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Allergy Advisor Digest - July 2010
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Work-related sensitization and respiratory symptoms in carpentry apprentices exposed to wood dust and diisocyanates.

Multiple epinephrine doses for stinging insect hypersensitivity reactions treated in the emergency department.

Socio-economic status, geographic remoteness and childhood food allergy and anaphylaxis in Australia.

How do we know when peanut and tree nut allergy have resolved, and how do we keep it resolved?

Impact of cross-reactive carbohydrate determinants on wood dust sensitization.

Exposure to dogs is associated with a decreased tumour necrosis factor-alpha-producing capacity in early life.

Component-based allergen-microarray in the diagnosis of cow's milk and hen's egg allergy.

Severe type 1-allergy to raw bell pepper.

Gal d 6 is the second allergen characterized from egg yolk.

Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization.

Survey on the prevalence of peanut, tree nut, and shellfish allergy in 2 Asian populations.

Specific IgE of common foods in Chinese children with eczema.

Respiratory allergy induced by exclusive polysensitization to serum albumins of furry animals.

Cypress pollen does not cross-react to plant-derived foods.

Prospective study of sensitization and food allergy to flaxseed in 1317 subjects.

Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanusyao.

Work-related sensitization and respiratory symptoms in carpentry apprentices exposed to wood dust and diisocyanates.
This study evaluated the frequency of work-related specific sensitization and respiratory symptoms in 101 carpentry apprentices with occupational exposure to wood dust and diisocyanates. Half the participants (56%) had work-related respiratory symptoms: 54% due to wood dust, 15% due diisocyanates, and 9% to both. Participants with respiratory symptoms related to wood dust exposure had a significantly lower forced expiratory volume in 1 second compared with symptomatic individuals due to diisocyanates and asymptomatic individuals. Sensitization to wood was detected in 9% of participants, all of whom were atopic with a history of rhinitis and a high total IgE level. Sensitization to diisocyanates was detected in 2% of exposed participants.

Work-related sensitization and respiratory symptoms in carpentry apprentices exposed to wood dust and diisocyanates.
Campo P, Aranda A, Rondon C, Donia I, az-Perales A, Canto G, Lisbona FJ, Pineda F, Blanca M.
Ann Allergy Asthma Immunol 2010 Jul;105(1):24-30

Multiple epinephrine doses for stinging insect hypersensitivity reactions treated in the emergency department.
The object of this study was to establish the frequency of receiving more than 1 dose of epinephrine in patients presenting to the emergency department (ED) with stinging insect hypersensitivity (SIH) reactions. A medical record review of all 153 patients with SIH reactions presenting to 3 Eds in Boston, Massachusetts, were reviewed. Bees were the most frequently reported triggering insect (74%). A total of 59% of patients experienced large local reactions, whereas 36% had systemic reactions (10% cutaneous systemic and 26% anaphylaxis). Overall, 35% of patients with systemic reactions received epinephrine, and among this subset, 16% received more than 1 dose. Most patients with systemic reactions (67%) were discharged to home. Among patients with systemic SIH reactions who received epinephrine, 16% received a second dose. Physicians should consider prescribing 2 doses of self-injectable epinephrine for patients at risk for systemic SIH reactions.

Multiple epinephrine doses for stinging insect hypersensitivity reactions treated in the emergency department.
Rudders SA, Banerji A, Katzman DP, Clark S, Camargo CA.
Ann Allergy Asthma Immunol 2010 Jul;105(1):85-93

