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Allergy Advisor Digest - September 2011
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Clinical value of morphine, pholcodine and poppy seed IgE assays in drug-abusers and allergic people.

Anaphylaxis to olive fruit due to lipoprotein sensitization.

Effect of exposure and sensitization to indoor allergens on asthma control level.

Trends in occupational airway diseases in German hairdressers

Cosensitization to orange seed and cashew nut.

Spice allergy. A review

Diagnosis and management of hymenoptera venom allergy: British Society for Allergy and Clinical Immunology (BSACI) guidelines.

Health effects of polychlorinated biphenyls.

Occupational asthma caused by triglycidyl isocyanurate.

Shrimp allergy in Italian adults: high prevalence of sensitivity to novel high molecular weight allergens.

Epitope mapping of Atlantic Salmon major allergen by peptide microarray immunoassay.

An odorant-binding protein as a new allergen from Siberian hamster

IgG to various beta-glucans in a human adult population.

Usefulness of lymphocyte stimulation test for the diagnosis of intestinal cow's milk allergy in infants.

New lentil allergen identified: Lipid transfer protein Len c 3.

Influence of enzymatic hydrolysis on the allergenicity of roasted peanut protein extract.

Alternaria in patients with allergic rhinitis.

Causes of ant sting anaphylaxis in Australia.

Single nut or total nut avoidance in nut allergic children: outcome of nut challenges to guide exclusion diets.

Phadiatop Infant((R)) detects IgE-mediated diseases among pre-school children: a prospective study.

beta-lactam allergy and cross-reactivity.

Sensitivity to animals' allergens in people working with animals.

Allergy to materials used in dental procedures.

Molecular Allergology in practice: about an allergy to LTP

Clinical value of morphine, pholcodine and poppy seed IgE assays in drug-abusers and allergic people.
The diagnosis of anaphylactic reactions due to opiates during anaesthesia can be difficult, since in most cases various drugs may have been administered. Detection of specific IgE to poppy seed might be a marker for sensitisation to opiates in allergic people and heroin-abusers. This study assessed the clinical value of morphine, pholcodine and poppy seed skin-prick and IgE determination in people suffering hypersensitivity reactions during anaesthesia or analgesia and drug-abusers with allergic symptoms.

Heroin abusers and patients who suffered severe reactions during anaesthesia and analgesia were selected from a database of 23,873 patients. 149 patients and 200 controls were included. All patients with positive prick to opiates showed positive prick and IgE to poppy seeds, but not to morphine or pholcodine IgE. Among drug-abusers, 13/42 patients (31%) presented opium hypersensitivity confirmed by challenge tests. Among non-drug abusers, sensitisation to opiates was higher in people allergic to tobacco (25%), P<.001. Prick tests and IgE against poppy seed had a good sensitivity (95.6% and 82.6%, respectively) and specificity (98.5% and 100%, respectively) in the diagnosis of opiate allergy.

The study concludes that opiates may be significant allergens. Drug-abusers and people sensitised to tobacco are at risk. Both the prick and specific IgE tests efficiently detected sensitisation to opiates.

Clinical value of morphine, pholcodine and poppy seed IgE assays in drug-abusers and allergic people.
Armentia A, Ruiz-Munoz P, Quesada JM, Postigo I, Herrero M, Martin-Gil FJ, Gonzalez-Sagrado M, Martin B, Castrodeza J.
Allergol Immunopathol (Madr) 2011 Sep 20;

Anaphylaxis to olive fruit due to lipoprotein sensitization.
A 21-year-old woman with house dust mite allergic rhinitis and asthma reported three episodes of oropharyngeal and palmar itching, cough and dyspnoea, a few minutes after eating a snack with onion, gherkin, red pepper and olive. She did not have a history of food allergy and tolerated other foods. Skin prick tests were positive to different mites and negative to pollens (including olive pollen). Prick-by-prick with olive fruit (raw material) was positive and resulted in general

skin itching. Prick-by-prick with olive oil was positive and led to general itching. Speci?c IgE was >100 kU/L to D. pteronyssinus, L. destructor and T. putrescentiae and negative for pollens and foods. IgE-binding bands of 14.4, 20.1, 30 and 45 kDa were detected in the lipid-soluble fraction isolated from olive fruit. No IgE-binding bands were detected in the water- soluble fraction. The most abundant oil body-associated proteins belong to the oleosin family, and much of the oil body surface may be covered by oleosin.

Anaphylaxis to olive fruit due to lipoprotein sensitization.
varez-Eire MG, Pineda de la LF, Varela LS, Gonzalez de la CC, Ricardo PR.
Allergol Immunopathol (Madr) 2011 Sep 13;

Effect of exposure and sensitization to indoor allergens on asthma control level.
This study concludes that the level of exposure to multiple indoor allergens, but not sensitization, is associated with the asthma control level determined by peak expiratory flow variation.

