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Allergy Advisor Digest - October 2011
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Hen egg hair mask-induced food allergy

Anaphylaxis caused by tomato lipid transfer protein.

Rosaceae-associated exercise-induced anaphylaxis with positive SPT and negative IgE reactivity to Pru p 3.

Anaphylactic reaction to povidone secondary to drug ingestion in a young child.

Prevalence and real clinical impact of Cupressus sempervirens and Juniperus communis sensitisations in Tuscan 'Maremma', Italy.

Systemic allergic reaction due to intranasal budesonide.

Recent advances in research on lacquer allergy.

Maize: a new occupational allergen in the pharmaceutical industry.

Anaphylactic shock to iodinated povidone.

Histamine and allergen skin reactivity in the elderly population

Usefulness of specific IgE antibodies to omega-5 gliadin in the diagnosis and follow-up of Japanese children with wheat allergy.

Occupational IgE-mediated Softwood allergy: characterization of the causative allergen.

Minor interference of cross-reactive carbohydrates with the diagnosis of respiratory allergy

Diagnostic value of the serum-specific IgE Ratio of omega-5 Gliadin to wheat in adult patients with wheat-induced anaphylaxis.

Anaphylaxis in a New York City pediatric emergency department.

Cucumber anaphylaxis in a latex-sensitized patient.

A polysensitized patient with several severe food allergies - Molecular study results

Anaphylactic reaction to phuk-waan-ban in a patient with latex allergy.

Secondary soy allergy in children with birch pollen allergy may cause both chronic and acute symptoms.

Atlas of the most important allergenic pollens in Mexico.

Sensitization to allergens in a group of children with primary renal tubular acidosis.

Aeroallergen sensitization in wheezing children from Rosario, Argentina

Hen egg hair mask-induced food allergy
A 46-year-old woman who treated her hair with a homemade egg-white based mask. After one year of weekly applications, the ingestion of egg triggered rhinitis, choking and systemic urticaria. Though the breakdown of oral tolerance to egg has been reported elsewhere in the literature, to the best of the authors knowledge, this is the first case of hair mask-induced allergy.

Hen egg hair mask-induced food allergy: a case report.
Antonicelli L, Braschi MC, Cinti B.
Eur Ann Allergy Clin Immunol 2011 Aug;43(4):127-128

Anaphylaxis caused by tomato lipid transfer protein.
Anaphylaxis induced by tomato. Inhibition studies carried out in-vitro showed the complete cross-reactivity between the relevant tomato allergen and purified peach lipid transferprotein (LTP). Tomato LTP may sometimes cause severe allergic reactions.

Anaphylaxis caused by tomato lipid transfer protein.
Asero R, Mistrello G, Amato S.
Eur Ann Allergy Clin Immunol 2011 Aug;43(4):125-126

Rosaceae-associated exercise-induced anaphylaxis with positive SPT and negative IgE reactivity to Pru p 3.
A 12 years-old boy with seasonal allergy to olive and cypressus pollens, experienced two distinct episodes of Food-dependent-exercise-induced anaphylaxis (FDEIA), during intense exercise, about 30 minutes after eating a peach with peel or some cherries. SPT with commercial peach extract and fresh Rosacee fruits were positive while SPT with a date palm profilin-enriched extract was negative. Total IgE wase 44 kU/l and IgE for peach, cherry, Prup 3, Prup 1, Bet v 1, Bet v 2, Bet v 4 were negative. SPT with Prup 3 was negative. An oral food challenge, performed at rest using a commercial peach juice, was negative. Immunoblot with peach extract was negative.

The main peculiarity of this case of FDEIA was the discrepancy between positive SPT and negative in-vitro findings. The positive SPT with the commercial peach extract suggested hypersensitivity to lipid transfer protein; however, no IgE reactivity to rPrup 3 was found in-vitro. The negative immunoblot analysis, possibly caused by the low levels of specific IgE, did not allow investigation as to the nature of the relevant allergen protein. The authors suggest that it was possible that this patient reacted to a different peach allergen or, alternatively, that the allergen was an isoform of LTP different from that in the Uni-CAP.

Rosaceae-associated exercise-induced anaphylaxis with positive SPT and negative IgE reactivity to Pru p 3.
Bianchi A, Di Rienzo BA, Bondanini F, Mistrello G, Carlucci A, Tripodi S.
Eur Ann Allergy Clin Immunol 2011 Aug;43(4):122-124

Anaphylactic reaction to povidone secondary to drug ingestion in a young child.
Povidone is commonly used as an excipient in different pharmaceutical products; in artificial tears and contact lens preservation solutions; as an additive in foodstuffs (E-1202), serving as a support for edulcorants, and in food supplements in the form of tablets and pills; as an antiseptic (Betadine®); and as a dispersant and stabiliser in hair sprays.

