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 Allergy Advisor Digest - June 2010
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Read Serum IgE measurement and detection of food allergy in pediatric patients with eosinophilic esophagitis.
Read Determination of storage conditions for shrimp extracts: analysis of specific IgE-allergen profiles.
Read A survey of serum specific-lgE to common allergens in primary school children of Taipei City.
Read Cross-reactive carbohydrate determinants strongly affect the results of the basophil activation test in hymenoptera-venom allergy.
Read Immunological characterization of Can f 4: a dog dander allergen cross-reactive with a 23 kDa odorant-binding protein in cow dander.
Read Classification and pathophysiology of radiocontrast media hypersensitivity.
Read Anaphylaxis and insect allergy.
Read Food allergy and oral allergy or pollen-food syndrome.
Read Important variations in parvalbumin content in common fish species: a factor possibly contributing to variable allergenicity.
Read Plant-expressed recombinant mountain cedar allergen Jun a 1 is allergenic and has limited pectate lyase activity.
Read Comparison of IgE-binding capacity, cross-reactivity and biological potency of allergenic non-specific lipid transfer proteins from peach, cherry and hazelnut.
Read Basophil activation marker CD203c is useful in the diagnosis of hen's egg and cow's milk allergies in children.
Read Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy.
Read Peanut allergy and allergic airways inflammation.
Read Anaphylaxis to Mango: ten cases reported in the Allergy Vigilance Networ
Read Assessment of the role of aeroallergens in patients with chronic urticaria
Read Hyaluronidase allergy: a rare cause of periorbital inflammation.
Read Nickel allergy presenting as mobile phone contact dermatitis.
Read Lipocalin-type prostaglandin D synthase and egg white cystatin react with IgE antibodies from children with egg allergy.
Read Cloning, expression, characterization, cross-reactivity of manganese superoxide dismutase allergen from pistachio Nut.
Read Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma.
Read Five cases of food allergy to vegetable worm (Cordyceps sinensis)
Read Geographical variations in the prevalence of atopic sensitization in six study sites across Canada.

Allergy and Intolerance Abstracts
Serum IgE measurement and detection of food allergy in pediatric patients with eosinophilic esophagitis.
The measurement of serum specific IgE levels has not been studied in pediatric eosinophilic esophagitis (EE). This study comparee the results of serum IgE testing, patch testing, and epicutaneous skin testing to measure allergic sensitization in a cross-sectional study of 53 pediatric patients with EE. The overall prevalence of food and inhalant sensitization was 80%, with higher total IgE levels in sensitized vs nonsensitized patients (median, 150 vs 13 IU/mL). For foods, serum IgE measurement detected more positive results than did skin prick testing. Specific IgE to milk was most common (43%). Inhalants were implicated as frequently as were foods. In keeping with this, 32% of patients had a cluster of multiple sensitivities that included pollens, soy, grains, peanut, and tree nuts and had higher total IgE levels. Patch tests were positive in 39% of patients (rye, wheat, and soy were the most common). Therefore, most, but not all, patients with EE are highly atopic individuals with frequent allergic sensitivities. Thus, serum IgE measurement of low-titer IgE antibody may be useful in identifying relevant food sensitivities and in distinguishing subgroups of patients with EE, making a more directed approach to food avoidance possible.

Serum IgE measurement and detection of food allergy in pediatric patients with eosinophilic esophagitis.  
Erwin EA, James HR, Gutekunst HM, Russo JM, Kelleher KJ, Platts-Mills TA.
Ann Allergy Asthma Immunol 2010 Jun;104(6):496-502

Index
Allergy and Intolerance Abstracts
Determination of storage conditions for shrimp extracts: analysis of specific IgE-allergen profiles.
The consumption of shrimp is a common cause of food hypersensitivity reactions. Due to the lack of a wide variety of commercial shrimp extracts for skin prick tests (SPTs), the authors selected various shrimp species for the preparation of local shrimp extracts. The objective of the study was to determine the potency of the shrimp extracts under different storage conditions and durations. Specific IgE-allergen profiles of eight shrimp-allergic patients were investigated by using sera incubated with extracts prepared from lyophilized raw or boiled shrimp, which were stored at 4 degress C or -20 degress C for up to 4 weeks. When stored at -20 degress C, most allergens were preserved after 4 weeks. However, storage at 4 degress C results in few allergens remaining after 2 weeks. Boiled-shrimp extracts stored at 4 degree C and -20 degress C contained higher amounts of IgE-allergen complexes than raw-shrimp extracts. Moreover, in both raw and boiled shrimp extracts, the IgE bound 36-40 kDa allergens constituted the major proteins since they were observed in all IgE-allergen profiles. Therefore the authors recommend that shrimp extracts are stored at -20 degress C for 4 weeks to prevent the loss of allergens.

Determination of storage conditions for shrimp extracts: analysis of specific IgE-allergen profiles.  
Piboonpocanun S, Boonchoo S, Pariyaprasert W, Visitsunthorn N, Jirapongsananuruk O.
Asian Pac J Allergy Immunol 2010 Mar;28(1):47-52

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Allergy and Intolerance Abstracts
A survey of serum specific-lgE to common allergens in primary school children of Taipei City.
This Taiwanese study investigated changes in common allergen sensitivities among children in Taipei City. A total of 142 primary schools in Taipei City, which included 25,094 students aged 7-8 years, were surveyed using an ISAAC questionnaire to screen for allergies. For positive responders, serum allergen-specific IgE was confirmed using the Pharmacia CAP system. A total of 1,500 students (5.98%) had confirmed sensitivities to allergens. Dust mite sensitivity among these children was nearly 90%. The prevalences of sensitivities to Dermatophagoides pteronyssinus, D. farinae and Blomia tropicalis were 90.79%, 88.24%, and 84.63%, respectively. Dog dander (29.95%) was the second most common aeroallergen to induce sensitivity. Allergies to cat dander (8.69%) and to cockroach (15.48%) had decreased dramatically compared with previous analyses. Among the food allergens studied, the most common allergens that induced sensitization were (in order of prevalence) crab, milk, egg white, and shrimp (88.08%, 22.45%, 24.23%, and 21.44%, respectively). Mold and pollen sensitization was identified in fewer than 2% of the schoolchildren. Dust mites remain the most common allergen to induce allergic sensitization among children in Taipei City, while cockroach and mold sensitivities have dramatically declined. Food allergens should also be considered as a trigger of respiratory allergy. Except for dust mites, American cockroach and crab, allergens commonly reported to induce sensitization in other Asian counties are not common in Taiwan.

