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 Allergy Advisor Digest - February 2012
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Read Patch testing: what allergists should know.
Read Extreme patch test reactivity to p-phenylenediamine but not to other allergens in children.
Read Non-fragrance allergens in specific cosmetic products.
Read Contact allergy to the 26 specific fragrance ingredients to be declared on cosmetic products in accordance with the EU cosmetics directive.
Read Allergic contact dermatitis caused by chromium in a mobile phone.
Read Airborne contact dermatitis to triclosan.
Read Risk of sensitization to preservatives
Read Thermographic imaging during nasal peanut challenge may be useful in the diagnosis of peanut allergy.
Read Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children.
Read Plant chitinase III Ziz m 1 stimulates multiple cytokines, most predominantly interleukin-13, from peripheral blood mononuclear cells of latex-fruit allergic patients.
Read Analysis of available diagnostic tests for latex sensitization in an at-risk population.
Read The RCPCH care pathway for food allergy in children: an evidence and consensus based national approach.
Read The RCPCH care pathway for children with drug allergies: an evidence and consensus based national approach.
Read Determinants of food allergy.
Read Fungi and allergic lower respiratory tract diseases.
Read The US Food and Drug Administration review of the safety and effectiveness of nonstandardized allergen extracts.
Read Natural course of cow's milk allergy in children with atopic dermatitis.
Read Has European Union legislation to reduce exposure to chromate in cement been effective in reducing the incidence of allergic contact dermatitis attributed to chromate in the UK?
Read Sensitisation to common allergens and respiratory symptoms in endotoxin exposed workers: a pooled analysis.
Read NIAID-sponsored 2010 guidelines for managing food allergy: applications in the pediatric population.
Read Inhalant abuse of computer cleaner manifested as angioedema.
Read Methylisothiazolinone contact allergy: a review.
Read A small bird gives severe consequences.

Abstracts shared in February 2012 Advisor Digest Newsletter

Read Presence of functional, autoreactive human milk-specific IgE in infants with cow's milk allergy.
Read Patch testing is a useful investigation in children with eczema.
Read Absence of clinical symptoms upon introduction of egg into the diet of milk-allergic infants not previously sensitised to egg.
Read IgE antibodies to animal-derived lipocalin, kallikrein and secretoglobin are markers of bronchial inflammation in severe childhood asthma
Read The sensitivity and clinical course of patients with wheat-dependent exercise-induced anaphylaxis sensitized to hydrolyzed wheat protein in facial soap.
Read Allergic asthma after flour inhalation in subjects without occupational exposure to flours.
Read Contact sensitization in very young children.
Read Hypersensitivity to total parenteral nutrition fat-emulsion component in an egg-allergic child.
Read Chacinero's lung - hypersensitivity pneumonitis due to dry sausage dust.
Read Seminal plasma hypersensitivity reactions: an updated review.

Allergy and Intolerance Abstracts
Patch testing: what allergists should know.
"Patch testing is a standardized, in vivo diagnostic test for type IV hypersensitivity reactions, resulting in allergic contact dermatitis, which clinically resembles eczema. Common allergens include fragrance chemicals, hair dyes, metals, rubber accelerators and preservatives. Known allergens at particular concentrations in optimal vehicles are tested on the upper back under occlusion for 2 days. Readings according to international criteria are usually performed on days 2 and 4. Irritant reactions can closely resemble allergic ones, and further tests may be necessary to discriminate. Interpretation of the relevance of the reactions can also be difficult, perhaps requiring repeated open application testing, work-site visits etc. Monitoring of trends in patch test positivity can be effective in primary prevention of type IV allergy."

Patch testing: what allergists should know.  
White JM.
Clin Exp Allergy 2012 Feb;42(2):180-185

Index
Allergy and Intolerance Abstracts
Extreme patch test reactivity to p-phenylenediamine but not to other allergens in children.
According to clinical impression, extreme patch test reactions (+++) to p-phenylenediamine (PPD) are not uncommon in children. This study investigated the patch test reactivity in children (aged 1-14 years) in comparison with other age groups and other allergens. A strikingly higher proportion of +++ reactions to PPD was found in children than in all other age groups (p < 0.001). No such difference was observed for the other allergens. The main suspected exposures associated with extreme reactions to PPD in children were hair dyes and 'henna tattoos'.

Extreme patch test reactivity to p-phenylenediamine but not to other allergens in children.  
Spornraft-Ragaller P, Schnuch A, Uter W.
Contact Dermatitis 2011 Oct;65(4):220-226

Click to view abstract

Index
Allergy and Intolerance Abstracts
Non-fragrance allergens in specific cosmetic products.
Between January 2000 and December 2010, the specific cosmetic products having caused allergic contact dermatitis, as well as the individual allergenic cosmetic ingredients present in them, were recorded by use of a standardized form. Among 11 different categories of cosmetic product, skin care products, followed by hair care and body-cleansing products, were most often involved. The presence of the allergenic ingredient(s) in a specific cosmetic product was confirmed according to the ingredient label in 959 of 1448 records. Six hundred and twenty-one of 959 concerned non-fragrance components, preservatives being responsible for 58% of them. Reactions to formaldehyde and formaldehyde-releasers were most often correlated with body-cleansing products, particularly 2-bromo-2-nitropropane-1,3-diol and skin care products. They were followed by the methylchloroisothiazolinone/methylisothiazolinone mixture, most frequently found as allergens in hair care and intimate hygiene products, and facial cleansers (in the last category together with diazolidinyl urea). Octocrylene was by far the most frequent (photo)allergen in sun care products.

Non-fragrance allergens in specific cosmetic products.  
Travassos AR, Claes L, Boey L, Drieghe J, Goossens A.
Contact Dermatitis 2011 Nov;65(5):276-285

Click to view abstract

Index
Allergy and Intolerance Abstracts
Contact allergy to the 26 specific fragrance ingredients to be declared on cosmetic products in accordance with the EU cosmetics directive.
The EU Cosmetics Directive states that 26 specific fragrance ingredients, known to cause allergic contact dermatitis, must be declared on the ingredient lists of cosmetic products. This study investigate frequencies of sensitization to the 26 individual fragrances and evaluate their importance as screening markers of fragrance allergy. This was a retrospective study based on data from the Department of Dermato-Allergology, Copenhagen University Hospital Gentofte. Eczema patients (n = 1508) were patch tested (January 2008 to July 2010) with the 26 fragrance ingredients. Sensitization to the 26 fragrances was identified in 115 (7.6%) subjects. The most frequent allergens were Evernia furfuracea (n = 50), Evernia prunastri (n = 31), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (n = 24). Including fragrance mix I, fragrance mix II and Myroxylon pereirae, 196 (13.0%) had a fragrance allergy. Testing with the 26 fragrances additionally identified 23 subjects who would otherwise have gone undetected. The majority (75.7%) of positive reactions to the 26 fragrances were of clinical relevance. Sensitization to the 26 individual fragrance ingredients was identified in 7.6% of the subjects patch tested. Most reactions were of clinical relevance. Fragrance-allergic subjects would be missed if testing with the individual fragrance ingredients was not performed.

Contact allergy to the 26 specific fragrance ingredients to be declared on cosmetic products in accordance with the EU cosmetics directive.  
Heisterberg MV, Menne T, Johansen JD.
Contact Dermatitis 2011 Nov;65(5):266-275

Click to view abstract

Index
Allergy and Intolerance Abstracts
Allergic contact dermatitis caused by chromium in a mobile phone.
Allergic contact dermatitis caused by chromium in a mobile phone.

Allergic contact dermatitis caused by chromium in a mobile phone.  
Tan S, Nixon R.
Contact Dermatitis 2011 Oct;65(4):246-247

Index
Allergy and Intolerance Abstracts
Airborne contact dermatitis to triclosan.
Airborne contact dermatitis to triclosan. Triclosan is a preservative in cosmetic products, soaps, detergents, shampoos, bath additives, deodorants, foot powders and sprays, disposable paper products, antiodor insoles and hose, laundry products. Also in the treatment of textiles.

