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 Allergy Advisor Digest - July 2014
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Read In patients with LTP syndrome food-specific IgE show a predictable hierarchical order.
Read Casein-Specific Il-4 And Il-13 Secreting T Cells: a tool to implement diagnosis of cow's milk allergy.
Read Basophil response to peanut allergens in Mediterranean peanut-allergic patients.
Read Fatal anaphylaxis with neuromuscular blocking agents: a risk factor and management analysis.
Read EAACI Food Allergy and Anaphylaxis Guidelines. Food allergy health-related quality of life measures.
Read Peanut allergens are rapidly transferred in human breast milk and can prevent sensitization in mice.
Read Association between egg and staphylococcal superantigen IgE sensitizations in atopic dermatitis.
Read Allergic reactions to foods by inhalation in children.
Read Respiratory allergy to airborne fungi in Sao Luis - MA.
Read Additional indications for the low allergenic properties of the apple cultivars Santana and Elise.
Read A new facial expression to botox!.
Read Allergic contact dermatitis to indium in jewellery.
Read International consensus on (ICON) anaphylaxis - CONSENSUS DOCUMENT

Abstracts shared in July 2014 Advisor Digest Newsletter

Read Tetranychus urticae (Red spider mite) allergy in a population without occupational exposure.
Read Increased risk of peanut allergy in infants of Asian-born parents compared to those of Australian born parents.
Read Act d 12 and Act d 13 from kiwi seeds: implication in IgE cross-reactivity with peanut and tree nuts.
Read Tolerance to egg proteins in egg sensitized infants without previous consumption.
Read Epidemiological link between wheat allergy and exposure to hydrolyzed wheat protein in facial soap.
Read Occupational hypersensitivity pneumonitis in a baker: a new cause.
Read Chronic food protein-induced enterocolitis syndrome caused by cow's milk proteins passed through breast milk.
Read Cor a 14: Missing Link in the Molecular Diagnosis of Hazelnut Allergy?
Read Comparison of specific IgE antibodies to wheat component allergens in two phenotypes of wheat allergy.
Read Exposure from baby wipes causing hand dermatitis.
Read Allergic contact stomatitis to dodecyl gallate.

Allergy and Intolerance Abstracts
In patients with LTP syndrome food-specific IgE show a predictable hierarchical order.
The objective of this study was to assess whether IgE to vegetable foods show predictable trends in lipid transfer protein (LTP) allergic patients. Clinical allergy to plant foods other than peach was sought in 15 consecutive peach-allergic adults monosensitized to LTP. IgE specific for peach, apple, hazelnut, walnut, peanut, lentil, maize, soybean, tomato, sesame, mustard melon, kiwi, and celery as well as to mugwort pollen was measured. Peach-specific IgE levels exceeded IgE to all other study foods. The higher were peach-specific IgE levels, the higher was the probability that other plant-derived foods scored positive. Mean IgE levels specific for all study foods were strongly correlated to peach specific IgE. Food-specific IgE followed a rather precise hierarchy, both in terms of number of positive in-vitro tests and of IgE levels, with apple at the second place after peach, followed by walnut, hazelnut, peanut, lentil, maize, soybean, tomato, kiwi, sesame, mustard, melon, and celery. Such hierarchy was not necessarily paralleled by clinical allergy as lentil, maize, and soybean scored positive in the majority of patients, but induced allergy in 0, 1, and 0 patients, respectively. IgE levels were not necessarily correlated with the severity of clinical allergy. Little or no IgE reactivity to mugwort pollen was found. Therefore, in LTP syndrome, IgE reactivity to foods other than peach is in most cases predictable and follows a regular sequence that probably depends on the degree of homology with Pru p3. The reasons why some foods are tolerated by most patients despite elevated IgE reactivity remains to be elucidated.

In patients with LTP syndrome food-specific IgE show a predictable hierarchical order.  
Asero R.
Eur Ann Allergy Clin Immunol 2014 Jul;46(4):142-146

Click to view abstract

Index
Allergy and Intolerance Abstracts
Casein-Specific Il-4 And Il-13 Secreting T Cells: a tool to implement diagnosis of cow's milk allergy.
The aim of this study was to evaluate the diagnostic potential of a functional assay quantifying allergen-specific Th2 cells in CMA children. 29 children aged 2.8 to 10.5 yrs underwent a double blind placebo control food challenge (DBPCFC) to cow's milk. Blood was collected before performing the DBPCFC and peripheral mononuclear cells were cultured in an 18 hours ELISpot assay with casein, alpha-lactalbumin or beta-lactoglobulin. 17 (59%) children reacted to cow's milk and were therefore considered as allergic to cow's milk (CMA). The mean number of casein-specific IL-4 and IL-13 secreting T cells was higher in CMA than in non-CMA children (p=0.009, p=0.004 respectively). Moreover, it was inversely correlated to the cow's milk tolerated cumulative dose (p=0.003, p=0.0009 respectively). For a cut-off of 10 IL-4- and 12 IL-13 secreting T cells, sensitivity and negative predictive value were 100%. Enumeration of casein-specific IL-4 and IL-13 secreting T cells appears a promising tool to improve diagnosis and, if confirmed in larger studies, could permit less frequent use of the oral food challenge.