A survey of serum specific-lgE to common allergens in primary school children of Taipei City.  
Wan KS, Yang W, Wu WF.
Asian Pac J Allergy Immunol 2010 Mar;28(1):1-6

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Allergy and Intolerance Abstracts
Cross-reactive carbohydrate determinants strongly affect the results of the basophil activation test in hymenoptera-venom allergy.
The aim of this study was to investigate the biological activity of CCD-sIgE and the suitability of the basophil activation test (BAT) in hymenoptera venom-allergic patients (honeybee venom (HBV) and yellow jacket venom (YJV) having CCD-sIgE. The study concludes that in vitro basophil activation test (BAT) clearly demonstrates biological activity of cross-reactive carbohydrate determinants-sIgE (CCD-sIgE). However, because most of the patients showed a mono-positive intracutaneous skin tests (IC) and activation of basophils with the IC-negative venom was significantly lower compared with the IC-positive one, the present data suggest that CCD-sIgE is clinically irrelevant in these patients.

Cross-reactive carbohydrate determinants strongly affect the results of the basophil activation test in hymenoptera-venom allergy.  
Mertens M, Amler S, Moerschbacher BM, Brehler R.
Clin Exp Allergy 2010 Jun 7;

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Allergy and Intolerance Abstracts
Immunological characterization of Can f 4: a dog dander allergen cross-reactive with a 23 kDa odorant-binding protein in cow dander.
The object of this study was to purify, clone and characterize dog dander allergen Can f 4. Can f 4 was cloned and used to produce recombinant Can f 4 in Escherichia coli. A 23 kDa protein from cow dander, displaying cross-reactivity with Can f 4, was purified. Recombinant Can f 4 displayed close immunological and biochemical similarity to purified natural Can f 4 and bound IgE antibodies from 13/37 (35%) sera of dog allergic subjects. Can f 4 reactive sera showed IgE binding to a 23 kDa protein present in cow dander extract, related to a family of odorant-binding proteins. The dog and cow proteins shared 37% sequence identity and their cross-reactivity was demonstrated by IgE inhibition experiments.

Molecular and immunological characterization of Can f 4: a dog dander allergen cross-reactive with a 23 kDa odorant-binding protein in cow dander.  
Mattsson L, Lundgren T, Olsson P, Sundberg M, Lidholm J.
Clin Exp Allergy 2010 Jun 7;

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Allergy and Intolerance Abstracts
Classification and pathophysiology of radiocontrast media hypersensitivity.
"Hypersensitivity reactions to radiocontrast media (RCM) are unpredictable and are a concern for radiologists and cardiologists. Immediate hypersensitivity reactions manifest as anaphylaxis, and an allergic IgE-mediated mechanism has been continuously discussed for decades. Non-immediate reactions clinically are exanthemas resembling other drug-induced non-immediate hypersensitivities. During the past years, evidence is increasing that some of these reactions may be immunological. Repeated reactions after re-exposure, positive skin tests, and presence of specific IgE antibodies as well as positive basophil activation tests in some cases, and positive lymphocyte transformation or lymphocyte activation tests in others, indicate that a subgroup of both immediate and non-immediate reactions are of an allergic origin, although many questions remain unanswered. Recently reported cases highlight that pharmacological premedication is not safe to prevent RCM hypersensitivity in patients with previous severe reactions. These insights may have important consequences. A large multicenter study on the value of skin tests in RCM hypersensitivity concluded that skin testing is a useful tool for diagnosis of RCM allergy. It may have a role for the selection of a safe product in previous reactors, although confirmatory validation data is still scarce. In vitro tests to search for RCM-specific cell activation still are in development. In conclusion, recent data indicate that RCM hypersensitivity may have an allergic mechanism and that allergological testing is useful and may indicate tolerability."

Classification and pathophysiology of radiocontrast media hypersensitivity.  
Brockow K, Ring J.
Chem Immunol Allergy 2010;95157-169

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Allergy and Intolerance Abstracts
Anaphylaxis and insect allergy.
"PURPOSE OF REVIEW: Anaphylaxis is an acute-onset and potentially life-threatening allergic reaction that can be caused by numerous allergic triggers including stinging insects. This review focuses on recent advances, natural history, risk factors and therapeutic considerations.

RECENT FINDINGS: Recent work suggests that concerns over insect allergy diagnosis continue to exist. This is especially true with individuals who have a convincing history of a serious life-threatening anaphylactic event, but lack the necessary diagnostic criteria of venom-specific IgE by skin test or in-vitro diagnostic methods to confirm the diagnosis. The role of occult mastocytosis or increased basophile reactivity may play a role in this subset population. Additionally, epinephrine continues to be underutilized as the primary acute intervention for an anaphylactic reaction in the emergent setting.

SUMMARY: The incidence of anaphylaxis continues to rise across all demographic groups, especially those less than 20 years of age. Fortunately, the fatalities related to anaphylaxis appear to have decreased over the past decades. Our understanding of various triggers, associated risk factors, as well as an improved understanding and utilization of biological markers such as serum tryptase have improved. Our ability to treat insect anaphylaxis by venom immunotherapy is highly effective. Unfortunately, anaphylaxis continues to be underappreciated and undertreated especially in regard to insect sting anaphylaxis. This includes the appropriate use of injectable epinephrine as the primary acute management tool. These findings suggest that continued education of the general population, primary care healthcare providers and emergency departments is required."