Effect of exposure and sensitization to indoor allergens on asthma control level.
Shirai T, Yasueda H, Saito A, Taniguchi M, Akiyama K, Tsuchiya T, Suda T, Chida K.
Allergol Int 2011 Sep 25;

Trends in occupational airway diseases in German hairdressers
Hairdressers are exposed to several allergens and irritants known to cause obstructive airway diseases (OAD). In the early 1990s, high incidence rates of OAD were observed in German hairdressers. It was expected that modification of formulations would resolve the problem of high OAD rates in hairdressers. From 1998 until 2003, the total number of confirmed cases of allergen-, latex- and irritant-induced OAD stayed at a plateau of 60 cases annually in hairdressers, after which a downward trend was apparent. The number of irritant-induced OAD cases did not fall during this overall downward trend. Hair dyes and acid perms were most often identified as the substances causing OAD in hairdressers. In healthcare professionals, the downward trend in OAD is more pronounced than in hairdressers, mainly due to a decrease in latex-induced cases.

Trends in occupational airway diseases in German hairdressers: frequency and causes.
Dulon M, Peters C, Wendeler D, Nienhaus A.
Am J Ind Med 2011 Jun;54(6):486-493

Cosensitization to orange seed and cashew nut.
This study was initiated after one of the authors treated a 6-year- old boy with cashew allergy who chewed and swallowed the seeds while eating a mandarin. He developed a systemic reaction within 1 hour of ingestion, including periorbital edema, widespread pruritus, abdominal pain, and nausea. The SPT result was positive to mandarin seed and cashew but negative to mandarin juice. The results of skin prick tests (SPTs) from 100 patients showing high rates of cosensitization to cashew and orange seed. Half of the children had positive cashew SPT results, and half had negative cashew SPT results but positive SPT results to another tree nut and/or peanut. Age of the study participants ranged from 10 months to 18 years, with 40 boys and 60 girls. Thirty-five patients had positive SPT results to both orange seed and cashew, 7 had positive results to orange seed but not cashew, and a further 15 had positive results to cashew but not orange seed. The study cohort was almost exclusively sensitized to orange seed and not juice.

Cosensitization to orange seed and cashew nut.
O'Sullivan MD, Somerville C.
Ann Allergy Asthma Immunol 2011 Sep;107(3):282-283

Spice allergy. A review
A review on spice allergy: Spice allergy seems to be rare, reportedly affecting between 4 and 13 of 10,000 adults and occurring more often in women because of cosmetic use. No figures were available on children. Most spice allergens are degraded by digestion; therefore, IgE sensitization is mostly through inhalation of cross-reacting pollens, particularly mugwort and birch. The symptoms are more likely to be respiratory when exposure is by inhalation and cutaneous if by contact. Studies on skin testing and specific IgE assays are limited and showed low reliability. The diagnosis primarily depends on a good history taking and confirmation with oral challenge. The common use of spice blends makes identifying the particular offending component difficult, particularly because their components are inconsistent.

Spice allergy.
Chen JL, Bahna SL.
Ann Allergy Asthma Immunol 2011 Sep;107(3):191-199

Diagnosis and management of hymenoptera venom allergy: British Society for Allergy and Clinical Immunology (BSACI) guidelines.
This guidance for the management of patients with hymenoptera venom allergy has been prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI). The guideline is based on evidence as well as on expert opinion and is for use by both adult physicians and pediatricians practising allergy. During the development of these guidelines, all BSACI members were included in the consultation process using a web-based system. Their comments and suggestions were carefully considered by the SOCC. Where evidence was lacking, consensus was reached by the experts on the committee. Included in this guideline are epidemiology, risk factors, clinical features, diagnostic tests, natural history of hymenoptera venom allergy and guidance on undertaking venom immunotherapy (VIT). There are also separate sections on children, elevated baseline tryptase and mastocytosis and mechanisms underlying VIT. Finally, we have made recommendations for potential areas of future research

Diagnosis and management of hymenoptera venom allergy: British Society for Allergy and Clinical Immunology (BSACI) guidelines.
Krishna MT, Ewan PW, Diwakar L, Durham SR, Frew AJ, Leech SC, Nasser SM.
Clin Exp Allergy 2011 Sep;41(9):1201-1220

Health effects of polychlorinated biphenyls.
A 38-year-old man, a technical engineer dealing with maintenance and repairs of transformers for more than 10 years, was evaluated for 8 years duration of rough hands, not responding to in- termittent, irregular topical treatment with topical steroids and barrier creams. His job entailed heavy exposure to transformer oils. Polychlorinated biphenyl was ascertained to be the cause of his skin condition.

The commercial utility of PCBs is based largely on their chemical stability, low flammability, and their desirable physical properties as electrical insulators, particularly in transformers. They are also used as lubricants for turbines and pumps, in the formulation of cutting oils for metal treatments and to a lesser extent in ap- plications such as plasticisers, surface coatings, adhesives, pesticides, carbonless copy paper, inks, dyes, and waxes. Exposure in the workplace occurs mostly by breathing air containing PCBs and by touching substances that contain PCBs.