Casein-Specific Il-4 And Il-13 Secreting T Cells: a tool to implement diagnosis of cow's milk allergy.  
Michaud B, Aroulandom J, Baiz N, Amat F, Gouvis-Echraghi R, Candon S, Foray AP, Couderc R, Bach JF, Chatenoud L, Just J.
Allergy 2014 Jul 10;

Click to view abstract

Index
Allergy and Intolerance Abstracts
Basophil response to peanut allergens in Mediterranean peanut-allergic patients.
Ara h 1, Ara h 2, and Ara h 3 are important sensitizers in peanut allergy. Ara h 9 has also been shown to be relevant in the Mediterranean area. We evaluated the basophil response to peanut allergens and Pru p 3 in Mediterranean patients: Group 1, peanut and peach allergy; Group 2, peanut allergy and tolerance to peach; Group 3, peach allergy and tolerance to peanut; Group 4, nonallergic subjects that tolerate both peanut and peach. Compared to controls (Group 4), there was an increased basophil activation with Ara h 2 (P = 0.031) and Pru p 3 (P = 0.009) in Group 1 and with Ara h 1 (P = 0.016), Ara h 2 (P = 0.001), and Ara h 9 (P = 0.016) in Group 2. Importantly, only Ara h 2 showed an increased activation (P = 0.009) in Group 2 compared to Group 3. Ara h 2 is the best discriminating allergen for peanut allergy diagnosis in a Mediterranean population showing two patterns: patients also allergic to peach, responding to Ara h 2 and Pru p 3, and patients allergic only to peanut, responding to Ara h 1, Ara h 2, and Ara h 9

Basophil response to peanut allergens in Mediterranean peanut-allergic patients.  
Mayorga C, Gomez F, Aranda A, Koppelman SJ, az-Perales A, Blanca-Lopez N, Blazquez AB, Blanca M, Torres MJ.
Allergy 2014 Jul;69(7):964-968

Click to view abstract

Index
Allergy and Intolerance Abstracts
Fatal anaphylaxis with neuromuscular blocking agents: a risk factor and management analysis.
The aim of this study was to evaluate mortality rate in France from anaphylactic reactions to neuromuscular blocking agents (NMBAs), to identify risk factors for a fatal outcome, and to describe management of the cases that proved fatal. Two thousand and twenty-two cases of NMBA hypersensitivity were retrieved, of which 84 were fatal (4.1%). Among the 1247 cases of severe NMBA anaphylaxis (grades 3 and 4), independent risk factors associated with a fatal outcome in a multivariate analysis were male gender, an emergency setting, a history of hypertension or of other cardiovascular disease, obesity, and ongoing beta-blocker treatment. All 31 patients with a fatal outcome received epinephrine in a titrated manner according to international guidelines.

Fatal anaphylaxis with neuromuscular blocking agents: a risk factor and management analysis.  
Reitter M, Petitpain N, Latarche C, Cottin J, Massy N, Demoly P, Gillet P, Mertes PM.
Allergy 2014 Jul;69(7):954-959

Click to view abstract

Index
Allergy and Intolerance Abstracts
EAACI Food Allergy and Anaphylaxis Guidelines. Food allergy health-related quality of life measures.
Instruments have been developed and validated for the measurement of health-related quality of life in patients with food allergy. This guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Guidelines for Food Allergy and Anaphylaxis Group. It draws on a systematic review of the literature on quality of life instruments for food allergy and the Appraisal of Guidelines for Research & Evaluation (AGREE II) guideline development process. Guidance is provided on the use of such instruments in research, and the current limitations of their use in clinical practice are described. Gaps in current knowledge as well as areas of future interest are also discussed. This document is relevant to healthcare workers dealing with food-allergic patients, scientists engaging in food allergy research and policy makers involved in regulatory aspects concerning food allergy and safety

EAACI Food Allergy and Anaphylaxis Guidelines. Food allergy health-related quality of life measures.  
Muraro A, Dubois AE, DunnGalvin A, Hourihane JO, de Jong NW, Meyer R, Panesar SS, Roberts G, Salvilla S, Sheikh A, Worth A, Flokstra-de Blok BM.
Allergy 2014 Jul;69(7):845-853