Anaphylactic reaction to povidone secondary to drug ingestion in a young child. Contact dermatitis associated to povidone-iodine is not rare, though immediate hypersensitivity reactions to this substance are unusual, with few cases of anaphylaxis documented in the literature. A case of anaphylactic reaction in a 4 year old boy is described. The patient had suffered an episode of asthma and rhinitis at the age of three years and 10 months, developing 1-2 h after receiving Estilsona® (prednisolone oral solution), perioral and nasal swelling and erythema, and eye itching with conjunctival reddening. The condition lasted 4-6 h, and no other manifestations were described. The patient had used this medication several times before without reactions. An open oral provocation test with the suspect drug (Estilsona®) was performed a number of times, each resulting in symptoms. One month later the study was conducted testing all the components and excipients. Prick test with betadine solution was positive as well as with pure non-iodinated povidone. Specific serum IgE against PVP was not detected. A month after diagnosis, the boy by mistake received Zinnat® sachets 250 mg (cefuroxime axetyl and povidone K30) which resulted in anaphylaxis.

Anaphylactic reaction to povidone secondary to drug ingestion in a young child.
Michavila-Gomez AV, Moreno-Palanques MA, Ferrer-Vazquez M, Ferriols-Leisart R, Bartolome B.
Allergol Immunopathol (Madr) 2011 Oct 11;

Prevalence and real clinical impact of Cupressus sempervirens and Juniperus communis sensitisations in Tuscan 'Maremma', Italy.
Thhis study's aim was to evaluate the impact of Cupressus sempervirens (Cs) (Italian Funeral Cypress) and Juniperus communis (Jc) (Juniper berry) sensitisations in 'Maremma' in southern Tuscany. 811 consecutive outpatients with suspected allergic respiratory symptoms underwent skin prick tests (SPT) for common allergens and for Cs and Jc. SPT was negative in 295 (36.37%) subjects. A Cs/Jc sensitisation was found in 294 (36.25%): 289 (98.3%) were sensitised to Cs whereas 198 (67.34%) to Jc. There was a co-sensitisation between Cs and Jc in 193 (65.6%) subjects. Cs/Jc mono-sensitisation was found in 39 (13.6%) subjects. A higher number of Cs/Jc sensitised subjects reported winter (131-44.55%) and spring (124-42.2%) symptoms compared to Cs/Jc non-sensitised and non-allergic subjects. Most Cs/Jc sensitised subjects reported rhinitis and conjunctivitis, whereas only few reported coughing and asthma. The most frequent co-sensitisation was with grass, olive and other trees in Cs/Jc subjects. Those who reported winter symptoms, likely influenced by Cupressaceae, rhinitis was the main symptom whereas asthma was less frequent. Cs/Jc sensitisation resulted to be a risk factor for rhinitis whereas the probability of being asthmatic was reduced.

Prevalence and real clinical impact of Cupressus sempervirens and Juniperus communis sensitisations in Tuscan 'Maremma', Italy.
Sposato B, Scalese M.
Allergol Immunopathol (Madr) 2011 Oct 5;

Systemic allergic reaction due to intranasal budesonide.
A 34-year-old non-atopic woman started treatment with nasal budesonide for a common cold. On the second day of treatment the patient developed, 8 h after the administration of 256 mcg (two puff per nostril each time), lips, nose, and eyelid angioedema and pruritic urticarial papules in face, chest and arms. The symptoms remitted gradually over 3-4 days after treatment with hydroxyzine. Previously the patient had tolerated nasal budesonide without adverse effects. Prick and intradermal test were performed with a battery of corticosteroids, with the excipients carboxymethylcellulose, Tween 80, and benzylalcohol. Prick tests with corticosteroids battery and excipients were negative. Intradermal test with budesonide was positive at 48 h and negative with the rest of tested corticosteroids and excipients. Patch tests were positive only with budesonide.

Systemic allergic reaction due to intranasal budesonide.
vila-Fernandez G, Vazquez-Cortes S, Chamorro-Gomez M, Elices-Apellaniz A.
Allergol Immunopathol (Madr) 2011 Oct 5;

Recent advances in research on lacquer allergy.
Also called Varnish Tree, Japanese lacquer Tree, Japanese Varnish Tree and Japanese Sumac, is a species of genus Toxicodendron (formerly Rhus) that grows in East Asia, in regions of China, Korea and Japan. The trees are cultivated and tapped for their toxic sap, which is used as a highly durable lacquer to make Chinese, Korean and Japanese lacquerware.

Allergic contact dermatitis caused by contact with lacquer sap and lacquerware affects the welfare of lacquer workers and the lacquerware industry. Many studies of the mechanism of urushiol allergy, including animal models, have been carried out and have established several hypotheses. In order to provide a comprehensive understanding of lacquer allergy, the authors review recent advances in the research on lacquer allergy including the chemical properties of lacquer lipid components, allergic mechanism analyses, immunological explanations, allergy medications, and the prevention combined with the research results from the laboratory.

