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| | Allergy Advisor Digest - May 2010
Editor: Dr. Harris A. Steinman |
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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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| | Skin prick test evaluation of Dermatophagoides pteronyssinus diagnostic extracts from Europe, Mexico, and USA. |
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| | Baker's asthma and wheat-dependent exercise-induced anaphylaxis |
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| | Two cases of eosinophilic gastroenteritis whose causative allergens are usefully diagnosed by patch test. |
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| | Allergic contact dermatitis from aluminium in deodorants. |
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| | Linalool--a significant contact sensitizer after air exposure. |
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| | Allergic contact dermatitis to decyl glucoside in Tinosorb M. |
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| | Cross-contamination of foods and implications for food allergic patients. |
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| | Ant venoms. A review |
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| | Local angioedema following exposure to sun. |
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| | Watermelon profilin: characterization of a major allergen as a model for plant-derived food profilins. |
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| | Greater epitope recognition of shrimp allergens by children than adults suggests that shrimp sensitization decreases with age. |
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| | Recombinant allergen-based IgE testing to distinguish bee and wasp allergy. |
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| | US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. |
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| | Early recovery from cow's milk allergy. |
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| | A population-based study on peanut, tree nut, fish, shellfish, and sesame allergy prevalence in Canada. |
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| | IgE antibody serology: A primer for the practicing North American allergist/immunologist. |
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| | Peanut lectins |
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| | Controversy - hypersensitivity to food additives is a clinical reality: Pro |
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| | Seminal allergy |
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| | Contact allergy in the aeronautics industry |
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| | Cow milk is an allergen which must be declared on labels |
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| | Late-onset of IgE sensitization to microbial allergens in young children with atopic dermatitis. |
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| | An epidemic of furniture-related dermatitis: searching for a cause. |
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| | Blomia tropicalis as a potent allergen in house dust and its role in allergic asthma in Kolkata Metropolis, India. |
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| | Alternaria-sensitivity in children with moderate-severe asthma is associated with HLA-DR and HLA-DQ. |
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| | IgE-mediated hypersensitivity reactions to methylprednisolone. |
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Skin prick test evaluation of Dermatophagoides pteronyssinus diagnostic extracts from Europe, Mexico, and USA.
The objective of this study was to compare biological activity of various European D pteronyssinus diagnostic extracts against an FDA-validated extract using quantitative skin prick tests. Six diagnostic D pteronyssinus extracts (1 reference extract; 3 European extracts; 1 US-Mexican extract, which is imported as raw material from the United States and sold in Mexico; and 1 Mexican extract) were tested during 2 skin prick test sessions as a concentrate and 2 serial 2-fold dilutions, in quadruplicate, on the backs of 19 patients with D pteronyssinus allergic rhinitis. The study concludes that the study confirmed the results from previous in vitro testing that various diagnostic extracts of D pteronyssinus used in Europe and Mexico are less potent than those used in the United States.
Skin prick test evaluation of Dermatophagoides pteronyssinus diagnostic extracts from Europe, Mexico, and the United States.
Larenas-Linnemann D, Matta JJ, Shah-Hosseini K, Michels A, Mosges R.
Ann Allergy Asthma Immunol 2010 May;104(5):420-425
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Baker's asthma and wheat-dependent exercise-induced anaphylaxis
A 47 years-old woman with baker's asthma for several years developed anaphylaxis following energetic walking after ingestion of wheat. The combination of exercise, wheat and aspirin induced urticaria and marked elevation of blood gliadin levels. A diagnosis of wheat-dependent exercise-induced anaphylaxis (WDEIA) was made from a high titer of omega-5 gliadin specific IgE in her serum and the result of a challenge test. Several bands were detected in her serum which were beta-, gamma- and omega-5 gliadin based on their relative molecular mass. The authors suggest that wheat gliadins might be causative allergen of both baker's asthma and WDEIA in this case.
Analysis of causative allergen of the patient with baker's asthma and wheat-dependent exercise-induced anaphylaxis (wdeia). [Japanese]
Ueno M, Adachi A, Fukumoto T, Nishitani N, Fujiwara N, Matsuo H, Kohno K, Morita E.
Arerugi 2010 May;59(5):552-557
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Two cases of eosinophilic gastroenteritis whose causative allergens are usefully diagnosed by patch test.
Case 1: 67-years-old woman with pollen allergy noticed oppressive feeling of chest and back, and heart burn after accidental ingestion of her dental filling and dental treatment. Peripheral blood eosinophils increased to 38.0%. Cedar and cypress specific IgE were positive. Case 2: a 42-years-old-woman with pollen allergy and asthma experienced repeated urticaria, heartburn, diarrhea and peripheral eosinophilia (25%). Specific IgE was positive only for cypress. High infiltrates of eosinophils in the mucosa of alimentary tract resulted in a diagnosis of eosinophilic gastroenteritis in both. In case 1, based on the history and patch-test-positive finding of formalin and 2-hydroxyethyl methacrylate, these were diagnosed as the causative allergens. In case 2, a patch-test-positive finding of garlic and sesame and improvement after removal of the two allergens, led to the conclusion that these two may be causative allergens. The authors conclude that in these two cases, patch test was useful to identify the allergens.
Two cases of eosinophilic gastroenteritis whose causative allergens are usefully diagnosed by patch test. [Japanese]
Adachi A.
Arerugi 2010 May;59(5):545-551
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Allergic contact dermatitis from aluminium in deodorants.
Allergic contact dermatitis from aluminium in deodorants. (Awaiting full text)
Allergic contact dermatitis from aluminium in deodorants.