Airborne contact dermatitis to triclosan.  
Savage L, Rose R, Wilkinson M.
Contact Dermatitis 2011 Oct;65(4):239-240

Index
Allergy and Intolerance Abstracts
Risk of sensitization to preservatives
This study estimated the risk of sensitization to selected preservatives. The occurrence of preservatives in 3541 leave-on products based on the labelling of the ingredients was documented. Frequency of sensitization to preservatives was analysed on the basis of Information Network of Departments of Dermatology data for 2006-2009. As an estimate of sensitization risk, the sensitization exposure quotient (SEQ) was calculated. The SEQs varied greatly, offering a ranking regarding risk of sensitization: phenoxyethanol (SEQ: 0.06), benzyl alcohol (0.30), parabens (0.35), sorbates (0.92), benzoates (1.35), formaldehyde-releasers (1.6), methylisothiazolinone (MI) (1.7), iodopropynyl butylcarbamate (3.4), methylchloroisothiazolinone/MI (9.0), and 2-bromo-2-nitropropane-1,3-diol (13). There was a good correlation between the ranking of substances according to potency (hazard) and the ranking of the SEQ (risk).

Risk of sensitization to preservatives estimated on the basis of patch test data and exposure, according to a sample of 3541 leave-on products.  
Schnuch A, Mildau G, Kratz EM, Uter W.
Contact Dermatitis 2011 Sep;65(3):167-174

Click to view abstract

Index
Allergy and Intolerance Abstracts
Thermographic imaging during nasal peanut challenge may be useful in the diagnosis of peanut allergy.
This feasibility study shows thermography can detect inflammation caused by nasal challenges whilst employing one thousand-fold less peanut than an oral challenge. This novel technique could be developed to provide a rapid, safe and objective clinical allergy test

Thermographic imaging during nasal peanut challenge may be useful in the diagnosis of peanut allergy.  
Clark A, Mangat J, King Y, Islam S, Anagnostou K, Foley L, Deighton J, Ewan P.
Allergy 2012 Feb 6;

Index
Allergy and Intolerance Abstracts
Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children.
The aim of the study was to evaluate the basophil allergen threshold sensitivity (CD-sens) and antibodies to peanut allergen components in relation to DBPCFC in the diagnoses of peanut allergy in children. Twenty-five children had a positive DBPCFC, and 92% of these were positive in CD-sens to peanut and Ara h 2. Two children with a positive DBPCFC were classified as 'low-responders' and were not further evaluated. Children positive in DBPCFC had higher CD-sens values to peanut compared with children negative in DBPCFC. A positive DBPCFC correspond with increased levels of IgE-antibody to Ara h 1, 2 and 3 compared with those with a negative challenge. All children with a negative CD-sens were negative in DBPCFC. In this study, a negative CD-sens to peanut excluded peanut allergy. Both tests, CD-sens to peanut and immunoassay for IgE-antibody to the peanut components, appear to be safe, time saving and cost-effective complements to DBPCFC.

Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children.  
Glaumann S, Nopp A, Johansson SG, Rudengren M, Borres MP, Nilsson C.
Allergy 2012 Feb;67(2):242-247

Index
Allergy and Intolerance Abstracts
Plant chitinase III Ziz m 1 stimulates multiple cytokines, most predominantly interleukin-13, from peripheral blood mononuclear cells of latex-fruit allergic patients.
Indian jujube is a fruit abundantly cultivated in Taiwan. Its major allergen in latex-fruit syndrome is Ziz m 1 of the chitinase III family. The Ziz m 1 Pichia (rZiz m 1-P) has chitinase activity but not Ziz m 1 E. coli (rZiz m 1-E). This study examined whether plant chitinase III, using rZiz m 1-P and rZiz m 1-E, can stimulate allergic inflammation similar to that of mammalian chitinases. Five patients allergic to latex-Indian jujube and five nonallergic controls were evaluated. Interleukin-13 significantly increased in rZiz m 1-P stimulated PBMC of allergic subjects but was undetectable when stimulated with rZiz m 1-E. The stimulation index significantly increased in IL-13, IL-5, IL-1beta, and tumor necrosis factor beta after rZiz m 1-P stimulation. The biological function of chitinase activity is required for Ziz m 1 to induce a Th2-specific immune response. This is the first report on PBMC responses of latex-fruit syndrome subjects toward an active exogenous plant class III chitinase that can stimulate multiple cytokines, especially IL-13, from allergic subjects. This implies the role of cross-reactive food allergens in propagating allergic inflammation among allergic subjects.

Plant chitinase III Ziz m 1 stimulates multiple cytokines, most predominantly interleukin-13, from peripheral blood mononuclear cells of latex-fruit allergic patients.  
Lee MF, Lin SJ, Wang NM, Wu HJ, Chen YH.
Ann Allergy Asthma Immunol 2012 Feb;108(2):113-116

Index
Allergy and Intolerance Abstracts
Analysis of available diagnostic tests for latex sensitization in an at-risk population.
Lack of a Food and Drug Administration (FDA)-approved skin testing reagent for latex allergy in the United States requires reliance on patient history and serologic assays for diagnosis. This study determined the diagnostic sensitivity, specificity, and predictive values of an FDA-cleared antilatex IgE serology test and an enzyme-linked immunosorbent assay (ELISA) with various sources of latex protein antigens in an at-risk but unselected population of health care workers. The performance of the FDA-cleared antilatex IgE serologic test for latex allergy has much lower sensitivity than previously reported. This finding confirms that this serologic test should be used only for patients with a history of latex allergy and not for screening the population with a low prevalence of latex sensitization.

Analysis of available diagnostic tests for latex sensitization in an at-risk population.  
Accetta Pedersen DJ, Klancnik M, Elms N, Wang ML, Hoffmann RG, Kurup VP, Kelly KJ.
Ann Allergy Asthma Immunol 2012 Feb;108(2):94-97

Index
Allergy and Intolerance Abstracts
The RCPCH care pathway for food allergy in children: an evidence and consensus based national approach.
The Royal College of Paediatrics and Child Health (RCPCH) Science and Research Department was commissioned by the Department of Health to develop national care pathways for children with allergies; food allergy is the second pathway. The pathways focus on defining the competences required to improve the equity of care received by children with allergic conditions. The food allergy pathway was developed by a multidisciplinary working group and was based on a comprehensive review of the evidence. The pathway was reviewed by a broad group of stakeholders including the public and approved by the Allergy Care Pathways Project Board and the RCPCH Clinical Standards Committee. The National Institute of Health and Clinical Excellence simultaneously established a short guideline review of community practice for children with food allergy; close communication was established between the two groups. The results are presented in two sections: a pathway algorithm and the competences. The entry points are defined and the ideal pathway of care is described from initial recognition and confirmed diagnosis through to follow-up. The range of manifestations of food allergy/intolerance is much more diverse than hitherto recognised and diagnosis can be problematic as many patients do not have classical IgE mediated disease. The pathway provides a guide for training and development of services to facilitate improvements in delivery as close to the patient's home as possible. The authors recommend that this pathway is implemented locally by a multidisciplinary team with a focus on creating networks.

