosis in patients with allergic asthma, rhinitis and conjunctivitis in the South of Mexico City 2007-2013. [Spanish]  
Gaspar-Lopez A, Lopez-Rocha E, Rodriguez-Mireles K, Segura-Mendez N, Del Rivero-Hernandez L.
Rev Alerg Mex 2014 Jul;61(3):147-152

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Allergy and Intolerance Abstracts
Profilin as a severe food allergen in allergic patients overexposed to grass pollen.
This study evaluated the role of profilins as severe food allergens in allergic patients overexposed to grass who were referred for severe food reactions, and were sensitized to profilins. 26 patients were included, classified into two groups,mild (17) and severe reactors (9), based on clinical history and subsequently provoked orally with purified profilin in a double-blind placebo-controlled food challenge set-up. A significant number of patients presented severe positive food challenge test reactions at low doses of the allergen profilin. Patients prone to suffer from severe reactions had lower IgG4/IgE ratio to major grass allergens than those who didn't. The nature of the observed reactions, and the low level of allergen eliciting the reactions, suggest that intake through the oral mucosa might constitute a relevant route of exposure to food allergens.

Profilin as a severe food allergen in allergic patients overexposed to grass pollen.  
Alvarado MI, Jimeno L, De La TF, Boissy P, Rivas B, Lazaro M, Barber D.
Allergy 2014 Aug 14;

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Allergy and Intolerance Abstracts
High resolution crystal structure and IgE recognition of the major grass pollen allergen Phl p 3.
Group 3 and group 2 grass pollen allergens are cross-reactive allergens containing conformational IgE epitopes. They lack relevant IgE cross-reactivity with group 1 allergens and therefore need to be included in diagnostic tests and allergen-specific treatments in addition to group 1 allergens.

High resolution crystal structure and IgE recognition of the major grass pollen allergen Phl p 3.  
Devanaboyina SC, Cornelius C, Lupinek C, Fauland K, Dall'Antonia F, Nandy A, Hagen S, Flicker S, Valenta R, Keller W.
Allergy 2014 Aug 14;

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Allergy and Intolerance Abstracts
Prevalence of common food allergies in Europe: a systematic review and meta-analysis.
This systematic review aimed to provide up-to-date estimates of the prevalance of food allergens in Europe.Studies published in Europe were identified from searches of databases. Data were pooled using random-effects meta-analyses. The overall pooled estimates for all age groups of self-reported lifetime prevalence of allergy to cow's milk, egg, wheat, soy, peanut, tree nuts, fish, and shellfish were 6.0%, 2.5% (2.3-2.7), 3.6% (3.0-4.2), 0.4% (0.3-0.6), 1.3% (1.2-1.5), 2.2% (1.8-2.5), and 1.3% (0.9-1.7), respectively. The prevalence of food-challenge-defined allergy to cow's milk, egg, wheat, soy, peanut, tree nuts, fish, and shellfish was 0.6% (0.5-0.8), 0.2% (0.2-0.3), 0.1% (0.01-0.2), 0.3% (0.1-0.4), 0.2% (0.2-0.3), 0.5% (0.08-0.8), 0.1% (0.02-0.2), and 0.1% (0.06-0.3), respectively. Allergy to cow's milk and egg was more common among younger children, while allergy to peanut, tree nuts, fish, and shellfish was more common among the older ones. There were insufficient data to compare the estimates of soy and wheat allergy between the age groups. Allergy to most foods, except soy and peanut, appeared to be more common in Northern Europe.

