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 Allergy Advisor Digest - September 2013
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Read No matrix effect in double-blind, placebo-controlled egg challenges in egg allergic children.
Read Monosodium glutamate avoidance for chronic asthma in adults and children.
Read Is gluten a cause of gastrointestinal symptoms in people without celiac disease?
Read Patterns of sensitization to inhalant and food allergens - findings from the German health interview and examination survey for children and adolescents.
Read Association of indoor dampness and molds with rhinitis risk: A systematic review and meta-analysis.
Read The value of specific ige to peanut and its component Ara h 2 in the diagnosis of peanut allergy.
Read Cat, dog and house dust mite allergen levels on children's soft toys.
Read Is chlorogenic acid responsible for allergic reactions?
Read Mortality Related to Honey-Bee stings in Mexico from 1988 to 2009.
Read Allergy to ranitidine: one case report and literature review.
Read Food-sensitization by prick-to-prick skin tests and atopy patch tests in Mexican children with allergic diseases.
Read Anaphylaxis due to ingestion of ivy syrup (Hedera helix).
Read Mugwort-fennel-allergy-syndrome associated with sensitization to an allergen homologous to Api g 5.
Read Thaumatin-Like Protein (TLP 1), an allergen from Sapodilla Fruit (Manilkara zapota).
Read Diagnosis of immediate hypersensitivity reactions to radiocontrast media.
Read Cofactors in anaphylaxis.
Read Tolerance of a cow's milk-based hydrolyzed formula in patients with eosinophilic esophagitis triggered by milk.
Read Favorable trends in the frequency of U.S. emergency department visits for food allergy
Read The allergenic potency of Japanese hop pollen is increasing with environmental changes in Korea.
Read Seasonal variation in skin sensitivity to aeroallergens.
Read Association between pet ownership and the sensitization to pet allergens in adults with various allergic diseases.
Read Peanut Allergen Threshold Study (PATS): validation of eliciting doses using a novel single-dose challenge protocol.
Read A 5-year study of systemic reactions using both shared and patient-specific vaccines.
Read Recent 5-year trends of asthma severity and allergen sensitization among children in southern Thailand.
Read Comparison of conjunctival and nasal provocation tests in allergic rhinitis children with Dermatophagoides pteronyssinus sensitization.

Abstracts shared in September 2013 Advisor Digest Newsletter

Read Role of Art v 3 in pollinosis of patients allergic to Pru p 3.
Read Unlocking the resistance to wheat lipid transfer protein.
Read Fungal protein MGL_1304 in sweat is an allergen for atopic dermatitis patients.
Read Asian spice Szechuan pepper sets lips trembling
Read Analysis of the pollen allergen content of twelve olive cultivars grown in Portugal.
Read Anaphylaxis only to a home-made rose wine from a variety of grape.
Read Bovine Serum Albumin: a double allergy risk.
Read Characterization of causative allergens for Wheat-Dependent Exercise-Induced anaphylaxis sensitized with hydrolyzed wheat proteins in facial soap.
Read Evaluation of latex subclinical sensitization by way of the basophil activation test and specific IgE to latex recombinant allergens.
Read Is Bjerkandera allergy affected by the arrival of yellow sand dust?
Read Where to prick the apple for skin testing?
Read A case of fixed drug eruption due to doxycycline and erythromycin present in food.
Read Oral food challenge to wheat: a near-fatal anaphylaxis and review of 93 food challenges in children

Allergy and Intolerance Abstracts
No matrix effect in double-blind, placebo-controlled egg challenges in egg allergic children.
Diagnostic and accidental food allergic reactions may be modified by the matrix containing the allergenic food, as demonstrated previously with peanut effected by the fat content of the challenge matrix on the severity of the challenge reactions. This study examined whether the fat content of the food matrix is related to eliciting dose and reaction severity in DBPCFCs with heated hen's egg. In contrast to similar research with peanut, no significant influence of the fat content of the matrix was found on the eliciting dose or severity of the reaction in 59 DBPCFCs with hen's egg. Matrix fat content differences comparable to those reported here may not be an important co-determinant of reaction severity for all allergenic foods.