Recent advances in research on lacquer allergy.
Ma XM, Lu R, Miyakoshi T.
Allergol Int 2011 Oct 25;0(0):

Maize: a new occupational allergen in the pharmaceutical industry.
Starch is a widespread excipient of tablets. The major food allergen of maize, Zea m 14 is a heatresistant lipid transfer protein. A 19-year-old girl, apprentice of a pharmaceutical company, noticed an erythematous itching rash on both hands and the face associated with dyspnea everyday 2 hours after starting work in tablet manufacturing. Main excipients of these tablets are maize starch, microcrystalline cellulose and lactose. Total IgE level was 46 kU/l. Specific IgE to

maize and latex was not detected. A type I sensitization to maize bran

was detected by skin prick test, then by intracutaneous tests for maize bran and flour. Nasal provocation test with maize bran revealed a strong positive reaction with sneezing, conjunctival injection and pruritus of the nose and eyes after 6 min. Moreover, the nasal flow diminished. Western blot of maize flour incubated with patient serum showed a marked band at 50 kDa possibly matching the reduced soluble protein allergen of the maize endosperm.

Maize: a new occupational allergen in the pharmaceutical industry.
Maniu CM, Faupel U, Siebenhaar G, Hunzelmann N.
Allergy 2010 Jul;65(7):930-931

Anaphylactic shock to iodinated povidone.
A report of "an exceptional case of grade 3 anaphylactic shock with iodinated povidone administered via a rectal route."

Anaphylactic shock to iodinated povidone. [French]
Palobart C, Cros J, Orsel I, Nathan N.
Ann Fr Anesth Reanim 2009 Feb;28(2):168-70.

Histamine and allergen skin reactivity in the elderly population
This Korean study investigated skin reactivity and influencing factors in the elderly population (n=854). Older age and female sex were associated with reduced histamine skin reactivity in elderly subjects. This age-related decrease was apparent only among women, the reasons for which were not identified. In contrast to histamine, wheal response size induced by 2 major allergens, Dermatophagoides pteronyssinus and Dermatophagoides farinae, did not show sex differences and did not decrease with age among the subjects showing allergen-induced wheal size greater than 0 mm.

Histamine and allergen skin reactivity in the elderly population: results from the Korean Longitudinal Study on Health and Aging.
Song WJ, Lee SM, Kim MH, Kim SH, Kim KW, Cho SH, Min KU, Chang YS.
Ann Allergy Asthma Immunol 2011 Oct;107(4):344-352

Usefulness of specific IgE antibodies to omega-5 gliadin in the diagnosis and follow-up of Japanese children with wheat allergy.
Gliadins have been implicated in IgE-mediated allergy to ingested wheat. omega-5 gliadin seems to be a clinically relevant allergen component in children with immediate wheat allergy (WA), but contradictory results have been published. This study investigated whether specific IgE (sIgE) antibodies to recombinant omega-5 gliadin could be used as a marker for oral wheat challenge outcome in wheat-sensitized children and to study whether measurements of sIgE to omega-5 gliadin are useful in monitoring children with WA to assess whether the allergy is outgrown or persistent. Eighty-eight serum samples from children sensitized to wheat were collected consecutively. sIgE to omega-5 gliadin was related to a physician's diagnosis of WA. Sixty-seven of 88 children sensitized to wheat were diagnosed as having WA. The geometric mean concentrations of sIgE to omega-5 gliadin were 2.04 kU(A)/L (range, <0.35-100 kU(A)/L) in children with WA and 0.40 kU(A)/L (range, <0.35-1.8 kU(A)/L) in children without WA. At follow-up, after being on a wheat-free diet for approximately 2 years, the sIgE titers to omega-5 gliadin were below 0.35 kU(A)/L (mean, 0.34 kU(A)/L; range, 0.34-2.3 kU(A)/L) in 10 of 15 children with outgrown WA. Conversely, in 12 of 14 children with persistent WA, the sIgE titers to omega-5 gliadin were still elevated (mean, 5.89 kU(A)/L; range, 0.34-16.3 kU(A)/L). The study concludes that sIgE to omega-5 gliadin can be used as an accurate alternative to potentially dangerous wheat food challenges in monitoring WA.

Usefulness of specific IgE antibodies to omega-5 gliadin in the diagnosis and follow-up of Japanese children with wheat allergy.
Shibata R, Nishima S, Tanaka A, Borres MP, Morita E.
Ann Allergy Asthma Immunol 2011 Oct;107(4):337-343

Occupational IgE-mediated Softwood allergy: characterization of the causative allergen.
A case report of softwood allergy in a carpenter exposed to different wood dusts. Skin tests and IgE tests against wood were performed with specifically tailored ImmunoCAPs and cross-reactive carbohydrate determinants. Potential allergens were identified by IgE. The clinical relevance was verified by challenge tests. Specific IgE to softwood (spruce, pine and larch wood), beech wood, natural rubber latex (NRL) and horseradish peroxidase (HRP) were detected. Allergens in spruce wood, the dominant allergen source, were identified as peroxidases. Softwood were the strongest inhibitors. HRP reduced IgE binding to softwood to <50%, indicating predominantly proteinogenic epitopes, whereas IgE binding to NRL and beech wood was reduced to >50% by HRP, indicating predominantly glycogenic IgE epitopes. Skin and challenge tests underlined that softwoods were the source of sensitization.