Prevalence of common food allergies in Europe: a systematic review and meta-analysis.  
Nwaru BI, Hickstein L, Panesar SS, Roberts G, Muraro A, Sheikh A.
Allergy 2014 Aug;69(8):992-1007

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Allergy and Intolerance Abstracts
The diagnostic accuracy of specific IgE to Ara h 6 in adults is as good as Ara h 2.
Specific IgE (sIgE) to Ara h 2 is useful in diagnosing peanut allergy. This study assessed the diagnostic value of sIgE to Ara h 6, another 2S albumin, in an adult population suspected of peanut allergy. sIgE to Ara h 2 and Ara h 6 was measured by ImmunoCAP ISAC 112. Of 107 challenged subjects, 65 had a positive challenge (61%). The discriminative ability of sIgE to Ara h 2 and Ara h 6 was comparable. Positive predictive value for both tests was 95% using a cutoff value >/=1 ISU/l with poor corresponding sensitivity values (58% for Ara h 2, 62% for Ara h 6), but good specificity values (95% for both tests). In conclusion, the diagnostic value of sIgE to Ara h 6 on population level was as good as sIgE to Ara h 2. On individual level, however, 5% of the subjects showed contradicting results between both tests using a cutoff of 0.3 ISU/l, leading to a risk of misdiagnosis if only one of both tests is used.

The diagnostic accuracy of specific IgE to Ara h 6 in adults is as good as Ara h 2.  
Klemans RJ, Knol EF, Bruijnzeel-Koomen CA, Knulst AC.
Allergy 2014 Aug;69(8):1112-1114

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Allergy and Intolerance Abstracts
Wheat - dependent exercise-induced anaphylaxis occurred with a delayed onset of 10 to 24 hours after wheat ingestion: a case report.
Wheat-dependent exercise-induced anaphylaxis (WDEIA) usually occurs 1 to 4 hours after wheat ingestion and the pathophysiology of WDEIA remains unknown. It is recommended that WDEIA patients refrain from exercise for 4 to 6 hours after wheat ingestion. We report a case of a 51-year-old man who experienced 5 anaphylaxis attacks; two of which occurred 10 to 24 hours after wheat ingestion and exercise. He has a history of chronic gastroenteritis that responds well to antihistamine drugs but not proton pump inhibitors (PPIs) and prokinetic agents. Abdominal CT results implied the possibility of superior mesenteric artery syndrome. We suggest that WDEIA occurs 6 hours after wheat ingestion in cases compounded by obstructive gastrointestinal diseases.

Wheat - dependent exercise-induced anaphylaxis occurred with a delayed onset of 10 to 24 hours after wheat ingestion: a case report.  
Rongfei Z, Wenjing L, Nan H, Guanghui L.
Allergy Asthma Immunol Res 2014 Jul;6(4):370-372

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Allergy and Intolerance Abstracts
Identification of the main allergen sensitizers in an Iran asthmatic population by molecular diagnosis.
202 adult Iranian asthmatic patients were assessed. Forty-five percent of all patients could be considered atopic individuals. Eighty-two percent of atopic patients were sensitized to pollen allergens. The Salsola kali (Sal k 1) and the Phleum pratense (rPhl p 1 and/or rPhl p 5) major allergens were the most common sensitizers among pollens (71% and 18%, respectively). Thirty-five percent of the atopic population was sensitized to cockroach. Four different allergens, including a previously unknown alpha-amylase, were identified in the cockroach extract.

Identification of the main allergen sensitizers in an Iran asthmatic population by molecular diagnosis.  
Teifoori F, Shams-Ghahfarokhi M, Postigo I, Razzaghi-Abyaneh M, Eslamifar A, Gutierrez A, Sunen E, Martinez J.
Allergy Asthma Clin Immunol 2014;10(1):41

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Allergy and Intolerance Abstracts
Risk of sensitization and allergy in Ragweed workers - a pilot study.
Due to its high allergenic potential Ambrosia artemisiifolia has become a health threat in many European countries during the last few decades. Hence, several cities and communities initiated ragweed eradication campaigns. In Berlin, Germany, so-called Ambrosia scouts are being assigned the task of finding and eliminating this weed. This study sought to evaluate the potential risk of sensitization and allergy in these individuals. 20 Ambrosia scouts were assessed by skin-prick test with inhalant allergens, immunoserological and pulmonary function tests. Despite close contact to ragweed over a median duration of 13.8 months, none of the participants became sensitized or allergic to ragweed. One individual developed a clinical non-relevant sensitization towards the taxiconomically-related plant mugwort.