No matrix effect in double-blind, placebo-controlled egg challenges in egg allergic children.  
Libbers L, Flokstra-de Blok BM, Vlieg-Boerstra BJ, van der HS, van der Meulen GN, Kukler J, Kerkhof M, Dubois AE.
Clin Exp Allergy 2013 Sep;43(9):1067-1070

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Allergy and Intolerance Abstracts
Monosodium glutamate avoidance for chronic asthma in adults and children.
The limited evidence available (n = 24) found no significant difference between MSG or the control challenge for the number of subjects who had a maximum fall in FEV(1) greater than 15% or 200 mL. There is no evidence to support the avoidance of MSG in adults with chronic asthma, but as data were limited, this review cannot provide a reliable evidence base for determining whether MSG avoidance is a worthwhile strategy. We could not find any studies conducted on the effect of MSG in children with chronic asthma. There is therefore, a need for further RCTs to investigate any relationship between MSG and asthma, especially in children. (Zhou 2012 ref.29227 5)

Monosodium glutamate avoidance for chronic asthma in adults and children.  
Zhou Y, Yang M, Dong BR.
Cochrane Database Syst Rev 2012 Jun 13;6:CD004357.

Abstract

Index
Allergy and Intolerance Abstracts
Is gluten a cause of gastrointestinal symptoms in people without celiac disease?
The avoidance of wheat- and gluten-containing products is a worldwide phenomenon. While celiac disease is a well-established entity, the evidence base for gluten as a trigger of symptoms in patients without celiac disease (so-called 'non-celiac gluten sensitivity' or NCGS) is limited. The problems lie in the complexity of wheat and the ability of its carbohydrate as well as protein components to trigger gastrointestinal symptoms, the potentially false assumption that response to a gluten-free diet equates to an effect of gluten withdrawal, and diagnostic criteria for coeliac disease. Recent randomized controlled re-challenge trials have suggested that gluten may worsen gastrointestinal symptoms, but failed to confirm patients with self-perceived NCGS have specific gluten sensitivity. Furthermore, mechanisms by which gluten triggers symptoms have yet to be identified. This review discusses the most recent scientific evidence and our current understanding of NCGS

Is gluten a cause of gastrointestinal symptoms in people without celiac disease?  
Biesiekierski JR, Muir JG, Gibson PR.
Curr Allergy Asthma Rep 2013 Sep 12;

Index
Allergy and Intolerance Abstracts
Patterns of sensitization to inhalant and food allergens - findings from the German health interview and examination survey for children and adolescents.
This study assessed the prevalence of allergic sensitization and to analyze patterns of sensitization to common inhalant and food allergens in a nationwide representative sample of children and adolescents in Germany. Data were collected from 2003 to 2006 within the KiGGS, the national Health Interview and Examination Survey covering a representative sample of 17,641 children and adolescents in Germany. Sensitization to at least 1 of the 20 tested allergens was detected in 40.2% of the participants. The highest sensitization prevalences were found for pollen from Timothy grass (22.7%; 21.5-23.9) and rye (21.2%; 20.0-22.4). Seven sensitization groups were identified, namely (in descending order of magnitude) 'Timothy grass/rye', 'house-dust mites', 'food/mugwort', 'birch/apple', 'animals', 'cow's milk/egg white' and 'moulds'.

Patterns of sensitization to inhalant and food allergens - findings from the German health interview and examination survey for children and adolescents.  
Schmitz R, Ellert U, Kalcklosch M, Dahm S, Thamm M.
Int Arch Allergy Immunol 2013 Sep 6;162(3):263-270

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Allergy and Intolerance Abstracts
Association of indoor dampness and molds with rhinitis risk: A systematic review and meta-analysis.
This meta-analysis provides new evidence that dampness and molds at home are determinants of rhinitis and its subcategories. The associations were strongest with mold odor, suggesting the importance of microbial causal agents. Our results provide evidence that justifies prevention and remediation of indoor dampness and mold problems, and such actions are likely to reduce rhinitis

Association of indoor dampness and molds with rhinitis risk: A systematic review and meta-analysis.  
Jaakkola MS, Quansah R, Hugg TT, Heikkinen SA, Jaakkola JJ.
J Allergy Clin Immunol 2013 Sep 10;

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Allergy and Intolerance Abstracts
The value of specific ige to peanut and its component Ara h 2 in the diagnosis of peanut allergy.
This study investigated the role of whole peanut- and peanut-component (Ara h 1, Ara h 2, Ara h 3, Ara h 6 and Ara h 8)–specific IgE levels in the diagnostic procedure of peanut allergy as well as the diagnostic properties of peanut-specific IgG and IgG4. Sixty-one children underwent oral peanut challenge tests for diagnostic purposes irrespective of their peanut-specific IgE levels. Peanut-specific serum IgE, IgG, and IgG4 levels were determined by ImmunoCAP FEIA and specific IgE against individual peanut proteins by Immuno Solid-phase Allergen Chip.Thirty-four of 61 patients (56%) had a peanut allergy. No significant difference was observed for peanut-specific IgG or peanut-specific IgG4 levels between patients who were allergic and tolerant patients, whereas peanut-specific IgE was significant higher in patients who were allergic than in tolerant patients (P < .005). Twenty-five of 61 children had peanut-specific IgE above a previously proposed cutoff level of 15 kUA/L; however, 7 of these 25 children (28%) were clinically tolerant. Ara h 2-specific IgE was significantly lower in tolerant than in patients with allergies (P < .0001). Interestingly, 94% of the patients with peanut allergies showed IgE-binding to Ara h 2. Unfortunately, 26% of the sensitized but tolerant patients have shown IgE binding to Ara h 2 too. Neither the level of specific IgE to peanut nor to Ara h 2 was able to clearly distinguish patients with clinical relevant peanut allergy from those who were clinical tolerant in our population. As expected, peanut-specific IgG and IgG4 did not improve the diagnostic procedure.