The RCPCH care pathway for food allergy in children: an evidence and consensus based national approach.  
Fox AT, Lloyd K, Arkwright PD, Bhattacharya D, Brown T, Chetcuti P, East M, Gaventa J, King R, Martinez A, Meyer R, Parikh A, Perkin M, Shah N, Tuthill D, Walsh J, Waddell L, Warner J.
Arch Dis Child 2011 Nov;96 Suppl 2i25-i29

Click to view abstract

Index
Allergy and Intolerance Abstracts
The RCPCH care pathway for children with drug allergies: an evidence and consensus based national approach.
The Royal College of Paediatrics and Child Health (RCPCH) was commissioned by the Department of Health to develop a drug allergy pathway. It focuses on defining the competences to improve the equity of care received by children. The drug pathway was developed by a multidisciplinary working group and was based on a comprehensive review of evidence. The team decided to focus on IgE-mediated reactions as these have the greatest potential to be life-threatening. The results are presented in four parts: evidence review, pathway mapping, external review and core knowledge documents. The evidence review found a high percentage of putative penicillin allergy is not confirmed by objective testing and that resensitisation to beta-lactam drugs was infrequent. It also highlighted the importance of a detailed history and accurate diagnosis along with clear communication of test results to both family and primary care. This pathway demonstrates the spectrum of drug allergy is varied and may differ for young children compared with older children and adults. The authors highlight the paucity of evidence to support allergy testing for most drugs, in children, other than supervised incremental provocation tests (when indicated). Acute presentations require emergency health professionals to address underlying allergic issues, including recognition and avoidance of potential drug allergy triggers. Non-acute presentations may include multi-system symptoms which may have a broad differential diagnosis; this document signposts to the relevant partners in the RCPCH care pathway portfolio. Management combines a care package including a definitive diagnosis, initiating treatments and ongoing education

The RCPCH care pathway for children with drug allergies: an evidence and consensus based national approach.  
du TG, Lloyd K, Sinnott L, Forster D, Austin M, Clark C, Tuthill D, Lucas JS, Brathwaite N, Warner J.
Arch Dis Child 2011 Nov;96 Suppl 2i15-i18

Click to view abstract

Index
Allergy and Intolerance Abstracts
Determinants of food allergy.
The determination of factors that make certain foods allergenic is still not clearly understood. Only a tiny fraction of thousands of proteins and other molecules is responsible for inducing food allergy. In this review, the authors present 3 examples of food allergies with disparate clinical presentations: peanut, soy, and mammalian meat. The potential relationships between allergen structure and function, emphasizing the importance of cross-reactive determinants, immunoglobulin E antibodies to the oligosaccharides, and the immune responses induced in humans are discussed.

Determinants of food allergy.  
Masilamani M, Commins S, Shreffler W.
Immunol Allergy Clin North Am 2012 Feb;32(1):11-33

Index
Allergy and Intolerance Abstracts
Fungi and allergic lower respiratory tract diseases.
"Asthma is a common disorder that in 2009 afflicted 8.2% of adults and children, 24.6 million persons, in the United States. In patients with moderate and severe persistent asthma, there is significantly increased morbidity, use of health care support, and health care costs. Epidemiologic studies in the United States and Europe have associated mold sensitivity, particularly to Alternaria alternata and Cladosporium herbarum, with the development, persistence, and severity of asthma. In addition, sensitivity to Aspergillus fumigatus has been associated with severe persistent asthma in adults. Allergic bronchopulmonary aspergillosis (ABPA) is caused by A fumigatus and is characterized by exacerbations of asthma, recurrent transient chest radiographic infiltrates, coughing up thick mucus plugs, peripheral and pulmonary eosinophilia, and increased total serum IgE and fungus-specific IgE levels, especially during exacerbation. The airways appear to be chronically or intermittently colonized by A fumigatus in patients with ABPA. ABPA is the most common form of allergic bronchopulmonary mycosis (ABPM); other fungi, including Candida, Penicillium, and Curvularia species, are implicated. The characteristics of ABPM include severe asthma, eosinophilia, markedly increased total IgE and specific IgE levels, bronchiectasis, and mold colonization of the airways. The term severe asthma associated with fungal sensitization (SAFS) has been coined to illustrate the high rate of fungal sensitivity in patients with persistent severe asthma and improvement with antifungal treatment. The immunopathology of ABPA, ABPM, and SAFS is incompletely understood. Genetic risks identified in patients with ABPA include HLA association and certain T(H)2-prominent and cystic fibrosis variants, but these have not been studied in patients with ABPM and SAFS. Oral corticosteroid and antifungal therapies appear to be partially successful in patients with ABPA. However, the role of antifungal and immunomodulating therapies in patients with ABPA, ABPM, and SAFS requires additional larger studies."

Fungi and allergic lower respiratory tract diseases.  
Knutsen AP, Bush RK, Demain JG, Denning DW, Dixit A, Fairs A, Greenberger PA, Kariuki B, Kita H, Kurup VP, Moss RB, Niven RM, Pashley CH, Slavin RG, Vijay HM, Wardlaw AJ.
J Allergy Clin Immunol 2012 Feb;129(2):280-291

Index
Allergy and Intolerance Abstracts
The US Food and Drug Administration review of the safety and effectiveness of nonstandardized allergen extracts.
Currently licensed nonstandardized allergen extracts were reviewed according to extract type. Available data were collected from medical and nonscientific search engines. Nomenclature was ascertained by consulting www.itis.gov or www.atcc.org. The FDA's Adverse Event Reporting System was probed for events associated with extract use. Provisional threshold levels of safety and effectiveness were established, and extracts were sorted according to whether they met the thresholds. In the Adverse Event Reporting System, there were 178 adverse event reports, including 13 deaths, associated with allergen extract use over 23 years. No single group of extracts predominated. Among 1269 allergen extracts reviewed, there were 480 for which use in the diagnosis and treatment of allergic disease were addressed in the literature, 207 for which only diagnostic use was addressed, 565 for which minimal or no supportive literature was identified, and 17 for which potential safety concerns were found. When used according to professional guidelines, almost all nonstandardized allergen extracts for diagnosis and therapy appear to be safe. Provisional thresholds of effectiveness were met by 54% of extracts reviewed

The US Food and Drug Administration review of the safety and effectiveness of nonstandardized allergen extracts.  
Slater JE, Menzies SL, Bridgewater J, Mosquera A, Zinderman CE, Ou AC, Maloney D, Cook CM, Rabin RL.
J Allergy Clin Immunol 2012 Feb 15;

Index
Allergy and Intolerance Abstracts
Natural course of cow's milk allergy in children with atopic dermatitis.
In this Korean study, the authors reviewed the medical records of 115 children who were diagnosed with AD and cow's milk allergy before 24 months of age. The median age for tolerance to cow's milk was found to be 67 months. Peak cow's milk-specific IgE level within 24 months after birth was the most important factor for prediction of the outcome of cow's milk allergy. In conclusion, half of the children younger than 24 months of age with AD and cow's milk allergy could tolerate cow's milk at 67 months of age. The peak cow's milk-specific IgE level within the first 24 months of birth is useful to predict the prognosis of cow's milk allergy in children with AD.

Natural course of cow's milk allergy in children with atopic dermatitis.  
Suh J, Lee H, Lee JH, Cho J, Yu JS, Kim J, Han Y, Ahn K, Lee SI.
J Korean Med Sci 2011 Sep;26(9):1152-1158

Click to view abstract

Index
Allergy and Intolerance Abstracts
Has European Union legislation to reduce exposure to chromate in cement been effective in reducing the incidence of allergic contact dermatitis attributed to chromate in the UK?
The timing of this significant decline in the UK incidence of chromate attributed ACD, and the greater decline in workers potentially exposed to cement strongly suggests that the EU Directive2003/53/EC was successful in reducing exposure to chromate in cement in the UK

Has European Union legislation to reduce exposure to chromate in cement been effective in reducing the incidence of allergic contact dermatitis attributed to chromate in the UK?  
Stocks SJ, McNamee R, Turner S, Carder M, Agius RM.
Occup Environ Med 2012 Feb;69(2):150-152

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Index
Allergy and Intolerance Abstracts
Sensitisation to common allergens and respiratory symptoms in endotoxin exposed workers: a pooled analysis.
Occupational endotoxin exposure has a protective effect on allergic sensitisation and hay fever but increases the risk for organic dust toxic syndrome and chronic bronchitis. Endotoxin's protective effects are most clearly observed among agricultural workers