Anaphylaxis and insect allergy.  
Demain JG, Minaei AA, Tracy JM.
Curr Opin Allergy Clin Immunol 2010 Jun 10;

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Allergy and Intolerance Abstracts
Food allergy and oral allergy or pollen-food syndrome.
"This paper reviews current concepts in our understanding of oral allergy or pollen-food syndrome. As technology has improved, much more accurate profiling of food allergic individuals is now possible, resulting in more precise diagnosis, elucidation of cross reactivity patterns and more helpful prediction of risk of anaphylaxis. "

"In-vitro screening of food allergic patients with large panels of allergens will change the accuracy of diagnosis resulting in better management. Allergens are now available for use in the allergist's office to improve diagnostic accuracy of skin tests in patients presenting with plant-food allergy. Knowledge of the specific sensitization of individual patients has consequences for both risk assessment and dietary management."

Food allergy and oral allergy or pollen-food syndrome.  
Katelaris CH.
Curr Opin Allergy Clin Immunol 2010 Jun;10(3):246-251

Index
Allergy and Intolerance Abstracts
Important variations in parvalbumin content in common fish species: a factor possibly contributing to variable allergenicity.
Although 95% of fish-allergic patients are sensitized to the major fish allergen parvalbumin, clinical reactions to different fish species vary considerably in symptoms, intensity and frequency in allergic subjects. This study aimed at the quantification of parvalbumin levels in salmon, trout, cod, carp, mackerel, herring, redfish and tuna.

Fish muscle extracts were separated and parvalbumin content was estimated. Individual antisera were raised against parvalbumins purified from seven fish species. Parvalbumin content was quantified in fish (raw/processed) and skin prick test (SPT) solutions. Parvalbumin contents were <0.5 mg per gram tissue for mackerel, 0.5-2 mg for salmon and trout, and >2 mg for cod, carp, redfish and herring. Using ELISA, parvalbumin content ranged from <0.05 mg for tuna, 0.3-0.7 mg for mackerel, 1-2.5 mg for salmon, trout and cod to >2.5 mg per gram raw muscle for carp, herring and redfish. The parvalbumin content of processed samples (cooked/commercial) was 20-60% lower. Allergen content in SPT samples ranged from 20 to 70 mug parvalbumin/ml of extract. No parvalbumin was found in tuna SPT solution. Therefore the parvalbumin content of most commonly consumed fish species varies considerably. Differences range from severalfold to one hundredfold. This has to be taken into account when designing food challenge tests and advising fish-allergic patients.

Important variations in parvalbumin content in common fish species: a factor possibly contributing to variable allergenicity.  
Kuehn A, Scheuermann T, Hilger C, Hentges F.
Int Arch Allergy Immunol 2010 Jun 17;153(4):359-366

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Allergy and Intolerance Abstracts
Plant-expressed recombinant mountain cedar allergen Jun a 1 is allergenic and has limited pectate lyase activity.
Jun a 1 (from Mountain cedar) is the dominant allergenic protein of this tree, but biologically active recombinant Jun a 1 has not been successfully expressed, despite numerous attempts with several expression systems. In this study, recombinant Jun a 1 was expressed and recovered in good quantity (100 mug/g Tobacco leaf material), was confirmed as Jun a 1, bound IgE from sera from cedar hypersensitive patients and inhibited IgE binding to native Jun a 1. Jun a 1 pectate lyase activity was demonstrated, which may explain the necrosis seen on host plants, which was similar to that of control plants expressing banana pectate lyase.

Plant-expressed recombinant mountain cedar allergen jun a 1 is allergenic and has limited pectate lyase activity.  
Liu Z, Bhattacharyya S, Ning B, Midoro-Horiuti T, Czerwinski EW, Goldblum RM, Mort A, Kearney CM.
Int Arch Allergy Immunol 2010 Jun 17;153(4):347-358

Index
Allergy and Intolerance Abstracts
Comparison of IgE-binding capacity, cross-reactivity and biological potency of allergenic non-specific lipid transfer proteins from peach, cherry and hazelnut.
This study investigated the allergenic properties of non-specific lipid transfer proteins (nsLTPs) from Rosaceae and non-Rosaceae foods. In peach-, cherry- or hazelnut-allergic patients, prevalence of sensitization, IgE-binding capacity, cross-reactivity and allergenic potency of Pru p 3 was compared with Pru av 3 (cherry) and Cor a 8 (hazelnut). The frequency of sensitization to corresponding nsLTPs was 88, 85, and 77% in peach-, hazelnut- and cherry-allergic patients, respectively. Concomitant allergic reactions to cherry and hazelnut were reported in 51 and 44% of peach-allergic patients, respectively. In contrast to cherry allergy, hazelnut allergy was not strictly associated to peach allergy. Sensitization to Cor a 8 or Pru av 3 was strongly correlated with IgE reactivity to Pru p 3, even when subjects tolerated peach. Specific IgE was highest for Rosaceae LTPs, and cross-inhibition experiments confirmed a stronger IgE-binding capacity of Pru p 3 than Cor a 8. The biological potency of Pru p 3 and Pru av 3 was similar but stronger for both nsLTPs than that of Cor a 8. Therefore clinical cross-reactivity of food-allergic patients in the Mediterranean area is likely attributed to a primary sensitization to Pru p 3 and serological cross-reactivity with homologous food nsLTPs. In comparison to Cor a 8, Rosaceae nsLTPs showed a stronger IgE-binding capacity and allergenic potency indicating a different epitope pattern.