Garg S, Loghdey S, Gawkrodger DJ.
Contact Dermatitis 2010 Jan;62(1):57-58
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Linalool--a significant contact sensitizer after air exposure.
Linalool is a widely used fragrance terpene. Pure linalool is not allergenic or a very weak allergen, but autoxidizes on air exposure and the oxidation products can cause contact allergy. Oxidized (ox.) linalool has previously been patch tested at a concentration of 2.0% in petrolatum (pet.) in 1511 patients, and 1.3% positive patch test reactions were observed. The objective of this study was to investigate the optimal patch test concentration for detection of contact allergy to ox. linalool. Raising the patch test concentration for ox. linalool gave a better detection of contact allergy, as many as 5-7% positive patch test reactions were detected. We suggest a patch test concentration of ox. linalool 6.0% pet. for future patch testing, giving a dose per unit area of 2.4 mg/cm(2) when 20 mg test substance is tested in small Finn Chambers
Linalool--a significant contact sensitizer after air exposure.
Christensson JB, Matura M, Gruvberger B, Bruze M, Karlberg AT.
Contact Dermatitis 2010 Jan;62(1):32-41
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Allergic contact dermatitis to decyl glucoside in Tinosorb M.
Decyl glucoside is a mild non-ionic surfactant used in cosmetic formularies including baby shampoo and in products for individuals with a sensitive skin. Many natural personal care companies use this cleanser because it is plant-derived, biodegradable, and gentle for all hair types. (http://en.wikipedia.org/wiki/Decyl_glucoside). A number of reports have occurred in the medical literature regarding contact allergy to this ingredient, including this one. Tinosorb M is a benzotriazole-based organic compound that is added to sunscreens to absorb UV rays.
Allergic contact dermatitis to decyl glucoside in Tinosorb M.
Andrade P, Goncalo M, Figueiredo A.
Contact Dermatitis 2010 Feb;62(2):119-120
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Cross-contamination of foods and implications for food allergic patients.
"Cross-contamination presents a risk of unknown magnitude for food allergic consumers. Published cases likely represent the tip of a rather large iceberg. Cross-contamination can occur in homes, restaurants, food manufacturing plants, and on farms. The frequency of cross-contamination as the cause of accidental exposures to allergenic foods is unknown. Food allergic individuals can react to ingestion of trace levels of the offending food, although a highly variable range of threshold doses exist among populations of food allergic individuals. The magnitude of the risk posed to food allergic consumers by cross-contamination is characterized by the frequency of exposure to cross-contaminated foods, the dose of exposure, and the individual's threshold dose. The food and food service industry (and food preparers in homes as well) have the responsibility to provide and prepare foods that are safe for food allergic consumers, but quality of life may be improved with the recognition that safe (though very low) thresholds do exist."
Cross-contamination of foods and implications for food allergic patients.
Taylor SL, Baumert JL.
Curr Allergy Asthma Rep 2010 Apr 24;
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Ant venoms. A review
The review summarizes knowledge about ants that are known to sting humans and their venoms. Fire ants and Chinese needle ants are showing additional spread of range. Fire ants are now important in much of Asia. Venom allergens have been characterized and studied for fire ants and jack jumper ants. The first studies of Pachycondyla venoms have been reported, and a major allergen is Pac c 3, related to Sol i 3 from fire ants. There are very limited data available for other ant groups.
Ant venoms.
Hoffman DR.
Curr Opin Allergy Clin Immunol 2010 May 4;
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Local angioedema following exposure to sun.
This study describes 5 patients who developed an angioedema following sun exposures. All patients reported an intensely stinging angioedema strictly limited to face and extremities, when exposed to solar light. Urticarial wheals were never observed or reported by patients, and oral antihistamines proved to be of no help in preventing or improving the condition of lesions. Laboratory and phototesting data allowed ruling out all other acquired or inherited diseases characterized by photosensitivity. The authors propose that solar angioedema should be considered a novel clinical entity.
Local angioedema following sun exposures: a report of five cases.
Calzavara-Pinton P, Sala R, Venturini M, Rossi MT, Tosoni C, Lodi RF, Zane C.
Int Arch Allergy Immunol 2010 May 20;153(3):315-320
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Watermelon profilin: characterization of a major allergen as a model for plant-derived food profilins.
Watermelon profilin has been reported to be a major allergen in watermelon. In this study, native profilin and recombinant profilin from watermelon were purified. Both show similar IgE reactivity in vitro and are biologically active.
Watermelon profilin: characterization of a major allergen as a model for plant-derived food profilins.
Cases B, Pastor-Vargas C, Gil DF, Perez-Gordo M, Maroto AS, de Las HM, Vivanco F, Cuesta-Herranz J.
Int Arch Allergy Immunol 2010 May 18;153(3):215-222
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Greater epitope recognition of shrimp allergens by children than adults suggests that shrimp sensitization decreases with age.