Occupational IgE-mediated Softwood allergy: characterization of the causative allergen.
Kespohl S, Kotschy-Lang N, Tomm JM, von BM, Maryska S, Bruning T, Raulf-Heimsoth M.
Int Arch Allergy Immunol 2011 Oct 7;157(2):202-208

Minor interference of cross-reactive carbohydrates with the diagnosis of respiratory allergy
IgE to N-glycans from plant and invertebrate glycoproteins induces extensive in vitro cross-reactivity. This study investigated the prevalence and diagnostic relevance of IgE to these N-glycans [cross-reactive carbohydrate determinants (CCDs)] in patients with suspicion of respiratory allergy. A total of 1,025 adult subjects with symptoms of rhinitis and/or asthma from a reference allergy clinic were studied. The prevalence of CCD sensitization (MUXF sIgE and/or bromelain-sIgE >/=0.1 kU(A)/l) was 18.0%. Male sex and atopy (SPT positivity) were associated with CCD sensitization. Sensitization was more frequent in patients sensitized to pollens than in those sensitized to mites, the most common inhalant allergens in the area. A history of Hymenoptera stings was associated with CCD sensitization and multiallergen IgE test positivity. CCD sensitization was not significantly associated with age, rural residence, alcohol consumption or smoking. Only 58 patients (5.6%) showed CCD-sIgE levels >/=0.35 kU(A)/l. CCD-induced inhibition of pollen-sIgE or mite-sIgE in patients with respective positive SPT was minimal or absent in most cases. In this population of predominantly mite-allergic patients, CCD sensitization was relatively rare and CCD-sIgE levels low. Thus, CCDs do not represent a major obstacle for the diagnosis of respiratory allergy in a specialized setting. Hymenoptera stings are associated with CCD sensitization.

Minor interference of cross-reactive carbohydrates with the diagnosis of respiratory allergy in standard clinical conditions.
Vidal C, Sanmartin C, Armisen M, Rodriguez V, Linneberg A, Gonzalez-Quintela A.
Int Arch Allergy Immunol 2011 Oct 6;157(2):176-185

Diagnostic value of the serum-specific IgE Ratio of omega-5 Gliadin to wheat in adult patients with wheat-induced anaphylaxis.
Wheat is an important food allergen associated with severe allergic reactions, including wheat-dependent exercise-induced anaphylaxis (WDEIA) and wheat-induced anaphylaxis (WIA). To diagnose WDEIA, an exercise challenge test following wheat ingestion is performed, which is time-consuming and unsafe. The compound omega-5 gliadin has been identified as a major allergen for WDEIA and WIA. This study evaluated the diagnostic value of serum IgE ratios of omega-5 gliadin to wheat in adult patients with WDEIA or WIA. 27 patients were enrolled and classified into 2 groups according to the severity of their allergic reactions to wheat. Group 1 included 17 patients with a history of anaphylaxis and group 2 included 10 patients having urticaria or atopic dermatitis. Serum IgE specific to wheat was increased in 47% of group 1 and 100% of group 2. However, all patients in group 1 had high serum IgE specific to omega-5 gliadin, whereas only 20% of group 2 showed increased levels. To identify a better diagnostic value, the log-transformed IgE ratio of omega-5 gliadin to wheat was calculated, with the cutoff value at 0.3. Based on these criteria, the authors found 100% sensitivity and specificity. Therefore this study confirms that the serum IgE ratio of omega-5 gliadin to wheat may be a useful marker for the diagnosis of WDEIA and WIA.

Diagnostic value of the serum-specific IgE Ratio of omega-5 Gliadin to wheat in adult patients with wheat-induced anaphylaxis.
Park HJ, Kim JH, Kim JE, Jin HJ, Choi GS, Ye YM, Park HS.
Int Arch Allergy Immunol 2011 Oct 5;157(2):147-150

Anaphylaxis in a New York City pediatric emergency department.
In this study of anaphylaxis in a New York City pediatric emergency department (PED), a review of PED records for anaphylactic reactions over 5 years were evaluated. Results were - 213 anaphylactic reactions in 192 children (97 male): 6 were infants, 20 had multiple reactions, and the median age was 8 years (age range, 4 months to 18 years). Sixty-two reactions were coded as anaphylaxis; 151 additional reactions met the second symposium anaphylaxis criteria. There was no increase in incidence over 5 years. The triggers included the following: foods, 71%; unknown, 15%; drugs, 9%; and 'other,' 5%. Food was more likely to be a trigger in multiple PED visits. Epinephrine was administered in 169 (79%) reactions.