Sensitisation to common allergens and respiratory symptoms in endotoxin exposed workers: a pooled analysis.  
Basinas I, Schlunssen V, Heederik D, Sigsgaard T, Smit LA, Samadi S, Omland O, Hjort C, Madsen AM, Skov S, Wouters IM.
Occup Environ Med 2012 Feb;69(2):99-106

Click to view abstract

Index
Allergy and Intolerance Abstracts
NIAID-sponsored 2010 guidelines for managing food allergy: applications in the pediatric population.
"Data from many studies have suggested a rise in the prevalence of food allergies during the past 10 to 20 years. Currently, no curative treatments for food allergy exist, and there are no effective means of preventing the disease. Management of food allergy involves strict avoidance of the allergen in the patient's diet and treatment of symptoms as they arise. Because diagnosis and management of the disease can vary between clinical practice settings, the National Institute of Allergy and Infectious Diseases (NIAID) sponsored development of clinical guidelines for the diagnosis and management of food allergy. The guidelines establish consensus and consistency in definitions, diagnostic criteria, and management practices. They also provide concise recommendations on how to diagnose and manage food allergy and treat acute food allergy reactions. The original guidelines encompass practices relevant to patients of all ages, but food allergy presents unique and specific concerns for infants, children, and teenagers. To focus on those concerns, we describe here the guidelines most pertinent to the pediatric population."

NIAID-sponsored 2010 guidelines for managing food allergy: applications in the pediatric population.  
Burks AW, Jones SM, Boyce JA, Sicherer SH, Wood RA, Assa'ad A, Sampson HA.
Pediatrics 2011 Nov;128(5):955-965

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Index
Allergy and Intolerance Abstracts
Inhalant abuse of computer cleaner manifested as angioedema.
A 25-year-old white man who was brought to the emergency department after inhaling aerosolized computer-cleaning spray composed of difluoroethane. He was found to have marked upper and lower lip facial swelling consistent with angioedema. The patient also had a prolonged QT interval, mild inspiratory stridor, but no urticaria. In this case, we believe the difluoroethane-related angioedema represents either idiopathic or bradykinin-induced angioedema.

Inhalant abuse of computer cleaner manifested as angioedema.  
Kurniali PC, Henry L, Kurl R, Meharg JV.
Am J Emerg Med 2012 Jan;30(1):265-265

Click to view abstract

Index
Allergy and Intolerance Abstracts
Methylisothiazolinone contact allergy: a review.
In the early 2000s the preservative methylisothiazolinone (MI) was released as an individual preservative for industrial products and, in 2005, it was permitted for use in cosmetic products. Up until then MI had been used only in combination with methylchloroisothiazolinone (MCI). MCI/MI is one of the most frequent causes of preservative contact allergy and early studies showed that both MI and MCI are sensitizers. The prevalence of MI contact allergy is already around 1.5% and sources of exposure are associated with occupation, cosmetic products or household products. Use of MI in industrial products is not restricted and cases of occupational contact allergy to MI, e.g. in painters, are reported. The frequency of use of MI in cosmetics is low, around 1%, while up to 16.5% of household products were preserved with MI. We found 19 (1.5%) out of 1272 cosmetic products labelled with MI, primarily rinse-off products, and analysed the concentration of MI by high-performance-liquid-chromatography the ultraviolet and mass spectrometry detection. The use concentration ranged between 2 and 100 ppm. Repeated exposure to MI showed that many patients allergic to MI reacted to 50 ppm which is half the maximum permitted concentration of MI in cosmetics. The recent cases and prevalence studies on MI contact allergy could be the first sign of an epidemic of MI contact allergy. The development in prevalence of MI contact allergy should be closely monitored by including MI in the European Baseline Series at 2000 ppm

Methylisothiazolinone contact allergy: a review.  
Lundov MD, Krongaard T, Menne TL, Johansen JD.
Br J Dermatol 2011 Dec;165(6):1178-1182

Click to view abstract

Index
Allergy and Intolerance Abstracts
A small bird gives severe consequences.
In this case we report how a 31 year-old woman developed hypersensitivity pneumonitis due to her budgerigar. The suspicion that her pet was the reason for her symptoms was confirmed by the finding of specific IgG antibodies against budgerigar proteins. Clinical studies demonstrated a restrictive lung disorder, increased lymphocytes in bronchoalveolar lavage and ground glass changes in high-resolution computed tomography. The patient's symptoms receded over the course of a few days after removal of the animal, and subsequent IgG levels fell.

A small bird gives severe consequences. [Danish]  
Authried G, Andersen A, Sherson DL.
Ugeskr Laeger 2011 Dec 5;173(49):3195-3196

Click to view abstract

Index

Allergen-, Food allergy-, Intolerance-related articles

Food allergy information and deriving action levels for use.  
Chan CH, Hattersley S.
BMJ 2011;343d7208

Advisory food labels: consumers with allergies need more than 'traces' of information.  
Turner PJ, Kemp AS, Campbell DE.
BMJ 2011;343d6180

Diagnosing and investigating adverse reactions in metal on metal hip implants.  
Fary C, Thomas GE, Taylor A, Beard D, Carr A, Glyn-Jones S.
BMJ 2011;343d7441

Don't forget angio-oedema associated with ACE inhibition.  
Zauli D.
BMJ 2011;343d7710

Presence of functional, autoreactive human milk-specific IgE in infants with cow's milk allergy.  
Jarvinen KM, Geller L, Bencharitiwong R, Sampson HA.
Clin Exp Allergy 2012 Feb;42(2):238-247

Patch testing: what allergists should know.  
White JM.
Clin Exp Allergy 2012 Feb;42(2):180-185

Contact allergy in the cleaning industry: analysis of contact allergy surveillance data of the Information Network of Departments of Dermatology.  
Liskowsky J, Geier J, Bauer A.
Contact Dermatitis 2011 Sep;65(3):159-166
Click to view abstract

Allergic contact dermatitis caused by isopropyl alcohol: a missed allergen?  
Garcia-Gavin J, Lissens R, Timmermans A, Goossens A.
Contact Dermatitis 2011 Aug;65(2):101-106
Click to view abstract

The risk for cross-reactions after a cutaneous delayed-type hypersensitivity reaction to heparin preparations is independent of their molecular weight: a systematic review.  
Weberschock T, Meister AC, Bohrt K, Schmitt J, Boehncke WH, Ludwig RJ.
Contact Dermatitis 2011 Oct;65(4):187-194
Click to view abstract

Extreme patch test reactivity to p-phenylenediamine but not to other allergens in children.  
Spornraft-Ragaller P, Schnuch A, Uter W.
Contact Dermatitis 2011 Oct;65(4):220-226
Click to view abstract

Correlation between lesion site and concentration of dimethyl fumarate in different parts of shoes in patients with contact dermatitis caused by dimethyl fumarate in footwear.  
Toledo F, Silvestre JF, Cuesta L, Borrego L, Perez M.
Contact Dermatitis 2011 Aug;65(2):92-95
Click to view abstract

Patch testing with hydroxyethyl-p-phenylenediamine sulfate - cross-reactivity with p-phenylenediamine.  
Frosch PJ, Kugler K, Geier J.
Contact Dermatitis 2011 Aug;65(2):96-100
Click to view abstract

Patch testing is a useful investigation in children with eczema.  
Moustafa M, Holden CR, Athavale P, Cork MJ, Messenger AG, Gawkrodger DJ.
Contact Dermatitis 2011 Oct;65(4):208-212
Click to view abstract

Allergic contact dermatitis caused by iodophor-impregnated surgical incise drape.  
Zokaie S, White IR, McFadden JD.
Contact Dermatitis 2011 Nov;65(5):309