This study sought to identify the IgE-binding epitopes of the 4 shrimp allergens and to characterize epitope recognition profiles of children and adults with shrimp allergy. Fifty-three subjects, 34 children and 19 adults, were selected with immediate allergic reactions to shrimp, increased shrimp-specific serum IgE levels, and positive immunoblot binding to shrimp. Subjects were tested by means of peptide microarray for IgE binding with synthetic overlapping peptides spanning the sequences of Litopenaeus vannamei shrimp tropomyosin, arginine kinase (AK), myosin light chain (MLC), and sarcoplasmic calcium-binding protein (SCP). The median shrimp IgE level was 4-fold higher in children than in adults (47 vs 12.5 kU(A)/L). The frequency of allergen recognition was higher in children (tropomyosin, 81% [94% for children and 61% for adults]; MLC, 57% [70% for children and 31% for adults]; AK, 51% [67% for children and 21% for adults]; and SCP, 45% [59% for children and 21% for adults]), whereas control subjects showed negligible binding. Seven IgE-binding regions were identified in tropomyosin by means of peptide microarray, confirming previously identified shrimp epitopes. In addition, 3 new epitopes were identified in tropomyosin, 5 epitopes were identified in MLC, 3 epitopes were identified in SCP, and 7 epitopes were identified in AK. Interestingly, frequency of individual epitope recognition, as well as intensity of IgE binding, was significantly greater in children than in adults for all 4 proteins. The study concludes that children with shrimp allergy have greater shrimp-specific IgE antibody levels and show more intense binding to shrimp peptides and greater epitope diversity than adults.
Greater epitope recognition of shrimp allergens by children than adults suggests that shrimp sensitization decreases with age.
Ayuso R, Sanchez-Garcia S, Lin J, Fu Z, Ibanez MD, Carrillo T, Blanco C, Goldis M, Bardina L, Sastre J, Sampson HA.
J Allergy Clin Immunol 2010 May 12;
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Recombinant allergen-based IgE testing to distinguish bee and wasp allergy.
The objective of this study was to establish recombinant allergen-based IgE tests to diagnose bee and yellow jacket wasp allergy. Sera from patients with bee and/or wasp allergy (n = 43) and patients with pollen allergy with false-positive IgE serology to venom extracts were tested for IgE reactivity in allergen extract-based tests or with purified allergens, including nonglycosylated recombinant (r) Api m 1, rApi m 2, rVes v 5, and insect cell-expressed, glycosylated rApi m 2 as well as 2 natural plant glycoproteins (Phl p 4, bromelain). The patients with venom allergy could be diagnosed with a combination of E coli-expressed rApi m 1, rApi m 2, and rVes v 5 whereas patients with pollen allergy remained negative. For a group of 29 patients for whom the sensitizing venom could not be identified with natural allergen extracts, testing with nonglycosylated allergens allowed identification of the sensitizing venom. Recombinant nonglycosylated allergens also allowed definition of the sensitizing venom for those 14 patients who had reacted either with bee or wasp venom extracts. By IgE inhibition studies, it is shown that glycosylated Api m 2 contains carbohydrate epitopes that cross-react with natural Api m 1, Ves v 2, natural Phl p 4, and bromelain, thus identifying cross-reactive structures responsible for serologic false-positive test results or double-positivity to bee and wasp extracts. Therefore nonglycosylated recombinant bee and wasp venom allergens allow the identification of patients with bee and wasp allergy and should facilitate accurate prescription of venom immunotherapy.
Recombinant allergen-based IgE testing to distinguish bee and wasp allergy.
Mittermann I, Zidarn M, Silar M, Markovic-Housley Z, Aberer W, Korosec P, Kosnik M, Valenta R.
J Allergy Clin Immunol 2010 May 11;
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US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up.
This study sought to determine the US prevalence of self-reported peanut, tree nut (TN), and sesame allergy in 2008 and compare results with comparable surveys conducted in 1997 and 2002. A total of 5,300 households (13,534 subjects) were surveyed (participation rate, 42% vs 52% in 2002 and 67% in 1997). Peanut allergy, TN allergy, or both was reported by 1.4% of subjects compared with 1.2% in 2002 and 1.4% in 1997. For adults, the prevalence was 1.3%, which was not significantly different from prior surveys. However, the prevalence of peanut or TN allergy for children younger than 18 years was 2.1% compared with 1.2% in 2002 and 0.6% in 1997. The prevalence of peanut allergy in children in 2008 was 1.4% compared with 0.8% in 2002 and 0.4% in 1997. The prevalence of childhood TN allergy increased significantly across the survey waves (1.1% in 2008, 0.5% in 2002, and 0.2% in 1997). Sesame allergy was reported by 0.1%. The study concludes that although caution is required in comparing surveys, peanut allergy, TN allergy, or both continue to be reported by more than 1% of the US population (eg, >3 million subjects) and appear to be increasingly reported among children over the past decade. Sesame allergy is reported much less commonly. (Sicherer 2010 ref.25011 7)
US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up.
Sicherer SH, Munoz-Furlong A, Godbold JH, Sampson HA.
J Allergy Clin Immunol 2010 May 10;
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Early recovery from cow's milk allergy.
This study concludes that attaining tolerance to cow's milk is associated with decreased epitope binding by IgE and a concurrent increase in corresponding epitope binding by IgG4
Early recovery from cow's milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow's milk epitopes.
Savilahti EM, Rantanen V, Lin JS, Karinen S, Saarinen KM, Goldis M, Makela MJ, Hautaniemi S, Savilahti E, Sampson HA.
J Allergy Clin Immunol 2010 May 10;
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A population-based study on peanut, tree nut, fish, shellfish, and sesame allergy prevalence in Canada.
The objective of this study was to determine the prevalence of peanut, tree nut, fish, shellfish, and sesame allergy in Canada. A cross-Canada, random telephone survey was conduceted. Food allergy was defined as perceived (based on self-report), probable (based on convincing history or self-report of physician diagnosis), or confirmed (based on history and evidence of confirmatory tests). Of 10,596 households surveyed in 2008 and 2009, 3666 responded (34.6% participation rate), of which 3613 completed the entire interview, representing 9667 individuals. The prevalence of perceived peanut allergy was 1.00%; tree nut, 1.22%; fish, 0.51%; shellfish, 1.60% ; and sesame, 0.10%. The prevalence of probable allergy was 0.93%; 1.14%; 0.48%; 1.42%; and 0.09%, respectively.