(A review article on polychlorinated biphenyls)

Health effects of polychlorinated biphenyls
Gantsho N.
Current Allergy and Clinical Immunology 2011;24(3):162-164

Occupational asthma caused by triglycidyl isocyanurate.
Several cases of allergic contact dermatitis, two cases of occupational asthma from over one decade ago and one case of hypersensitivity pneumonitis have been documented in painters who use polyester powder paint containing triglycidyl isocyanurate (TGIC). This study reports on a 28-year-old female who, 4 months after beginning work in a powder-coating factory, developed asthma-like symptoms. Serial peak-flow measurements performed during both working and non-working periods demonstrated peak-flow variability of up to 46% on work days. The patient was placed in the chamber and exposed to TGIC (4% in lactose) at a mean concentration of 3.61 mg/m(3) for a total of 15 min. A 20% fall in FEV(1) from baseline was elicited at 10 min, together with cough and wheezing. No late response was demonstrated. No IgE was detected by ELISA testing and no IgE-binding bands were found by immunoblot analysis of patient and control serum.

Occupational asthma caused by triglycidyl isocyanurate.
Sastre J, Carnes J, Garcia del PM, Manso L, Aguado E, Fernandez-Nieto M.
Int Arch Occup Environ Health 2011 Jun;84(5):547-549

Shrimp allergy in Italian adults: high prevalence of sensitivity to novel high molecular weight allergens.
This study investigated which allergens are involved in Italian shrimp-allergic adults. Sera from 116 shrimp-allergic patients selected in 14 Italian allergy centers were studied. Immunoblots showed much variability. IgE reactivity at about 30 kDa (tropomyosin) was found in <50% of cases, and reactivity at about 67 kDa and >90 kDa was frequent. Further reactivities at 14-18, 25, 43-50, about 60 and about 80 kDa were detected. Most subjects had a history of shrimp-induced systemic symptoms irrespective of the relevant allergen protein. IgE to Pen a 1 were detected in sera from 46 (41%) patients. Skin reactivity to HDM was found in 43/61 (70%) Pen 1-negative subjects and inhibition studies showed that pre-adsorption of sera with HDM extract induced a marked weakening of the signal at >67 kDa. Therefore several allergens other than tropomyosin are involved in shrimp allergy in adult Italian patients. Some hitherto not described high molecular weight allergens seem particularly relevant in this population and their cross-reactivity with HDM allergens makes them novel potential panallergens of invertebrates.

Shrimp allergy in Italian adults: a multicenter study showing a high prevalence of sensitivity to novel high molecular weight allergens.
Asero R, Mistrello G, Amato S, Ariano R, Colombo G, Conte ME, Crivellaro M, De CM, Della TF, Emiliani F, Lodi RF, Longo R, Macchia D, Minale P, Murzilli F, Nebiolo F, Quercia O, Senna GE, Villa.
Int Arch Allergy Immunol 2011 Sep 5;157(1):3-10

Epitope mapping of Atlantic Salmon major allergen by peptide microarray immunoassay.
Peptide-based microarray immunoassay offers an advantage of scale and parallel design over previous methods of epitope mapping. It has been used to map epitopes of some food allergens but has never been used with fish allergens. The authors sought to develop a peptide microarray immunoassay to map allergenic fish epitopes of two isoforms of Atlantic salmon (Salmo salar) parvalbumin, Sal s 1 beta 1 and Sal s 1 beta 2. Sera from 16 fish-allergic patients with specific IgE to salmon parvalbumin were used. Three antigenic regions, not previously described, were identified in Sal s 1 beta 1. Two of them correlated with those previously reported in Gad c 1, parvalbumin from Baltic cod (Gadus callarias). No allergenic regions were found in Sal s 1 beta 2. This could be explained by crucial amino acid substitutions between isoforms.

Epitope mapping of Atlantic Salmon major allergen by peptide microarray immunoassay.
Perez-Gordo M, Lin J, Bardina L, Pastor-Vargas C, Cases B, Vivanco F, Cuesta-Herranz J, Sampson HA.
Int Arch Allergy Immunol 2011 Sep 5;157(1):31-40

An odorant-binding protein as a new allergen from Siberian hamster
Anaphylaxis following a bite from a Siberian hamster (SH; Phodopus sungorus) is described. Skin prick tests with hair, urine and salivary gland extracts from SH were positive and negative for hair extracts from other rodents. The patient serum revealed 3 IgE-binding bands of about 18, 21 and 23 kDa which showed no inhibition with rabbit, mouse and gerbil hair extracts. The IgE-binding bands were identified as an odorant-binding protein belonging to the lipocalin family. Analysis of the 3 IgE-binding bands found in the hair, urine and salivary glands of SH showed a new allergenic protein lacking cross-reactivity with allergens from other rodents. The 3 bands were likely isoforms of a single allergen.

An odorant-binding protein as a new allergen from Siberian hamster (Phodopus sungorus).
Torres JA, Pastor-Vargas C, de Las HM, Vivanco F, Cuesta J, Sastre J.
Int Arch Allergy Immunol 2011 Sep 7;157(1):109-112

IgG to various beta-glucans in a human adult population.
Fungal beta-(1,3)-glucans are pro-inflammatory agents, and exposures to beta-(1,3)-glucans are associated with respiratory tract symptoms. IgG anti-(1,3)-glucan titers are measured in diagnosis of fungal infections. Although other beta-glucan structures exist, like beta-(1,6)-glucans, little is known about their antigenic or pro-inflammatory properties. This study investigated IgG titers and specificities in human sera against different beta-glucans with varying structures and concludes that IgG to beta-(1,3)- and beta-(1,6)-glucans can be found in normal human sera. Beta-(1,6)-glucans appear to be much more potent antigens. The health impact of high anti-beta-(1,6)-glucan antibody levels remains unclear and further investigations are needed.