Risk of sensitization and allergy in Ragweed workers - a pilot study.  
Brandt O, Zuberbier T, Bergmann KC.
Allergy Asthma Clin Immunol 2014;10(1):42

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Allergy and Intolerance Abstracts
Anaphylaxis caused by linseed included in baked bread
A 29-year-old female experienced anaphylaxis caused by linseed included in homemade bread, the first report of linseed-induced allergy in Japan. Skin-prick tests and basophil degranulation tests using extracts of the ingredients and commercially available linseeds were positive for linseed. The patient's serum was also positive for linseed-specific IgE.

Case report: anaphylaxis caused by linseed included in baked bread. [Japanese]  
Koizumi Y, Arai H, Nagase H, Kano S, Tachizawa N, Sagawa T, Yamaguchi M, Ohta K.
Arerugi 2014 Aug;63(7):945-950

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Index

Allergen-, Food allergy-, Intolerance-related articles

Wheat allergy in children - new tools for diagnostics.  
Makela MJ, Eriksson C, Kotaniemi-Syrjanen A, Palosuo K, Marsh J, Borres M, Kuitunen M, Pelkonen AS.
Clin Exp Allergy 2014 Aug 21;
Click to view abstract

IgE antibodies specific to alpha-gal: an example of clinically relevant cross-reactive anti-carbohydrate antibodies.  
Rispens T.
Clin Exp Allergy 2014 Aug;44(8):1008-1011

Predicting reactions severity at challenge in egg-allergic patients.  
Vazquez-Ortiz M, Alvaro M, Piquer M, Dominguez O, Machinena A, Martin-Mateos MA, Plaza AM.
Clin Exp Allergy 2014 Aug;44(8):1096-1097

Bet v 1 - a Trojan horse for small ligands boosting allergic sensitization?  
Asam C, Batista AL, Moraes AH, de P, Almeida FC, Aglas L, Kitzmuller C, Bohle B, Ebner C, Ferreira F, Wallner M, Valente AP.
Clin Exp Allergy 2014 Aug;44(8):1083-1093
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Egg allergy: the relevance of molecular-based allergy diagnostics.  
Tosca MA, Pistorio A, Accogli A, Silvestri M, Rossi GA, Ciprandi G.
Clin Exp Allergy 2014 Aug;44(8):1094-1095

Allergic reactions to Anisakis found in fish.  
Nieuwenhuizen NE, Lopata AL.
Curr Allergy Asthma Rep 2014 Aug;14(8):455
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Perioperative anaphylaxis.  
Galvao VR, Giavina-Bianchi P, Castells M.
Curr Allergy Asthma Rep 2014 Aug;14(8):452
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Hypersensitivity drug reactions.  
Thong BY, Blanca M.
Curr Opin Allergy Clin Immunol 2014 Aug;14(4):269-270

Drug hypersensitivity. Preface.  
Demoly P.
Immunol Allergy Clin North Am 2014 Aug;34(3):xv-xvi

The complexity of drug hypersensitivity. Foreword.  
Alam R.
Immunol Allergy Clin North Am 2014 Aug;34(3):xiii-xxiv