A population-based study on peanut, tree nut, fish, shellfish, and sesame allergy prevalence in Canada.
Ben-Shoshan M, Harrington DW, Soller L, Fragapane J, Joseph L, St PY, Godefroy SB, Elliot SJ, Clarke AE.
J Allergy Clin Immunol 2010 May 6;
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IgE antibody serology: A primer for the practicing North American allergist/immunologist.
"The allergist/immunologist judiciously diagnoses allergic disease by using confirmatory IgE antibody data from in vivo and in vitro assays after the collection of a clinical history. After an overview of historical events, clinically available allergen-specific IgE assays from Phadia, Siemens, and Hycor are contrasted by their design and performance characteristics. The assays share comparable working ranges, analytical sensitivities, and excellent precision, reproducibility, and linearity to a performance standard of <15% coefficients of variation. However, multiple interlaboratory studies have confirmed that the 3 IgE antibody assays either detect different populations of IgE antibody or do not measure the same antibodies with comparable efficiencies. The clinical consequence is that IgE antibody results from the 3 assays are not interchangeable or equivalent. Data generated with one assay cannot be directly extrapolated to published predictive outcomes based on IgE antibody levels from a different assay. The transition from allergen extract-based to allergenic components reagents is discussed, emphasizing the chip-based microarray's strength in identifying IgE antibody cross-reactivity. US Food and Drug Administration-cleared point-of-care IgE antibody lateral flow cassettes are overviewed. Finally, IgE antibody concentration, affinity, clonality (epitope specificity), and specific activity (specific/total IgE ratio) are examined as humoral immune response parameters measured by serologic assays that affect effector cell degranulation and ultimately allergic disease expression."
Human IgE antibody serology: A primer for the practicing North American allergist/immunologist.
Hamilton RG, Williams PB.
J Allergy Clin Immunol 2010 May 6;
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Peanut lectins
"Plant lectins or phyto-agglutinins are proteins that specifically recognize the glycan chains on the cell surface. Lectins from the Leguminosae (Fabaceae) have been classified in different groups according to the simple sugars they recognize. Two main groups have been identified: the galactose-specific lectins (peanut lectin [PNA], soybean lectin [SBA]) and the mannose-specific lectins (green pea lectin [PSA], lentil lectin [LCA]). Peanut lectin, a seed storage protein localized in the peanut's protein bodies, has been identified as a minor peanut allergen. As a consequence of its galactose-binding specificity, it has been used successfully to isolate T lymphocytes. Sera from the majority of peanut-allergic patients react with PNA and they also react with the closely-related lectins PSA and LCA; they interact weakly with SBA and PHA lectins. IgE-binding epitopes have been identified on the molecular surface of PNA. A few of these epitopes are structurally-related to those of PSA and LCA, which could account for the observed IgE-binding cross-reactivity between PNA and other legume lectins."
La lectine de larachide
P. Rougé, R. Culerrier, C. Granier, F. Rancé, A. Barre
Rev Fr Allergol 2010;50(3):281-284
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Controversy - hypersensitivity to food additives is a clinical reality: Pro
"In the 1980s, hypersensitivity to food additives and their adverse effects on health were widely publicized. Today, in spite of its low prevalence, about 1%, it still exists. After a review of some epidemiologic data and a short history of regulatory mechanisms in Europe and USA, additives can be separated into three groups to facilitate diagnosis: IgE-dependent (cochineal, erythrosine, red rice, annatto, carrageenans, adragant gums, lyzozyme), additives confirmed by DBPCFC (tartrazine, sulfites, benzoates, nitrites, diacetyl, fragrances), and disputed substances (monosodium glutamate, aspartame). Allergists are encouraged to rigorously investigate different food categories, using prick-tests correlated with IgE levels and confirmation by DBPCFC when continuing to look for the cause of these reactions."
Controverse lhypersensibilité aux additifs alimentaires est une réalité clinique : pour / Controversy hypersensitivity to food additives is a clinical reality: Pro
C. Sauvage
Rev Fr Allergol 2010;50(3):288-291
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Late-onset of IgE sensitization to microbial allergens in young children with atopic dermatitis.
This study concludes that IgE sensitization to microbial allergens (staphylococcal superantigen group, Malassezia species and C. albicans) is associated with an older age group in young children with mild to moderate atopic dermatitis.
Late-onset of IgE sensitization to microbial allergens in young children with atopic dermatitis.
Ong PY, Ferdman RM, Church JA.
Br J Dermatol 2010 Jan;162(1):159-161
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An epidemic of furniture-related dermatitis: searching for a cause.
Sitting in new chairs or sofas has elicited dermatitis in numerous patients in Finland and in the U.K. since autumn 2006. The cause of the dermatitis seemed to be an allergen in the furniture materials. The objective of this study was to determine the cause of the dermatitis in patients with furniture-related dermatitis. 42 patients with furniture-related dermatitis were studied. Sensitization to dimethyl fumarate was seen in all the patients with furniture-related dermatitis. Concurrent sensitization or cross-reactions were common among the sensitized patients.
An epidemic of furniture-related dermatitis: searching for a cause.
Lammintausta K, Zimerson E, Hasan T, Susitaival P, Winhoven S, Gruvberger B, Beck M, Williams JD, Bruze M.
Br J Dermatol 2010 Jan;162(1):108-116
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Blomia tropicalis as a potent allergen in house dust and its role in allergic asthma in Kolkata Metropolis, India.