Comparison of IgE-binding capacity, cross-reactivity and biological potency of allergenic non-specific lipid transfer proteins from peach, cherry and hazelnut.  
Hartz C, Lauer I, Del Mar San Miguel Moncin, Cistero-Bahima A, Foetisch K, Lidholm J, Vieths S, Scheurer S.
Int Arch Allergy Immunol 2010 Jun 17;153(4):335-346

Index
Allergy and Intolerance Abstracts
Basophil activation marker CD203c is useful in the diagnosis of hen's egg and cow's milk allergies in children.
This study concludes that assessment of food antigen-induced CD203c expression on basophils is useful in the diagnosis of hen's egg and cow's milk allergies in children and to determine if children will outgrow FA as well as in decision making regarding whether or not to perform OFCs

Basophil activation marker CD203c is useful in the diagnosis of hen's egg and cow's milk allergies in children.  
Sato S, Tachimoto H, Shukuya A, Kurosaka N, Yanagida N, Utsunomiya T, Iguchi M, Komata T, Imai T, Tomikawa M, Ebisawa M.
Int Arch Allergy Immunol 2010;152 Suppl 154-61

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Allergy and Intolerance Abstracts
Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy.
In this prospective Israeli study the feeding history of 13,019 infants was obtained by means of telephone interview (95.8%) or questionnaire (4.2%). The cumulative incidence for IgE-mediated CMA was 0.5%. Only 0.05% of the infants who were started on regular CMP formula within the first 14 days versus 1.75% who were started on formula between the ages of 105 and 194 days had IgE-mediated CMA. The odds ratio was 19.3 (95% CI, 6.0-62.1) for development of IgE-mediated CMA among infants with exposure to CMP at the age of 15 days or more (P < .001). Sixty-four patients with IgE-mediated CMA tolerated soy, and none had a proved allergy to soy. The study concludes that IgE-mediated CMA in this cohort is much less common than generally reported. Early exposure to CMP as a supplement to breast-feeding might promote tolerance. Finally, soy is a reasonable feeding alternative in patients with IgE-mediated CMA

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy.  
Katz Y, Rajuan N, Goldberg MR, Eisenberg E, Heyman E, Cohen A, Leshno M.
J Allergy Clin Immunol 2010 Jun 9;

Click to view abstract

Index
Allergy and Intolerance Abstracts
Peanut allergy and allergic airways inflammation.
Asthma is a major risk cofactor for anaphylactic deaths in children with peanut allergy. Peanut allergy is generally thought to be a lifelong condition, but some children outgrow their coexistent asthma. It has recently been shown that children who have 'outgrown' their asthma symptoms may have ongoing eosinophilic airways inflammation. The aims of our study were to look at fractional exhaled nitric oxide levels (FeNO), as a non-invasive marker of eosinophilic airways inflammation, in peanut allergic children and assess whether children with outgrown asthma had elevated levels. Ninety four peanut allergic children (aged 4-15 yr) were assessed. In children with peanut allergy, the researchers found that those who had outgrown asthma had elevated FeNO levels in keeping with ongoing eosinophilic airways inflammation.

Peanut allergy and allergic airways inflammation.  
Hughes JL, Brown T, Edgar JD, Shields MD.
Pediatr Allergy Immunol 2010 Jun 20;

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Allergy and Intolerance Abstracts
Anaphylaxis to Mango: ten cases reported in the Allergy Vigilance Networ
"The prevalence of mango allergy is about 0.2 % out of all food allergies. The Allergy vigilance network reports 10 cases of severe mango anaphylaxis. Nine patients are women. Eight subjects are sensitized to mugwort pollen, and two to birch pollen. Six patients have food allergy to Apiaceae and two to pistachio, another Anacardiacea. The reaction was elicited by an industrial juice in four cases. Data about cross-reactivity with Art v 1, Bet v 1, Bet v 6, Api g 1, Api g 2, Dau c 1 and two thermostable major allergens are discussed as well as the cross reactivity between mango seeds and cashew nut. The potential risk of cross allergy between mango and tree nuts that are Anacardiaceae is a source of concern, because of the increasing consumption of cashew nut in France."

Anaphylaxie à la mangue : dix cas rapportés au Réseau allergovigilance aspects cliniques et fréquence actuelle / Anaphylaxis Mango: ten cases reported in the Allergy Vigilance Network - clinical and current frequency  
M. Morisset, D.-A. Moneret-Vautrin, P. Beaumont, B. Bonnefoy-Guionnet, M.-P. Chataignaullt, A. Cheynel, J.-P. Sacre, I. Sullerot, L. Parisot
Rev Fr Allergol 2010;50(4):406-409

Click to view abstract Click to view abstract

Index
Allergy and Intolerance Abstracts
Assessment of the role of aeroallergens in patients with chronic urticaria
The purpose of this study was to investigate the possible role of aeroallergens in patients with chronic idiopathic urticaria (CIU), and without allergic respiratory diseases. Two hundred patients with CU and no associated allergic respiratory diseases were recruited over an eight-month period from the Allergy Outpatient Clinic at Ain Shams University Hospital, Egypt. CU was diagnosed by history, physical examination and laboratory tests, which included tests for autoimmunity. Patients who had no obvious etiological factor for CU were further studied for sensitivity to common aeroallergens by skin prick test (SPT); cases that were positive for aeroallergens were further investigated by a specific IgE study.

Twenty-six of 200 patients (13%) had an etiological factor for urticaria, and were excluded from the study. The remaining 174 patients (87%) were diagnosed as CIU, and underwent SPT. Skin test positivity to aeroallergens only was significantly higher among patients with CIU than among controls (17.2% as compared to 3.5%). Among patients with CIU, the most common aeroallergens were mites (13.8%), followed by pollens (5.2%), and mixed molds (4%). All these aeroallergens were significantly more prevalent among cases than among healthy controls. Multiple allergen sensitivity was also significantly more prevalent among cases than controls. Specific IgE level was elevated (superior to 0.35 kU/L) to allergens in all cases with positive SPT.

