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 Allergy Advisor Digest - August 2012
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Read Occupational food-related hand dermatoses
Read Pathogenesis of food allergy in the pediatric patient.
Read Serum IgE reactivity profiles indicates absence of de novo IgE sensitizations in adults.
Read Green head ant anaphylaxis.
Read Contact allergy to gold in patients with oral lichen lesions.
Read Bullous drug eruption with Nigella sativa oil.
Read Type I variant of Kounis syndrome secondary to wasp sting.

Abstracts shared in August 2012 Advisor Digest Newsletter

Read Skin prick test and specific serum IgE in the diagnostic evaluation of suspected cow's milk and hen's egg allergy in children: does one replace the other?
Read Cercarial dermatitis, a neglected allergic disease.
Read Chromium in leather footwear - risk assessment of chromium allergy and dermatitis.
Read Exposure to cats: update on risks for sensitization and allergic diseases.
Read Utility of casein-specific IgE levels in predicting reactivity to baked milk.
Read Sensitization to cross-reactive carbohydrate determinants in 2 patients with Hymenoptera venom allergy and alcoholic cardiomyopathy.
Read Dietary baked egg accelerates resolution of egg allergy in children.
Read Tolerability of a fully maturated cheese in cow's milk allergic children
Read Colonoscopic allergen provocation test with rBet v 1 in patients with pollen-associated food allergy.
Read Profilin cross-reactive panallergen causes latex sensitization in the pediatric population allergic to pollen.
Read Anaphylaxis induced by lentil inhalation.

Allergy and Intolerance Abstracts
Occupational food-related hand dermatoses
Protein contact dermatitis is a distinct kind of dermatitis seen in patients with occupational food contact. This Danish study evaluated the frequency of occupational food-related hand dermatoses and test results in patients occupationally exposed to foods. Of all patients (n = 372), 57.0% had irritant contact dermatitis, 22.0% had protein contact dermatitis, 2.4% had contact urticaria, and 1.8% had allergic contact dermatitis. Frequent risk occupations were cooking in restaurants, baking, and kitchen work. Substantially more patients reacted in skin prick testing with fresh foods than with food extracts.

Occupational food-related hand dermatoses seen over a 10-year period.  
Vester L, Thyssen JP, Menne T, Johansen JD.
Contact Dermatitis 2012 May;66(5):264-270

Click to view abstract

Index
Allergy and Intolerance Abstracts
Pathogenesis of food allergy in the pediatric patient.
This review highlights our current understanding of the pathogenesis of IgE-mediated food allergy.

Pathogenesis of food allergy in the pediatric patient.  
Chin S, Vickery BP.
Curr Allergy Asthma Rep 2012 Aug 30;

Click to view abstract

Index
Allergy and Intolerance Abstracts
Serum IgE reactivity profiles indicates absence of de novo IgE sensitizations in adults.
To address the question of whether and how frequently adult allergic patients and nonallergic subjects have IgE sensitizations to new allergen molecules, a retrospective analysis of serum samples using an allergen microarray that contained 85

different purified allergen molecules was performed. The 85 allergens on the chip represented 50 allergen families with experimentally confirmed cross-reactivity. Sera were collected in 1997 and 2007 from 12 adult allergic patients with confirmed allergy to various airborne and food allergens and from 10 subjects with a negative history of allergy. At first glance, 8 of the 12 allergic patients and one of the 10 nonallergic subjects seemed to exhibit IgE reactivity to new allergens in 2007. When the allergens were grouped into families of cross-reactive allergens, it turned out that 6 of the 12 allergic patients and the nonallergic subject mounted IgE antibodies to new allergen families in 2007. Six subjects showed IgE reactivity to 1 additional allergen family, and 1 patient showed IgE reactivities to 3 different allergen families In summary, having analyzed 85 allergens belonging to 50 allergen families, no sensitization to a new allergen family could be detected, except 1 possible sensitization to a single allergen (ie, Act d 2) that could not be reinvestigated (Fig 2). By contrast, IgE reactivities to several allergen families disappeared and were not detectable after 10 years in 2007.

Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults.  
Lupinek C, Marth K, Niederberger V, Valenta R.
J Allergy Clin Immunol 2012 Aug 3;

Index
Allergy and Intolerance Abstracts
Green head ant anaphylaxis.
A four-year-old girl developed anaphylaxis following ant stings at her parent's property in country New South Wales. The offending insect was identified by an entomologist as the green head ant.