In a study conducted in Kolkata Metropolis, India, skin prick test was performed on 1079 patients between the age group 550 years using a variety of 16 common aero-allergens. Among patients with asthma to house dust and house dust mite allergen tests were as follows: house dust (96.22%), D. pteronyssinus (75.06%), B. tropicalis (72%), and D. farinae (63.72%). The frequency of positive skin response was found to be independent of age and sex. The total serum IgE levels in patients varied between 7.3 and 4040 IU/ml. Specific IgE antibody test proved that 83% patients showed sensitivity toward at least 1 of the allergens tested.
Allergic Response to Common Inhalants (n = 1079)
Allergens / No. Positive / % Positive
Cocos nucifera - 783 - 72.58
Brassica nigra - 598 - 55.42
Delonix sp. - 522 - 48.38
Azadirachta indica - 467 - 43.25
Caesalpinia sp. - 431 - 40.02
Aspergillus fumigatus - 240 - 22.28
Aspergillus niger - 198 - 18.32
Candida albicans - 166 - 15.39
Cladosporium sp. - 125 - 11.58
Alternaria alternate - 44 - 4.1
Dog dander - 99 - 9.23
Cat dander - 61 - 5.71
House dust - 1035 - 96.22
D. pteronyssinus - 809 - 75.06
D. farinae - 688 - 63.72
Blomia tropicalis - 778 - 72.00
Incrimination of Blomia tropicalis as a potent allergen in house dust and its role in allergic asthma in Kolkata Metropolis, India.
Podder S, Gupta SK, Saha GK.
WAO Journal 2010;3(5):182-187
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Alternaria-sensitivity in children with moderate-severe asthma is associated with HLA-DR and HLA-DQ.
In children with Alternaria-sensitive moderate-severe asthma, there was increased Th2 sensitivity to Alternaria stimulation. This was associated with HLA-DR restriction and with increased frequency of HLA-DRB1*13 and HLA-DRB1*03. There was decreased frequency of HLA-DQB1*03 in Alternaria-sensitive moderate-severe asthma, suggesting HLA-DQB1*03 may be protective of the development of Alternaria-sensitive severe asthma
Mold-sensitivity in children with moderate-severe asthma is associated with HLA-DR and HLA-DQ.
Knutsen AP, Vijay HM, Kumar V, Kariuki B, Santiago LA, Graff R, Wofford JD, Shah MR.
Allergy 2010 May 10;
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IgE-mediated hypersensitivity reactions to methylprednisolone.
This study confirms the existence of immediate allergic reactions to methylprednisolone (MP) and that some are mediated by specific IgE antibodies. Skin testing, ImmunoCAP and the BAT are useful to confirm the diagnosis. Three patients were diagnosed by the presence of a positive skin test in the immediate reading with MP, two by prick and one by intradermal testing, and one patient was skin test negative and diagnosed by drug provocation test (DPT). All four patients had good tolerance to hydrocortisone (HC) and dexamethasone (DX). The BAT was positive for just MP in those patients with positive skin tests, with all patients being negative for HC and DX. Two patients were also ImmunoCAP positive to MP.
IgE-mediated hypersensitivity reactions to methylprednisolone.
Aranda A, Mayorga C, Ariza A, Dona I, Blanca-Lopez N, Canto G, Blanca M, Torres MJ.
Allergy 2010 May 10;
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Allergen-, Food allergy-, Intolerance-related articles
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Deming, anaphylaxis, and the tarantella. |
deShazo RD.
Ann Allergy Asthma Immunol 2010 May;104(5):359-360
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Aspergillus fumigatus. |
Weber RW.
Ann Allergy Asthma Immunol 2010 May;104(5):A3
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Systemic IgE-mediated reaction to a dietary slimming bar. |
Cabanillas MB, Crespo JF, Burbano C, Rodriguez J.
Ann Allergy Asthma Immunol 2010 May;104(5):450
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Skin prick test evaluation of Dermatophagoides pteronyssinus diagnostic extracts from Europe, Mexico, and the United States. |
Larenas-Linnemann D, Matta JJ, Shah-Hosseini K, Michels A, Mosges R.
Ann Allergy Asthma Immunol 2010 May;104(5):420-425
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Sensitivity and specificity of skin tests in the diagnosis of clarithromycin allergy. |
Mori F, Barni S, Pucci N, Rossi E, Azzari C, de MM, Novembre E.
Ann Allergy Asthma Immunol 2010 May;104(5):417-419
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Analysis of causative allergen of the patient with baker's asthma and wheat-dependent exercise-induced anaphylaxis (wdeia). [Japanese] |
Ueno M, Adachi A, Fukumoto T, Nishitani N, Fujiwara N, Matsuo H, Kohno K, Morita E.
Arerugi 2010 May;59(5):552-557
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Two cases of eosinophilic gastroenteritis whose causative allergens are usefully diagnosed by patch test. [Japanese] |
Adachi A.
Arerugi 2010 May;59(5):545-551
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Food allergy. [Japanese] |
Ito S.
Arerugi 2010 May;59(5):497-506
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Allergic contact dermatitis associated with mugwort (Artemisia vulgaris). |
Haw S, Cho HR, Lee MH.
Contact Dermatitis 2010 Jan;62(1):61-63
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Occupational contact dermatitis from ninhydrin in a police officer. |
Soost S, Zuberbier T, Zuberbier M, Worm M.
Contact Dermatitis 2010 Jan;62(1):59-60
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Allergic contact dermatitis from aluminium in deodorants. |
Garg S, Loghdey S, Gawkrodger DJ.