Anaphylaxis in a New York City pediatric emergency department: Triggers, treatments, and outcomes.
Huang F, Chawla K, Jarvinen KM, Nowak-Wegrzyn A.
J Allergy Clin Immunol 2011 Oct 22;

Cucumber anaphylaxis in a latex-sensitized patient.
A 76-year-old woman experienced dizziness, vomiting, dyspnea, thoracic erythema, and vaginal itching within 5 minutes of eating cucumber. She had been diagnosed 3 months earlier with papaya urticaria and latex sensitization. Skin prick tests were positive for cucumber, watermelon, papaya, and latex and negative for melon and profilin extracts. Latex-specific IgE was positive. Cucumber-specific serum IgE was negative. Immunoblot analysis of the patient's serum revealed a 30- to 32-kDa protein band in the cucumber (peel) and papaya extracts. Immunoblot inhibition with latex extract demonstrated inhibition of the band in both extracts. Immunoblot inhibition with cucumber-papaya and papaya-cucumber revealed inhibition of the same band in the cucumber and papaya extracts, respectively. A diagnosis of IgE-mediated allergy to cucumber and papaya was made and the authors suggest that the results strongly suggest that the allergen(s) implicated are associated with latex sensitization. To their knowledge, this is the first report of cucumber-latex and cucumber-papaya cross-reactivity. (Vlaicu 2011 ref.26863 7)

Cucumber anaphylaxis in a latex-sensitized patient.
Vlaicu PC, Rusu LC, Ledesma A, Vicente M, Cuevas M, Zamorano M, Antolín D, Alvarez E, De La Hoz B.
J Investig Allergol Clin Immunol 2011;21(3):236-9.

A polysensitized patient with several severe food allergies - Molecular study results
A patient with pollen allergy multi-sensitized to different pollens, who also reports symptoms of food allergy: oral syndrome, urticaria and exercise induced anaphylaxis. Results of IgE determinations using microarray technique (ISAC) showed that the aeroallergens involved were typical from a Mediterranean environment; exercised-induced anaphylaxis was certainly related to tomato LTP whereas for episodes of oral syndrome and urticaria from peach LTP, storage proteins from lentils and soya were likely also involved. (Pauli 2010 ref.26975 5)

Molecular study of allergies in practice: About a polysensitized patient presenting several severe food allergies.
Pauli G, Chivato T.
Miscellaneous 592 2010;50(6):513-515

Anaphylactic reaction to phuk-waan-ban in a patient with latex allergy.
Frst report of anaphylactic reaction to Phuk-waan-ban in latex allergic patients. A patient with occupational natural rubber allergy developed an anaphylactic reaction with urticarial rash 20-30 minutes after ingestion of phuk-waan-ban. Specific IgE to latex was CAP class 3. Positive skin prick tests to latex and cooked and raw phuk-waan-ban crude extract confirmed allergic reactions. Cross-reactivity between phuk-waan-ban and latex was confirmed by using IgE inhibition test.

Sauropus androgynus, also known as katuk, star gooseberry, or sweet leaf, is a shrub grown in some tropical regions as a leaf vegetable. Its multiple upright stems can reach 2.5 meters high and bear dark green oval leaves 5-6 cm long. It is one of the most popular leaf vegetables in South Asia and Southeast Asia and is notable for high yields and palatability. The shoot tips have been sold as tropical asparagus. In Vietnam, the locals cook it with crab meat, minced pork or dried shrimp to make soup. In Malaysia, it is commonly stir-fried with egg or dried anchovies. In Indonesia, the leaves of the plant are used to make infusion, believed to improve the flow of breast milk for breastfeeding mothers. (http://en.wikipedia.org/wiki/Sauropus_androgynus)

Anaphylactic reaction to phuk-waan-ban in a patient with latex allergy.
Stirapongsasuti P, Tanglertsampan C, Aunhachoke K, Sangasapaviliya A.
Miscellaneous 592 2010 May;93(5):616-9.

Secondary soy allergy in children with birch pollen allergy may cause both chronic and acute symptoms.
Secondary soy allergy occurring in tree pollen allergic patients may cause acute symptoms. This study selected children with birch pollen allergy suspected of also being soy allergic (SA). Soy allergy was proven based on one of the following: (i) a clear-cut clinical history; (ii) a positive provocation test; and (iii) elimination and reintroduction of soy. Skin prick tests (SPT) were performed with a commercial soy extract and with soy flour. Specific IgE to Gly m 4, Gly m 5, and Gly m 6 was determined by means of ImmunoCAP and ISAC. Eight soy-tolerant atopic children being CAP rGly m 4-negative served as a control group for skin testing. Of 15 subjects with birch pollen allergy and being suspected of soy allergy, eight of them proved to be SA; 7/15 subjects proved to be soy tolerant (ST). Besides acute symptoms in 8/8 SA subjects, 3/8 subjects also had been suffering from severe chronic complaints because of soy allergy. SPT with commercial soy extract was negative in all SA and ST subjects tested. SPT with soy flour was positive in 8/8 SA and in 5/6 ST subjects, but negative in all 8 controls; the median weal diameter was 7.7 mm in SA subjects, compared to 3 mm in ST subjects. The median IgE level to rGly m 4 using CAP and ISAC was, respectively, 32.4 kU/l and 4.0 ISU in SA subjects, compared to 6.2 kU/l and 0.4 ISU in ST subjects. Analysis of IgE to nGly m 5 and nGly m 6, using CAP or ISAC, showed no significant differences between SA and ST subjects.