Socio-economic status, geographic remoteness and childhood food allergy and anaphylaxis in Australia.
The objective of this study was to examine the association between socio-economic status (SES), geographic remoteness and childhood FA and anaphylaxis in Australia. Sales of infant hypoallergenic formulae (IHF) and EpiPens in children aged 0-4 years and hospital anaphylaxis admission rates in age groups 0-4, 5-14, 15-24, 25-64 and 65+ years were used as proxy markers of FA and anaphylaxis in Australia. Annual IHF sales rates were higher in those with the greatest compared with the least socio-economic advantage. EpiPen sales trends were also higher in those with the greatest socio-economic advantage in all age groups, most marked in those aged 0-4 and 5-14 years. Formula sales rates were higher in major cities than remote/very remote regions with similar EpiPen sales trends, particularly in ages 0-4 and 5-14 years. Socio-economic advantage and geographic remoteness remained statistically significant in multivariable analysis of prescription rates and were unchanged by adjustment for health services access. While anaphylaxis admission rates were higher in those with the greatest compared with the least socio-economic advantage in children aged 0-4 years, the opposite was observed in older age groups. There was no association between geographic remoteness and anaphylaxis admissions.

Socio-economic status, geographic remoteness and childhood food allergy and anaphylaxis in Australia.
Mullins RJ, Clark S, Camargo CA.
Clin Exp Allergy 2010 Jul 16;

How do we know when peanut and tree nut allergy have resolved, and how do we keep it resolved?
"Over the last two decades, the prevalence of peanut and tree nut allergy has increased throughout the western world. Adverse reactions to these foods account for over 50% of all deaths resulting from food-related anaphylaxis. Until recently, evidence suggested that all peanut and tree nut allergy were permanent. It is now known that about 20% and 10%, respectively, of young patients outgrow peanut and tree nut allergies. Achieving tolerance is associated with increasing circulating T regulatory cells and reduced production of allergen-specific IgE. Reliable predictors of resolution are not yet available. A direct correlation between skin test weal size and allergen-specific IgE, at the time of diagnosis and likelihood of resolution, has been reported. Resolution of peanut or tree nut allergy cannot be determined conclusively by either allergen-specific IgE analysis or by skin prick testing. Oral food challenge is the gold standard for determining resolution of food allergy. Food challenges should only be undertaken in a clinical setting fully equipped to deal with a potential severe adverse reaction. Approximately 8% of patients who outgrow peanut allergy may suffer a recurrence, but recurrent tree nut allergy has not been reported to date. Infrequent ingestion of peanut may be related to the re-emergence of allergy. Induction of tolerance through oral immunotherapy or sublingual immunotherapy is now being actively studied, but remains experimental. Studies have reported short-term desensitization to peanut, but ongoing follow-up will determine whether tolerance is achieved long term."

How do we know when peanut and tree nut allergy have resolved, and how do we keep it resolved?
Byrne AM, Malka-Rais J, Burks AW, Fleischer DM.
Clin Exp Allergy 2010 Jul 20;

Impact of cross-reactive carbohydrate determinants on wood dust sensitization.
The objective was to determine the prevalence and quantitative level of specific immunoglobulin E (sIgE) to beech and pine wood in exposed workers. Danish workers (n=701) were investigated for sIgE to beech and pine. The prevalence of wood sensitization among all workers was 3.7%. There was no association between sensitization prevalence or sIgE concentrations and self-reported allergic symptoms. Beech- and pine-sensitized workers showed a high prevalence of CCD sensitization (73%). However, workers with a single sensitization to wood had no sIgE to CCDs. Specifying IgE epitopes demonstrated that sera of workers reporting allergic symptoms recognized proteinogenic IgE-epitopes on wood allergens, whereas workers without allergic symptoms had primarily sIgE-epitopes to glycogenic structures. Although 96% of the wood-sensitized workers were atopic, no significant correlation was found between wood sensitization and sIgE to beech and birch pollen, but an association was found between sIgE against CCDs and pine pollen. The authors recommend the application of CCD tools to assess the relevance of individual wood sensitization.

Impact of cross-reactive carbohydrate determinants on wood dust sensitization.
Kespohl S, Schlunssen V, Jacobsen G, Schaumburg I, Maryska S, Meurer U, Bruning T, Sigsgaard T, Raulf-Heimsoth M.
Clin Exp Allergy 2010 Jul;40(7):1099-1106

Exposure to dogs is associated with a decreased tumour necrosis factor-alpha-producing capacity in early life.
This study concludes that having a dog in the household in infancy and already during pregnancy may be associated with reduced innate immune responses in early childhood. "The observed attenuation of cytokine production may help in preventing exaggerated immune responses against harmless antigens later in life. Thus, intensive exposure to dogs in early life may be beneficial during normal immune maturation".