The value of specific ige to peanut and its component Ara h 2 in the diagnosis of peanut allergy.  
Lucila C. Lopes de Oliveira, Martina Aderhold, Marianne Brill, Gabriele Schulz, et al.
J Allergy Clin Immunol: In Practise 2013;1(4):394-398

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Allergy and Intolerance Abstracts
Cat, dog and house dust mite allergen levels on children's soft toys.
This study has shown that soft toys can harbour cat and dog allergen as well as HDM allergens, some with very high levels. Cat and dog ownership resulted in higher Fel d 1 and Can f 1 levels on soft toys and mattresses. The levels of Fel d 1, Can f 1 and HDM allergens on soft toys could be of importance to sensitized asthmatic children.

Cat, dog and house dust mite allergen levels on children's soft toys.  
Fu-Sheng WF, Wu MW, Ting MH, Crane J, Siebers R.
J Asthma 2013 Sep 12;

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Allergy and Intolerance Abstracts
Is chlorogenic acid responsible for allergic reactions?
A difficult abstract to understand, hence posted in its entirety.

Objective:

The non-allergy of chlorogenic acid was demonstrated by the study result of allergy with different purity of chlorogenic acid and comprehensive analysis of literature.

Method:

The allergies of different samples, which contained the different purity of chlorogenic acid extracts, chlorogenic acid for injection, interior solution of dialysis, external solution of dialysis, post-term chlorogenic acid for injection and chlorogenic acid for injection with degradation, were validated with active systemic anaphylaxis and passive cutaneous anaphylaxis on rats and guinea pigs respectively. The range of molecular weight of macromolecular remains after dialysis were identified by LC-MS.

Result:

Allergic reactions were happened in dialysis isolated macromolecular substances, which were identified by LC-MS, and lower purity extracts (purity of chlorogenic acid < or = 40%), while the reactions were not happened in isolated micromolecular substances and high purity samples (purity of chlorogenic acid > or = 92%).

Conclusion:

Macromolecules in lower purity of chlorogenic acid extracts were relative closely to the allergen causing anaphylaxis, but not the chlorogenic acid, which was demonstrated according to the study result and analysis of literatures home and abroad.

Comprehensive research and evaluation of chlorogenic acid allergy. [Chinese]  
Wu X, Yang H, Lin D, Zhang J, Luo F, Xu X.
Miscellaneous 592 2010 Dec;35(24):3357-61.

Abstract

Index
Allergy and Intolerance Abstracts
Mortality Related to Honey-Bee stings in Mexico from 1988 to 2009.
Mexico is the third worldes honey country exporter and sixth producer. Africanized bees arrived in Mexico in 1986. Between 1988 and 1998 there were 360 honey-bee related accidents, involving over 5000 people. From 1988 to 2009 there were 480 demised persons with an annual average of 21.8. Regarding age, people over 50 years were the most affected ones. The largest number of fatal cases, 340, occurred from 1990 to 1999, with an annual average of 34, and between 2000 and 2009, the number of cases decreased to 118. There was an average of 21 annual death cases related to honey-bee stings from 1988 to 2009. Toxic reactions caused by multiple stings are the most likely cause of death in the majority of cases.

Mortality Related to Honey-Bee stings in Mexico from 1988 to 2009. [Spanish]  
Becerril-Ngeles M, Zquez No, rias-Martinez MI.
Rev Alerg Mex 2013 Apr;60(2):58-62

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Allergy and Intolerance Abstracts
Allergy to ranitidine: one case report and literature review.
A case report of a 9-months-old girl with a ranitidine allergic reaction with the diagnosis established by a non-intentional challenge test.