Allergic contact dermatitis caused by nickel in a green eye pencil.  
Travassos AR, Bruze M, Dahlin J, Goossens A.
Contact Dermatitis 2011 Nov;65(5):307-308

Provocation test with metallic palladium in a palladium-allergic patient.  
Thyssen JP, Johansen JD, Jellesen MS, Menne T.
Contact Dermatitis 2011 Nov;65(5):304-306

Octyldodecyl xyloside: a novel contact allergen.  
Wilkinson M, Powis RA.
Contact Dermatitis 2011 Nov;65(5):302-304

Non-fragrance allergens in specific cosmetic products.  
Travassos AR, Claes L, Boey L, Drieghe J, Goossens A.
Contact Dermatitis 2011 Nov;65(5):276-285
Click to view abstract

Contact allergy to the 26 specific fragrance ingredients to be declared on cosmetic products in accordance with the EU cosmetics directive.  
Heisterberg MV, Menne T, Johansen JD.
Contact Dermatitis 2011 Nov;65(5):266-275
Click to view abstract

A case of occupational allergic contact dermatitis in a plumber performing pipeline repair.  
Liippo J, Lammintausta K.
Contact Dermatitis 2011 Oct;65(4):247-248

Allergic contact dermatitis caused by chromium in a mobile phone.  
Tan S, Nixon R.
Contact Dermatitis 2011 Oct;65(4):246-247

Facial leucoderma following eczema: a new case induced by spectacle frames.  
Crepy MN, sefa-Colas L, Krief P, Langlois E, Guillemot M, Choudat D.
Contact Dermatitis 2011 Oct;65(4):243-245

Occupational allergic contact dermatitis of the ears caused by thiurams in a headset.  
Pfohler C, Korner R, Muller CS, Vogt T.
Contact Dermatitis 2011 Oct;65(4):242-243

Ascaridole, a sensitizing component of tea tree oil, patch tested at 1% and 5% in two series of patients.  
Bakker CV, Blomeke B, Coenraads PJ, Schuttelaar ML.
Contact Dermatitis 2011 Oct;65(4):240-241

Airborne contact dermatitis to triclosan.  
Savage L, Rose R, Wilkinson M.
Contact Dermatitis 2011 Oct;65(4):239-240

Contact allergy and allergic contact dermatitis in children - a review of current data.  
Simonsen AB, Deleuran M, Johansen JD, Sommerlund M.
Contact Dermatitis 2011 Nov;65(5):254-265
Click to view abstract

Allergic contact dermatitis caused by methylphenidate.  
Vashi NA, Souza A, Cohen N, Franklin B, Cohen DE.
Contact Dermatitis 2011 Sep;65(3):183-185

Acute bullous irritant contact dermatitis caused by EMLA(R) cream.  
Kluger N, Raison-Peyron N, Michot C, Guillot B, Bessis D.
Contact Dermatitis 2011 Sep;65(3):181-183

Multiple contact allergies to benzophenones.  
Sasseville D, Nantel-Battista M, Molinari R.
Contact Dermatitis 2011 Sep;65(3):179-181

Two cases of airborne allergic contact dermatitis caused by methylisothiazolinone in paint.  
Lundov MD, Mosbech H, Thyssen JP, Menne T, Zachariae C.
Contact Dermatitis 2011 Sep;65(3):176-179

Allergic contact dermatitis caused by tetracaine contained in otic drops.  
Garcia-Gavin J, onso-Gonzalez J, Gutierrez-Gonzalez E, varez-Perez A, Fernandez-Redondo V, Toribio J.
Contact Dermatitis 2011 Sep;65(3):175-176

Nickel and cobalt allergy before and after nickel regulation--evaluation of a public health intervention.  
Thyssen JP.
Contact Dermatitis 2011 Sep;65 Suppl 11-68
Click to view abstract

Patch testing with formaldehyde and formaldehyde-releasers: multicentre study in Spain (2005-2009).  
Latorre N, Borrego L, Fernandez-Redondo V, Garcia-Bravo B, Gimenez-Arnau AM, Sanchez J, Silvestre JF.
Contact Dermatitis 2011 Nov;65(5):286-292
Click to view abstract

A Summary of shoe allergic contact dermatitis caused by dimethyl fumarate in Spain.  
Silvestre JF, Toledo F, Mercader P, Gimenez-Arnau AM.
Contact Dermatitis 2011 Aug;65(2):122-123

Contact sensitization to quaternium-15 acting as a warning sign for curare allergy.  
Osdoit S, Guillet MH, Guillet G.
Contact Dermatitis 2011 Aug;65(2):120-122

Occupational contact allergy to omeprazole and fluoxetine.  
Sanz-Gallen P, Nogue S, Herrera-Mozo I, Delclos GL, Valero A.
Contact Dermatitis 2011 Aug;65(2):118-119

Action spectrum for etofenamate photoallergic contact dermatitis.  
Kerr A, Becher G, Ibbotson S, Ferguson J.
Contact Dermatitis 2011 Aug;65(2):117-118

Nickel on the Dutch market: 10 years after entry into force of the EU Nickel Directive.  
Biesterbos J, Liden C, van d.
Contact Dermatitis 2011 Aug;65(2):115-117

Patch testing in fixed drug eruptions--a 20-year review.  
Andrade P, Brinca A, Goncalo M.
Contact Dermatitis 2011 Oct;65(4):195-201
Click to view abstract

Patch testing in children with hand eczema. A 5-year multicentre study in Spain.  
Toledo F, Garcia-Bravo B, Fernandez-Redondo V, De la CJ, Gimenez-Arnau AM, Borrego L, Carrascosa JM, rmario-Hita JC, Sanchez-Pedreno P, Hervella M, Gonzalez R, Silvestre JF.
Contact Dermatitis 2011 Oct;65(4):213-219
Click to view abstract

Risk of sensitization to preservatives estimated on the basis of patch test data and exposure, according to a sample of 3541 leave-on products.  
Schnuch A, Mildau G, Kratz EM, Uter W.
Contact Dermatitis 2011 Sep;65(3):167-174
Click to view abstract

Hand eczema in hairdressers: a Danish register-based study of the prevalence of hand eczema and its career consequences.  
Lysdal SH, Sosted H, Andersen KE, Johansen JD.
Contact Dermatitis 2011 Sep;65(3):151-158
Click to view abstract

Contact allergy and human biomonitoring--an overview with a focus on metals.  
Thyssen JP, Roeske-Nielsen A, Johansen JD.
Contact Dermatitis 2011 Sep;65(3):125-137
Click to view abstract

Value of patch tests in clindamycin-related drug eruptions.  
Pereira N, Canelas MM, Santiago F, Brites MM, Goncalo M.
Contact Dermatitis 2011 Oct;65(4):202-207
Click to view abstract

Efficacy of oral hyposensitization in allergic contact dermatitis caused by nickel.  
Bonamonte D, Cristaudo A, Nasorri F, Carbone T, De PO, Angelini G, Cavani A.
Contact Dermatitis 2011 Nov;65(5):293-301
Click to view abstract

Prevalence of benzocaine and lidocaine patch test sensitivity in Denmark: temporal trends and relevance.  
Thyssen JP, Engkilde K, Menne T, Johansen JD.
Contact Dermatitis 2011 Aug;65(2):76-80
Click to view abstract

The likelihood of remission of food allergy in children: when is the optimal time for challenge?  
Wood RA.
Curr Allergy Asthma Rep 2012 Feb;12(1):42-47

Occupational causes of sarcoidosis.  
Newman KL, Newman LS.
Curr Opin Allergy Clin Immunol 2012 Feb 9;

Immunological and inflammatory responses to organic dust in agriculture.  
Poole JA, Romberger DJ.
Curr Opin Allergy Clin Immunol 2012 Feb 2;

Irritant-induced asthma.  
Labrecque M.
Curr Opin Allergy Clin Immunol 2012 Feb 9;