A case of ant anaphylaxis.  
Mehr S, Brown S.
J Paediatr Child Health 2012 Mar;48(3):E101-E104

Click to view abstract

Index
Allergy and Intolerance Abstracts
Contact allergy to gold in patients with oral lichen lesions.
The aetiology of oral lichen lesions is obscure. In this study the frequency of contact allergy to gold in 83 patients with oral lichen lesions was compared with that in two control groups, comprising 319 age- and gender-matched patients with dermatitis selected from files and 83 clinically examined dermatitis patients. All patients were tested epicutaneously with gold sodium thiosulphate. The two control groups tested were under examination for a tentative diagnosis of allergic dermatitis not related to oral problems. The frequency of contact allergy to gold was 28.9% in the patients with oral lichen lesions, 18.2% in patients selected from files, and 22.9% in the clinically examined control patients. The difference in frequency between patients with oral lichen lesions and those taken from files was statistically significant

Contact allergy to gold in patients with oral lichen lesions.  
Ahlgren C, Bruze M, Moller H, Gruvberger B, Axell T, Liedholm R, Nilner K.
Acta Derm Venereol 2012 Mar;92(2):138-143

Click to view abstract

Index
Allergy and Intolerance Abstracts
Bullous drug eruption with Nigella sativa oil.
Nigella sativa (Black cumin) is classically used for its various therapeutic properties, particularly in the field of allergic diseases. A 53-year-old woman was hospitalized for febrile rash consisting of erythematous plaques with vesicles and bullous lesions. She had Nigella sativa oil applied to her skin and ingested it for two weeks. Cutaneous histopathology revealed sub-epidermal detachment and necrosis of the epidermal surface consistent with toxic epidermal necrolysis. The lesions healed slowly, but depigmented macules persisted three months later. Patch tests for Nigella sativa oil were strongly positive.

Bullous drug eruption with Nigella sativa oil. [French]  
Gelot P, Bara-Passot C, Gimenez-Arnau E, Beneton N, Maillard H, Celerier P.
Ann Dermatol Venereol 2012 Apr;139(4):287-291

Click to view abstract

Index
Allergy and Intolerance Abstracts
Type I variant of Kounis syndrome secondary to wasp sting.
A 53-year-old, previously healthy man was admitted to the emergency department of the University of Parma because of erythematosus rash followed by chest discomfort 30 minutes after being stung on the neck by a wasp. A diagnosis of Type I variant of Kounis syndrome secondary to wasp sting was made. Kounis syndrome (KS) is described as “the coincidental occurrence of chest pain and allergic reactions accompanied by clinical and laboratory findings of classic angina pectoris caused by inflammatory mediators released during the allergic insult.” Three types of syndrome are recognized: type 1 appears in patients with normal coronary arteries, type 2 occurs in patients with a preexisting atheromatous disease, and type 3 (drug-eluting stent thrombosis) occurs in patients with stent thrombosis.

Type I variant of Kounis syndrome secondary to wasp sting.  
Ridolo E, Olivieri E, Montagni M, Rolli A, Senna GE.
Ann Allergy Asthma Immunol 2012 Jul;109(1):79-81

Index

Allergen-, Food allergy-, Intolerance-related articles

The complexity of allergic patients' IgE repertoire correlates with serum concentration of allergen-specific IgE.  
Willumsen N, Holm J, Christensen LH, Wurtzen PA, Lund K.
Clin Exp Allergy 2012 Aug;42(8):1227-1236
Click to view abstract

Wheat-dependent exercise-induced anaphylaxis: Pros and cons of recombinant omega-5gliadin and glutenins, or their epitope peptides, in diagnosis.  
Tuckova L, Sanchez D, Tlaskalova-Hogenova H, Panzner P.
Clin Exp Allergy 2012 Aug;42(8):1146-1149

Old questions and novel clues: Complexity of IgE repertoires.  
Kleine-Tebbe J.
Clin Exp Allergy 2012 Aug;42(8):1142-1145

Recombinant high molecular weight-glutenin subunit-specific IgE detection is useful in identifying wheat-dependent exercise-induced anaphylaxis complementary to recombinant omega-5 gliadin-specific IgE test.  
Takahashi H, Matsuo H, Chinuki Y, Kohno K, Tanaka A, Maruyama N, Morita E.
Clin Exp Allergy 2012 Aug;42(8):1293-1298
Click to view abstract

Skin prick test and specific serum IgE in the diagnostic evaluation of suspected cow's milk and hen's egg allergy in children: does one replace the other?  
Mehl A, Niggemann B, Keil T, Wahn U, Beyer K.
Clin Exp Allergy 2012 Aug;42(8):1266-1272
Click to view abstract