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Index
Allergy and Intolerance Abstracts
Peanut allergens are rapidly transferred in human breast milk and can prevent sensitization in mice.
Food allergens have been evidenced in breast milk under physiological conditions, but the kinetic and the role of this passage in food allergies are still unclear. This study aimed to analyze the passage of peanut allergens in human breast milk and their allergenicity/immunomodulatory properties. Human breast milk was collected from two non-atopic peanut-tolerant mothers before and at different time points after ingestion of 30 g of commercial roasted peanut. Ara h 6, Ara h 6 immune complexes, and the IgE binding capacity of breast milk samples were measured using specific immunoassays. Human breast milk obtained before or after peanut ingestion was administered intragastrically to BALB/c mice at different ages. Ara h 6 is detected as soon as 10 min after peanut ingestion, with peak values observed within the first hour after ingestion. The transfer is long-lasting, small quantities of peanut allergens being detected over a 24-h period. IgG-Ara h 6 and IgA-Ara h 6 immune complexes are evidenced, following a different kinetic of excretion than free allergens. Peanut allergens transferred in milk are IgE reactive and can induce an allergic reaction in vitro. However, administration of human breast milk to young mice, notably before weaning, does not lead to sensitization, but instead to partial oral tolerance.

Peanut allergens are rapidly transferred in human breast milk and can prevent sensitization in mice.  
Bernard H, Ah-Leung S, Drumare MF, Feraudet-Tarisse C, Verhasselt V, Wal JM, Creminon C, del-Patient K.
Allergy 2014 Jul;69(7):888-897

Click to view abstract

Index
Allergy and Intolerance Abstracts
Association between egg and staphylococcal superantigen IgE sensitizations in atopic dermatitis.
Because IgE sensitization to foods is frequently an early manifestation in infants with AD, this study aimed to examine if food IgE levels may identify AD patients with more severe disease, and whether IgE sensitization to food may predict IgE sensitization to staphylococcal superantigens. Fifty-one young children with AD were included in the study. Of the five common food allergens (cow's milk, egg white, soybean, wheat, and peanut), only IgE levels to egg white correlated significantly with eczema severity in young children with AD. IgE sensitization to egg white was significantly associated with IgE sensitization to staphylococcal superantigens in older children

Association between egg and staphylococcal superantigen IgE sensitizations in atopic dermatitis.  
Ong PY.
Allergy Asthma Proc 2014 Jul;35(4):346-348

Click to view abstract

Index
Allergy and Intolerance Abstracts
Allergic reactions to foods by inhalation in children.
This article focuses on hypersensitivity reactions after inhalation of food particles as primary cause for food allergy. This is an increasingly recognized problem in children. Some children tolerate the food when it is eaten but they experience reactions to airborne food particles such as peanut, cow's milk, and fish. The exposure can be trivial, as in mere smelling or being in the vicinity of the food. Usually, respiratory manifestations include rhinoconjunctivitis, coughing, wheezing, and asthma, but in some cases even anaphylaxis has been observed.

Allergic reactions to foods by inhalation in children.  
Leonardi S, Pecoraro R, Filippelli M, Miraglia Del GM, Marseglia G, Salpietro C, Arrigo T, Stringari G, Rico S, La RM, Caffarelli C.
Allergy Asthma Proc 2014 Jul;35(4):288-294

Click to view abstract

Index
Allergy and Intolerance Abstracts
Respiratory allergy to airborne fungi in Sao Luis - MA.
In this study of 158 patients in Sao Luis - MA, of the 158 patients diagnosed with asthma, 71 had rhinitis and 32 had sinusitis. There was a statistically significant relationship between dyspnea and seropositivity for Fusarium and Penicillium and between cough and seropositivity for Aspergillus. Anti-Penicillium (79.7%) and anti-Fusarium IgE (77.8%) were found to have the highest prevalence of seropositivity in individuals with asthma and rhinitis/sinusitis.

Respiratory allergy to airborne fungi in Sao Luis - MA: clinical aspects and levels of IgE in a structured asthma program.  
Bezerra GF, de Almeida FC, Neto da Silva MA, Nascimento AC, Meireles Guerra RN, Viana GM, Muniz Filho WE, Costa MD, Zaror L, Brandao N.
J Asthma 2014 Jul 9;1-7

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Index
Allergy and Intolerance Abstracts
Additional indications for the low allergenic properties of the apple cultivars Santana and Elise.
This study investigated if the low allergenic properties of Elise and Santana apples, as previously identified in a Dutch population, could be generalised within North West Europe. Prick-to-prick tests (PTP) were performed in eighty-five adult patients with OAS to fresh apple in Great Britain, Switzerland and Northern Italy, before the birch pollen season, using the putatively low allergenic apple cultivars Elise, Santana, Granny Smith, Modi and Mcintosh, as well as the putatively high allergenic apple cultivars Golden Delicious and Kanzi. No significant differences in percentages of negative responses of PTPs were found between the three countries. Negative responses did not differ from negative responses to the different apple cultivars we previously found in 2006/2007 in the Netherlands. The size of the PTPs of all apple cultivars tested were correlated to the size of the skin prick tests with birch pollen. These results add to the indications for the low allergenic properties of the low allergenic apple cultivars Santana and Elise, as the number of negative responses were reproducible in three countries within the birch pollen region and were similar to previous results in the Netherlands. These results justify oral challenge studies with Elise and Santana within the birch pollen region, to establish the low allergenic properties for the benefit for apple allergic consumers for definite conclusions.