Validation of self-testing as a method to estimate the prevalence of nickel allergy.  
Josefson A, Svensson A, Farm G, Engfeldt M, Meding B.
Acta Derm Venereol 2011 Sep;91(5):526-530
Click to view abstract

Severe systemic reaction to topical imiquimod.  
Heikkinen AK, Susitaival P.
Acta Derm Venereol 2011 Sep;91(5):594-595

Generalized fixed drug eruption caused by pazufloxacin.  
Sawada Y, Nakamura M, Tokura Y.
Acta Derm Venereol 2011 Sep;91(5):600-601

Pseudoleucoderma after injections of afamelanotide in a patient with atopic dermatitis.  
von BW, Siebenhaar G, Hunzelmann N.
Acta Derm Venereol 2011 Sep;91(5):578-579

Absence of clinical symptoms upon introduction of egg into the diet of milk-allergic infants not previously sensitised to egg.  
Del-Rio CG, Martinez J, Fernandez-Cantalejo PJ.
Allergol Immunopathol (Madr ) 2012 Feb 3;

Double-blind, placebo-controlled food challenges in Brazilian children: Adaptation to clinical practice.  
Gushken AK, Castro AP, Yonamine GH, Corradi GA, Pastorino AC, Jacob CM.
Allergol Immunopathol (Madr ) 2012 Feb 10;

Thermographic imaging during nasal peanut challenge may be useful in the diagnosis of peanut allergy.  
Clark A, Mangat J, King Y, Islam S, Anagnostou K, Foley L, Deighton J, Ewan P.
Allergy 2012 Feb 6;

Prevention of oral food allergy sensitization via skin application of food allergen in a mouse model.  
Li W, Zhang Z, Saxon A, Zhang K.
Allergy 2012 Feb 17;

IgE antibodies to animal-derived lipocalin, kallikrein and secretoglobin are markers of bronchial inflammation in severe childhood asthma: Airway Diseases.  
Nordlund B, Konradsen JR, Kull I, Borres MP, Onell A, Hedlin G, Gronlund H.
Allergy 2012 Feb 17;

Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children.  
Glaumann S, Nopp A, Johansson SG, Rudengren M, Borres MP, Nilsson C.
Allergy 2012 Feb;67(2):242-247

The response of children with asthma to ambient particulate is modified by tobacco smoke exposure.  
Rabinovitch N, Silveira L, Gelfand EW, Strand M.
Am J Respir Crit Care Med 2011 Dec 15;184(12):1350-1357
Click to view abstract

Fungal allergen beta-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells.  
Neveu WA, Bernardo E, Allard JL, Nagaleekar V, Wargo MJ, Davis RJ, Iwakura Y, Whittaker LA, Rincon M.
Am J Respir Cell Mol Biol 2011 Dec;45(6):1133-1141
Click to view abstract

Sweet's syndrome following oral ciprofloxacin therapy. [French]  
Baybay H, Elhatimi A, Idrissi R, Gallouj S, Mikou O, Khabbal Y, Harmouch T, Amarti A, Meziane M, Mernissi FZ.
Ann Dermatol Venereol 2011 Aug;138(8-9):606-607

Hypersensitivity reactions during treatment with infliximab, etanercept, and adalimumab.  
Puxeddu I, Giori L, Rocchi V, Bazzichi L, Bombardieri S, Tavoni A, Migliorini P, Del C.
Ann Allergy Asthma Immunol 2012 Feb;108(2):123-124

Plant chitinase III Ziz m 1 stimulates multiple cytokines, most predominantly interleukin-13, from peripheral blood mononuclear cells of latex-fruit allergic patients.  
Lee MF, Lin SJ, Wang NM, Wu HJ, Chen YH.
Ann Allergy Asthma Immunol 2012 Feb;108(2):113-116

Allergen of the month-rice.  
Weber RW.
Ann Allergy Asthma Immunol 2012 Feb;108(2):A11

Capsaicin not homeopathic.  
Smith WB, Mullins RJ.
Ann Allergy Asthma Immunol 2012 Feb;108(2):132

Gastroesophageal hymenoptera stings add to causes of idiopathic anaphylaxis.  
Stoevesandt J, Grundmeier N, Trautmann A.
Ann Allergy Asthma Immunol 2012 Feb;108(2):125-126

Analysis of available diagnostic tests for latex sensitization in an at-risk population.  
Accetta Pedersen DJ, Klancnik M, Elms N, Wang ML, Hoffmann RG, Kurup VP, Kelly KJ.
Ann Allergy Asthma Immunol 2012 Feb;108(2):94-97

Multiple drug intolerance syndrome: prevalence, clinical characteristics, and management.  
Macy E, Ho NJ.
Ann Allergy Asthma Immunol 2012 Feb;108(2):88-93

Do hypoallergenic cats and dogs exist?  
Butt A, Rashid D, Lockey RF.
Ann Allergy Asthma Immunol 2012 Feb;108(2):74-76

Immunomodulatory and therapeutic potential of a mycelial lectin from Aspergillus nidulans.  
Singh RS, Bhari R, Rana V, Tiwary AK.
Appl Biochem Biotechnol 2011 Sep;165(2):624-638
Click to view abstract

The RCPCH care pathway for children at risk of anaphylaxis: an evidence and consensus based national approach to caring for children with life-threatening allergies.  
Clark A, Lloyd K, Sheikh A, Alfaham M, East M, Ewan P, Jewkes F, King R, Leech S, Maconochie I, Sinnott L, Sohi D, Tomlin S, Warner J.
Arch Dis Child 2011 Nov;96 Suppl 2i6-i9
Click to view abstract

The RCPCH care pathway for children with venom allergies: an evidence and consensus based national approach.  
Brathwaite N, du TG, Lloydhope K, Sinnott L, Forster D, Austin M, Clark C, Tuthill D, Lucas J, Warner J.
Arch Dis Child 2011 Nov;96 Suppl 2i38-i40
Click to view abstract

The RCPCH care pathway for children with latex allergies: an evidence- and consensus-based national approach.  
Lucas JS, du TG, Lloyd K, Sinnott L, Forster D, Austin M, Clark C, Tuthill D, Brathwaite N, Warner J.
Arch Dis Child 2011 Nov;96 Suppl 2i30-i33
Click to view abstract

The RCPCH care pathway for food allergy in children: an evidence and consensus based national approach.  
Fox AT, Lloyd K, Arkwright PD, Bhattacharya D, Brown T, Chetcuti P, East M, Gaventa J, King R, Martinez A, Meyer R, Parikh A, Perkin M, Shah N, Tuthill D, Walsh J, Waddell L, Warner J.
Arch Dis Child 2011 Nov;96 Suppl 2i25-i29
Click to view abstract

The RCPCH care pathway for children with drug allergies: an evidence and consensus based national approach.  
du TG, Lloyd K, Sinnott L, Forster D, Austin M, Clark C, Tuthill D, Lucas JS, Brathwaite N, Warner J.
Arch Dis Child 2011 Nov;96 Suppl 2i15-i18
Click to view abstract

The sensitivity and clinical course of patients with wheat-dependent exercise-induced anaphylaxis sensitized to hydrolyzed wheat protein in facial soap. [Japanese]  
Hiragun M, Ishii K, Hiragun T, Shindo H, Mihara S, Matsuo H, Hide M.
Arerugi 2011 Dec;60(12):1630-1640

Problem of biotin deficiency associated with milk allergic child. [Japanese]  
Imai T, Ebisawa M.
Arerugi 2011 Dec;60(12):1614-1620

Drug eruption up to date. [Japanese]  
Aihara M.
Arerugi 2011 Dec;60(12):1606-1613

A pediatric case of anaphylaxis due to octreotide.  
Azkur D, Yoldas T, Toyran M, Kocabas CN.
Asian Pac J Allergy Immunol 2011 Dec;29(4):361-363