IgG to various beta-glucans in a human adult population.
Noss I, Wouters IM, Smit LA, Meijer E, Pronk A, Heederik DJ, Doekes G.
Int Arch Allergy Immunol 2011 Sep 7;157(1):98-108

Usefulness of lymphocyte stimulation test for the diagnosis of intestinal cow's milk allergy in infants.
This study strongly suggests that the lymphocyte stimulation test for kappa-casein is a useful diagnostic test for intestinal cow's milk allergy.

Usefulness of lymphocyte stimulation test for the diagnosis of intestinal cow's milk allergy in infants.
Kimura M, Oh S, Narabayashi S, Taguchi T.
Int Arch Allergy Immunol 2011 Sep 6;157(1):58-64

New lentil allergen identified: Lipid transfer protein Len c 3.
Two allergens, Len c 1 and 2, have been reported previously. This study investigated lentil LTP (lipid transfer protein) as a potential new allergen. Natural LTP was purified from lentil extract and expressed as recombinant allergen. Sera from 10 lentil-allergic and/or -sensitized patients (Spain: 6, Italy: 1 and the Netherlands: 3) were used to further characterize lentil LTP. Natural lentil LTP was identified and designated as allergen Len c 3. By CAP, 9/10 sera showed specific IgE to Len c 3. Recombinant ® Len c 3 was successfully purified. The natural (n) Len c 3 CAP was completely inhibited by rLen c 3/rPru p 3. IgE binding to lentil pH 3 extract blot was completely inhibited by rLen c 3.

Lentil (Lens culinaris) Lipid Transfer Protein Len c 3: A Novel Legume Allergen.
Akkerdaas J, Finkina EI, Balandin SV, Santos MS, Knulst A, Fernandez-Rivas M, Asero R, van RR, Ovchinnikova TV.
Int Arch Allergy Immunol 2011 Sep 6;157(1):51-57

Influence of enzymatic hydrolysis on the allergenicity of roasted peanut protein extract.
Roasted peanut protein extract was hydrolyzed by the sequential and individual action of 2 food-grade enzymes, an endoprotease (Alcalase) and an exoprotease (Flavourzyme). Immunoblot and ELISA assays showed an important decrease of IgE reactivity and Ara h 1, Ara h 2 and Ara h 3 levels in the first 30 min of hydrolyzation with Alcalase. In contrast, individual treatment with Flavourzyme caused an increase in IgE reactivity detected by ELISA at 30 min and led to a 65% inhibition of IgE reactivity at the end of the assay (300 min). Ara h 1 and the basic subunit of Ara h 3 were still recognized after treatment with Flavourzyme for 300 min.

Influence of enzymatic hydrolysis on the allergenicity of roasted peanut protein extract.
Cabanillas B, Pedrosa MM, Rodriguez J, Muzquiz M, Maleki SJ, Cuadrado C, Burbano C, Crespo JF.
Int Arch Allergy Immunol 2011 Sep 6;157(1):41-50

Alternaria in patients with allergic rhinitis.
This study suggests Alternaria as a major allergen that its presence in the nasal cavity and subsequent development of sensitization have significant role in the induction of allergic rhinitis

Alternaria in patients with allergic rhinitis.
Mokhtari AM, Mokhtari Amirmajdi NA, Eftekharzadeh M, Jabari AF, Tavakol AJ, Shakeri MT.
Iran J Allergy Asthma Immunol 2011 Sep;10(3):221-226

Causes of ant sting anaphylaxis in Australia.
This study determined the Australian native ant species associated with ant sting anaphylaxis, geographical distribution of allergic reactions, and feasibility of diagnostic venom-specific IgE (sIgE) testing. 376 participants reported 735 systemic reactions. Of 299 participants for whom a cause was determined, 265 had reacted clinically to Myrmecia species and 34 to green-head ant (Rhytidoponera metallica). Of those with reactions to Myrmecia species, 176 reacted to jack jumper ant (Myrmecia pilosula species complex), 18 to other jumper ants (15 to Myrmecia nigrocincta, three to Myrmecia ludlowi) and 56 to a variety of bulldog ants, with some participants reacting to more than one type of bulldog ant. Variable serological cross-reactivity between bulldog ant species was observed, and sera from patients with bulldog ant allergy were all positive to one or more venoms extracted from Myrmecia forficata, Myrmecia pyriformis and Myrmecia nigriceps. Therefore 4 main groups of Australian ants cause anaphylaxis. Serum sIgE testing enhances the accuracy of diagnosis and is a prerequisite for administering species-specific venom immunotherapy.