Exposure to dogs is associated with a decreased tumour necrosis factor-alpha-producing capacity in early life.
Lappalainen MH, Huttunen K, Roponen M, Remes S, Hirvonen MR, Pekkanen J.
Clin Exp Allergy 2010 Jul 13;

Component-based allergen-microarray in the diagnosis of cow's milk and hen's egg allergy.
This study assessed the clinical performance of microarray for specific IgE (sIgE) detection in children with challenge-proven/excluded cow's milk (CM) or hen's egg (HE) allergy. The microarray components Bos d 8 for CM (27/58 patients) and Gal d 1 (20/46 patients) and Gal d 2 (24/46) for HE were the most frequently recognized allergens. Use of 95% clinical decision points (CDP) for sIgE to Bos d 8 and Gal d 1 resulted in higher negative predictive values (78% and 79%, respectively) than those obtained with the ImmunoCAP (57% and 59%). The study concludes that these results show that in children with suspected CM or HE allergy, the microarray has a good ability to predict the FCT results. In a clinical application perspective, the microarray could be used as a second-level assay, if the ImmunoCAP sIgE is <95% CDP.

Performance of a component-based allergen-microarray in the diagnosis of cow's milk and hen's egg allergy.
D'Urbano LE, Pellegrino K, Artesani MC, Donnanno S, Luciano R, Riccardi C, Tozzi AE, Rava L, De BF, Cavagni G.
Clin Exp Allergy 2010 Jul 13;

Severe type 1-allergy to raw bell pepper.
A report of a patient experiencing anaphylaxis after ingestion of raw bell pepper. The patient was also sensitized to grass and birch pollen experiencing possibly pollen-associated food allergy as a result of Bet v 1 cross-reactivity. An 11 kDa protein was indicated, which has not been described yet which may be a new allergenic structure of the bell pepper plant or a fragment of the Bet v 1-homologous bell pepper protein.

Severe type 1-allergy to raw bell pepper. [German]
Ruger RD, Wagner S, Simon JC, Treudler R.
Hautarzt 2010 Apr;61(4):339-342

Gal d 6 is the second allergen characterized from egg yolk.
Only one allergen from the egg yolk, alpha-livetin (Gal d 5) has been described thus far. A new egg yolk allergen was detected studying 27 egg allergic patients. 5 of the 27 patients (18%) detected a yolk allergen of an apparent molecular weight of 35 kDa. Heating and reduction treatments did not affect its allergenicity, although digestion with simulated gastric fluid diminished the IgE-binding capacity of the allergen. The N-terminal amino acid sequence corresponded with the YGP42 protein, a fragment of the vitellogenin-1 precursor. The allergen was designated Gal d 6.

Gal d 6 is the second allergen characterized from egg yolk.
Amo A, Rodríguez-Pérez R, Blanco J, Villota J, Juste S, Moneo I, Caballero ML.
J Agric Food Chem 2010 Jun 23;58(12):7453-7.

Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization.
Extract from cowshed dust (CDE) is a source of immunomodulating substances. The authors have previously shown that such substances protect from experimental allergic disorders in a mouse model of asthma. The objective of this study was to identify immunomodulatory molecules in extracts of dust from an allergy protective farming environment. The authors found that plant arabinogalactans are contained in CDE in high concentrations. The source of this arabinogalactan is fodder, in particular a prevalent grass species known as Alopecurus pratensis. Treatment of murine dendritic cells with grass arabinogalactan resulted in autocrine IL-10 production. The authors conclude that grass arabinogalactans are important immunomodulatory substances that contribute to the protection from allergic airway inflammation, airway hyperresponsiveness, and atopic sensitization in a mouse model of asthma.

Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization.
Peters M, Kauth M, Scherner O, Gehlhar K, Steffen I, Wentker P, von ME, Holst O, Bufe A.
J Allergy Clin Immunol 2010 Jul 9;

Survey on the prevalence of peanut, tree nut, and shellfish allergy in 2 Asian populations.
There has been a substantial increase in the prevalence of peanut and tree nut allergy in Western populations in the last 2 decades. However, there is an impression that peanut and tree nut allergy is relatively uncommon in Asia. This study evaluatee the prevalence of peanut, tree nut, and shellfish allergy in schoolchildren in 2 Asian countries (Singapore and Philippines). A total of 25,692 schoolchildren responded to the survey (response rate, 74.2%). Of these, 23,425 responses fell within the study protocol's 4 to 6 and 14 to 16 year age groups and were included in the analysis. The prevalence of convincing peanut and tree nut allergy were similar in both local Singapore (4-6 years, 0.64%, 0.28%; 14-16 years, 0.47%, 0.3%, respectively) and Philippine (14-16, 0.43%, 0.33%, respectively) schoolchildren, but was higher in the Singapore expatriates (4-6 years, 1.29%, 1.12%; 14-16 years, both 1.21%, respectively; 4-6 years, expatriates vs local Singaporeans: peanut). Conversely, shellfish allergy was more common in the local Singapore (4-6 years, 1.19%; 14-16 years, 5.23%) and Philippine (14-16 years, 5.12%) schoolchildren compared with expatriate children (4-6 years, 0.55%; 14-16 years, 0.96%). When data were pooled, respondents born in Western countries were at higher risk of peanut and tree nut allergy compared with those born in Asia.

A population-based questionnaire survey on the prevalence of peanut, tree nut, and shellfish allergy in 2 Asian populations.
Shek LP, Cabrera-Morales EA, Soh SE, Gerez I, Ng PZ, Yi FC, Ma S, Lee BW.
J Allergy Clin Immunol 2010 Jul 10;

Specific IgE of common foods in Chinese children with eczema.
This Chinese study evaluated whether any association existed between atopic dermatitis (AD) severity, quality of life, total IgE, eosinophil counts, and the number of food items sensitized. Specific IgE of ten common food items was measured for a group of consecutive AD patients (n = 85) enrolled during a randomized trial and correlated the findings with eczema severity. Twenty-four patients (28%) were negative for any of the ten common food items. The most commonly sensitized foods were shrimp (54%), egg white (43%), wheat (42%), and peanut (41%). Atopy to beef as a protein and orange as a fruit were least common among the food items studied, even among patients positive for 8-9 IgE items.

Specific IgE of common foods in Chinese children with eczema.
Hon KL, Chan IH, Chow CM, Wang SS, Lam CW, Ng PC, Leung TF.
Pediatr Allergy Immunol 2010 Jul 1;

Respiratory allergy induced by exclusive polysensitization to serum albumins of furry animals.
A 27-year-old woman experienced conjunctival and severe respiratory symptoms after contact with several animals such as cats, dogs, rabbits, horses, cows etc. In vivo and in vitro procedures revealed allergic sensitization to animal-derived allergens only. Total IgE was 59.3 kU/L. Immunoblotting showed specific IgE-mediated sensitization to cow's, rabbit's and horse's serum albumins (SA). The authors conclude that this case confirms the role of serum albumen as cross-reacting agent in allergic sensitization to furry animals.

Respiratory allergy induced by exclusive polysensitization to serum albumins of furry animals.
Liccardi G, Dente B, Restani P, Senna G, Falagiani P, Ballabio C, D'Amato G.
Eur Ann Allergy Clin Immunol 2010 Jun;42(3):127-130

Cypress pollen does not cross-react to plant-derived foods.
Some studies hypothesize the existence of cross-reactivity between allergy to Cupressus sempervirens pollen and plant-derived foods. This study aimed to assess whether this holds true: 72 patients monosensitized to cypress pollen were investigated for food allergy to peach, apple, tomato and Juniperius oxycedrus berry. No patient had a history of clinical allergy or showed in-vitro or in-vitro reactivity to peach, apple, and tomato. Two patients scored positive on SPT with Juniperius oxycedrus berry but in-vitro tests ruled out cross-reactivity with the corresponding pollen.