Additional indications for the low allergenic properties of the apple cultivars Santana and Elise.  
Vlieg-Boerstra BJ, van de Weg WE, van der HS, Skypala I, Bures P, Ballmer-Weber BK, Hoffmann-Sommergruber K, Zauli D, Ricci G, Dubois AE.
Plant Foods Hum Nutr 2013 Dec;68(4):391-395

Index
Allergy and Intolerance Abstracts
A new facial expression to botox!.
Botulinum toxin (Botox) injection into the lower esophageal sphincter (LES) has been used for the treatment of achlasia cardia since the 1990s. Currently it is indicated for patients who are not candidates for definitive therapy like Heller's myotomy or pneumatic dilation and in those who have recurrence of symptoms after definitive treatments. We present a case of severe anaphylaxix due to Botox. The purpose of this case is to highlight one of the under-reported adverse effects of Botox. Anaphylactic reactions to Botox are very rare with only one other case being reported and have not been emphasized enough to be widely known in clinical practice.

A new facial expression to botox!.  
Aggarwal A, Kaul V, Kaur G, Banas E, Sampath P, Roy AK.
Am J Emerg Med 2014 Mar;32(3):290-296

Index
Allergy and Intolerance Abstracts
Allergic contact dermatitis to indium in jewellery.
A 39-year-old woman from Adelaide who developed allergic contact dermatitis to the rare allergen indium in her ring. This case illustrates the usefulness of CABA in facilitating patch testing throughout Australia, especially when rare allergens are involved.

Allergic contact dermatitis to indium in jewellery: diagnosis made possible through the use of the Contact Allergen Bank Australia.  
Gamboni SE, Simmons I, Palmer A, Nixon RL.
Australas J Dermatol 2013 May;54(2):139-140

Index
Allergy and Intolerance Abstracts
International consensus on (ICON) anaphylaxis - CONSENSUS DOCUMENT
ICON: Anaphylaxis provides a unique perspective on the principal evidence-based anaphylaxis guidelines developed and published independently from 2010 through 2014 by four allergy/immunology organizations. These guidelines concur with regard to the clinical features that indicate a likely diagnosis of anaphylaxis -- a life-threatening generalized or systemic allergic or hypersensitivity reaction.

International consensus on (ICON) anaphylaxis - CONSENSUS DOCUMENT  
F Estelle R Simons, Ledit RF Ardusso, M Bilò, Victoria Cardona, Motohiro Ebisawa et al.
WAO Journal 2014;7:9-

Click to view abstract Click to view abstract

Index

Allergen-, Food allergy-, Intolerance-related articles

Patch testing and histopathology in Thai patients with hyperpigmentation due to Erythema dyschromicum perstans, Lichen planus pigmentosus, and pigmented contact dermatitis.  
Tienthavorn T, Tresukosol P, Sudtikoonaseth P.
Asian Pac J Allergy Immunol 2014 Jun;32(2):185-192
Click to view abstract

Cow's milk protein allergy: immunological response in children with cow's milk protein tolerance.  
Sommanus S, Kerddonfak S, Kamchaisatian W, Vilaiyuk S, Sasisakulporn C, Teawsomboonkit W, Benjaponpitak S.
Asian Pac J Allergy Immunol 2014 Jun;32(2):171-177
Click to view abstract

Botanical briefs: cashew apple (Anacardium occidentale).  
Bae-Harboe YS, Masterpol KS.
Cutis 2013 Oct;92(4):174-176

Eczematous-type multiple drug allergy from isoniazid and ethambutol with positive patch test results.  
Ozkaya E.
Cutis 2013 Sep;92(3):121-124

Inhaled environmental allergens and toxicants as determinants of the asthma phenotype.  
Sokol K, Sur S, Ameredes BT.
Adv Exp Med Biol 2014;79543-73

In patients with LTP syndrome food-specific IgE show a predictable hierarchical order.  
Asero R.
Eur Ann Allergy Clin Immunol 2014 Jul;46(4):142-146
Click to view abstract

Tetranychus urticae allergy in a population without occupational exposure.  
Santos N, Iraola V, Placido JL.
Eur Ann Allergy Clin Immunol 2014 Jul;46(4):137-141
Click to view abstract

Are profilins relevant allergens or confusion allergens?  
Sanchez-Salguero CA.
Allergol Immunopathol (Madr ) 2014 Jul;42(4):267-268

Fingertip dermatitis: occupational acrylate cross reaction.  
Tammaro A, Narcisi A, Abruzzese C, Giulianelli V, Madjaroff R, Parisella FR, Cortesi G.
Allergol Int 2014 Jul 25;