The study concludes that secondary soy allergy may cause severe chronic besides acute symptoms. SPT with soy flour is a sensitive and specific tool in detecting soy sensitization. SPT with soy flour, CAP rGly m 4, and ISAC rGLY m 4 are valuable tools in the diagnosis of birch-pollen-associated secondary soy allergy.

Secondary soy allergy in children with birch pollen allergy may cause both chronic and acute symptoms.
De Swert LF, Gadisseur R, Sjolander S, Raes M, Leus J, Van HE.
Pediatr Allergy Immunol 2011 Oct 21;

Atlas of the most important allergenic pollens in Mexico.
The importance of pollens as etiologic agents of allergy in Mexico is out of question, as have been demonstrated since 1940 in several studies performed in order to identify allergenic flora in many cities of Mexico. With the aim to improve the knowledge about pollens related to allergic diseases we made an atlas with photographs of the most relevant allergenic pollens in Mexico according to skin tests performed in allergic patients. Photographs of 31 taxa and a brief description of their microscopic features are presented along with their taxonomical relationships.

Atlas of the most important allergenic pollens in Mexico. [Spanish]
Rosas-Alvarado A, Bautista-Huerta M, Velazquez-Samano G.
Rev Alerg Mex 2011 May;58(3):162-170

Sensitization to allergens in a group of children with primary renal tubular acidosis.
Some reports associate certain urinary system illnesses with allergies. In this study of a group of children with primary renal tubular acidosis (RTA), 43 children aged 5 months to 9 years (mean, 3.4 +/- 1.8 years), were evaluated. The most common symptoms at the beginning of disease were: failure to thrive and lack of appetite. Twenty-one parents (48.8%) noticed an association between the introduction of cow s milk and the beginning of symptoms. Skin tests were positive in 27.9%. Total IgE levels were elevated in 34.9%, ranged from 5.9 to 324 IU/mL. Allergen-specific IgE was positive in 25.6%, mainly for milk, wheat and egg white. The milk precipitins test was positive in 9 patients (21%). The authors conclude that although this study demonstrated the existence of allergen sensitization in a group of children with RTA, it is necessary to look for this association in studies with larger sample size and to use tests with higher specificity and sensitivity.

Prevalence of sensitization to inhaled and food allergens in a group of children with primary renal tubular acidosis. [Spanish]
Bojorquez-Ochoa A, Morfin-Maciel BM, Garcia-Caballero R, Hernandez T, Barbosa C, Zaltzman-Girsevich S.
Rev Alerg Mex 2011 Apr;58(2):87-92

Aeroallergen sensitization in wheezing children from Rosario, Argentina
This Argentinian study assessed the prevalence of aeroallergen sensitization in a pediatric population with recurrent episodes of wheezing. Overall, 58% of the patients presented sensitization to dust mite, 13% to pollen, 9% to epithelium, 8% to fungi, 6% to cockroach, and 1% to soybean hull. Overall, 60% of the patients were positive to at least one of the extracts, and the authors observed a significant and gradual increase in the frequency of sensitization in older age-groups.

Aeroallergen sensitization in wheezing children from Rosario, Argentina
Patricia Pendino, Claudio Aguero, Paola Cavagnero, Karina Lopez, Ivan Kriunis, Jorge Molinas
WAO Journal 2011;4(10):

Allergen-, Food allergy-, Intolerance-related articles

Hen egg hair mask-induced food allergy: a case report.
Antonicelli L, Braschi MC, Cinti B. Eur Ann Allergy Clin Immunol 2011 Aug;43(4):127-128

Anaphylaxis caused by tomato lipid transfer protein.
Asero R, Mistrello G, Amato S. Eur Ann Allergy Clin Immunol 2011 Aug;43(4):125-126

Rosaceae-associated exercise-induced anaphylaxis with positive SPT and negative IgE reactivity to Pru p 3.
Bianchi A, Di Rienzo BA, Bondanini F, Mistrello G, Carlucci A, Tripodi S. Eur Ann Allergy Clin Immunol 2011 Aug;43(4):122-124

Peach allergy. Beyond the classic 3 allergens?
Asero R, Cecchi L. Eur Ann Allergy Clin Immunol 2011 Aug;43(4):101-102

Eczematous dermatitis caused by tetrazepam.
Vazquez-Cortes S, Davila FG, Elices AA, Nieto LS, Chamorro GM. Allergol Immunopathol (Madr) 2011 Oct 1;

Anaphylactic reaction to povidone secondary to drug ingestion in a young child.
Michavila-Gomez AV, Moreno-Palanques MA, Ferrer-Vazquez M, Ferriols-Leisart R, Bartolome B. Allergol Immunopathol (Madr) 2011 Oct 11;

Prevalence and real clinical impact of Cupressus sempervirens and Juniperus communis sensitisations in Tuscan 'Maremma', Italy.
Sposato B, Scalese M. Allergol Immunopathol (Madr) 2011 Oct 5;