Assessment of the role of aeroallergens in patients with chronic urticaria  
M.M. Refaat, E.N. Ossman, M.N. Farres, M.M. El-Khodeery, N.A. Arafa, M.Y. Attia
Rev Fr Allergol 2010;50(4):394-397

Click to view abstract Click to view abstract

Index
Allergy and Intolerance Abstracts
Hyaluronidase allergy: a rare cause of periorbital inflammation.
"Hyaluronidase is a bovine or ovine testicular protein that is used as an adjunct to co-administered medicaments and fluids to enhance their dispersion and absorption through the degradation of hyaluronan. While it is a known potential allergen, there are few reports of hyaluronidase hypersensitivity. A 56-year-old lady presented 8 hours post glaucoma surgery with ipsilateral lacriminorrhoea, periorbital erythema, oedema, proptosis, pruritus and conjunctival chemosis. Right ocular motility was restricted and visual acuity was reduced. The reaction settled with oral corticosteroids and antihistamines. Hyaluronidase allergy was confirmed on skin prick testing. Hyaluronidase allergy is rare. In the few cases reported, reactions occurred at various doses and were acute (intraoperative), early (within hours), intermediate (within days) or delayed (within weeks). Anaphylaxis has also been described. Primary sensitization appears to be a prerequisite for most reactions. The variability in onset of symptoms and the response to skin testing would suggest that type I and type IV hypersensitivity may both contribute to this response. In this case, the timing fitted with a late phase type 1 reaction. This case shows that despite being less common than haemorrhage for acute reactions and infection for delayed reactions, allergy can account for orbital inflammation following ophthalmic surgery."

Hyaluronidase allergy: a rare cause of periorbital inflammation.  
Borchard K, Puy R, Nixon R.
Australas J Dermatol 2010 Feb;51(1):49-51

Index
Allergy and Intolerance Abstracts
Nickel allergy presenting as mobile phone contact dermatitis.
A 39-year-old man presented with a 6-month history of a treatment-resistant facial dermatitis. The patient regularly used his mobile phone, predominantly on the left cheek. Patch testing confirmed the clinical suspicion of mobile phone contact dermatitis from nickel contained in the phone casing. Although infrequently reported, with the trend towards metallic mobile phone casings and the high incidence of nickel sensitization in the community, the incidence of mobile phone contact dermatitis is likely to increase.

Nickel allergy presenting as mobile phone contact dermatitis.  
Roberts H, Tate B.
Australas J Dermatol 2010 Feb;51(1):23-25

Index
Allergy and Intolerance Abstracts
Lipocalin-type prostaglandin D synthase and egg white cystatin react with IgE antibodies from children with egg allergy.
Egg white protein is composed of over 30 proteins; many of which have neither been identified nor their allergenicities characterized. Ovalbumin, ovomucoid, ovotransferrin, lysozyme, and ovomucin are known to be major allergens found in egg white. This study set out to analyze whether unknown proteins that bind to IgE antibodies in serum from patients with egg allergy exist in egg white. Diluted egg white proteins were separated and immunolabeling was performed on individual patient sera from 19 child patients with egg white allergy and 11 negative control subjects. Egg white proteins were separated into 63 spots. Twenty-five of the 63 reacted with egg allergy patients' sera, and 10 of the 25 reactive spots showed IgE-reactivity to controls as well. Specific bindings to the IgE from egg allergy patients were found in 15 spots; one of which was confirmed as ovotransferrin. Among the other 14 protein spots, egg white cystatin and lipocalin-type prostaglandin D synthase (L-PGDS) were newly identified proteins that reacted with IgE in patients with egg allergy.

Lipocalin-type prostaglandin D synthase and egg white cystatin react with IgE antibodies from children with egg allergy.  
Suzuki M, Fujii H, Fujigaki H, Shinoda S, Takahashi K, Saito K, Wada H, Kimoto M, Kondo N, Seishima M.
Allergol Int 2010 Jun;59(2):175-183

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Allergy and Intolerance Abstracts
Cloning, expression, characterization, cross-reactivity of manganese superoxide dismutase allergen from pistachio Nut.
Superoxide dismutase (s) has been identified as a panallergen and studied in different allergenic sources. Manganese Superoxide Dismutase (MnSOD) in pistachio may cause allergic reactions in atopic subjects. This study describes the cloning, expression, and purification of MnSOD from pistachio nut. The purified pistachio MnSOD was recognized by IgE in 10 (40%) out of the 25 sera tested. Results also showed that this protein might trigger some cross-reactions toward IgE antibodies and therefore could be considered as a panallergen.

Cloning, Expression, Characterization, and Computational Approach for Cross-Reactivity Prediction of Manganese Superoxide Dismutase Allergen from Pistachio Nut.  
Noorbakhsh R, Mortazavi SA, Sankian M, Shahidi F, Assarehzadegan MA, Varasteh A.
Allergol Int 2010 Jun 25;59(3):

Index
Allergy and Intolerance Abstracts
Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma.
Five hundred and forty-six inner-city adolescents enrolled in the Asthma Control Evaluation study underwent exhaled nitric oxide (FE(NO)) measurement, lung function testing, and completion of a questionnaire. Among sensitized participants, allergen-specific IgE levels were correlated with the corresponding settled dust allergen levels for cockroach, dust mite, and mouse (r = 0.38, 0.34, 0.19, respectively; P < 0.0001 for cockroach and dust mite and P = 0.03 for mouse), but not cat (r = -0.02, P = 0.71). Higher cockroach-, mite-, mouse-, and cat-specific IgE levels were associated with higher FE(NO) concentrations, poorer lung function, and higher blood eosinophils. Higher cat, dust mite, and mouse allergen-specific IgE levels were also associated with an increasing risk of exacerbations or hospitalization.

Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma.  
Matsui EC, Sampson HA, Bahnson HT, Gruchalla RS, Pongracic JA, Teach SJ, Gergen PJ, Bloomberg GR, Chmiel JF, Liu AH, Kattan M, Sorkness CA, Steinbach SF, Story RE, Visness CM.
Allergy 2010 Jun 17;

Index
Allergy and Intolerance Abstracts
Five cases of food allergy to vegetable worm (Cordyceps sinensis)
Cordyceps sinensis is a highly valued medicinal fungi of traditional Chinese medicine. Cordyceps sinensis is believed to have many beneficial properties. Cordyceps is a genus of ascomycete fungi (sac fungi) that includes about 400 described species. All Cordyceps species are endoparasitoids, mainly on insects and other arthropods (they are thus entomopathogenic fungi); a few are parasitic on other fungi. Cordyceps sinensis, known in English commonly as caterpillar fungus is considered a medicinal mushroom in oriental medicines, such as Traditional Chinese Medicines and Traditional Tibetan medicine.