Cypress pollen does not cross-react to plant-derived foods.
Panzani R, Ariano R, Mistrello G.
Eur Ann Allergy Clin Immunol 2010 Jun;42(3):125-126

Prospective study of sensitization and food allergy to flaxseed in 1317 subjects.
Foods containing flaxseed proteins rich inpolyunsaturatedfatty acids are new on the market. This study evaluated the frequency of sensitization to flaxseed in patients attending an allergy department. Natural, heated and extruded flaxseeds were evaluated. Prick-prick tests to natural flaxseed were positive in 5.8% of the 1317 patients. 73 of 77 PP-positive patients were atopic. There was cross-reactivity with five seeds. Peanut, soybean, rapeseed, lupine and wheat, and with rape pollen. Inhibition studies confirmed the presence of specific IgE to cross-reactive carbohydrate determinants (CCD). 0.15% of this population presented with food allergy to flaxseed and positive PP to heated and extruded flaxseed. Two sera showed that clinically relevant allergens in industrial products had MW between 25 and 38 kDa. FTIR spectroscopy showed major modifications in 3 and alpha structures following industrial processing.

Conclusion: Positive prick tests to natural flaxseed were mainly due to cross-reactions. Flaxseed allergy is rare and could be detected by PIP to heated extruded flaxseed. Increasing consumption callsfor monitoring of clinical risk.

Prospective study of sensitization and food allergy to flaxseed in 1317 subjects.
Fremont S, Moneret-Vautrin DA, Franck P, Morisset M, Croizier A, Codreanu F, Kanny G.
Eur Ann Allergy Clin Immunol 2010 Jun;42(3):103-111

Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanusyao.
Horsefly bite can cause allergic reactions in humans. This study purified and characterized IgE-binding proteins from horsefly salivary glands. Two IgE-binding proteins, Tab a 1 and Tab a 2 with molecular weight of 26 and 35 kd, respectively, were purified and characterized from horsefly salivary glands of Tabanus yao. Immunoblotting demonstrated IgE binding by 32 and 34 of 37 (86.5% and 91.8%) subjects' sera to Tab a 1 and Tab a 2, respectively. They were identified as an antigen 5-related (Ag 5) protein and hyaluronidase, respectively. In addition, these proteins showed some IgE-binding capacity to sera of subjects with wasp sting allergy. Therefore these allergens are thus not only found in stinging but also found in hematophagous insects. These results also provided support for the presence of the so-called wasp-horsefly syndrome (WHS).

Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanusyao.
Ma D, Li Y, Dong J, An S, Wang Y, Liu C, Yang X, Yang H, Xu X, Lin D, Lai R.
Allergy 2010 Jul 2;

Allergen-, Food allergy-, Intolerance-related articles

Work-related sensitization and respiratory symptoms in carpentry apprentices exposed to wood dust and diisocyanates.
Campo P, Aranda A, Rondon C, Donia I, az-Perales A, Canto G, Lisbona FJ, Pineda F, Blanca M. Ann Allergy Asthma Immunol 2010 Jul;105(1):24-30

Dermatophagoides species.
Weber RW. Ann Allergy Asthma Immunol 2010 Jul;105(1):A4

Detection of airborne Par j 1 and Par j 2 allergens in relation to Urticaceae pollen counts in different bioclimatic areas.
Jato V, Rodriguez-Rajo FJ, Gonzalez-Parrado Z, Elvira-Rendueles B, Moreno-Grau S, Vega-Maray A, Fernandez-Gonzalez D, Asturias JA, Suarez-Cervera M. Ann Allergy Asthma Immunol 2010 Jul;105(1):50-56

Bronchial reactivity in schoolchildren allergic to food.
Krogulska A, Dynowski J, Wasowska-Krolikowska K. Ann Allergy Asthma Immunol 2010 Jul;105(1):31-38