Contact Dermatitis 2010 Jan;62(1):57-58
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Concomitant contact allergy to methylchloroisothiazolinone/methylisothiazolinone and formaldehyde-releasing preservatives. |
Statham BN, Smith EV, Bodger OG, Green CM, King CM, Ormerod AD, Sansom JE, English JS, Wilkinson MS, Gawkrodger DJ, Chowdhury MM.
Contact Dermatitis 2010 Jan;62(1):56-57
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Contact allergy to epoxy resins--a 10-year study. |
Canelas MM, Goncalo M, Figueiredo A.
Contact Dermatitis 2010 Jan;62(1):55
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Epicutaneous patch testing in drug hypersensitivity syndrome (DRESS). |
Santiago F, Goncalo M, Vieira R, Coelho S, Figueiredo A.
Contact Dermatitis 2010 Jan;62(1):47-53
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Contact and photocontact sensitization in chronic actinic dermatitis: a changing picture. |
Chew AL, Bashir SJ, Hawk JL, Palmer R, White IR, McFadden JP.
Contact Dermatitis 2010 Jan;62(1):42-46
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Linalool--a significant contact sensitizer after air exposure. |
Christensson JB, Matura M, Gruvberger B, Bruze M, Karlberg AT.
Contact Dermatitis 2010 Jan;62(1):32-41
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Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers alle. |
de GA, White IR, Flyvholm MA, Lensen G, Coenraads PJ.
Contact Dermatitis 2010 Jan;62(1):18-31
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Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics. |
de Groot AC, White IR, Flyvholm MA, Lensen G, Coenraads PJ.
Contact Dermatitis 2010 Jan;62(1):2-17
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Allergy 'sucks': leeches may also be harmful. |
Kukova G, Gerber PA, Antal AS, Homey B.
Contact Dermatitis 2010 Feb;62(2):124-125
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Occupational allergic contact dermatitis to HBTU [(o-benzotriazole-10yl)-N,N,N',N,-tetramethyluronium hexafluorophosphate]. |
McAleer MA, Bourke B, Bourke J.
Contact Dermatitis 2010 Feb;62(2):123
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Occupational allergic contact dermatitis to olanzapine. |
Lowney AC, McAleer MA, Bourke J.
Contact Dermatitis 2010 Feb;62(2):123-124
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Allergic contact dermatitis to dimethyl fumarate in footwear. |
Fraga A, Silva R, Filipe P, Scharrer K, Borges Da CJ, Nussbaum P, Gomes MM.
Contact Dermatitis 2010 Feb;62(2):121-123
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Peristomal allergic contact dermatitis to stoma-adhesive paste containing monobutyl ester/maleic acid of polymethylvinylether (Gantrez 425) but not to Isopropyl ester/maleic anhydride of polymethylvinylether (Gantrez 335). |
Field S, O'Sullivan C, Murphy M, Bourke JF.
Contact Dermatitis 2010 Feb;62(2):120-121
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Allergic contact dermatitis to decyl glucoside in Tinosorb M. |
Andrade P, Goncalo M, Figueiredo A.
Contact Dermatitis 2010 Feb;62(2):119-120
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An unusual case of cell phone dermatitis. |
Guarneri F, Guarneri C, Patrizia CS.
Contact Dermatitis 2010 Feb;62(2):117
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Lymphomatoid photocontact dermatitis to benzydamine hydrochloride. |
varez-Garrido H, Sanz-Munoz C, Martinez-Garcia G, Miranda-Romero A.
Contact Dermatitis 2010 Feb;62(2):117-119
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Temporal trends of preservative allergy in Denmark (1985-2008). |
Thyssen JP, Engkilde K, Lundov MD, Carlsen BC, Menne T, Johansen JD.
Contact Dermatitis 2010 Feb;62(2):102-108
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Active sensitization and contact allergy to methyl 2-octynoate. |
Heisterberg MV, Vigan M, Johansen JD.
Contact Dermatitis 2010 Feb;62(2):97-101
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Sensitization to dimethyl fumarate with multiple concurrent patch test reactions. |
Lammintausta K, Zimerson E, Winhoven S, Susitaival P, Hasan T, Gruvberger B, Williams J, Beck M, Bruze M.
Contact Dermatitis 2010 Feb;62(2):88-96
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The epidemiology of hand eczema in the general population--prevalence and main findings. |
Thyssen JP, Johansen JD, Linneberg A, Menne T.
Contact Dermatitis 2010 Feb;62(2):75-87
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Allergic contact dermatitis to natural resin rare among gum rosin extractors? |
Scherrer M, Junqueira AF.
Contact Dermatitis 2010 Jan;62(1):64-65
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Occupational asthma and lower airway disease among world trade center workers and volunteers. |
de la Hoz RE.
Curr Allergy Asthma Rep 2010 Apr 28;
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A developmental, community, and psychosocial approach to food allergies in children. |
Houle CR, Leo HL, Clark NM.
Curr Allergy Asthma Rep 2010 May 13;
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Management of the patient with multiple food allergies. |
Wang J.
Curr Allergy Asthma Rep 2010 Apr 30;
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Allergenicity of carbohydrates and their role in anaphylactic events. |
Commins SP, Platts-Mills TA.
Curr Allergy Asthma Rep 2010 Jan;10(1):29-33
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Dangerous allergens: why some allergens are bad actors. |
Georas SN, Rezaee F, Lerner L, Beck L.
Curr Allergy Asthma Rep 2010 Mar;10(2):92-98
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Food Allergy: Transfused and Transplanted. |
Atkins D, Malka-Rais J.
Curr Allergy Asthma Rep 2010 Apr 14;
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Feeding Disorders in Food Allergic Children. |
Haas AM.