This article describes 5 cases of food allergy to vegetable worm showing cross-reactivity with silkworm pupae.

Five cases of food allergy to vegetable worm (Cordyceps sinensis) showing cross-reactivity with silkworm pupae.  
Choi GS, Shin YS, Kim JE, Ye YM, Park HS.
Allergy 2010 Jun 14;

Index
Allergy and Intolerance Abstracts
Geographical variations in the prevalence of atopic sensitization in six study sites across Canada.
Adults aged 20-44 years in six study sites across Canada underwent allergy skin testing using 14 allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae) cat, cockroach, grasses (Timothy grass, Kentucky grass), molds (Cladosporium herbarium, Alternaria alternata, Aspergillus fumigatus, Penicillium), trees (tree mix, birch, Olea europea), and common ragweed. The overall prevalence of atopy was 62.7%. There was significant geographical variation in the prevalence of atopy in the six study sites (lowest 55.6% in Prince Edward Island, highest 66.0 in Montreal) and of sensitization to each of the allergens tested even after adjustment for confounders. When the first eight of the nine allergens in the ECRHS were used to estimate the prevalence of atopic sensitization, the prevalence of atopy in Canada was 57% compared with 35.2% overall for centers in the ECRHS.

Geographical variations in the prevalence of atopic sensitization in six study sites across Canada.  
Chan-Yeung M, Anthonisen NR, Becklake MR, Bowie D, Sonia BA, mich-Ward H, Ernst P, Sears MR, Siersted HC, Sweet L, Van TL, Manfreda J.
Allergy 2010 Jun 14;

Index

Allergen-, Food allergy-, Intolerance-related articles

Comparison of the skin-prick test and Phadia ImmunoCAP as tools to diagnose house-dust mite allergy.  
Jung YG, Cho HJ, Park GY, Min JY, Kim HY, Dhong HJ, Chung SK, Kim SW.
Am J Rhinol Allergy 2010 May;24(3):226-229
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Serum IgE measurement and detection of food allergy in pediatric patients with eosinophilic esophagitis.  
Erwin EA, James HR, Gutekunst HM, Russo JM, Kelleher KJ, Platts-Mills TA.
Ann Allergy Asthma Immunol 2010 Jun;104(6):496-502

On the cover. Eucalyptus globulus.  
Weber RW.
Ann Allergy Asthma Immunol 2010 Jun;104(6):A3

The role of component-resolved testing in food allergy and oral allergy syndrome.  
Thompson JC, Kroker GF.
Ann Allergy Asthma Immunol 2010 Jun;104(6):543-544

Occupational asthma caused by gerbil: purification and partial characterization of a new gerbil allergen.  
de las HM, Cuesta-Herranz J, Cases B, de MJ, Fernandez-Nieto M, Sastre J, Vivanco F, Pastor-Vargas C.
Ann Allergy Asthma Immunol 2010 Jun;104(6):540-542

A case of generalized urticaria caused by arrowroot ingestion.  
Kim JH, Kim JE, Choi GS, Ye YM, Park HS.
Ann Allergy Asthma Immunol 2010 Jun;104(6):539-540

Determination of storage conditions for shrimp extracts: analysis of specific IgE-allergen profiles.  
Piboonpocanun S, Boonchoo S, Pariyaprasert W, Visitsunthorn N, Jirapongsananuruk O.
Asian Pac J Allergy Immunol 2010 Mar;28(1):47-52

Comparison between Siriraj mite allergen vaccine and standardized commercial mite vaccine by skin prick testing in normal Thai adults.  
Visitsunthorn N, Pacharn P, Jirapongsananuruk O, Weeravejsukit S, Sripramong C, Sookrung N, Bunnag C.
Asian Pac J Allergy Immunol 2010 Mar;28(1):41-45
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A survey of serum specific-lgE to common allergens in primary school children of Taipei City.  
Wan KS, Yang W, Wu WF.
Asian Pac J Allergy Immunol 2010 Mar;28(1):1-6

Occupational asthma due to colistin in a pharmaceutical worker.  
Gomez-Olles S, Madrid-San MF, Cruz MJ, Munoz X.
Chest 2010 May;137(5):1200-1202
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Cross-reactive carbohydrate determinants strongly affect the results of the basophil activation test in hymenoptera-venom allergy.  
Mertens M, Amler S, Moerschbacher BM, Brehler R.
Clin Exp Allergy 2010 Jun 7;

Molecular and immunological characterization of Can f 4: a dog dander allergen cross-reactive with a 23 kDa odorant-binding protein in cow dander.  
Mattsson L, Lundgren T, Olsson P, Sundberg M, Lidholm J.
Clin Exp Allergy 2010 Jun 7;

Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation.  
Wang H, Mobini R, Fang Y, Barrenas F, Zhang H, Xiang Z, Benson M.
Clin Exp Allergy 2010 Jun 7;
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Component-resolved diagnosis of allergy: more is better?  
Salcedo G, az-Perales A.
Clin Exp Allergy 2010 Jun;40(6):836-838

Insect venoms.  
Muller UR.
Chem Immunol Allergy 2010;95141-156
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In vitro diagnosis of anaphylaxis.  
Sanz ML, Gamboa PM, Garcia-Figueroa BE, Ferrer M.
Chem Immunol Allergy 2010;95125-140
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T-cell response to allergens.  
Ozdemir C, Akdis M, Akdis CA.
Chem Immunol Allergy 2010;9522-44
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History and classification of anaphylaxis.  
Ring J, Behrendt H, de WA.
Chem Immunol Allergy 2010;951-11
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Anaphylactic reactions to local anesthetics.  
Ring J, Franz R, Brockow K.
Chem Immunol Allergy 2010;95190-200
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Anaphylaxis to general anesthetics.  
Moneret-Vautrin DA, Mertes PM.
Chem Immunol Allergy 2010;95180-189
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Analgesics.  
Szczeklik A.
Chem Immunol Allergy 2010;95170-179
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Classification and pathophysiology of radiocontrast media hypersensitivity.  
Brockow K, Ring J.
Chem Immunol Allergy 2010;95157-169