Hypersensitivity from intravenous iron products.  
Bircher AJ, Auerbach M.
Immunol Allergy Clin North Am 2014 Aug;34(3):707-7xi
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In vitro diagnosis of delayed-type drug hypersensitivity: mechanistic aspects and unmet needs.  
Naisbitt DJ, Nattrass RG, Ogese MO.
Immunol Allergy Clin North Am 2014 Aug;34(3):691-705, x
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In vitro diagnosis of immediate IgE-mediated drug hypersensitivity: warnings and (unmet) needs.  
Uyttebroek AP, Sabato V, Bridts CH, Ebo DG.
Immunol Allergy Clin North Am 2014 Aug;34(3):681-9, x
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Place of excipients in systemic drug allergy.  
Barbaud A.
Immunol Allergy Clin North Am 2014 Aug;34(3):671-9, x
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Allergic contact dermatitis from the vehicle components of topical pharmaceutical products.  
Goossens RA.
Immunol Allergy Clin North Am 2014 Aug;34(3):663-66x
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Antiviral drug allergy.  
Milpied-Homsi B, Moran EM, Phillips EJ.
Immunol Allergy Clin North Am 2014 Aug;34(3):645-62, ix
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Hypersensitivity to antiepileptic drugs.  
Ye YM, Thong BY, Park HS.
Immunol Allergy Clin North Am 2014 Aug;34(3):633-43, ix
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Hypersensitivity reactions to biologic agents.  
Vultaggio A, Castells MC.
Immunol Allergy Clin North Am 2014 Aug;34(3):615-32, ix
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Vaccine allergy.  
Caubet JC, Ponvert C.
Immunol Allergy Clin North Am 2014 Aug;34(3):597-613, ix
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Adverse events to nontargeted and targeted chemotherapeutic agents: emphasis on hypersensitivity responses.  
Baldo BA, Pagani M.
Immunol Allergy Clin North Am 2014 Aug;34(3):565-96, viii
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Hypersensitivity to contrast media and dyes.  
Brockow K, Sanchez-Borges M.
Immunol Allergy Clin North Am 2014 Aug;34(3):547-64, viii
Click to view abstract

Local and general anesthetics immediate hypersensitivity reactions.  
Volcheck GW, Mertes PM.
Immunol Allergy Clin North Am 2014 Aug;34(3):525-46, viii
Click to view abstract

Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs.  
Torres MJ, Barrionuevo E, Kowalski M, Blanca M.
Immunol Allergy Clin North Am 2014 Aug;34(3):507-viii
Click to view abstract

Antibiotic allergy.  
Romano A, Warrington R.
Immunol Allergy Clin North Am 2014 Aug;34(3):489-506, vii
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Management of nonimmediate hypersensitivity reactions to drugs.  
Roujeau JC, Haddad C, Paulmann M, Mockenhaupt M.
Immunol Allergy Clin North Am 2014 Aug;34(3):473-87, vii
Click to view abstract

Drug allergy diagnosis.  
Chiriac AM, Demoly P.
Immunol Allergy Clin North Am 2014 Aug;34(3):461-71, vii
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Rate, triggers, severity and management of anaphylaxis in adults treated in a Canadian emergency department.  
Asai Y, Yanishevsky Y, Clarke A, La VS, Delaney JS, Alizadehfar R, Joseph L, Mill C, Morris J, Ben-Shoshan M.
Int Arch Allergy Immunol 2014 Aug 26;164(3):246-252
Click to view abstract

Allergen analysis of sea urchin roe using sera from five patients.  
Tanaka K, Kondo Y, Inuo C, Nakajima Y, Tsuge I, Doi S, Yanagihara S, Yoshikawa T, Urisu A.
Int Arch Allergy Immunol 2014 Aug 16;164(3):222-227
Click to view abstract

A hospital-based survey on food allergy in the population of Kolkata, India.  
Dey D, Ghosh N, Pandey N, Gupta BS.
Int Arch Allergy Immunol 2014 Aug 16;164(3):218-221
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Oleaceae pollen allergy and its cross-reactivity in the mediterranean area in the context of globalization.  
Berghi NO.
Iran J Allergy Asthma Immunol 2014 Aug;13(4):290-295
Click to view abstract

Component-Resolved Diagnosis (CRD): is it worth it? frequency and differentiation in rhinitis patients with mite reactivity.  
Mohamad Yadzir ZH, Misnan R, Abdullah N, Bakhtiar F, Leecyous B, Murad S.
Iran J Allergy Asthma Immunol 2014 Aug;13(4):240-246
Click to view abstract