Allergy to ranitidine: one case report and literature review. [Spanish]  
Cuevas-Castillejos H, Cuevas-Castillejos JE, Garcia-Murray O, Larenas-Linnemann D.
Rev Alerg Mex 2013 Jan;60(1):41-48

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Allergy and Intolerance Abstracts
Food-sensitization by prick-to-prick skin tests and atopy patch tests in Mexican children with allergic diseases.
This Mexican study evaluated the frequency of sensitization to food antigens by skin tests, prick-to-prick and atopy patch tests, in a group of allergic children in a pediatric hospital. The results of skin tests with foods, prick-to-prick and atopy patch tests, in the clinical records of 170 and 140 children respectively, with a diagnosis of asthma, allergic rhinitis, atopic dermatitis, food allergy or eosinophilic gastroenteropathies were evaluated. Immediate hypersensitivity tests with fresh foods (prick-to-prick) were positive in 135 cases. Cow's milk was positive in 28.8%, followed by egg white with 20.1% and banana in 19.4%. In the group of 1 to 5 years, cow's milk was positive in 26.9%. In children with a previous diagnosis of food allergy cow's milk was positive in 27.1%. In delayed hypersensitivity tests (patch tests) there were 105 positive results; soybean was positive in 53.3% of cases tested, followed by peanut and chocolate with 50.5%. In the group with atopic dermatitis soybean was positive in 55.6%. In the group of 1 to 5 years, soybean was positive in 52.1%.

Frequency of food-sensitization by prick-to-prick skin tests and atopy patch tests in children with allergic diseases. [Spanish]  
Maya-Epelstein J, Rosas-Vargas MN, Del-Rio-Navarro B.
Rev Alerg Mex 2012 Jul;59(3):123-130

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Allergy and Intolerance Abstracts
Anaphylaxis due to ingestion of ivy syrup (Hedera helix).
Common ivy is an ornamental plant, that is ubiquitous in Mexico. Its allergens can cause contact dermatitis, asthma and allergic rhinitis. Two cases of anaphylaxis related to common ivy syrup ingestion is describe. Skin prick test with Hedera helix syrup, and a common ivy syrup commercial presentation, as well as Hedera helix pollen extract were used. Skin prick test with the commercial presentation and with the pollen extract were positive in both patients.

Anaphylaxis due to ingestion of ivy syrup (Hedera helix). Report of two cases. [Spanish]  
Morfin-Maciel BM, Rosas-Alvarado A, Vel Zquez-S Mano.
Rev Alerg Mex 2012 Jan;59(1):31-36

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Allergy and Intolerance Abstracts
Mugwort-fennel-allergy-syndrome associated with sensitization to an allergen homologous to Api g 5.
The cross-reactive allergen responsible for the so called 'mugwort-celery-spice-syndrome', a pollen-food allergy that occurs in a minority of mugwort pollen-allergic patients, is still undefined. This study's objective was to identify the allergen responsible for the cross-reactivity between mugwort pollen and plant-derived foods. The serum from one index patient with both fennel and mugwort pollen allergy was used to identify IgE-reactive allergens. On inhibition experiments, serum absorption with fennel extract completely inhibited the IgE response to mugwort. On immmunoblot analysis periodate treatment caused the disappearance of all bands of IgE reactivity except one at about 60 kDa. The 60 kDa bands from both mugwort and fennel PAGE-SDS gels revealed the presence of distinct proteins. The N-terminal amino acid sequencing gave the same major amino acid sequence corresponding to an Api g 5-like allergen. Evidence of a fennel-specific protein with sequence similarity to phosphoglyceromutase from Apium graveolens was demonstrated.

Mugwort-fennel-allergy-syndrome associated with sensitization to an allergen homologous to Api g 5.  
Borghesan F, Mistrello G, mato Et AS.
Eur Ann Allergy Clin Immunol 2013 Aug;45(4):130-137

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Allergy and Intolerance Abstracts
Thaumatin-Like Protein (TLP 1), an allergen from Sapodilla Fruit (Manilkara zapota).
Allergy to sapodilla fruit ingestion is rare. A basic thaumatin-like protein (TLP 2) has been identified as the major allergen. The present study was aimed at identifying and characterizing additional allergens from sapodilla. Allergic subjects were identified by case history, skin prick test (SPT) and allergen-specific IgE. SPT and ELISA confirmed a subject with oral allergy syndrome (OAS) to sapodilla and custard apple. Two proteins (26.9 and 24.5 kDa) were detected as allergens, of which the latter in SP2 has already been identified as basic TLP (TLP 2). The 26.9 kDa protein present in SP1 was identified as an acidic TLP. Presence of a basic beta-1,3-glucanase in SP3 was inferred. Evolutionary relatedness to olive, grape and kiwi fruit allergenic TLPs were inferred by phylogenetic analysis.