Causes of ant sting anaphylaxis in Australia: the Australian Ant Venom Allergy Study.
Brown SG, van EP, Wiese MD, Mullins RJ, Solley GO, Puy R, Taylor RW, Heddle RJ.
Med J Aust 2011 Jul 18;195(2):69-73

Single nut or total nut avoidance in nut allergic children: outcome of nut challenges to guide exclusion diets.
Children with diagnosed nut allergy are typically advised by health professionals to exclude all nuts from their diets, irrespective of the outcome of allergy testing, to avoid inadvertent contact through contamination or the possible development of new allergies. Over a 5-year period from 2006, the authors challenged 145 children diagnosed as peanut allergic or tree nut allergic. In those with peanut allergy challenged to tree nuts, none of the 72 with negative PTs to tree nuts reacted on challenge whilst 7 of 22 (31.2%) with positive PTs did. In patients with tree nut allergy challenged to peanuts and/or other tree nuts, 3 of 38 (7.9%) with negative PT results and 5 of 13 (38.4%) with positive PT results reacted. In conclusion, children allergic to peanuts with negative allergy tests to tree nuts had no co-existing allergy, but were at risk of tree nut allergy where PTs were positive. Children with tree nut allergy were at risk of co-existing peanut or other tree nut allergy whether PTs were positive or negative. Oral challenges to clarify allergy status in all nuts show co-existing allergies even in young children and in so doing may reduce anxiety, minimize unnecessary dietary restrictions and prevent later episodes of anaphylaxis through uninformed exposure.

Single nut or total nut avoidance in nut allergic children: outcome of nut challenges to guide exclusion diets.
Ball H, Luyt D, Bravin K, Kirk K.
Pediatr Allergy Immunol 2011 Sep 19;

Phadiatop Infant((R)) detects IgE-mediated diseases among pre-school children: a prospective study.
IgE-sensitization to food and inhalant allergens may precede and accompany the appearance of clinical symptoms of allergic diseases. The aim was to study the diagnostic capacity of Phadiatop(®) Infant (Phinf) for detecting IgE-sensitization at 5 yr of age and further to evaluate the predictive capacity of Phinf longitudinally with regard to sensitization and allergic symptoms in pre-school children.

Two hundred and one children with complete data on sIgE testing for 10 individual allergens, Phinf analyses, and clinical evaluations at 2 and 5 yr of age were evaluated. The diagnostic performance of Phinf, applied at the age of 5 and compared to specific IgE testing, gave a sensitivity of 84% and a specificity of 98%. The positive and negative predictive values were 97% and 92%, respectively. A positive Phinf test at 2 yr increased the odds 35.6-fold for IgE-sensitization and 14.7-fold for any allergic symptom at 5 yr of age. The association (OR) between Phinf and current symptoms was, at 2 and 5 yr of age, 3.6 and 18.4, respectively. Therefore Phinf seems to be a reliable tool for predicting future sensitization as well as allergic symptoms in young children

Phadiatop Infant((R)) detects IgE-mediated diseases among pre-school children: a prospective study.
Nilsson C, Lilja G, Nordlund M, Berthold M, Borres MP.
Pediatr Allergy Immunol 2011 Sep 19;

beta-lactam allergy and cross-reactivity.
Penicillins and cephalosporins are the most widely used antibiotics for the treatment of common infections, and they are the two main classes of beta-lactams. On the basis of the time of appearance of the reaction after drug intake and for diagnostic purposes, hypersensitivity reactions to beta-lactams have been classified as immediate or non-immediate. The diagnostic evaluation of allergic reactions to beta-lactams has changed over the last decade, for several reasons. In many countries, major and minor determinants for skin testing are not available. In immediate allergic reactions, the sensitivity of skin testing is decreasing. For non-immediate reactions, skin testing appears to be less sensitive than previously reported. The drug provocation test is still necessary for diagnosis. In this education review series, we described three cases of beta-lactam allergy: first, a child with an IgE-mediated allergy to benzyl-penicillin; second, a child with a non-allergic hypersensitivity to amoxicillin; and in the third patient, we will discuss about cross-reactivity between penicillins and cephalosporins. These cases are correlated with the practical management of evaluating beta-lactam allergy.

beta-lactam allergy and cross-reactivity.
tanaskovic-Markovic M.
Pediatr Allergy Immunol 2011 Sep 19;

Sensitivity to animals' allergens in people working with animals.
This Spanish study determined the frequency of sensitization to animal allergens extracts in workers of the Bioterio of the Autonomous University of Puebla. Twenty nine subjects with animal-related professional activities were included, mean age 32.3 years, male predominance (82.8%) and years of work 6.3. Laboratory animal workers were exposed mostly to dogs (83%). Nearly half of the workers reported clinical manifestations at work. Sixty-two percent of them had at least one positive skin test to animal allergen extracts.