Effects of enzymatic hydrolysis on the allergenicity of whey protein concentrates.  
Duan C, Yang L, Li A, Zhao R, Huo G.
Iran J Allergy Asthma Immunol 2014 Aug;13(4):231-239
Click to view abstract

Four-food group elimination diet for adult eosinophilic esophagitis: A prospective multicenter study.  
Molina-Infante J, Arias A, Barrio J, Rodriguez-Sanchez J, Sanchez-Cazalilla M, Lucendo AJ.
J Allergy Clin Immunol 2014 Aug 27;
Click to view abstract

IgE allergen component-based profiling and atopic manifestations in patients with Netherton syndrome.  
Hannula-Jouppi K, Laasanen SL, Heikkila H, Tuomiranta M, Tuomi ML, Hilvo S, Kluger N, Kivirikko S, Hovnanian A, Makinen-Kiljunen S, Ranki A.
J Allergy Clin Immunol 2014 Aug 23;

Food allergy: A practice parameter update-2014.  
Sampson HA, Aceves S, Bock SA, James J, Jones S, Lang D, Nadeau K, Nowak-Wegrzyn A, Oppenheimer J, Perry TT, Randolph C, Sicherer SH, Simon RA, Vickery BP, Wood R, Sampson HA, Randolph C, Bern.
J Allergy Clin Immunol 2014 Aug 28;
Click to view abstract

Influence of early-life exposures on food sensitization and food allergy in an inner-city birth cohort.  
McGowan EC, Bloomberg GR, Gergen PJ, Visness CM, Jaffee KF, Sandel M, O'Connor G, Kattan M, Gern J, Wood RA.
J Allergy Clin Immunol 2014 Aug 13;
Click to view abstract

B-cell linear epitopes mapping of antigen-5 allergen from Polybia paulista wasp venom.  
Aparecido Dos Santos-Pinto JR, azari Dos SL, Arcuri HA, Ribeiro da Silva MA, Pego PN, Santos KS, Castro FM, Kalil JE, De-Simone SG, Palma MS.
J Allergy Clin Immunol 2014 Aug 13;

IL-9 is a key component of memory T cell peanut-specific responses from children with peanut allergy.  
Brough HA, Cousins DJ, Munteanu A, Wong YF, Sudra A, Makinson K, Stephens AC, Arno M, Ciortuz L, Lack G, Turcanu V.
J Allergy Clin Immunol 2014 Aug 8;
Click to view abstract

Decreased bone mineral density in young adult IgE-mediated cow's milk-allergic patients.  
Nachshon L, Goldberg MR, Schwartz N, Sinai T, mitzur-Levy R, Elizur A, Eisenberg E, Katz Y.
J Allergy Clin Immunol 2014 Aug 1;
Click to view abstract

Recombinant allergens rarely allow identification of Hymenoptera venom-allergic patients with negative specific IgE to whole venom preparations.  
Rafei-Shamsabadi D, Muller S, Pfutzner W, Spillner E, Rueff F, Jakob T.
J Allergy Clin Immunol 2014 Aug;134(2):493-494

Component-resolved diagnosis of wheat flour allergy in baker's asthma.  
Gomez-Casado C, Garrido-Arandia M, Pereira C, Catarino M, Parro V, Armentia A, Quirce S, Armentia B, Barranco P, Blanca M, Campo P, az-Perales A.
J Allergy Clin Immunol 2014 Aug;134(2):480-483

Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response.  
Dhingra N, Shemer A, Correa da RJ, Rozenblit M, Fuentes-Duculan J, Gittler JK, Finney R, Czarnowicki T, Zheng X, Xu H, Estrada YD, Cardinale I, Suarez-Farinas M, Krueger JG, Guttman-Yassky E.
J Allergy Clin Immunol 2014 Aug;134(2):362-372
Click to view abstract

Occupational egg allergy in an embryological research facility.  
Jones M, Skidmore A, Glozier N, Welch J, Hunter AS, Cullinan P.
Occup Med 2013 Jul;63(5):348-53.