Multiple epinephrine doses for stinging insect hypersensitivity reactions treated in the emergency department.
Rudders SA, Banerji A, Katzman DP, Clark S, Camargo CA. Ann Allergy Asthma Immunol 2010 Jul;105(1):85-93

Socio-economic status, geographic remoteness and childhood food allergy and anaphylaxis in Australia.
Mullins RJ, Clark S, Camargo CA. Clin Exp Allergy 2010 Jul 16;

CD14, a key candidate gene associated with a specific immune response to cockroach.
Gao P, Grigoryev DN, Rafaels NM, Mu D, Wright JM, Cheadle C, Togias A, Beaty TH, Mathias RA, Schroeder JT, Barnes KC. Clin Exp Allergy 2010 Jul 4;

Cow's milk allergy as a predictor of bronchial hyperresponsiveness and airway inflammation at school age.
Malmberg LP, Saarinen KM, Pelkonen AS, Savilahti E, Makela MJ. Clin Exp Allergy 2010 Jul 4;

The HealthNuts population-based study of paediatric food allergy: validity, safety and acceptability.
Osborne NJ, Koplin JJ, Martin PE, Gurrin LC, Thiele L, Tang ML, Ponsonby AL, Dharmage SC, Allen KJ. Clin Exp Allergy 2010 Jul 1;

Authentication of food allergen quality by physicochemical and immunological methods.
Sancho AI, Hoffmann-Sommergruber K, Alessandri S, Conti A, Giuffrida MG, Shewry P, Jensen BM, Skov P, Vieths S. Clin Exp Allergy 2010 Jul;40(7):973-986

The role of cross-reactive carbohydrate determinants in the diagnosis of occupational allergy.
Quirce S, Salcedo G. Clin Exp Allergy 2010 Jul;40(7):962-964

How do we know when peanut and tree nut allergy have resolved, and how do we keep it resolved?
Byrne AM, Malka-Rais J, Burks AW, Fleischer DM. Clin Exp Allergy 2010 Jul 20;

Impact of cross-reactive carbohydrate determinants on wood dust sensitization.
Kespohl S, Schlunssen V, Jacobsen G, Schaumburg I, Maryska S, Meurer U, Bruning T, Sigsgaard T, Raulf-Heimsoth M. Clin Exp Allergy 2010 Jul;40(7):1099-1106

Exposure to dogs is associated with a decreased tumour necrosis factor-alpha-producing capacity in early life.
Lappalainen MH, Huttunen K, Roponen M, Remes S, Hirvonen MR, Pekkanen J. Clin Exp Allergy 2010 Jul 13;

Performance of a component-based allergen-microarray in the diagnosis of cow's milk and hen's egg allergy.
D'Urbano LE, Pellegrino K, Artesani MC, Donnanno S, Luciano R, Riccardi C, Tozzi AE, Rava L, De BF, Cavagni G. Clin Exp Allergy 2010 Jul 13;

IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring.
Matson AP, Thrall RS, Rafti E, Lingenheld EG, Puddington L. Clin Mol Allergy 2010 Jul 13;8(1):9

Severe type 1-allergy to raw bell pepper. [German]
Ruger RD, Wagner S, Simon JC, Treudler R. Hautarzt 2010 Apr;61(4):339-342

Cedar allergen harvest from tobacco: plant biotechnology for recombinant allergens.
Takai T. Int Arch Allergy Immunol 2010 Jul 14;153(4):431-433

From Bench to Bedside: Use of Proteomics for Identification and Production of Recombinant Allergens.
Andre C. Int Arch Allergy Immunol 2010 Jul 14;153(4):428-430

Gal d 6 is the second allergen characterized from egg yolk.
Amo A, Rodríguez-Pérez R, Blanco J, Villota J, Juste S, Moneo I, Caballero ML. J Agric Food Chem 2010 Jun 23;58(12):7453-7.