A multicentre retrospective study of 66 Italian children with food protein-induced enterocolitis syndrome: different management for different phenotypes.  
Sopo SM, Giorgio V, Iacono ID, Novembre E, Mori F, Onesimo R.
Clin Exp Allergy 2012 Aug;42(8):1257-1265
Click to view abstract

Cercarial dermatitis, a neglected allergic disease.  
Kolarova L, Horak P, Skirnisson K, Mareckova H, Doenhoff M.
Clin Rev Allergy Immunol 2012 Aug 23;
Click to view abstract

Occupational contact allergy to cocamidopropyl betaine and its impurities.  
Suuronen K, Pesonen M, alto-Korte K.
Contact Dermatitis 2012 May;66(5):286-292
Click to view abstract

Allergic contact dermatitis probably caused by mercaptobenzothiazole in thermal undergarments.  
Tomc C, Kwasniak L, Shoureshi P, Nedorost S.
Contact Dermatitis 2012 May;66(5):294-295

Chromium in leather footwear - risk assessment of chromium allergy and dermatitis.  
Thyssen JP, Strandesen M, Poulsen PB, Menne T, Johansen JD.
Contact Dermatitis 2012 May;66(5):279-285
Click to view abstract

Patch test characteristics of patients referred for suspected contact allergy of the feet--retrospective 10-year cross-sectional study of the IVDK data.  
Landeck L, Uter W, John SM.
Contact Dermatitis 2012 May;66(5):271-278
Click to view abstract

Occupational food-related hand dermatoses seen over a 10-year period.  
Vester L, Thyssen JP, Menne T, Johansen JD.
Contact Dermatitis 2012 May;66(5):264-270
Click to view abstract

Patch testing with constituents of Compositae mixes.  
Paulsen E, Andersen KE.
Contact Dermatitis 2012 May;66(5):241-246
Click to view abstract

Sesquiterpene lactone mix as a diagnostic tool for Asteraceae allergic contact dermatitis: chemical explanation for its poor performance and Sesquiterpene lactone mix II as a proposed improvement.  
Jacob M, Brinkmann J, Schmidt TJ.
Contact Dermatitis 2012 May;66(5):233-240
Click to view abstract

Pathogenesis of food allergy in the pediatric patient.  
Chin S, Vickery BP.
Curr Allergy Asthma Rep 2012 Aug 30;
Click to view abstract

Exposure to cats: update on risks for sensitization and allergic diseases.  
Dharmage SC, Lodge CL, Matheson MC, Campbell B, Lowe AJ.
Curr Allergy Asthma Rep 2012 Aug 10;
Click to view abstract

Hypersensitivity reactions in the anesthesia setting/allergic reactions to anesthetics.  
Mertes PM, Demoly P, Malinovsky JM.
Curr Opin Allergy Clin Immunol 2012 Aug;12(4):361-368
Click to view abstract

Diagnostic issues in pediatric drug allergy.  
Caubet JC, Eigenmann PA.
Curr Opin Allergy Clin Immunol 2012 Aug;12(4):341-347
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Progress in understanding hypersensitivity drug reactions: an overview.  
Blanca M, Thong B.
Curr Opin Allergy Clin Immunol 2012 Aug;12(4):337-340

Acetaminophen-induced exanthem of the breasts.  
Arora R, Maddox CL.
Cutis 2012 Jun;89(6):284-286
Click to view abstract

Food allergy in atopic dermatitis. [German]  
Wichmann K, Heratizadeh A, Werfel T.
Hautarzt 2012 Apr;63(4):315-324
Click to view abstract

Exciting and clinically relevant advances in the diagnosis of food allergies. [German]  
Merk HF, Werfel T.
Hautarzt 2012 Apr;63(4):286-287

Food-associated anaphylaxis. Data from the anaphylaxis registry. [German]  
Dolle S, Hompes S, Grunhagen J, Worm M.
Hautarzt 2012 Apr;63(4):294-298
Click to view abstract

Severe toxic dermatitis after injection lipolysis. [German]  
Mokosch A, Mota R, Gerber PA, Homey B.
Hautarzt 2012 Apr;63(4):282-284
Click to view abstract

Update on meat allergy. alpha-Gal: a new epitope, a new entity?. [German]  
Jappe U.
Hautarzt 2012 Apr;63(4):299-306
Click to view abstract

Special aspects of food allergy in children. [German]  
Niggemann B.
Hautarzt 2012 Apr;63(4):288-293
Click to view abstract

Windows of lead exposure sensitivity, attained height, and body mass index at 48 months.  
Afeiche M, Peterson KE, Sanchez BN, Schnaas L, Cantonwine D, Ettinger AS, Solano-Gonzalez M, Hernandez-Avila M, Hu H, Tellez-Rojo MM.
J Pediatr 2012 Jun;160(6):1044-1049
Click to view abstract