Systemic allergic reaction due to intranasal budesonide.
vila-Fernandez G, Vazquez-Cortes S, Chamorro-Gomez M, Elices-Apellaniz A. Allergol Immunopathol (Madr) 2011 Oct 5;

Streptococcal tonsillitis as a cause of urticaria Tonsillitis and urticaria.
Calado G, Loureiro G, Machado D, Tavares B, Ribeiro C, Pereira C, Luis AS. Allergol Immunopathol (Madr) 2011 Oct 5;

Serum IgE and eosinophil count in allergic rhinitis-Analysis using a modified Bayes' theorem.
Demirjian M, Rumbyrt JS, Gowda VC, Klaustermeyer WB. Allergol Immunopathol (Madr) 2011 Oct 4;

Recent advances in research on lacquer allergy.
Ma XM, Lu R, Miyakoshi T. Allergol Int 2011 Oct 25;0(0):

Maize: a new occupational allergen in the pharmaceutical industry.
Maniu CM, Faupel U, Siebenhaar G, Hunzelmann N. Allergy 2010 Jul;65(7):930-931

The 8-year follow-up of the PIAMA intervention study assessing the effect of mite-impermeable mattress covers.
Gehring U, de Jongste JC, Kerkhof M, Oldewening M, Postma D, van Strien RT, Wijga AH, Willers SM, Wolse A, Gerritsen J, Smit HA, Brunekreef B. Allergy 2011 Oct 25;

Diagnostic value of the allergen, Pru p 1 in adult patients with birch pollen-associated oral allergy syndrome.
Hwang EK, Kim JH, Nam YH, Jin HJ, Park HS. Allergy 2011 Dec;66(12):1621-1622

Storage mites are the main sensitizers among adults in northern Vietnam: Results from a population survey.
Hoang TL, Nguyen VT, Lundback B, Ronmark E. Allergy 2011 Dec;66(12):1620-1621

IgE-binding epitopes: a reappraisal.
Aalberse RC, Crameri R. Allergy 2011 Oct;66(10):1261-1274

Antenatal risk factors for peanut allergy in children.
Binkley KE, Leaver C, Ray JG. Allergy Asthma Clin Immunol 2011 Oct 4;7(1):17

Anaphylactic shock to iodinated povidone. [French]
Palobart C, Cros J, Orsel I, Nathan N. Ann Fr Anesth Reanim 2009 Feb;28(2):168-70.

On the cover - brown rat.
Weber RW. Ann Allergy Asthma Immunol 2011 Oct;107(4):A6

Fixed drug eruption caused by mesna.
Weiss KM, Jariwala S, Wachs J, Jerschow E. Ann Allergy Asthma Immunol 2011 Oct;107(4):377-378

Adverse reactions to the allergen conjunctival provocation test.
Mourao EM, Rosario NA. Ann Allergy Asthma Immunol 2011 Oct;107(4):373-374

Histamine and allergen skin reactivity in the elderly population: results from the Korean Longitudinal Study on Health and Aging.
Song WJ, Lee SM, Kim MH, Kim SH, Kim KW, Cho SH, Min KU, Chang YS. Ann Allergy Asthma Immunol 2011 Oct;107(4):344-352

Usefulness of specific IgE antibodies to omega-5 gliadin in the diagnosis and follow-up of Japanese children with wheat allergy.
Shibata R, Nishima S, Tanaka A, Borres MP, Morita E. Ann Allergy Asthma Immunol 2011 Oct;107(4):337-343

Clinical evaluation of omega-5 gliadin-specific IgE test. [Japanese]
Otsuji K, Futamura M, Kando N, Hayashi K, Ito K. Arerugi 2011 Aug;60(8):971-982

Occupational IgE-mediated Softwood allergy: characterization of the causative allergen.
Kespohl S, Kotschy-Lang N, Tomm JM, von BM, Maryska S, Bruning T, Raulf-Heimsoth M. Int Arch Allergy Immunol 2011 Oct 7;157(2):202-208

May the reduction of exposure to specific sensitizers be an alternative to work cessation in occupational asthma? results from a follow-up study.
Talini D, Novelli F, Melosini L, Bacci E, Bartoli ML, Cianchetti S, Dente FL, Di FA, Vagaggini B, Paggiaro PL. Int Arch Allergy Immunol 2011 Oct 7;157(2):186-193

Minor interference of cross-reactive carbohydrates with the diagnosis of respiratory allergy in standard clinical conditions.
Vidal C, Sanmartin C, Armisen M, Rodriguez V, Linneberg A, Gonzalez-Quintela A. Int Arch Allergy Immunol 2011 Oct 6;157(2):176-185

Specific IgE toward allergenic molecules is a new prognostic marker in patients with Sezary syndrome.
Scala E, Abeni D, Palazzo P, Liso M, Pomponi D, Lombardo G, Picchio MC, Narducci MG, Russo G, Mari A. Int Arch Allergy Immunol 2011 Oct 6;157(2):159-167