Contact sensitizer 2,4-dinitrochlorobenzene is a highly potent human TRPA1 agonist.  
Saarnilehto M, Chapman H, Savinko T, Lindstedt K, Lauerma AI, Koivisto A.
Allergy 2014 Jul 19;
Click to view abstract

Increased risk of peanut allergy in infants of Asian-born parents compared to those of Australian born parents.  
Koplin J, Peters R, Ponsonby AL, Gurrin L, Hill D, Tang M, Dharmage S, Allen K.
Allergy 2014 Jul 14;
Click to view abstract

Detailed characterization of Act d 12 and Act d 13 from kiwi seeds: implication in IgE cross-reactivity with peanut and tree nuts.  
Sirvent S, Canto B, Gomez F, Blanca N, Cuesta-Herranz J, Canto G, Blanca M, Rodriguez R, Villalba M, Palomares O.
Allergy 2014 Jul 14;
Click to view abstract

Dilemmas of allergy diagnosis in perioperative anaphylaxis.  
Brockow K.
Allergy 2014 Jul 12;
Click to view abstract

Casein-Specific Il-4 And Il-13 Secreting T Cells: a tool to implement diagnosis of cow's milk allergy.  
Michaud B, Aroulandom J, Baiz N, Amat F, Gouvis-Echraghi R, Candon S, Foray AP, Couderc R, Bach JF, Chatenoud L, Just J.
Allergy 2014 Jul 10;
Click to view abstract

Tolerance to egg proteins in egg sensitized infants without previous consumption.  
Alvaro M, Garcia-Paba B, Giner T, Piquer M, Dominguez O, Lozano J, Jimenez R, Machinena A, Martin-Mateos MA, Plaza AM.
Allergy 2014 Jul 10;
Click to view abstract

Epidemiological link between wheat allergy and exposure to hydrolyzed wheat protein in facial soap.  
Fukutomi Y, Taniguchi M, Nakamura H, Akiyama K.
Allergy 2014 Jul 8;
Click to view abstract

First European data from the network of severe allergic reactions (NORA).  
Worm M, Moneret-Vautrin A, Scherer K, Lang R, Fernandez-Rivas M, Cardona V, Kowalski M, Jutel M, Poziomkowska-Gesicka I, Papadopoulos N, Beyer K, Mustakov T, Christoff G, Bilo M, Muraro A, H.
Allergy 2014 Jul 2;
Click to view abstract

The accuracy of allergometric test for diagnosis of food allergy.  
Miceli SS, Scala G.
Allergy 2014 Jul;69(7):969

Disease-specific health-related quality of life instruments for IgE-mediated food allergy.  
Salvilla SA, Dubois AE, Flokstra-de Blok BM, Panesar SS, Worth A, Patel S, Muraro A, Halken S, Hoffmann-Sommergruber K, DunnGalvin A, Hourihane JO, Regent L, de Jong NW, Roberts G, Sheikh A.
Allergy 2014 Jul;69(7):834-844
Click to view abstract

Basophil response to peanut allergens in Mediterranean peanut-allergic patients.  
Mayorga C, Gomez F, Aranda A, Koppelman SJ, az-Perales A, Blanca-Lopez N, Blazquez AB, Blanca M, Torres MJ.
Allergy 2014 Jul;69(7):964-968
Click to view abstract

Efficacy of IgE-targeted vs empiric six-food elimination diets for adult eosinophilic oesophagitis.  
Rodriguez-Sanchez J, Gomez TE, Lopez VB, de la Santa BE, Martin DF, Garcia RC, Feo BF, Olmedo CJ, Reales FP, Molina-Infante J.
Allergy 2014 Jul;69(7):936-942
Click to view abstract

Geographic and temporal variations in pollen exposure across Europe.  
Smith M, Jager S, Berger U, Sikoparija B, Hallsdottir M, Sauliene I, Bergmann KC, Pashley CH, de WL, Majkowska-Wojciechowska B, Rybnicek O, Thibaudon M, Gehrig R, Bonini M, Yankova R, Damial.
Allergy 2014 Jul;69(7):913-923
Click to view abstract

Fatal anaphylaxis with neuromuscular blocking agents: a risk factor and management analysis.  
Reitter M, Petitpain N, Latarche C, Cottin J, Massy N, Demoly P, Gillet P, Mertes PM.
Allergy 2014 Jul;69(7):954-959
Click to view abstract

EAACI Food Allergy and Anaphylaxis Guidelines. Food allergy health-related quality of life measures.  
Muraro A, Dubois AE, DunnGalvin A, Hourihane JO, de Jong NW, Meyer R, Panesar SS, Roberts G, Salvilla S, Sheikh A, Worth A, Flokstra-de Blok BM.
Allergy 2014 Jul;69(7):845-853
Click to view abstract