The T-cell response to Amb a 1 is characterized by 3 dominant epitopes and multiple MHC restriction elements.
Jahn-Schmid B, Wopfner N, Hubinger G, Asero R, Ebner C, Ferreira F, Bohle B. J Allergy Clin Immunol 2010 Jul 15;

Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly.
Campana R, Vrtala S, Maderegger B, Jertschin P, Stegfellner G, Swoboda I, Focke-Tejkl M, Blatt K, Gieras A, Zafred D, Neubauer A, Valent P, Keller W, Spitzauer S, Valenta R. J Allergy Clin Immunol 2010 Jul 15;

Peanut-induced intestinal allergy is mediated through a mast cell-IgE-FcepsilonRI-IL-13 pathway.
Wang M, Takeda K, Shiraishi Y, Okamoto M, Dakhama A, Joetham A, Gelfand EW. J Allergy Clin Immunol 2010 Jul 10;

Comparison of the allergic and nonallergic CD4(+) T-cell responses to the major dog allergen Can f 1.
Parviainen S, Taivainen A, Liukko A, Nieminen A, Rytkonen-Nissinen M, Kinnunen T, Virtanen T. J Allergy Clin Immunol 2010 Jul 10;

Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization.
Peters M, Kauth M, Scherner O, Gehlhar K, Steffen I, Wentker P, von ME, Holst O, Bufe A. J Allergy Clin Immunol 2010 Jul 9;

Food allergen advisory labeling and product contamination with egg, milk, and peanut.
Ford LS, Taylor SL, Pacenza R, Niemann LM, Lambrecht DM, Sicherer SH. J Allergy Clin Immunol 2010 Jul 9;

A population-based questionnaire survey on the prevalence of peanut, tree nut, and shellfish allergy in 2 Asian populations.
Shek LP, Cabrera-Morales EA, Soh SE, Gerez I, Ng PZ, Yi FC, Ma S, Lee BW. J Allergy Clin Immunol 2010 Jul 10;

Trends in pediatric emergency department visits for food-induced anaphylaxis.
Rudders SA, Banerji A, Vassallo MF, Clark S, Camargo CA. J Allergy Clin Immunol 2010 Jul 9;

Selective allergic reactions to clavulanic acid: a report of 9 cases.
Sanchez-Morillas L, Perez-Ezquerra PR, Reano-Martos M, Laguna-Martinez JJ, Sanz ML, Martinez LM. J Allergy Clin Immunol 2010 Jul;126(1):177-179

Specific IgE of common foods in Chinese children with eczema.
Hon KL, Chan IH, Chow CM, Wang SS, Lam CW, Ng PC, Leung TF. Pediatr Allergy Immunol 2010 Jul 1;

Sensitization patterns to food and inhalant allergens in childhood: A comparison of non-sensitized, monosensitized, and polysensitized children.
Baatenburg de JA, Dikkeschei LD, Brand PL. Pediatr Allergy Immunol 2010 Jul 13;

Respiratory allergy induced by exclusive polysensitization to serum albumins of furry animals.
Liccardi G, Dente B, Restani P, Senna G, Falagiani P, Ballabio C, D'Amato G. Eur Ann Allergy Clin Immunol 2010 Jun;42(3):127-130

Cypress pollen does not cross-react to plant-derived foods.
Panzani R, Ariano R, Mistrello G. Eur Ann Allergy Clin Immunol 2010 Jun;42(3):125-126

Prospective study of sensitization and food allergy to flaxseed in 1317 subjects.
Fremont S, Moneret-Vautrin DA, Franck P, Morisset M, Croizier A, Codreanu F, Kanny G. Eur Ann Allergy Clin Immunol 2010 Jun;42(3):103-111

Airborne allergy to tomato proteins.
Asero R, Mistrello G, Amato S. Allergy 2010 Jul 5;

The role of hen's egg-specific IgE, IgG and IgG4 in the diagnostic procedure of hen's egg allergy.
Ahrens B, Lopes de Oliveira LC, Schulz G, Borres MP, Niggemann B, Wahn U, Beyer K. Allergy 2010 Jul 5;

Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanusyao.
Ma D, Li Y, Dong J, An S, Wang Y, Liu C, Yang X, Yang H, Xu X, Lin D, Lai R. Allergy 2010 Jul 2;

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