Sensitivity to animals' allergens in people working with animals. [Spanish]
Macias WA, Escamilla WC, Pazos Salazar NG, Valdes Burnes DA, Gonzalez Diaz SN.
Rev Alerg Mex 2010 Nov;57(6):185-189

Allergy to materials used in dental procedures.
The number of patients with pathology originated by dental materials has increased. The scarce knowledge about it delays diagnosis. The study of biomaterials used in odontologic procedures and its harmful effect must be encouraged, as well as its pathological manifestations which require more clinical investigation and diffusion, with the aim to give more and better information to dentists, family and allergy physicians so that they can provide prompt and successful care

Allergy to materials used in dental procedures. [Spanish]
Valencia Zavala MP, Sanchez Olivas MA, Velazquez SG, Sepulveda G, Flores I, Velazco A, Vega Robledo GB.
Rev Alerg Mex 2010 Nov;57(6):202-207

Molecular Allergology in practice: about an allergy to LTP
A report on a patient with multiple food allergy based on an allergy to lipid transfer protein (LTP) and prior cutaneous or inhalant sensitization to cannabis plants.

Allergologie moléculaire en pratique : à propos dune allergie aux LTP / Molecular Allergology in practice: about an allergy to LTP
C. Metz-Favre, F. De Blay
Rev Fr Allergol 2011;51(5):512-514

Allergen-, Food allergy-, Intolerance-related articles

Daily effects of air pollutants and pollen types on asthma and COPD hospital emergency visits in the industrial and Mediterranean Spanish city of Cartagena.
Cirera L, Garcia-Marcos L, Gimenez J, Moreno-Grau S, Tobias A, Perez-Fernandez V, Elvira-Rendeles B, Guillen JJ, Navarro C. Allergol Immunopathol (Madr) 2011 Sep 2;

Urticaria caused by dimenhydrinate.
Paffumi I, Saitta S, Isola S, Gangemi S. Allergol Immunopathol (Madr) 2011 Sep 1;

Clinical value of morphine, pholcodine and poppy seed IgE assays in drug-abusers and allergic people.
Armentia A, Ruiz-Munoz P, Quesada JM, Postigo I, Herrero M, Martin-Gil FJ, Gonzalez-Sagrado M, Martin B, Castrodeza J. Allergol Immunopathol (Madr) 2011 Sep 20;

Anaphylaxis to olive fruit due to lipoprotein sensitization.
varez-Eire MG, Pineda de la LF, Varela LS, Gonzalez de la CC, Ricardo PR. Allergol Immunopathol (Madr) 2011 Sep 13;

The Differences in the Involvements of Loci of Promoter Region and Ile50Val in Interleukin-4 Receptor alpha Chain Gene between Atopic Dermatitis and Japanese Cedar Pollinosis.
Tanaka T, Hitomi Y, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata A, Sugimoto N, Hatta K, Eboshida A, Konoshita T, Nakamura H. Allergol Int 2011 Sep 25;

Effect of exposure and sensitization to indoor allergens on asthma control level.
Shirai T, Yasueda H, Saito A, Taniguchi M, Akiyama K, Tsuchiya T, Suda T, Chida K. Allergol Int 2011 Sep 25;

Evaluating the effects of testing period on pollinosis symptoms using an allergen challenge chamber.
Yuki A, Terada T, Ichihara T, Fujii K, Hyo S, Kawata R, Takenaka H. Allergol Int 2011 Sep 25;

Prevention and treatment of DNA vaccine encoding cockroach allergen Bla g 1 in a mouse model of allergic airway inflammation.
Zhou B, Ensell M, Zhou Y, Nair U, Glickstein J, Kermany MH, Cai Q, Cai C, Liu W, Deng YP, Kakigi A, Barbieri M, Mora M, Kanangat S, Yoo TJ. Allergy 2011 Sep 29;

Thunderstorm-related asthma epidemic owing to Olea Europaea pollen sensitization.
Losappio L, Heffler E, Contento F, Cannito C, Rolla G. Allergy 2011 Sep 2;

Asthma and rhinitis by storage mites.
Sanchez-Machin I, Gonzalez P, Iglesias-Souto J, Iraola V, Matheu V. Allergy 2011 Sep 29;

Spontaneous resolution of diphtheria-tetanus vaccine hypersensitivity in a pediatric population.
Begin P, Vu MQ, Picard M, Paradis L, Roches AD. Allergy 2011 Sep 2;

Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells.
Daubner B, Groux-Keller M, Hausmann OV, Kawabata T, Naisbitt DJ, Park BK, Wendland T, Lerch M, Pichler WJ. Allergy 2011 Sep 21;

Trends in occupational airway diseases in German hairdressers: frequency and causes.
Dulon M, Peters C, Wendeler D, Nienhaus A. Am J Ind Med 2011 Jun;54(6):486-493

Neosensitization to allergens after resolution of allergic airways inflammation: a new role for airway dendritic cells.
Schwarze J, Mackenzie KJ. Am J Respir Crit Care Med 2011 Aug 1;184(3):283-284

Can specific IgE discriminate between intrinsic and atopic asthma?
Camarda LE, Grayson MH. Am J Respir Crit Care Med 2011 Jul 15;184(2):152-153

Presence in sputum of functional dust mite-specific IgE antibodies in intrinsic asthma.
Mouthuy J, Detry B, Sohy C, Pirson F, Pilette C. Am J Respir Crit Care Med 2011 Jul 15;184(2):206-214

A patient with salmon roe allergy showing taxonomy-unrelated cross-reactivity with sea urchin roe.
Kondo Y, Tanaka K, Inuo C, Tsuge I, Urisu A. Ann Allergy Asthma Immunol 2011 Sep;107(3):283-284