Peanut allergens are rapidly transferred in human breast milk and can prevent sensitization in mice.  
Bernard H, Ah-Leung S, Drumare MF, Feraudet-Tarisse C, Verhasselt V, Wal JM, Creminon C, del-Patient K.
Allergy 2014 Jul;69(7):888-897
Click to view abstract

Association between egg and staphylococcal superantigen IgE sensitizations in atopic dermatitis.  
Ong PY.
Allergy Asthma Proc 2014 Jul;35(4):346-348
Click to view abstract

Allergic reactions to foods by inhalation in children.  
Leonardi S, Pecoraro R, Filippelli M, Miraglia Del GM, Marseglia G, Salpietro C, Arrigo T, Stringari G, Rico S, La RM, Caffarelli C.
Allergy Asthma Proc 2014 Jul;35(4):288-294
Click to view abstract

Occupational hypersensitivity pneumonitis in a baker: a new cause.  
Gerfaud-Valentin M, Reboux G, Traclet J, Thivolet-Bejui F, Cordier JF, Cottin V.
Chest 2014 Apr;145(4):856-858

Effectiveness of mite-impermeable covers: a hypothesis-generating meta-analysis.  
van Boven FE.
Clin Exp Allergy 2014 Jul 22;
Click to view abstract

Systems biology approaches to enhance our understanding of drug hypersensitivity reactions.  
Perkins J, Barrionuevo E, Ranea J, Blanca M, Cornejo-Garcia J.
Clin Exp Allergy 2014 Jul 15;
Click to view abstract

Does cobalt spot testing of copper items result in false-positive test reactions?  
Thyssen JP, Johansen JD, Menne T, Jellesen MS.
Contact Dermatitis 2013 Dec;69(6):387-388

Henna stone: a lesser-known solid material from which to obtain black henna paste.  
Ozkaya E, Yazganoglu KD.
Contact Dermatitis 2013 Dec;69(6):386

Glyceryl (mono)caprylate - a new contact allergen.  
Herbert VG, Spiro JM, Reich K, Steinkraus V, Karimi J, Martin V, Breuer K.
Contact Dermatitis 2013 Dec;69(6):383-385

Patch test reaction to p-phenylenediamine can persist for more than 1 month.  
Uchida S, Oiso N, Matsunaga K, Kawada A.
Contact Dermatitis 2013 Dec;69(6):382-383

Allergic contact dermatitis caused by self-adhesive electrocardiography electrodes in an infant.  
Deswysen AC, Zimerson E, Goossens A, Bruze M, Baeck M.
Contact Dermatitis 2013 Dec;69(6):379-381

Allergic contact dermatitis caused by menthoxypropanediol in a lip cosmetic.  
Franken L, de GA, Laheij-de Boer AM.
Contact Dermatitis 2013 Dec;69(6):377-378

Systemic allergic dermatitis caused by thiamine after iontophoresis.  
Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Munoz D.
Contact Dermatitis 2013 Dec;69(6):375-376

Patch testing with serial dilutions and thin-layer chromatograms of oak moss absolutes containing high and low levels of atranol and chloroatranol.  
Mowitz M, Zimerson E, Svedman C, Bruze M.
Contact Dermatitis 2013 Dec;69(6):342-349

Coupled exposure to ingredients of cosmetic products: I. Fragrances.  
Uter W, Yazar K, Kratz EM, Mildau G, Liden C.
Contact Dermatitis 2013 Dec;69(6):335-341

Cigarette exposure in very early life leads to persistent respiratory effects.  
Johnson CC, Wegienka GR.
Am J Respir Crit Care Med 2014 Feb 15;189(4):380-381

Quantification of pulmonary inflammation after segmental allergen challenge using turbo-inversion recovery-magnitude magnetic resonance imaging.  
Vogel-Claussen J, Renne J, Hinrichs J, Schonfeld C, Gutberlet M, Schaumann F, Winkler C, Faulenbach C, Krug N, Wacker FK, Hohlfeld JM.
Am J Respir Crit Care Med 2014 Mar 15;189(6):650-657

IgE mediated anaphylaxis in a patient with systemic mastocytosis. [French]  
Escande H, Bennani I, Bulai LC, Uthurriague C, Paul C, Nougue J.
Ann Dermatol Venereol 2013 Oct;140(10):641-644

Allergic contact dermatitis due to methoxy PEG-22 dodecyl glycol present in a cosmetic cold cream. [French]  
Lasek-Duriez A, Castelain MC, Modiano P.
Ann Dermatol Venereol 2013 Aug;140(8-9):528-530

Chronic food protein-induced enterocolitis syndrome caused by cow's milk proteins passed through breast milk.  
Miceli SS, Monaco S, Greco M, Scala G.
Int Arch Allergy Immunol 2014 Jul 15;164(3):207-209
Click to view abstract