Cross-sectional comparison of the characteristics of respiratory allergy in immigrants and Italian children.  
Lombardi C, Fiocchi A, Raffetti E, Donato F, Canonica GW, Passalacqua G.
Pediatr Allergy Immunol 2014 Aug;25(5):473-480
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Exclusive breastfeeding is associated with reduced cow's milk sensitization in early childhood.  
Liao SL, Lai SH, Yeh KW, Huang YL, Yao TC, Tsai MH, Hua MC, Huang JL.
Pediatr Allergy Immunol 2014 Aug;25(5):456-461
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Effects of reforestation on tree pollen sensitization in inhabitants of Nuevo Leon, Mexico. [Spanish]  
Palma-Gomez S, Gonzalez-Diaz SN, rias-Cruz A, ias-Weinmann A, maro-Vivian LE, Perez-Vanzzini R, Gutierrez-Mujica JJ, Yong-Rodriguez A.
Rev Alerg Mex 2014 Jul;61(3):162-167
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Prevalence of pollinosis in patients with allergic asthma, rhinitis and conjunctivitis in the South of Mexico City 2007-2013. [Spanish]  
Gaspar-Lopez A, Lopez-Rocha E, Rodriguez-Mireles K, Segura-Mendez N, Del Rivero-Hernandez L.
Rev Alerg Mex 2014 Jul;61(3):147-152
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Frequency of sensitization to aeroallergens in patients with seasonal and perennial allergic conjunctivitis. [Spanish]  
Cortes-Morales G, Velasco-Medina AA, rroyo-Cruz ME, Velazquez-Samano G.
Rev Alerg Mex 2014 Jul;61(3):141-146
Click to view abstract

Allergy to short-acting beta2-agonists in a COPD patient: Is an immunological mechanism involved?  
Manso L, Valbuena T, Padial MA, Reche M, Zafra MP, Del P, Pascual CY.
Allergol Immunopathol (Madr ) 2014 Aug 2;

Prevalence of parent-reported food allergy in infants and preschoolers in Brazil.  
Guimaraes TC, Goncalves LC, Silva RM, Segundo GR.
Allergol Immunopathol (Madr ) 2014 Aug 1;

Profilin as a severe food allergen in allergic patients overexposed to grass pollen.  
Alvarado MI, Jimeno L, De La TF, Boissy P, Rivas B, Lazaro M, Barber D.
Allergy 2014 Aug 14;
Click to view abstract

Effects of a pre-existing food allergy on the oral introduction of food proteins: Findings from a murine model.  
Kulis M, Wesley BA.
Allergy 2014 Aug 25;
Click to view abstract

High resolution crystal structure and IgE recognition of the major grass pollen allergen Phl p 3.  
Devanaboyina SC, Cornelius C, Lupinek C, Fauland K, Dall'Antonia F, Nandy A, Hagen S, Flicker S, Valenta R, Keller W.
Allergy 2014 Aug 14;
Click to view abstract

Prevalence of common food allergies in Europe: a systematic review and meta-analysis.  
Nwaru BI, Hickstein L, Panesar SS, Roberts G, Muraro A, Sheikh A.
Allergy 2014 Aug;69(8):992-1007
Click to view abstract

The diagnostic accuracy of specific IgE to Ara h 6 in adults is as good as Ara h 2.  
Klemans RJ, Knol EF, Bruijnzeel-Koomen CA, Knulst AC.
Allergy 2014 Aug;69(8):1112-1114
Click to view abstract

Wheat - dependent exercise-induced anaphylaxis occurred with a delayed onset of 10 to 24 hours after wheat ingestion: a case report.  
Rongfei Z, Wenjing L, Nan H, Guanghui L.
Allergy Asthma Immunol Res 2014 Jul;6(4):370-372
Click to view abstract