Update on epidemiology of pollinosis in Japan: changes over the last 10 years  
Nakae, K.; Baba, K.
Clin Exp Allergy Rev 2010;10 (1):2-7
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Prevalence of Japanese cedar pollinosis in Tokyo: a survey conducted by the Tokyo Metropolitan Government.  
Nishihata, S.; Murata, T.; Inoue, S.; Okubo, K.; Sahashi, N.; Takahashi, H.; Hirooka, J.; Hoshiyama, Y.; Murayama, K.; Mezawa, A.; Yokoyama, T.; Endo, T.; Saiga, T.; Saito, Y.
Clin Exp Allergy Rev 2010;10 (1):8-11
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Japanese cedarJapanese cypress pollen-dispersion information and the initial therapy.  
Endo T.
Clin Exp Allergy Rev 2010;10 (1):39-43
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Anaphylaxis and insect allergy.  
Demain JG, Minaei AA, Tracy JM.
Curr Opin Allergy Clin Immunol 2010 Jun 10;

Diagnosis and treatment of allergy to hymenoptera venoms.  
Hamilton RG.
Curr Opin Allergy Clin Immunol 2010 Jun 10;
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Avoidance or exposure to foods in prevention and treatment of food allergy?  
Prescott SL, Bouygue GR, Videky D, Fiocchi A.
Curr Opin Allergy Clin Immunol 2010 Jun;10(3):258-266

Food allergy and oral allergy or pollen-food syndrome.  
Katelaris CH.
Curr Opin Allergy Clin Immunol 2010 Jun;10(3):246-251

Food allergy and eosinophilic gastroenteritis and colitis.  
Bischoff SC.
Curr Opin Allergy Clin Immunol 2010 Jun;10(3):238-245
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The role of the gut mucosal immunity in the development of tolerance against allergy to food.  
Chahine BG, Bahna SL.
Curr Opin Allergy Clin Immunol 2010 Jun;10(3):220-225
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Botanical briefs: poisonwood (Metopium toxiferum).  
Hossler EW.
Cutis 2010 Apr;85(4):178-179

Implant allergies. [German]  
Thomas P, Thomsen M.
Hautarzt 2010 Mar;61(3):255-262
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Pen ch 13 major fungal allergen decreases CD44 expression in human bronchial epithelial cells.  
Tai HY, Tam MF, Chou H, Perng DW, Shen HD.
Int Arch Allergy Immunol 2010 Jun 17;153(4):367-371
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Important variations in parvalbumin content in common fish species: a factor possibly contributing to variable allergenicity.  
Kuehn A, Scheuermann T, Hilger C, Hentges F.
Int Arch Allergy Immunol 2010 Jun 17;153(4):359-366

Plant-expressed recombinant mountain cedar allergen jun a 1 is allergenic and has limited pectate lyase activity.  
Liu Z, Bhattacharyya S, Ning B, Midoro-Horiuti T, Czerwinski EW, Goldblum RM, Mort A, Kearney CM.
Int Arch Allergy Immunol 2010 Jun 17;153(4):347-358

Comparison of IgE-binding capacity, cross-reactivity and biological potency of allergenic non-specific lipid transfer proteins from peach, cherry and hazelnut.  
Hartz C, Lauer I, Del Mar San Miguel Moncin, Cistero-Bahima A, Foetisch K, Lidholm J, Vieths S, Scheurer S.
Int Arch Allergy Immunol 2010 Jun 17;153(4):335-346

Basophil activation marker CD203c is useful in the diagnosis of hen's egg and cow's milk allergies in children.  
Sato S, Tachimoto H, Shukuya A, Kurosaka N, Yanagida N, Utsunomiya T, Iguchi M, Komata T, Imai T, Tomikawa M, Ebisawa M.
Int Arch Allergy Immunol 2010;152 Suppl 154-61

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy.  
Katz Y, Rajuan N, Goldberg MR, Eisenberg E, Heyman E, Cohen A, Leshno M.
J Allergy Clin Immunol 2010 Jun 9;
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Targeting Toll-like receptors on dendritic cells modifies the T(H)2 response to peanut allergens in vitro.  
Pochard P, Vickery B, Berin MC, Grishin A, Sampson HA, Caplan M, Bottomly K.
J Allergy Clin Immunol 2010 Jun 8;
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Contribution of IgE and immunoglobulin free light chain in the allergic reaction to cow's milk proteins.  
Schouten B, van Esch BC, van Thuijl AO, Blokhuis BR, Groot KT, Hofman GA, Moro GE, Boehm G, Arslanoglu S, Sprikkelman AB, Willemsen LE, Knippels LM, Redegeld FA, Garssen J.
J Allergy Clin Immunol 2010 Jun;125(6):1308-1314
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Occupational asthma caused by the predatory beneficial mites Amblyseius californicus and Amblyseius cucumeris.  
Skousgaard SG, Thisling T, Bindslev-Jensen C, Baelum J.
Occup Environ Med 2010 Apr;67(4):287

Peanut allergy and allergic airways inflammation.  
Hughes JL, Brown T, Edgar JD, Shields MD.
Pediatr Allergy Immunol 2010 Jun 20;