Conclusions: An acidic TLP (TLP 1) was identified as a new allergen in sapodilla. TLP 1 is a single polypeptide (207 residues) belonging to the thaumatin family of the GH64-TLP-SF superfamily. Clinically, sapodilla should be considered in the list of fruits causing OAS

Characterization and gene cloning of an acidic Thaumatin-Like Protein (TLP 1), an allergen from Sapodilla Fruit (Manilkara zapota).  
shok Kumar HG, Hegde VL, Shetty SM, Venkatesh YP.
Allergol Int 2013 Sep 25;

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Allergy and Intolerance Abstracts
Diagnosis of immediate hypersensitivity reactions to radiocontrast media.
No consensus exists on the diagnostic approach for immediate hypersensitivity reactions (IHR) to radiocontrast media (RCM). This study analyzed the diagnostic value of a skin test (ST), drug provocation test (DPT) and basophil activation test (BAT) in patients with symptoms compatible with IHR to RCM. Ninety patients with symptoms suggestive of IHR to RCM were evaluated. Eight (8.9%) cases were confirmed as having IHR, 5 (62.5%) by ST and 3 (37.5%) by DPT. Five from those confirmed as IHR (62.5%) had a positive BAT. Therefore hypersensitivity to RCM was confirmed in 9%, by ST or DPT. BAT proved a valuable method for diagnosis.

Diagnosis of immediate hypersensitivity reactions to radiocontrast media.  
Salas M, Gomez F, Fernandez TD, Dona I, Aranda A, Ariza A, Blanca-Lopez N, Mayorga C, Blanca M, Torres MJ.
Allergy 2013 Sep;68(9):1203-1206

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Allergy and Intolerance Abstracts
Cofactors in anaphylaxis.
Next to physical exercise or alcohol consumption, co-administration of nonsteroidal anti-inflammatory drugs (NSAID) or concomitant infectious diseases are well-documented cofactors of anaphylaxis. Registries for anaphylaxis document a role for cofactors in about 30% of anaphylactic reactions. Using 'wheat-dependent exercise-induced anaphylaxis' (WDEIA) as a model disease, studies demonstrated that exercise increases skin prick test reactivity to and bioavailability of the allergen. Additional data indicate that alcohol consumption and NSAID administration display similar effects. Cofactors are increasingly accepted to play a fundamental role in eliciting anaphylaxis. Consequently, to improve patient management modalities, a better understanding of the underlying mechanisms is warranted. This review aims to update clinicians and clinical scientists on recent developments.

About the role and underlying mechanisms of cofactors in anaphylaxis.  
Wolbing F, Fischer J, Koberle M, Kaesler S, Biedermann T.
Allergy 2013 Sep;68(9):1085-1092

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Allergy and Intolerance Abstracts
Tolerance of a cow's milk-based hydrolyzed formula in patients with eosinophilic esophagitis triggered by milk.
Most adult patients with EoE triggered by cow's milk tolerate a cow's milk-based extensively hydrolyzed formula, thus providing them with a safe, economical alternative to cow's milk.

Tolerance of a cow's milk-based hydrolyzed formula in patients with eosinophilic esophagitis triggered by milk.  
Lucendo AJ, Arias A, Gonzalez-Cervera J, Mota-Huertas T, Yague-Compadre JL.
Allergy 2013 Aug;68(8):1065-1072

Index
Allergy and Intolerance Abstracts
Favorable trends in the frequency of U.S. emergency department visits for food allergy
Several studies suggest an increase in both the prevalence of food allergy and in the frequency of emergency department (ED) visits for food-related allergic reactions, including anaphylaxis. This study evaluates time trends in the frequency of ED visits for food allergy, with a focus on possible differences by age. Data from two multicenter ED-based studies were used to identify the proportion of patients assigned to the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes with actual food-related acute allergic reaction and the proportion of these patients with food-induced anaphylaxis. We multiplied these proportions against counts from nationally representative data (2001-2009) to estimate the number of U.S. ED visits for each ICD-9-CM code with likely food allergy. Over the 9-year study period, there were approximately 1,892,000 ED visits for food allergy. The number of ED visits for food allergy did not significantly change among children aged <18 years (77,000 visits in 2001 versus 92,000 visits in 2009; p = 0.85), but among adults aged >/=18 years, there was a decline (147,000 visits versus 97,000 visits; p = 0.046). Looking across all ED visits (any cause), the proportion of ED visits for food allergy was stable for children (0.29% versus 0.28%; p = 0.22) but decreased for adults (0.18% versus 0.09%; p = 0.01). The number of U.S. ED visits for food-related acute allergic reactions is significantly higher than prior reports. These results also suggest that the frequency of ED visits for food allergy was stable or decreased from 2001 to 2009, despite reports suggesting an ongoing rise in the prevalence of food allergy.