Specific B-cell Epitope of Per a 1: A Major Allergen of American Cockroach (Periplaneta americana) and Anatomical Localization.  
Sookrung N, Khetsuphan T, Chaisri U, Indrawattana N, Reamtong O, Chaicumpa W, Tungtrongchitr A.
Allergy Asthma Immunol Res 2014 Jul;6(4):325-332
Click to view abstract

Identification of the main allergen sensitizers in an Iran asthmatic population by molecular diagnosis.  
Teifoori F, Shams-Ghahfarokhi M, Postigo I, Razzaghi-Abyaneh M, Eslamifar A, Gutierrez A, Sunen E, Martinez J.
Allergy Asthma Clin Immunol 2014;10(1):41
Click to view abstract

Children under 15 kg with food allergy may be at risk of having epinephrine auto-injectors administered into bone.  
Kim L, Nevis IF, Tsai G, Dominic A, Potts R, Chiu J, Kim HL.
Allergy Asthma Clin Immunol 2014;10(1):40
Click to view abstract

Risk of sensitization and allergy in Ragweed workers - a pilot study.  
Brandt O, Zuberbier T, Bergmann KC.
Allergy Asthma Clin Immunol 2014;10(1):42
Click to view abstract

Evaluation of a skin testing protocol for diagnosing perioperative anaphylaxis due to isosulfan blue allergy.  
Baker MG, Cronin JA, Borish L, Lawrence MG.
Ann Allergy Asthma Immunol 2014 Sep;113(3):330-331

Unusual sensitization to parvalbumins from certain fish species.  
Raith M, Klug C, Sesztak-Greinecker G, Balic N, Focke M, Linhart B, Hemmer W, Swoboda I.
Ann Allergy Asthma Immunol 2014 Aug 29;

Allergy reaction mediated by Gal d 4 (lysozyme) after the induction of tolerance with egg.  
Infante S, Lopez-Matas MA, Carnes J, Fuentes V, Alonso E, Zapatero L.
Ann Allergy Asthma Immunol 2014 Aug 19;

Hypersensitivity reactions to contrast media injections: a nested case-control study.  
Ramirez E, Tong HY, Fiandor A, Martin-Hervas C, Rivero D, Onate M, Rueda C, Cabanas R, Moro M, Tapia M, Fernandez A, Moron S, Herrero A, Garzon G, Quirce S, Frias J.
Ann Allergy Asthma Immunol 2014 Aug 21;

Allergic blepharoconjunctivitis caused by acrylates promotes allergic rhinitis response.  
Dudek W, Wittczak T, Swierczynska-Machura D, Krecisz B, Nowakowska-Swirta E, Kiec-Swierczynska M, Palczynski C.
Ann Allergy Asthma Immunol 2014 Aug 22;

Allergen of the Month-Little-leaf linden.  
Weber RW.
Ann Allergy Asthma Immunol 2014 Aug;113(2):A15

A case of anaphylaxis to palivizumab.  
Savitz J, Geaney C, Banks TA.
Ann Allergy Asthma Immunol 2014 Aug;113(2):236-237

Systemic reactions to honeybee stings and nonsteroidal antinflammatory drugs.  
Pucci S, De PT, D'Alo S, Illuminati I, Makri E, Incorvaia C.
Ann Allergy Asthma Immunol 2014 Aug;113(2):237-238

Case report: anaphylaxis caused by linseed included in baked bread. [Japanese]  
Koizumi Y, Arai H, Nagase H, Kano S, Tachizawa N, Sagawa T, Yamaguchi M, Ohta K.
Arerugi 2014 Aug;63(7):945-950
Click to view abstract

Pollen dispersion of cryptmeria japonica in the autumn at the oita university faculty of medicine complex. [Japanese]  
Watanabe T, Suzuki M.
Arerugi 2014 Aug;63(7):920-927
Click to view abstract


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