Prevalence and clinical characteristics of adult-onset atopic dermatitis with positive skin prick testing to mites.  
Kulthanan K, Chularojanamontri L, Manapajon A, Nuchkull P.
Asian Pac J Allergy Immunol 2011 Dec;29(4):318-326

Predictors of childhood food allergy: significance and implications.  
Al-Hammadi S, Zoubeidi T, Al-Maskari F.
Asian Pac J Allergy Immunol 2011 Dec;29(4):313-317

Proteinases as molecular adjuvants in allergic airway disease.  
Porter PC, Yang T, Luong A, Delclos GL, Abramson SL, Kheradmand F, Corry DB.
Biochim Biophys Acta 2011 Nov;1810(11):1059-1065
Click to view abstract

Enhancement of gastrointestinal absorption of ovalbumin caused by spermine induces an increase in plasma histamine levels in mice sensitized to ovalbumin.  
Sugita Y, Takao K, Sugino Y, Kuwabara R, Shirahata A.
Biol Pharm Bull 2011 Mar;34(3):415-419
Click to view abstract

Yeast thioredoxin-enriched extracts for mitigating the allergenicity of foods.  
Taketani Y, Kinugasa K, Furukawa S, Nakamura H, Otsuki R, Yasuda H, Fujita T, Kanzaki K, Masutani H, Yodoi J.
Biosci Biotechnol Biochem 2011;75(10):1872-1879
Click to view abstract

In vitro diagnosis and monitoring of Hymenoptera venom hyposensitization. [German]  
Neis MM, Wurpts G, Wilbers L, Merk HF.
Hautarzt 2011 Sep;62(9):677-682
Click to view abstract

Medications. A rare cause for leg ulcers. [German]  
Dissemond J.
Hautarzt 2011 Jul;62(7):516-523
Click to view abstract

Papular drug eruption along the lines of Blaschko caused by lenalidomide. [German]  
Grape J, Frosch P.
Hautarzt 2011 Aug;62(8):618-620
Click to view abstract

Beyond skin testing: state of the art and new horizons in food allergy diagnostic testing.  
Caubet JC, Sampson HA.
Immunol Allergy Clin North Am 2012 Feb;32(1):97-109

Determinants of food allergy.  
Masilamani M, Commins S, Shreffler W.
Immunol Allergy Clin North Am 2012 Feb;32(1):11-33

Prolonged exposure to damp and moldy workplaces and new-onset asthma.  
Karvala K, Toskala E, Luukkonen R, Uitti J, Lappalainen S, Nordman H.
Int Arch Occup Environ Health 2011 Oct;84(7):713-721
Click to view abstract

Allergic asthma after flour inhalation in subjects without occupational exposure to flours: an experimental pilot study.  
Merget R, Sander I, van K, Beckmann U, Heinze E, Raulf-Heimsoth M, Bruening T.
Int Arch Occup Environ Health 2011 Oct;84(7):753-760
Click to view abstract

Peanut allergy: an increasingly common life-threatening disorder.  
Husain Z, Schwartz RA.
J Am Acad Dermatol 2012 Jan;66(1):136-143
Click to view abstract

Clinical differentiation of acute cutaneous graft-versus-host disease from drug hypersensitivity reactions.  
Byun HJ, Yang JI, Kim BK, Cho KH.
J Am Acad Dermatol 2011 Oct;65(4):726-732
Click to view abstract

Contact sensitization in very young children.  
Belloni FA, Romano I, Peserico A, Eichenfield LF.
J Am Acad Dermatol 2011 Oct;65(4):772-779
Click to view abstract

Cysteamine toxicity in patients with cystinosis.  
Besouw MT, Bowker R, Dutertre JP, Emma F, Gahl WA, Greco M, Lilien MR, McKiernan J, Nobili F, Schneider JA, Skovby F, van den Heuvel LP, Van't Hoff WG, Levtchenko EN.
J Pediatr 2011 Dec;159(6):1004-1011
Click to view abstract

Relationship between complotype and reported severity of systemic allergic reactions to peanut.  
Menikou S, Patel MP, Rose KL, Botto M, Warner JO, Pickering MC, Boyle RJ.
J Allergy Clin Immunol 2012 Feb 9;

Diagnosing nonimmediate reactions to cephalosporins.  
Romano A, Gaeta F, Valluzzi RL, Caruso C, Alonzi C, Viola M, Bousquet PJ.
J Allergy Clin Immunol 2012 Feb 7;

IgE against bed bug (Cimex lectularius) allergens is common among adults bitten by bed bugs.  
Price JB, Divjan A, Montfort WR, Stansfield KH, Freyer GA, Perzanowski MS.
J Allergy Clin Immunol 2012 Feb 1;

Prevalence of eczema and food allergy is associated with latitude in Australia.  
Osborne NJ, Ukoumunne OC, Wake M, Allen KJ.
J Allergy Clin Immunol 2012 Feb 1;

Fungi and allergic lower respiratory tract diseases.  
Knutsen AP, Bush RK, Demain JG, Denning DW, Dixit A, Fairs A, Greenberger PA, Kariuki B, Kita H, Kurup VP, Moss RB, Niven RM, Pashley CH, Slavin RG, Vijay HM, Wardlaw AJ.
J Allergy Clin Immunol 2012 Feb;129(2):280-291

The US Food and Drug Administration review of the safety and effectiveness of nonstandardized allergen extracts.  
Slater JE, Menzies SL, Bridgewater J, Mosquera A, Zinderman CE, Ou AC, Maloney D, Cook CM, Rabin RL.
J Allergy Clin Immunol 2012 Feb 15;

Microarray analysis of mucosal biopsy specimens in neonates with rectal bleeding: Is it really an allergic disease?  
Ohtsuka Y, Jimbo K, Inage E, Mori M, Yamakawa Y, Aoyagi Y, Suzuki M, Kudo T, Suzuki R, Shimizu T.
J Allergy Clin Immunol 2012 Feb 11;

Inaccuracies in Total Serum IgE Measurements by Immulite Caused by Omalizumab in Specimens.  
Hamilton RG.
J Asthma 2012 Feb 9;

Have Technological Innovations Made Unethical the Use of Human Subjects for Potency Assessments of Allergenic Extracts?  
Jason Behrmann
J Asthma & Allergy Educators 2011; 2: 272-281
Click to view abstract Click to view abstract

Food Allergy Policy and the Popular Press: Perspectives From Canadian Newspapers  
Christen Rachul and Timothy Caulfield
J Asthma & Allergy Educators 2011; 2: 282-287
Click to view abstract Click to view abstract

Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation.  
Jacobsen EA, Zellner KR, Colbert D, Lee NA, Lee JJ.
J Immunol 2011 Dec 1;187(11):6059-6068
Click to view abstract

Sensitization to aeroallergens in Korean children: a population-based study in 2010.  
Kim J, Hahm MI, Lee SY, Kim WK, Chae Y, Park YM, Han MY, Lee KJ, Kwon HJ, Jung JA, Kim SY, Ahn K.
J Korean Med Sci 2011 Sep;26(9):1165-1172
Click to view abstract

Natural course of cow's milk allergy in children with atopic dermatitis.  
Suh J, Lee H, Lee JH, Cho J, Yu JS, Kim J, Han Y, Ahn K, Lee SI.
J Korean Med Sci 2011 Sep;26(9):1152-1158
Click to view abstract

Treatment rather than avoidance may be within reach for children with food allergies.  
Slomski A.
JAMA 2012 Jan 25;307(4):345-6, 348

Thunderstorm asthma--a timely reminder.  
Howden ML, McDonald CF, Sutherland MF.
Med J Aust 2011 Nov 7;195(9):512-513

The mining and burning of coal: effects on health and the environment.  
Castleden WM, Shearman D, Crisp G, Finch P.
Med J Aust 2011 Sep 19;195(6):333-335
Click to view abstract