Favorable trends in the frequency of U.S. emergency department visits for food allergy, 2001-2009.  
Clark S, Espinola JA, Rudders SA, Banerji A, Camargo CA.
Allergy Asthma Proc 2013 Sep;34(5):439-445

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Allergy and Intolerance Abstracts
The allergenic potency of Japanese hop pollen is increasing with environmental changes in Korea.
The sensitization rate to Japanese Hop (Hop J) in respiratory allergy patients has increased in recent years in Korea. This study evaluated changes in the allergenic potency of Hop J pollen collected in 1998 and 2009. Thirty-five patients with allergic rhinitis and/or asthma were enrolled. Group I included 21 subjects sensitized to Hop J at an initial visit and group II included 14 subjects who developed a new sensitization. Hop J pollens were collected in 1998 and 2009 (98 and 09 extracts) and both urban and suburban environments (urban and suburban extracts). Serum specific IgE levels to the 09 and urban extracts in both groups increased significantly compared to those of the 98 and suburban extracts. IgE immunoblot demonstrated that the major 10 kDa allergen was intensified in group I, while it was newly generated in group II with additional components ranging from 12-95 kDa. When the 98 and 09 extracts were compared, intensification of the major allergen of 09 extract had occurred in both groups. The IgE binding components of the urban extract was stronger than those of suburban one.

The allergenic potency of Japanese hop pollen is increasing with environmental changes in Korea.  
Jin HJ, Choi GS, Shin YS, Kim JH, Kim JE, Ye YM, Park HS.
Allergy Asthma Immunol Res 2013 Sep;5(5):309-314

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Allergy and Intolerance Abstracts
Seasonal variation in skin sensitivity to aeroallergens.
Skin sensitivity to aeroallergens such as HDMs, pollens, and molds demonstrates seasonal variation in respiratory allergy patients. Non-respiratory allergy patients also showed seasonal variation in sensitivity to aeroallergens, which might be related to the 'priming' effect of allergens.

Seasonal variation in skin sensitivity to aeroallergens.  
Choi IS, Lee SS, Myeong E, Lee JW, Kim WJ, Jin J.
Allergy Asthma Immunol Res 2013 Sep;5(5):301-308

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Allergy and Intolerance Abstracts
Association between pet ownership and the sensitization to pet allergens in adults with various allergic diseases.
These results suggest that direct exposure to dogs contributes to the sensitization to dog allergens in patients with allergic diseases, whereas indirect exposure to cats and rabbits may induce sensitization to each animal's allergen. 401 patients with various allergic diseases were enrolled in this study. Skin prick tests were performed with 55 common inhalant and food allergens, including dog, cat, and rabbit allergens. The sensitization rate for animal allergens was 20.4% for dog, 15.0% for cat, and 9.0% for rabbit. Direct exposure to dogs (72.0%) was significantly higher than that of other animals (18.4% for cats and 16.7% for rabbits), whereas 'no contact' with cats (78.3%) and rabbits (83.3%) was significantly higher than with dogs (26.8%; P<0.0001).

Association between pet ownership and the sensitization to pet allergens in adults with various allergic diseases.  
Park YB, Mo EK, Lee JY, Kim JH, Kim CH, Hyun IG, Choi JH.
Allergy Asthma Immunol Res 2013 Sep;5(5):295-300

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Allergy and Intolerance Abstracts
Peanut Allergen Threshold Study (PATS): validation of eliciting doses using a novel single-dose challenge protocol.
The eliciting dose (ED) for a peanut allergic reaction in 5% of the peanut allergic population, the ED05, is 1.5 mg of peanut protein. This ED05 was derived from oral food challenges (OFC) that use graded, incremental doses administered at fixed time intervals. Individual patients' threshold doses were used to generate population dose-distribution curves using probability distributions from which the ED05 was then determined. It is important to clinically validate that this dose is predictive of the allergenic response in a further unselected group of peanut-allergic individuals. This multi-centre study involved three national level referral and teaching centres. (Cork University Hospital, Ireland, Royal Children's Hospital Melbourne, Australia and Massachusetts General Hospital, Boston, U.S.A.) The study is now in process and will continue to run until all centres have recruited 125 participates in each respective centre. The aim is to assess the precision of the predicted ED05 using a single dose (6 mg peanut = 1.5 mg of peanut protein) in the form of a cookie.