Curr Allergy Asthma Rep 2010 Apr 23;
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Cross-contamination of foods and implications for food allergic patients. |
Taylor SL, Baumert JL.
Curr Allergy Asthma Rep 2010 Apr 24;
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Food allergy: who's on first and what do they know? |
Atkins D.
Curr Allergy Asthma Rep 2010 Apr 24;
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Prevention of occupational asthma. |
Tarlo SM, Liss GM.
Curr Allergy Asthma Rep 2010 Apr 28;
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Patch testing in drug allergy. |
Friedmann PS, rdern-Jones M.
Curr Opin Allergy Clin Immunol 2010 May 18;
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A perspective of nanotechnology in hypersensitivity reactions including drug allergy. |
Montanez MI, Ruiz-Sanchez AJ, Perez-Inestrosa E.
Curr Opin Allergy Clin Immunol 2010 May 18;
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Mastocytosis and insect venom allergy. |
Bonadonna P, Zanotti R, Muller U.
Curr Opin Allergy Clin Immunol 2010 May 18;
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Ant venoms. |
Hoffman DR.
Curr Opin Allergy Clin Immunol 2010 May 4;
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Local angioedema following sun exposures: a report of five cases. |
Calzavara-Pinton P, Sala R, Venturini M, Rossi MT, Tosoni C, Lodi RF, Zane C.
Int Arch Allergy Immunol 2010 May 20;153(3):315-320
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Th2 immune response plays a critical role in the development of nickel-induced allergic contact dermatitis. |
Niiyama S, Tamauchi H, Amoh Y, Terashima M, Matsumura Y, Kanoh M, Habu S, Komotori J, Katsuoka K.
Int Arch Allergy Immunol 2010 May 20;153(3):303-314
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Increased adverse drug reactions to cephalosporins in penicillin allergy patients with positive penicillin skin test. |
Park MA, Koch CA, Klemawesch P, Joshi A, Li JT.
Int Arch Allergy Immunol 2010 May 19;153(3):268-273
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Watermelon profilin: characterization of a major allergen as a model for plant-derived food profilins. |
Cases B, Pastor-Vargas C, Gil DF, Perez-Gordo M, Maroto AS, de Las HM, Vivanco F, Cuesta-Herranz J.
Int Arch Allergy Immunol 2010 May 18;153(3):215-222
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Greater epitope recognition of shrimp allergens by children than adults suggests that shrimp sensitization decreases with age. |
Ayuso R, Sanchez-Garcia S, Lin J, Fu Z, Ibanez MD, Carrillo T, Blanco C, Goldis M, Bardina L, Sastre J, Sampson HA.
J Allergy Clin Immunol 2010 May 12;
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IgE sensitization to fungi mirrors fungal phylogenetic systematics. |
Soeria-Atmadja D, Onell A, Borga A.
J Allergy Clin Immunol 2010 May 11;
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Recombinant allergen-based IgE testing to distinguish bee and wasp allergy. |
Mittermann I, Zidarn M, Silar M, Markovic-Housley Z, Aberer W, Korosec P, Kosnik M, Valenta R.
J Allergy Clin Immunol 2010 May 11;
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Visualization of clustered IgE epitopes on alpha-lactalbumin. |
Hochwallner H, Schulmeister U, Swoboda I, Focke-Tejkl M, Civaj V, Balic N, Nystrand M, Harlin A, Thalhamer J, Scheiblhofer S, Keller W, Pavkov T, Zafred D, Niggemann B, Quirce S, Mari A, Paul.
J Allergy Clin Immunol 2010 May 11;
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US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. |
Sicherer SH, Munoz-Furlong A, Godbold JH, Sampson HA.
J Allergy Clin Immunol 2010 May 10;
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Early recovery from cow's milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow's milk epitopes. |
Savilahti EM, Rantanen V, Lin JS, Karinen S, Saarinen KM, Goldis M, Makela MJ, Hautaniemi S, Savilahti E, Sampson HA.
J Allergy Clin Immunol 2010 May 10;
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Ovalbumin content of influenza vaccines. |
Li JT, Rank MA, Squillace DL, Kita H.
J Allergy Clin Immunol 2010 May 6;
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AAAAI support of the EAACI Position Paper on IgG(4). |
Allan BS.
J Allergy Clin Immunol 2010 May 6;
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A population-based study on peanut, tree nut, fish, shellfish, and sesame allergy prevalence in Canada. |
Ben-Shoshan M, Harrington DW, Soller L, Fragapane J, Joseph L, St PY, Godefroy SB, Elliot SJ, Clarke AE.
J Allergy Clin Immunol 2010 May 6;
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Human IgE antibody serology: A primer for the practicing North American allergist/immunologist. |
Hamilton RG, Williams PB.
J Allergy Clin Immunol 2010 May 6;
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Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy. |
Sicherer SH, Wood RA, Stablein D, Burks AW, Liu AH, Jones SM, Fleischer DM, Leung DY, Grishin A, Mayer L, Shreffler W, Lindblad R, Sampson HA.
J Allergy Clin Immunol 2010 May;125(5):1077-1083
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A case of hypersensitivity to mosquito bite associated with Epstein-barr viral infection and natural killer cell lymphocytosis. |
Roh EJ, Chung EH, Chang YP, Myoung NH, Jee YK, Seo M, Kang JH.
J Korean Med Sci 2010 Feb;25(2):321-323
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JAMA patient page. Food allergies. |
Chang HJ, Burke AE, Glass RM.