Diet and nutritional status of children with food allergies.  
Flammarion S, Santos C, Guimber D, Jouannic L, Thumerelle C, Gottrand F, Deschildre A.
Pediatr Allergy Immunol 2010 Jun 14;
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Anaphylaxis in Israel: Experience with 92 hospitalized children.  
Hoffer V, Scheuerman O, Marcus N, Levy Y, Segal N, Lagovsky I, Monselise Y, Garty BZ.
Pediatr Allergy Immunol 2010 Jun 7;
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Anaphylaxie à la mangue : dix cas rapportés au Réseau allergovigilance aspects cliniques et fréquence actuelle / Anaphylaxis Mango: ten cases reported in the Allergy Vigilance Network - clinical and current frequency  
M. Morisset, D.-A. Moneret-Vautrin, P. Beaumont, B. Bonnefoy-Guionnet, M.-P. Chataignaullt, A. Cheynel, J.-P. Sacre, I. Sullerot, L. Parisot
Rev Fr Allergol 2010;50(4):406-409
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Thrombopénie induite par la rifampicine de découverte fortuite et sans sensibilisation préalable  
N. Chaouch, M. Mjid, M. Zarrouk, S. Cheikh Rouhou, F. Ben Hassen, S. Yaalaoui, H. Racil, A. Chabbou
Rev Fr Allergol 2010;50(4):410-412
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Première introduction d’aliments à la maison, proposition d’un schéma de progression accompagné de photos / First introduction of food at home, proposed a scheme of progress with photos  
C. Feuillet Dassonval, E. Bidat
Rev Fr Allergol 2010;50(4):413-414
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Assessment of the role of aeroallergens in patients with chronic urticaria  
M.M. Refaat, E.N. Ossman, M.N. Farres, M.M. El-Khodeery, N.A. Arafa, M.Y. Attia
Rev Fr Allergol 2010;50(4):394-397
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Allergie aux céphalosporines : intérêt des tests cutanés / Allergy to cephalosporins: value of skin tests  
C. Galera, D. Kacimi, A. Jolivet, P.J. Bousquet, P. Demoly
Rev Fr Allergol 2010;50(4):398-405
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Mite and cockroach sensitisation in patients with allergic rhinitis in the Free State.  
Seedat RY, Claassen J, Claassen AJ, Joubert G.
S Afr Med J 2010 Mar;100(3):160-163
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Indoor and outdoor allergens in Bloemfontein.  
Potter PC.
S Afr Med J 2010 Mar;100(3):155

Hyaluronidase allergy: a rare cause of periorbital inflammation.  
Borchard K, Puy R, Nixon R.
Australas J Dermatol 2010 Feb;51(1):49-51

Nickel allergy presenting as mobile phone contact dermatitis.  
Roberts H, Tate B.
Australas J Dermatol 2010 Feb;51(1):23-25

True blue football fan: tattoo reaction confined to blue pigment.  
Yoong C, Vun YY, Spelman L, Muir J.
Australas J Dermatol 2010 Feb;51(1):21-22
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Guidelines Treatment options in IgEmediated food allergy  

Allergo J 2010;3:187-195
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Nahrungsmittelallergie à la carte.  
M. Worm
Allergo J 2010;4:207-
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Journal Club Auf Nummer sicher bei Garnelenallergie Beikost: lieber früh als spät Aluminium-Kontaktallergie infolge SCIT? Cluster-SCIT: verträglicher durch Anti-IgE  

Allergo J 2010;4:214-217
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Original Article Food anaphylaxis: data from the anaphylaxis register  

Allergo J 2010;4:234
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CME Nahrungsmittelallergie - M. Worm  

Allergo J 2010;4:234
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Review Articles Increasing popularity of soy: which advice can we give to patients with birch pollinosis? Allergen families and molecular dia gnostics of IgE-mediated food-allergic reactions: from theory to practice  

Allergo J 2010;4:243-263
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Review Articles Haematogenous contact eczema induced by foods  

Allergo J 2010;4:264-274
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Lipocalin-type prostaglandin D synthase and egg white cystatin react with IgE antibodies from children with egg allergy.  
Suzuki M, Fujii H, Fujigaki H, Shinoda S, Takahashi K, Saito K, Wada H, Kimoto M, Kondo N, Seishima M.
Allergol Int 2010 Jun;59(2):175-183

Cloning, Expression, Characterization, and Computational Approach for Cross-Reactivity Prediction of Manganese Superoxide Dismutase Allergen from Pistachio Nut.  
Noorbakhsh R, Mortazavi SA, Sankian M, Shahidi F, Assarehzadegan MA, Varasteh A.
Allergol Int 2010 Jun 25;59(3):

Pathological Mechanisms and Clinical Features of Eosinophilic Chronic Rhinosinusitis in the Japanese Population.  
Takeno S, Hirakawa K, Ishino T.
Allergol Int 2010 Jun 25;59(3):
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Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma.  
Matsui EC, Sampson HA, Bahnson HT, Gruchalla RS, Pongracic JA, Teach SJ, Gergen PJ, Bloomberg GR, Chmiel JF, Liu AH, Kattan M, Sorkness CA, Steinbach SF, Story RE, Visness CM.
Allergy 2010 Jun 17;

Anaphylaxis to camel milk in an atopic child.  
Al-Hammadi S, El-Hassan T, Al-Reyami L.
Allergy 2010 Jun 17;

Projections of the effects of climate change on allergic asthma: the contribution of aerobiology.  
Cecchi L, D'Amato G, Ayres JG, Galan C, Forastiere F, Forsberg B, Gerritsen J, Nunes C, Behrendt H, Akdis C, Dahl R, nnesi-Maesano I.
Allergy 2010 Jun 17;
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Five cases of food allergy to vegetable worm (Cordyceps sinensis) showing cross-reactivity with silkworm pupae.  
Choi GS, Shin YS, Kim JE, Ye YM, Park HS.
Allergy 2010 Jun 14;

Geographical variations in the prevalence of atopic sensitization in six study sites across Canada.  
Chan-Yeung M, Anthonisen NR, Becklake MR, Bowie D, Sonia BA, mich-Ward H, Ernst P, Sears MR, Siersted HC, Sweet L, Van TL, Manfreda J.
Allergy 2010 Jun 14;

Possible in-cabin exposure to cat allergen: a 2010 airline survey on live animal transport and a review of literature.  
Mohrenschlager M, Ring J, Lauener R.
Allergy 2010 Jun 14;

Bet v 1 and its homologous food allergen Api g 1 stimulate dendritic cells from birch pollen-allergic individuals to induce different Th-cell polarization.  
Smole U, Wagner S, Balazs N, Radauer C, Bublin M, Allmaier G, Hoffmann-Sommergruber K, Breiteneder H.
Allergy 2010 Jun 14;
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