Peanut Allergen Threshold Study (PATS): validation of eliciting doses using a novel single-dose challenge protocol.  
Zurzolo GA, Allen KJ, Taylor SL, Shreffler WG, Baumert JL, Tang ML, Gurrin LC, Mathai ML, Nordlee JA, Dunngalvin A, Hourihane JO.
Allergy Asthma Clin Immunol 2013 Sep 12;9(1):35

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Allergy and Intolerance Abstracts
A 5-year study of systemic reactions using both shared and patient-specific vaccines.
The safety of shared specific vaccines (SSVs) has been questioned by some experts. The purpose of this study was to evaluate the safety of SSVs. Details of systemic allergic reactions after subcutaneous immunotherapy injections were captured on a standardized form from July 2005 to July 2010. There were no systemic reactions resulting from errors where the incorrect shared allergen was administered, but we did note one reaction after an erroneously administered PSV. There were two dosage errors associated with both shared and patient-specific immunotherapy. Most reactions were mild to moderate. Severe reactions with 911 activations were noted in six patients. Thirty percent of reactions occurred out of the office and the average time to reaction was 48 minutes. Epinephrine was administered in only 60% of patients. Epicutaneous reactivity to mites, cats, dogs, and pollen but not mold occurred significantly more in reactors. Differences in SRRs were encountered between satellite offices. Using a combination of SSV and PSV, SRRs were similar to previously reported studies; moreover, no systemic reactions occurred where a SSV was erroneously administered. SRR surveillance is a useful safety tool

A 5-year study of systemic reactions using both shared and patient-specific vaccines.  

Am J Rhinol Allergy 2013 Sep 6;

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Allergy and Intolerance Abstracts
Recent 5-year trends of asthma severity and allergen sensitization among children in southern Thailand.
This study investigated the possible changes in disease severity and allergen sensitization of children with asthma in an interim period of 5 years.

The mean ages of patients in the 2004 and 2009 groups were 7.54 and 7.73 years. Compared with patients in the 2004 group, the 2009 group had more severe asthma (p = 0.006). The prevalence of patients sensitized to both house dust (HD) and house dust mites (HDM) increased from 21.2% in 2004 to 34.3% in 2009 (p =0.007). Sensitization to allergens of HD, HDM and cockroach increased to 14.1% in 2009 from 9.1% in 2004 (p =0.021).

Recent 5-year trends of asthma severity and allergen sensitization among children in southern Thailand.  
Yuenyongviwat A, Koonrangsesomboon D, Sangsupawanich P.
Asian Pac J Allergy Immunol 2013 Sep;31(3):242-246

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Allergy and Intolerance Abstracts
Comparison of conjunctival and nasal provocation tests in allergic rhinitis children with Dermatophagoides pteronyssinus sensitization.
Nasal provocation tests (NPTs) are indicated in confirming the diagnosis of allergic rhinitis if the clinical history, skin tests or sIgE are inconclusive. NPTs are time- consuming, technically difficult and expensive to perform. Consequently, conjunctival provocation tests (CPTs), which are easier, cheaper and safer should be considered as an alternative method. This study compared CPTs with NPTs in allergic rhinitis children with house dust mite sensitization and concludes that CPT can be an alternative test for NPT in allergic rhinitis children with house dust mite sensitization, even if they do not have conjunctival symptoms.

Comparison of conjunctival and nasal provocation tests in allergic rhinitis children with Dermatophagoides pteronyssinus sensitization.  
Anantasit N, Vilaiyuk S, Kamchaisatian W, Supakornthanasarn W, Sasisakulporn C, Teawsomboonkit W, Benjaponpitak S.
Asian Pac J Allergy Immunol 2013 Sep;31(3):227-232

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Allergen-, Food allergy-, Intolerance-related articles

No matrix effect in double-blind, placebo-controlled egg challenges in egg allergic children.  
Libbers L, Flokstra-de Blok BM, Vlieg-Boerstra BJ, van der HS, van der Meulen GN, Kukler J, Kerkhof M, Dubois AE.
Clin Exp Allergy 2013 Sep;43(9):1067-1070
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Characteristics and purchasing behaviours of food-allergic consumers and those who buy food for them in Great Britain.  
Cochrane SA, Gowland MH, Sheffield D, Crevel RW.
Clin Transl Allergy 2013 Sep 23;3(1):31
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Monosodium glutamate avoidance for chronic asthma in adults and children.  
Zhou Y, Yang M, Dong BR.
Cochrane Database Syst Rev 2012 Jun 13;6:CD004357.
Abstract

Effects of Tobacco Smoke Exposure in Childhood on Atopic Diseases.  
Ciaccio CE, Gentile D.
Curr Allergy Asthma Rep 2013 Sep 21;
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Is gluten a cause of gastrointestinal symptoms in people without celiac disease?  
Biesiekierski JR, Muir JG, Gibson PR.
Curr Allergy Asthma Rep 2013 Sep 12;