JAMA 2010 May 12;303(18):1876
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Diagnosing and managing common food allergies: a systematic review. |
Chafen JJ, Newberry SJ, Riedl MA, Bravata DM, Maglione M, Suttorp MJ, Sundaram V, Paige NM, Towfigh A, Hulley BJ, Shekelle PG.
JAMA 2010 May 12;303(18):1848-1856
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Food allergy knowledge, attitudes, and beliefs of parents with food-allergic children in the United States. |
Gupta RS, Springston EE, Smith B, Kim JS, Pongracic JA, Wang X, Holl J.
Pediatr Allergy Immunol 2010 May 14;
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La lectine de larachide |
P. Rougé, R. Culerrier, C. Granier, F. Rancé, A. Barre
Rev Fr Allergol 2010;50(3):281-284
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Controverse lhypersensibilité aux additifs alimentaires est une réalité clinique : pour / Controversy hypersensitivity to food additives is a clinical reality: Pro |
C. Sauvage
Rev Fr Allergol 2010;50(3):288-291
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Il faut prémédiquer les allergiques avant un examen dimagerie avec produits de contraste : pour |
J.-M. Malinovsky, F. Lavaud, P.-M. Mertes
Rev Fr Allergol 2010;50(3):295-299
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Communications orales et posters: Allergènes |
Rev Fr Allergol 2010;50(3):308-314
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Communications orales et posters: Allergie alimentaire |
Rev Fr Allergol 2010;50(3):315-326
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Communications orales et posters: Allergie médicamenteuse |
Rev Fr Allergol 2010;50(3):327-338
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Lallergie au liquide séminal / Seminal allergy |
Tonnel A-B, Schlatter J.
Rev Fr Allergol 2010;50(3):197-199
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Les chéilites allergiques |
E. Collet, G. Jeudy, S. Dalac
Rev Fr Allergol 2010;50(3):238-243
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Quel bilan faire devant un eczéma des pieds ? |
D. Tennstedt
Rev Fr Allergol 2010;50(3):244-247
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Eczéma chez lenfant : quelles causes alimentaires, quels bilans ? |
F. Giordano-Labadie
Rev Fr Allergol 2010;50(3):106-108
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Dermatites eczématiformes et métiers de bouche |
C. Géraut, M.B. Cleenewerk, G. Jelen, L. Géraut, D. Tripodi
Rev Fr Allergol 2010;50(3):109-12
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Quest-ce que le lait ? |
A.-C. Vilain
Rev Fr Allergol 2010;50(3):124-127
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Lallergie au lait de chèvre ou de brebis |
E. Bidat
Rev Fr Allergol 2010;50(3):128-131
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Sensibilisation ou allergie aux venins dhyménoptères : comment faire la différence ? / The diagnosis of hymenoptera venom allergy |
F. Lavaud, J.-M. Perotin, J.-F. Fontaine and et le groupe insecte SFA/Anaforcal
Rev Fr Allergol 2010;50(3):132-136
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Allergie aux insectes piqueurs et maladie professionnelle |
J.-M. Renaudin
Rev Fr Allergol 2010;50(3):137-140
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Late-onset of IgE sensitization to microbial allergens in young children with atopic dermatitis. |
Ong PY, Ferdman RM, Church JA.
Br J Dermatol 2010 Jan;162(1):159-161
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An epidemic of furniture-related dermatitis: searching for a cause. |
Lammintausta K, Zimerson E, Hasan T, Susitaival P, Winhoven S, Gruvberger B, Beck M, Williams JD, Bruze M.
Br J Dermatol 2010 Jan;162(1):108-116
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Consumer available permanent hair dye products cause major allergic immune activation in an animal model. |
Bonefeld CM, Larsen JM, Dabelsteen S, Geisler C, White IR, Menne T, Johansen JD.
Br J Dermatol 2010 Jan;162(1):102-107
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Ammonium persulfate can initiate an asthmatic response in mice. |
De V, Cruz MJ, Haenen S, Wijnhoven K, Munoz X, Hoet PH, Morell F, Nemery B, Vanoirbeek JA.
Thorax 2010 Mar;65(3):252-257
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A method for measuring mouse respiratory allergic reaction to low-dose chemical exposure to allergens: an environmental chemical of uncertain allergenicity, a typical contact allergen and a non-sensitizing irritant. |
Fukuyama T, Tajima Y, Ueda H, Hayashi K, Shutoh Y, Harada T, Kosaka T.
Toxicol Lett 2010 May 19;195(1):35-43
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Incrimination of Blomia tropicalis as a potent allergen in house dust and its role in allergic asthma in Kolkata Metropolis, India. |
Podder S, Gupta SK, Saha GK.
WAO Journal 2010;3(5):182-187
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IgE in the human placenta: why there? |
Rindsjo E, Joerink M, Papadogiannakis N, Scheynius A.
Allergy 2010 May;65(5):554-560
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Mold-sensitivity in children with moderate-severe asthma is associated with HLA-DR and HLA-DQ. |
Knutsen AP, Vijay HM, Kumar V, Kariuki B, Santiago LA, Graff R, Wofford JD, Shah MR.
Allergy 2010 May 10;
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IgE-mediated hypersensitivity reactions to methylprednisolone. |
Aranda A, Mayorga C, Ariza A, Dona I, Blanca-Lopez N, Canto G, Blanca M, Torres MJ.
Allergy 2010 May 10;
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Season of birth and food-induced anaphylaxis in Boston. |
Vassallo MF, Banerji A, Rudders SA, Clark S, Camargo CA.
Allergy 2010 May 7;
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Sugar bandage is not effective for local reactions to bee stings. |
Mosbech H, Poulsen LK, Malling HJ.
Allergy 2010 May 7;
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