Diagnostic value of the serum-specific IgE Ratio of omega-5 Gliadin to wheat in adult patients with wheat-induced anaphylaxis.
Park HJ, Kim JH, Kim JE, Jin HJ, Choi GS, Ye YM, Park HS. Int Arch Allergy Immunol 2011 Oct 5;157(2):147-150

Mapping of IgE and IgG(4) antibody-binding epitopes in Cyn d 1, the major allergen of Bermuda grass pollen.
Yuan HC, Wu KG, Chen CJ, Su SN, Shen HD, Chen YJ, Peng HJ. Int Arch Allergy Immunol 2011 Oct 5;157(2):125-135

Occupational asthma caused by IgE-mediated sensitization to multiple woods.
Campo P, Aranda A, Palacin A, Montanez MI, az-Perales A, Blanca M. J Allergy Clin Immunol 2011 Oct 11;

How much of the farming effect is environmental?
Grabenhenrich L, Keil T. J Allergy Clin Immunol 2011 Oct;128(4):780-781

The protective effect of farm milk consumption on childhood asthma and atopy: The GABRIELA study.
Loss G, Apprich S, Waser M, Kneifel W, Genuneit J, Buchele G, Weber J, Sozanska B, Danielewicz H, Horak E, van Neerven RJ, Heederik D, Lorenzen PC, von ME, Braun-Fahrlander C. J Allergy Clin Immunol 2011 Oct;128(4):766-773

Anaphylaxis in a New York City pediatric emergency department: Triggers, treatments, and outcomes.
Huang F, Chawla K, Jarvinen KM, Nowak-Wegrzyn A. J Allergy Clin Immunol 2011 Oct 22;

Urinary tetranor-PGDM concentrations in aspirin-intolerant asthma and anaphylaxis.
Higashi N, Mita H, Yamaguchi H, Fukutomi Y, Akiyama K, Taniguchi M. J Allergy Clin Immunol 2011 Oct 22;

Hypersensitivity reactions due to nitrile gloves.
Gonzalo-Garijo MA, Caballero ML, Gil-Micharet MS, Moneo I, Perez-Calderon R, Garcia-Borruel L. J Allergy Clin Immunol 2011 Oct 21;

Drug hypersensitivity reactions: Inconsistency in the use of the classification of immediate and nonimmediate reactions.
Bircher AJ, Scherer HK. J Allergy Clin Immunol 2011 Oct 6;

Cucumber anaphylaxis in a latex-sensitized patient.
Vlaicu PC, Rusu LC, Ledesma A, Vicente M, Cuevas M, Zamorano M, Antolín D, Alvarez E, De La Hoz B. J Investig Allergol Clin Immunol 2011;21(3):236-9.

Molecular study of allergies in practice: About a polysensitized patient presenting several severe food allergies.
Pauli G, Chivato T. Miscellaneous 592 2010;50(6):513-515

Anaphylactic reaction to phuk-waan-ban in a patient with latex allergy.
Stirapongsasuti P, Tanglertsampan C, Aunhachoke K, Sangasapaviliya A. Miscellaneous 592 2010 May;93(5):616-9.

Alpha-nicotinic acetylcholine receptor and tobacco smoke exposure: Effects on bronchial hyperresponsiveness in children.
Torjussen TM, Lodrup Carlsen KC, Munthe-Kaas MC, Mowinckel P, Carlsen KH, Helms PJ, Gerritsen J, Whyte MK, Lenney W, Undlien DE, Shianna KV, Zhu G, Pillai SG. Pediatr Allergy Immunol 2011 Oct 21;

Familial aggregation of allergen-specific sensitization and asthma.
Kurzius-Spencer M, Guerra S, Sherrill DL, Halonen M, Elston RC, Martinez FD. Pediatr Allergy Immunol 2011 Oct 21;

Secondary soy allergy in children with birch pollen allergy may cause both chronic and acute symptoms.
De Swert LF, Gadisseur R, Sjolander S, Raes M, Leus J, Van HE. Pediatr Allergy Immunol 2011 Oct 21;

Allergen sensitization in Mexican adults with asthma: Experience at a teaching hospital. [Spanish]
Bedolla-Barajas M, Hernandez-Colin DD, Sainz-Hernandez J, Morales-Romero J. Rev Alerg Mex 2011 May;58(3):133-141

Atlas of the most important allergenic pollens in Mexico. [Spanish]
Rosas-Alvarado A, Bautista-Huerta M, Velazquez-Samano G. Rev Alerg Mex 2011 May;58(3):162-170

Prevalence of sensitization to inhaled and food allergens in a group of children with primary renal tubular acidosis. [Spanish]
Bojorquez-Ochoa A, Morfin-Maciel BM, Garcia-Caballero R, Hernandez T, Barbosa C, Zaltzman-Girsevich S. Rev Alerg Mex 2011 Apr;58(2):87-92

Aeroallergen sensitization in wheezing children from Rosario, Argentina
Patricia Pendino, Claudio Aguero, Paola Cavagnero, Karina Lopez, Ivan Kriunis, Jorge Molinas WAO Journal 2011;4(10):

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