Oral exposure to Mal d 1 affects the immune response in patients with birch pollen allergy.  
Geroldinger-Simic M, Kinaciyan T, Nagl B, Baumgartner-Durchschlag U, Huber H, Ebner C, Lidholm J, Bartel D, Vieths S, Jahn-Schmid B, Bohle B.
J Allergy Clin Immunol 2012 Aug 23;
Click to view abstract

Utility of casein-specific IgE levels in predicting reactivity to baked milk.  
Caubet JC, Nowak-Wegrzyn A, Moshier E, Godbold J, Wang J, Sampson HA.
J Allergy Clin Immunol 2012 Aug 23;

Sensitization to cross-reactive carbohydrate determinants in 2 patients with Hymenoptera venom allergy and alcoholic cardiomyopathy.  
Valcarcel MA, Vidal C, Armisen M, Rodriguez V, Gonzalez-Quintela A.
J Allergy Clin Immunol 2012 Aug 15;

Selective elimination diet based on skin testing has suboptimal efficacy for adult eosinophilic esophagitis.  
Molina-Infante J, Martin-Noguerol E, varado-Arenas M, Porcel-Carreno SL, Jimenez-Timon S, Hernandez-Arbeiza FJ.
J Allergy Clin Immunol 2012 Aug 3;

Overall prevalence of self-reported food allergy in Canada.  
Soller L, Ben-Shoshan M, Harrington DW, Fragapane J, Joseph L, St PY, Godefroy SB, La VS, Elliott SJ, Clarke AE.
J Allergy Clin Immunol 2012 Aug 3;

Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults.  
Lupinek C, Marth K, Niederberger V, Valenta R.
J Allergy Clin Immunol 2012 Aug 3;

Organ-specific symptoms during oral food challenge in children with food allergy.  
Ahrens B, Niggemann B, Wahn U, Beyer K.
J Allergy Clin Immunol 2012 Aug;130(2):549-551

Dietary baked egg accelerates resolution of egg allergy in children.  
Leonard SA, Sampson HA, Sicherer SH, Noone S, Moshier EL, Godbold J, Nowak-Wegrzyn A.
J Allergy Clin Immunol 2012 Aug;130(2):473-480

A case of ant anaphylaxis.  
Mehr S, Brown S.
J Paediatr Child Health 2012 Mar;48(3):E101-E104
Click to view abstract

Influenza vaccination of the egg-allergic individual: 2012 update.  
Mullins RJ, Gold MS.
Med J Aust 2012 Jun 18;196(11):682

Behavioral feeding problems and parenting stress in eosinophilic gastrointestinal disorders in children.  
Wu YP, Franciosi JP, Rothenberg ME, Hommel KA.
Pediatr Allergy Immunol 2012 Aug 13;
Click to view abstract

Clomipramine hypersensitivity with predominantly pulmonary involvement. [French]  
Gallego J, Hauss PA, Salaun M, Picard D, Bota S, Lachkar S, Dominique S, Thiberville L.
Rev Mal Respir 2012 Mar;29(3):430-434
Click to view abstract

Physiopathology of aspirin intolerant asthma. [French]  
Carsin A, Bienvenu J, Pacheco Y, Devouassoux G.
Rev Mal Respir 2012 Feb;29(2):118-127
Click to view abstract

Asthma triggered by food. [French]  
Rance F, Drouet M.
Rev Mal Respir 2012 Feb;29(2):105-107

Anaphylaxis to black widow spider antivenom.  
Hoyte CO, Cushing TA, Heard KJ.
Am J Emerg Med 2012 Jun;30(5):836-2
Click to view abstract

Contact sensitization to common haptens is associated with atopic dermatitis: new insight.  
Thyssen JP, Linneberg A, Engkilde K, Menne T, Johansen JD.
Br J Dermatol 2012 Jun;166(6):1255-1261
Click to view abstract

The composition of house dust mite is critical for mucosal barrier dysfunction and allergic sensitisation.  
Post S, Nawijn MC, Hackett TL, Baranowska M, Gras R, van Oosterhout AJ, Heijink IH.
Thorax 2012 Jun;67(6):488-495
Click to view abstract

Hypersensitivity reactions to dapsone: a systematic review.  
Lorenz M, Wozel G, Schmitt J.
Acta Derm Venereol 2012 Mar;92(2):194-199
Click to view abstract

Contact allergy to gold in patients with oral lichen lesions.  
Ahlgren C, Bruze M, Moller H, Gruvberger B, Axell T, Liedholm R, Nilner K.
Acta Derm Venereol 2012 Mar;92(2):138-143
Click to view abstract