Laboratory animal; allergy; asthma. [Italian]  
Corradi M, Romano C, Mutti A.
Med Lav 2011 Sep;102(5):428-444
Click to view abstract

Allergy among veterinary medicine students in The Netherlands.  
Samadi S, Spithoven J, Jamshidifard AR, Berends BR, Lipman L, Heederik DJ, Wouters IM.
Occup Environ Med 2012 Jan;69(1):48-55
Click to view abstract

Has European Union legislation to reduce exposure to chromate in cement been effective in reducing the incidence of allergic contact dermatitis attributed to chromate in the UK?  
Stocks SJ, McNamee R, Turner S, Carder M, Agius RM.
Occup Environ Med 2012 Feb;69(2):150-152
Click to view abstract

Sensitisation to common allergens and respiratory symptoms in endotoxin exposed workers: a pooled analysis.  
Basinas I, Schlunssen V, Heederik D, Sigsgaard T, Smit LA, Samadi S, Omland O, Hjort C, Madsen AM, Skov S, Wouters IM.
Occup Environ Med 2012 Feb;69(2):99-106
Click to view abstract

Allergy testing in childhood: using allergen-specific IgE tests.  
Sicherer SH, Wood RA.
Pediatrics 2012 Jan;129(1):193-197
Click to view abstract

The association of acetaminophen and asthma prevalence and severity.  
McBride JT.
Pediatrics 2011 Dec;128(6):1181-1185
Click to view abstract

Hypersensitivity to total parenteral nutrition fat-emulsion component in an egg-allergic child.  
Lunn M, Fausnight T.
Pediatrics 2011 Oct;128(4):e1025-e1028
Click to view abstract

NIAID-sponsored 2010 guidelines for managing food allergy: applications in the pediatric population.  
Burks AW, Jones SM, Boyce JA, Sicherer SH, Wood RA, Assa'ad A, Sampson HA.
Pediatrics 2011 Nov;128(5):955-965
Click to view abstract

Identification of fungal DNA in BALF from patients with home-related hypersensitivity pneumonitis.  
Unoura K, Miyazaki Y, Sumi Y, Tamaoka M, Sugita T, Inase N.
Respir Med 2011 Nov;105(11):1696-1703
Click to view abstract

Chacinero's lung - hypersensitivity pneumonitis due to dry sausage dust.  
Morell F, Cruz MJ, Gomez FP, Rodriguez-Jerez F, Xaubet A, Munoz X.
Scand J Work Environ Health 2011 Jul;37(4):349-356
Click to view abstract

Anaphylaxis-induced hyperfibrinogenolysis and the risk of Kounis syndrome: the dual action of tryptase.  
Kounis NG, Tsigkas G, Almpanis G, Kouni SN, Kounis GN, Mazarakis A.
Am J Emerg Med 2011 Nov;29(9):1229-1230

Inhalant abuse of computer cleaner manifested as angioedema.  
Kurniali PC, Henry L, Kurl R, Meharg JV.
Am J Emerg Med 2012 Jan;30(1):265-265
Click to view abstract

Anaphylactic shock due to intravenous amiodarone.  
Kurt IH, Yalcin F.
Am J Emerg Med 2012 Jan;30(1):265-2
Click to view abstract

Myocardial infarction secondary to contrast agent. Contrast effect or type II Kounis syndrome?  
Kocabay G, Karabay CY, Kounis NG.
Am J Emerg Med 2012 Jan;30(1):255-2
Click to view abstract

Life-threatening anaphylactoid shock caused by recombinant tissue plasminogen activator.  
Wang CT, Lin FC, Khor GT, Chen CH, Huang P.
Am J Emerg Med 2012 Jan;30(1):253-2
Click to view abstract

Ink sick: tattoo ink hypersensitivity vasculitis..  
Hessert MJ, Devlin J.
Am J Emerg Med 2011 Nov;29(9):1237-4

Use of prasugrel in a patient with clopidogrel hypersensitivity.  
Peppard SR, Held-Godgluck BM, Beddingfield R.
Ann Pharmacother 2011 Oct;45(10):e54
Click to view abstract

Drug-induced exanthem following dabigatran.  
Whitehead H, Boyd JM, Blais DM, Hummel J.
Ann Pharmacother 2011 Oct;45(10):e53
Click to view abstract

Allergic contact dermatitis to Myroxylon pereirae (Balsam of Peru) in papaw ointment causing cheilitis.  
Tan S, Tam MM, Nixon RL.
Australas J Dermatol 2011 Aug;52(3):222-223
Click to view abstract

Methylisothiazolinone contact allergy: a review.  
Lundov MD, Krongaard T, Menne TL, Johansen JD.
Br J Dermatol 2011 Dec;165(6):1178-1182
Click to view abstract

Cross-reactivity among some metals in a murine metal allergy model.  
Kinbara M, Nagai Y, Takano-Yamamoto T, Sugawara S, Endo Y.
Br J Dermatol 2011 Nov;165(5):1022-1029
Click to view abstract

Association between domestic mould and mould components, and asthma and allergy in children: a systematic review.  
Tischer C, Chen CM, Heinrich J.
Eur Respir J 2011 Oct;38(4):812-824
Click to view abstract

Can dog allergen alone, if combined with indoor pollution, be responsible for asthma in children?  
Liccardi G, Annesi-Maesano I, Salzillo A, D'Amato G.
Eur Respir J 2011 Sep;38(3):744-745

Management of occupational asthma: cessation or reduction of exposure? A systematic review of available evidence.  
Vandenplas O, Dressel H, Wilken D, Jamart J, Heederik D, Maestrelli P, Sigsgaard T, Henneberger P, Baur X.
Eur Respir J 2011 Oct;38(4):804-811
Click to view abstract

Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cells.  
Daito H, Kikuchi T, Sakakibara T, Gomi K, Damayanti T, Zaini J, Tode N, Kanehira M, Koyama S, Fujimura S, Ebina M, Ishii KJ, Akira S, Takai T, Watanabe A, Nukiwa T.
Eur Respir J 2011 Sep;38(3):688-701
Click to view abstract

Seminal plasma hypersensitivity reactions: an updated review.  
Sublett JW, Bernstein JA.
Mt Sinai J Med 2011 Sep;78(5):803-809
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Insect allergy..  
Tracy JM.
Mt Sinai J Med 2011 Sep;78(5):773-783
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Latex allergy..  
Gawchik SM.
Mt Sinai J Med 2011 Sep;78(5):759-772
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Immune reactions to drugs and diagnostic agents.  
Shepherd GM.
Mt Sinai J Med 2011 Sep;78(5):717-729
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Treatment of asthma and food allergy with herbal interventions from traditional Chinese medicine.  
Li XM.
Mt Sinai J Med 2011 Sep;78(5):697-716
Click to view abstract

Food allergy.  
Sicherer SH.
Mt Sinai J Med 2011 Sep;78(5):683-696
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Heminecrolysin, the first hemolytic dermonecrotic toxin purified from scorpion venom.  
Borchani L, Sassi A, Shahbazzadeh D, Strub JM, Tounsi-Guetteti H, Boubaker MS, Akbari A, Van DA, El AM.
Toxicon 2011 Jul;58(1):130-139
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A small bird gives severe consequences. [Danish]  
Authried G, Andersen A, Sherson DL.
Ugeskr Laeger 2011 Dec 5;173(49):3195-3196
Click to view abstract

Association of House Dust Allergen Concentrations With Residential Conditions in City and in Rural Houses  
Wardzynska, Aleksandra; Majkowska-Wojciechowska, Barbara; Pelka, Jolanta; Korzon, Leszek; Kaczala, Magdalena; Jarzebska, Marzanna; Gwardys, Tomasz; Kowalski, Marek L.
WAO Journal 2012;5(2):22-27 February
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