Cor a 14: Missing Link in the Molecular Diagnosis of Hazelnut Allergy?  
Faber MA, De Graag M, Van Der Heijden C, Sabato V, Hagendorens MM, Bridts CH, De Clerck LS, Ebo DG.
Int Arch Allergy Immunol 2014 Jul 15;164(3):200-206
Click to view abstract

Cutaneous or respiratory exposures to peanut allergens in mice and their impacts on subsequent oral exposure.  
Wavrin S, Bernard H, Wal JM, del-Patient K.
Int Arch Allergy Immunol 2014 Jul 15;164(3):189-199
Click to view abstract

Multiple nonsteroidal anti-inflammatory drug-induced cutaneous disease: relevance, natural evolution and relationship with atopy.  
Blanca-Lopez N, Dona I, Perkins JR, Canto G, Cornejo-Garcia JA, Blanca M.
Int Arch Allergy Immunol 2014 Jul 4;164(2):147-148

Non-specific lipid transfer proteins: a protein family in search of an allergenic pattern.  
Gadermaier G.
Int Arch Allergy Immunol 2014 Jul 10;164(3):169-170

Ready for a Milk Shake?  
Hochwallner H.
Int Arch Allergy Immunol 2014 Jul 10;164(3):167-168

Systemic contact dermatitis possibly related to metal implants.  
Lieberman P, Fonacier L.
J Allergy Clin Immunol Pract 2014 Jul;2(4):487

Hypersensitivity pneumonitis by Fusarium vasinfectum in a home environment.  
Ramirez RM, Jacobs RL.
J Allergy Clin Immunol Pract 2014 Jul;2(4):483-484

Low preparedness for food allergy as perceived by school staff: a EuroPrevall survey across Europe.  
Le TM, Kummeling I, Dixon D, Barreales TL, Ballmer-Weber B, Clausen M, Gowland MH, Majkowska-Wojciechowska B, Mustakov T, Papadopoulos NG, Knulst AC, Potts J, Stukas R, Burney P.
J Allergy Clin Immunol Pract 2014 Jul;2(4):480-482

Anaphylaxis during skin prick testing for amoxicillin allergy.  
Syrigou E, Syrigos K.
J Allergy Clin Immunol Pract 2014 Jul;2(4):478-479

Hypersensitivity to methylprednisolone sodium succinate in children with milk allergy.  
Levy Y, Segal N, Nahum A, Marcus N, Garty BZ.
J Allergy Clin Immunol Pract 2014 Jul;2(4):471-474

Fixed drug eruption to quinine: a case report and review of the literature.  
Genest G, Thomson DM.
J Allergy Clin Immunol Pract 2014 Jul;2(4):469-470

Penicillin skin testing is a safe and effective tool for evaluating penicillin allergy in the pediatric population.  
Fox SJ, Park MA.
J Allergy Clin Immunol Pract 2014 Jul;2(4):439-444
Click to view abstract

Nonsteroidal anti-inflammatory drugs are major causes of drug-induced anaphylaxis.  
Aun MV, Blanca M, Garro LS, Ribeiro MR, Kalil J, Motta AA, Castells M, Giavina-Bianchi P.
J Allergy Clin Immunol Pract 2014 Jul;2(4):414-420
Click to view abstract

Localized bullous fixed drug eruption following yellow fever vaccine.  
Sako EY, Rubin A, Young LC.
J Am Acad Dermatol 2014 May;70(5):e113-e114

Vancomycin-associated neutrophilic dermatitis histologically mimicking Cryptococcus.  
Boyd AS, Ortleb M.
J Am Acad Dermatol 2014 Apr;70(4):e86-e88

Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to surfactants.  
Shaughnessy CN, Malajian D, Belsito DV.
J Am Acad Dermatol 2014 Apr;70(4):704-708

Induction of remission of idiopathic anaphylaxis with rituximab.  
Borzutzky A, Morales PS, Mezzano V, Nussbaum S, Burks AW.
J Allergy Clin Immunol 2014 Jul 10;

Systemic and localized seminal plasma hypersensitivity patients exhibit divergent immunologic characteristics.  
Ghosh D, Bernstein JA.
J Allergy Clin Immunol 2014 Jul 3;

Respiratory allergy to airborne fungi in Sao Luis - MA: clinical aspects and levels of IgE in a structured asthma program.  
Bezerra GF, de Almeida FC, Neto da Silva MA, Nascimento AC, Meireles Guerra RN, Viana GM, Muniz Filho WE, Costa MD, Zaror L, Brandao N.
J Asthma 2014 Jul 9;1-7
Click to view abstract

The immunology of food allergy.  
Johnston LK, Chien KB, Bryce PJ.
J Immunol 2014 Mar 15;192(6):2529-2534

Comparison of specific IgE antibodies to wheat component allergens in two phenotypes of wheat allergy.  
Nam YH, Hwang EK, Jin HJ, Lee JM, Shin YS, Ye YM, Palacin A, Salcedo G, Lee SY, Park HS.
J Korean Med Sci 2013 Nov;28(11):1697-1699