Cosensitization to orange seed and cashew nut.
O'Sullivan MD, Somerville C. Ann Allergy Asthma Immunol 2011 Sep;107(3):282-283

Eosinophilia in conjunctival tear fluid among patients with pollen allergy.
Wiszniewska M, Pas-Wyroslak A, Palczynski C, Walusiak-Skorupa J. Ann Allergy Asthma Immunol 2011 Sep;107(3):281-282

Determination of ranges for reporting pollen aeroallergen levels in the Washington, DC, metropolitan area.
Kosisky SE, Marks MS, Yacovone MA, Nelson MR. Ann Allergy Asthma Immunol 2011 Sep;107(3):244-250

Spice allergy.
Chen JL, Bahna SL. Ann Allergy Asthma Immunol 2011 Sep;107(3):191-199

On The Cover - Aspergillus niger.
Weber RW. Ann Allergy Asthma Immunol 2011 Sep;107(3):A11

What makes an allergen an allergen?. [Japanese]
Takai T. Arerugi 2011 Jul;60(7):809-816

Another plausible explanation for mist inhaler's toxicity.
Seed MJ, Cullinan P, Agius R. BMJ 2011;343d4483

Diagnosis and management of hymenoptera venom allergy: British Society for Allergy and Clinical Immunology (BSACI) guidelines.
Krishna MT, Ewan PW, Diwakar L, Durham SR, Frew AJ, Leech SC, Nasser SM. Clin Exp Allergy 2011 Sep;41(9):1201-1220

Overview of serological-specific IgE antibody testing in children.
Cox L. Curr Allergy Asthma Rep 2011 Sep 23;

Oral food challenges in children: review and future perspectives.
Greenhawt M. Curr Allergy Asthma Rep 2011 Sep 8;

Health effects of polychlorinated biphenyls
Gantsho N. Current Allergy and Clinical Immunology 2011;24(3):162-164

Angular cheilitis, part 1: local etiologies.
Park KK, Brodell RT, Helms SE. Cutis 2011 Jun;87(6):289-295

Association of immunologically confirmed delayed drug reaction and human herpesvirus 6 viremia in a pediatric case of drug-induced hypersensitivity syndrome.
Hubiche T, Milpied B, Cazeau C, Taieb A, Leaute-Labreze C. Dermatology 2011;222(2):140-141

Occupational asthma caused by triglycidyl isocyanurate.
Sastre J, Carnes J, Garcia del PM, Manso L, Aguado E, Fernandez-Nieto M. Int Arch Occup Environ Health 2011 Jun;84(5):547-549

Lymphocyte stimulation test for the diagnosis of non-IgE-mediated cow's milk allergy: a step closer to a noninvasive diagnostic tool?
Giavi S, Megremis S, Papadopoulos NG. Int Arch Allergy Immunol 2011 Sep 5;157(1):1-2

Shrimp allergy in Italian adults: a multicenter study showing a high prevalence of sensitivity to novel high molecular weight allergens.
Asero R, Mistrello G, Amato S, Ariano R, Colombo G, Conte ME, Crivellaro M, De CM, Della TF, Emiliani F, Lodi RF, Longo R, Macchia D, Minale P, Murzilli F, Nebiolo F, Quercia O, Senna GE, Villa. Int Arch Allergy Immunol 2011 Sep 5;157(1):3-10

Epitope mapping of Atlantic Salmon major allergen by peptide microarray immunoassay.
Perez-Gordo M, Lin J, Bardina L, Pastor-Vargas C, Cases B, Vivanco F, Cuesta-Herranz J, Sampson HA. Int Arch Allergy Immunol 2011 Sep 5;157(1):31-40

An odorant-binding protein as a new allergen from Siberian hamster (Phodopus sungorus).
Torres JA, Pastor-Vargas C, de Las HM, Vivanco F, Cuesta J, Sastre J. Int Arch Allergy Immunol 2011 Sep 7;157(1):109-112

IgG to various beta-glucans in a human adult population.
Noss I, Wouters IM, Smit LA, Meijer E, Pronk A, Heederik DJ, Doekes G. Int Arch Allergy Immunol 2011 Sep 7;157(1):98-108

Bronchial allergen challenge using the medicaid dosimeter.
Schulze J, Rosewich M, Dressler M, Riemer C, Rose MA, Zielen S. Int Arch Allergy Immunol 2011 Sep 7;157(1):89-97

Usefulness of lymphocyte stimulation test for the diagnosis of intestinal cow's milk allergy in infants.
Kimura M, Oh S, Narabayashi S, Taguchi T. Int Arch Allergy Immunol 2011 Sep 6;157(1):58-64

Lentil (Lens culinaris) Lipid Transfer Protein Len c 3: A Novel Legume Allergen.
Akkerdaas J, Finkina EI, Balandin SV, Santos MS, Knulst A, Fernandez-Rivas M, Asero R, van RR, Ovchinnikova TV. Int Arch Allergy Immunol 2011 Sep 6;157(1):51-57