Drug-induced pseudoleucoderma: a commentary.  
Minder E.
Acta Derm Venereol 2012 Mar;92(2):220

Inverse association between rheumatoid arthritis and contact allergy.  
Engkilde K, Thyssen JP, Bangsgaard N, Menne T, Johansen JD.
Acta Derm Venereol 2012 Mar;92(2):175-176

Is there any relationship between allergic sensitization to milk and animal allergens in atopic adults?  
Liccardi G, Salzillo A, Piccolo A, Foglia M, Russo M, D'Amato M, Stanziola A, Bovenzi D, Sapio C, Pio R, D'Amato G.
Eur Ann Allergy Clin Immunol 2012 Jun;44(3):141-143
Click to view abstract

Anaphylaxis: lack of hospital doctors' knowledge of adrenaline (epinephrine) administration in adults could endanger patients' safety.  
Droste J, Narayan N.
Eur Ann Allergy Clin Immunol 2012 Jun;44(3):122-127
Click to view abstract

IgE-mediated metamizol allergy and the usefulness of the cellular allergen stimulation test.  
Couto M, Gaspar A, Piedade S, Arede C, Menezes M, Sousa MJ, Sousa G, Morais-Almeida M.
Eur Ann Allergy Clin Immunol 2012 Jun;44(3):113-116
Click to view abstract

Features of sensitization to airborne allergens among extra-European immigrants living in 2 distinct areas of Northern Italy.  
Asero R, Conte M, Senna GE.
Eur Ann Allergy Clin Immunol 2012 Jun;44(3):107-112
Click to view abstract

Colonoscopic allergen provocation test with rBet v 1 in patients with pollen-associated food allergy.  
Pickert CN, Lorentz A, Manns MP, Bischoff SC.
Allergy 2012 Aug 23;
Click to view abstract

Sensitization and symptoms associated with soybean exposure in processing plants in South Africa.  
Harris-Roberts J, Robinson E, Fishwick D, Fourie A, Rees D, Spies A, Curran A, Sen D, Barber C.
Am J Ind Med 2012 May;55(5):458-464
Click to view abstract

Occupational contact allergens: are they also associated with occupational asthma?  
Arrandale VH, Liss GM, Tarlo SM, Pratt MD, Sasseville D, Kudla I, Holness DL.
Am J Ind Med 2012 Apr;55(4):353-360
Click to view abstract

The incidence of work-related asthma-like symptoms and dust exposure in Norwegian smelters.  
Soyseth V, Johnsen HL, Henneberger PK, Kongerud J.
Am J Respir Crit Care Med 2012 Jun 15;185(12):1280-1285
Click to view abstract

Systemic reactivation of contact eczema following tramadol administration in a patient with buprenorphine-induced eczema. [French]  
Schmutz JL, Trechot P.
Ann Dermatol Venereol 2012 Apr;139(4):335-336

Bullous drug eruption with Nigella sativa oil. [French]  
Gelot P, Bara-Passot C, Gimenez-Arnau E, Beneton N, Maillard H, Celerier P.
Ann Dermatol Venereol 2012 Apr;139(4):287-291
Click to view abstract

Profilin cross-reactive panallergen causes latex sensitization in the pediatric population allergic to pollen.  
Casquete-Roman E, Rosado-Gil T, Postigo I, Guisantes JA, Fernandez M, Torres HE, Martinez-Quesada J.
Ann Allergy Asthma Immunol 2012 Sep;109(3):215-219
Click to view abstract

Allergen of the month-downy chess.  
Weber RW.
Ann Allergy Asthma Immunol 2012 Aug;109(2):A10

Allergy alerts in electronic health records for hospitalized patients.  
Gonzalez-Gregori R, Dolores Hernandez Fernandez De Rojas, Lopez-Salgueiro R, az-Palacios M, Garcia AN.
Ann Allergy Asthma Immunol 2012 Aug;109(2):137-140
Click to view abstract

Farming-associated environmental exposures and effect on atopic diseases.  
Poole JA.
Ann Allergy Asthma Immunol 2012 Aug;109(2):93-98

Adherence to environmental control measures.  
Desai M, Oppenheimer J.
Ann Allergy Asthma Immunol 2012 Aug;109(2):85-86

Drug allergy. [Japanese]  
Yamaguchi M.
Arerugi 2012 Jun;61(6):753-759

Anaphylaxis induced by lentil inhalation.  
Aysenur K, Akan A, Mustafa E, Muge T, Kocabas CN.
Asian Pac J Allergy Immunol 2012 Jun;30(2):167-169
Click to view abstract


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