Case report of occupational asthma induced by polyvinyl chloride and nickel.  
Song GW, Ban GY, Nam YH, Park HS, Ye YM.
J Korean Med Sci 2013 Oct;28(10):1540-1542

Insect allergy in children.  
Tan JW, Campbell DE.
J Paediatr Child Health 2013 Sep;49(9):E381-E387

2014 adult immunization schedule: recombinant flu vaccine expands options for people with egg allergies.  
Jin J.
JAMA 2014 Mar 5;311(9):893

Henna tattoo: infection or allergy?  
Ip N, Hoddes J.
Lancet 2014 Apr 19;383(9926):1436

Acute allergic reaction after intravenous saline injection: an unusual presentation of chlorhexidine allergy.  
Mushtaq U, Tan A, Tan JA, Smith WB.
Med J Aust 2014 Jun 2;200(10):599-600

A clinical case of occupational allergy to piperacilline. A novel diagnostic method: basophil activation test (BAT). [Italian]  
Marraccini P, Digiesi G, Pignatti P, Bordini L, Previdi M.
Med Lav 2013 Nov;104(6):434-439

Laboratory animal allergy: follow-up in a research centre. [Italian]  
Cauz P, Bovenzi M, Filon FL.
Med Lav 2014 Jan;105(1):30-36

The effects of climate and aero allergens changes in allergic rhinoconjunctivitis and allergic asthma patients in Mediterranean region between 2011 and 2012.  
Yalcin AD, Basaran S.
Med Sci Monit 2013;19710-711

The major cockroach allergen Bla g 4 binds tyramine and octopamine.  
Offermann LR, Chan SL, Osinski T, Tan YW, Chew FT, Sivaraman J, Mok YK, Minor W, Chruszcz M.
Mol Immunol 2014 Jul;60(1):86-94

Clinical practice. Hymenoptera-sting hypersensitivity.  
Casale TB, Burks AW.
N Engl J Med 2014 Apr 10;370(15):1432-1439

To live or not to live near a farm?  
Radon K.
Occup Environ Med 2014 Feb;71(2):79

Additional indications for the low allergenic properties of the apple cultivars Santana and Elise.  
Vlieg-Boerstra BJ, van de Weg WE, van der HS, Skypala I, Bures P, Ballmer-Weber BK, Hoffmann-Sommergruber K, Zauli D, Ricci G, Dubois AE.
Plant Foods Hum Nutr 2013 Dec;68(4):391-395

The anaphylactoid constituents in Xue-Sai-Tong injection.  
Xiang Z, Qiao T, Xiao H, Kang TG, Dou D, Li H, Kuang H.
Planta Med 2013 Aug;79(12):1043-1050

Allergic contact dermatitis to chlorhexidine.  
Toholka R, Nixon R.
Australas J Dermatol 2013 Nov;54(4):303-306

Allergic contact dermatitis to methylisothiazolinone: exposure from baby wipes causing hand dermatitis.  
Boyapati A, Tam M, Tate B, Lee A, Palmer A, Nixon R.
Australas J Dermatol 2013 Nov;54(4):264-267

Allergic contact dermatitis to indium in jewellery: diagnosis made possible through the use of the Contact Allergen Bank Australia.  
Gamboni SE, Simmons I, Palmer A, Nixon RL.
Australas J Dermatol 2013 May;54(2):139-140

Allergic contact stomatitis to dodecyl gallate? A review of the relevance of positive patch test results to gallates.  
Gamboni SE, Palmer AM, Nixon RL.
Australas J Dermatol 2013 Aug;54(3):213-217

Toxic epidermal necrolysis caused by over the counter eyedrops.  
Byrom L, Zappala T, Muir J.
Australas J Dermatol 2013 May;54(2):144-146

Ovalbumin modified with pyrraline, a Maillard reaction product, shows enhanced T-cell immunogenicity.  
Heilmann M, Wellner A, Gadermaier G, Ilchmann A, Briza P, Krause M, Nagai R, Burgdorf S, Scheurer S, Vieths S, Henle T, Toda M.
J Biol Chem 2014 Mar 14;289(11):7919-7928

Allergenius, an expert system for the interpretation of allergen microarray results  
Giovanni Melioli, Clive Spenser, Giorgio Reggiardo, Giovanni Passalacqua, Enrico Compalati et al
WAO Journal 2014;7:15-
Click to view abstract Click to view abstract

International consensus on (ICON) anaphylaxis - CONSENSUS DOCUMENT  
F Estelle R Simons, Ledit RF Ardusso, M Bilò, Victoria Cardona, Motohiro Ebisawa et al.
WAO Journal 2014;7:9-
Click to view abstract Click to view abstract

Happy 25th birthday, Bet v 1!  
Erika Jensen-Jarolim
WAO Journal 2014;7:14
Click to view abstract Click to view abstract


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