Influence of enzymatic hydrolysis on the allergenicity of roasted peanut protein extract.
Cabanillas B, Pedrosa MM, Rodriguez J, Muzquiz M, Maleki SJ, Cuadrado C, Burbano C, Crespo JF. Int Arch Allergy Immunol 2011 Sep 6;157(1):41-50

Alternaria in patients with allergic rhinitis.
Mokhtari AM, Mokhtari Amirmajdi NA, Eftekharzadeh M, Jabari AF, Tavakol AJ, Shakeri MT. Iran J Allergy Asthma Immunol 2011 Sep;10(3):221-226

Treatment of shiitake dermatitis by balneo PUVA therapy.
Scheiba N, Andrulis M, Helmbold P. J Am Acad Dermatol 2011 Aug;65(2):453-455

Low prevalence of IgE to cross-reactive carbohydrate determinants in beekeepers.
Carballada FJ, Gonzalez-Quintela A, Nunez R, Vidal C, Boquete M. J Allergy Clin Immunol 2011 Sep 2;

Occupation and COPD: A Brief Review.
Blanc PD. J Asthma 2011 Sep 7;

Causes of ant sting anaphylaxis in Australia: the Australian Ant Venom Allergy Study.
Brown SG, van EP, Wiese MD, Mullins RJ, Solley GO, Puy R, Taylor RW, Heddle RJ. Med J Aust 2011 Jul 18;195(2):69-73

Food allergy: is there a rising prevalence and if so why?
Allen KJ. Med J Aust 2011 Jul 4;195(1):5-7

Anaphylaxis from peanuts ingested by blood donors?
Vickery BP, Burks AW, Sampson HA. N Engl J Med 2011 Sep 1;365(9):867-868

Under-estimation of self-reported occupational exposure by questionnaire in hospital workers.
Donnay C, Denis MA, Magis R, Fevotte J, Massin N, Dumas O, Pin I, Choudat D, Kauffmann F, Le MN. Occup Environ Med 2011 Aug;68(8):611-617

Single nut or total nut avoidance in nut allergic children: outcome of nut challenges to guide exclusion diets.
Ball H, Luyt D, Bravin K, Kirk K. Pediatr Allergy Immunol 2011 Sep 19;

Risk factors for severe pediatric food anaphylaxis in Italy.
Calvani M, Cardinale F, Martelli A, Muraro A, Pucci N, Savino F, Zappala D, Panetta V. Pediatr Allergy Immunol 2011 Sep 19;

Phadiatop Infant((R)) detects IgE-mediated diseases among pre-school children: a prospective study.
Nilsson C, Lilja G, Nordlund M, Berthold M, Borres MP. Pediatr Allergy Immunol 2011 Sep 19;

beta-lactam allergy and cross-reactivity.
tanaskovic-Markovic M. Pediatr Allergy Immunol 2011 Sep 19;

Evaluation of flu vaccines with regard to their egg protein content.
Goldis ME, Bardina L, Gimenez G, Lin J, Sampson HA. Pediatr Allergy Immunol 2011 Sep;22(6):642-643

Sensitivity to animals' allergens in people working with animals. [Spanish]
Macias WA, Escamilla WC, Pazos Salazar NG, Valdes Burnes DA, Gonzalez Diaz SN. Rev Alerg Mex 2010 Nov;57(6):185-189

Skin prick tests with standardized extracts of mites of different precedence in patients with asthma and allergic rhinitis. [Spanish]
Rodriguez SO, Abou KF, Tinoco M, Celio MR, Meli VR, Barata HJ, Labrada RA. Rev Alerg Mex 2010 Nov;57(6):196-201

Allergy to materials used in dental procedures. [Spanish]
Valencia Zavala MP, Sanchez Olivas MA, Velazquez SG, Sepulveda G, Flores I, Velazco A, Vega Robledo GB. Rev Alerg Mex 2010 Nov;57(6):202-207

Zucchini allergy: A case report
E. Damiani, A.M. Aloia, M.G. Priore, S. Nardulli, L. Macchia, A. Ferrannini Rev Fr Allergol 2011;51(5):515-516

Les signes cliniques, le diagnostic et la prise en charge de lallergie aux protéines du lait de vache daprès les recommandations internationales du DRACMA / Clinical signs, diagnosis and management of allergy to cow's milk protein: DRACMA recommedations
F. Rancé, E. Bidat, A. Deschildre Rev Fr Allergol 2011;51(5):506-511

Allergologie moléculaire en pratique : à propos dune allergie aux LTP / Molecular Allergology in practice: about an allergy to LTP
C. Metz-Favre, F. De Blay Rev Fr Allergol 2011;51(5):512-514

Re: Hypersensitivity pneumonitis and metalworking fluids contaminated by mycobacteria.
Barber CM, Burton C, Robinson E, Crook B, Evans G, Fishwick D. Eur Respir J 2011 Aug;38(2):486-487

The protease allergen Pen c 13 induces allergic airway inflammation and changes in epithelial barrier integrity and function in a murine model.
Chen JC, Chuang JG, Su YY, Chiang BL, Lin YS, Chow LP. J Biol Chem 2011 Jul 29;286(30):26667-26679

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