Patterns of sensitization to inhalant and food allergens - findings from the German health interview and examination survey for children and adolescents.  
Schmitz R, Ellert U, Kalcklosch M, Dahm S, Thamm M.
Int Arch Allergy Immunol 2013 Sep 6;162(3):263-270

Tolerance of baked milk in patients with cow's milk-mediated eosinophilic esophagitis.  
Leung J, Hundal NV, Katz AJ, Shreffler WG, Yuan Q, Butterworth CA, Hesterberg PE.
J Allergy Clin Immunol 2013 Sep 28;

Role of Art v 3 in pollinosis of patients allergic to Pru p 3.  
Sanchez-Lopez J, Tordesillas L, Pascal M, Munoz-Cano R, Garrido M, Rueda M, Vilella R, Valero A, az-Perales A, Picado C, Bartra J.
J Allergy Clin Immunol 2013 Sep 27;
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Unlocking the resistance to wheat lipid transfer protein.  
Gamboa PM, Gonzalez C, Pereira C, Catarino M, Garcia-Lirio E, Soriano A, Pacios LF, az-Perales A.
J Allergy Clin Immunol 2013 Sep 12;

Association of indoor dampness and molds with rhinitis risk: A systematic review and meta-analysis.  
Jaakkola MS, Quansah R, Hugg TT, Heikkinen SA, Jaakkola JJ.
J Allergy Clin Immunol 2013 Sep 10;
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Component-resolved diagnosis of peach allergy and its relationship with prevalent allergenic pollens in China.  
Ma S, Yin J, Jiang N.
J Allergy Clin Immunol 2013 Sep;132(3):764-767

Fungal protein MGL_1304 in sweat is an allergen for atopic dermatitis patients.  
Hiragun T, Ishii K, Hiragun M, Suzuki H, Kan T, Mihara S, Yanase Y, Bartels J, Schroder JM, Hide M.
J Allergy Clin Immunol 2013 Sep;132(3):608-615
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Food Protein-Induced Enterocolitis Syndrome (FPIES): Current Management Strategies and Review of the Literature  
Kirsi M. Järvinen, Anna Nowak-Wegrzyn
J Allergy Clin Immunol: In Practise 2013;1(4):
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Guidance for the Nutrition Management of Gastrointestinal Allergy in Pediatrics  
Marion Groetch, Michelle Henry, Mary Beth Feuling, Jennifer Kim
J Allergy Clin Immunol: In Practise 2013;1(4):
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Relationship of Dog- and Cat-Specific IgE and IgG4 Levels to Allergic Symptoms on Pet Exposure  
Mary Burnett, Ganesa Wegienka, Suzanne Havstad, Haejin Kim, et al.
J Allergy Clin Immunol: In Practise 2013;1(4):350-353
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Ovomucoid is not superior to egg white testing in predicting tolerance to baked egg  
Lisa M. Bartnikas, William J. Sheehan, Katherine S. Larabee, Carter Petty, et al.
J Allergy Clin Immunol: In Practise 2013;1(4):354-360.e2
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The value of specific ige to peanut and its component Ara h 2 in the diagnosis of peanut allergy.  
Lucila C. Lopes de Oliveira, Martina Aderhold, Marianne Brill, Gabriele Schulz, et al.
J Allergy Clin Immunol: In Practise 2013;1(4):394-398
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A child with allergic contact dermatitis due to para-phenylenediamine  
Ahmet Zulfikar Akelma, Mehmet Nevzat Cizmeci, Evren Sarifakioglu, Emin Mete
J Allergy Clin Immunol: In Practise 2013;1(4):394-398
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Foods with precautionary allergen labeling in Australia rarely contain detectable allergen.  
Giovanni A. Zurzolo, Jennifer J. Koplin, Michael L. Mathai, Steve L. Taylor, et al.
J Allergy Clin Immunol: In Practise 2013;1(4):401-403.
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Ceftazidime-induced drug reaction with eosinophilia and systemic symptoms (DRESS) complicated by hemophagocytic lymphohistiocytosis  
Matthieu Picard, M. Isabel Fernandez, Anne Des Roches, Philippe Bégin, et al
J Allergy Clin Immunol: In Practise 2013;1(4):
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Anaphylaxis to cat in a child with exclusive sensitivity to Fel d 1  
Thomas B. Casale, Christina Cruz
J Allergy Clin Immunol: In Practise 2013;1(4):416-417
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Heating does not decrease immunogenicity of goat's and ewe's milk.  
Ramon Bencharitiwong, Stavroula Giavi, Andrea Vereda, Maria Dolores Ibáñez, et al.
J Allergy Clin Immunol: In Practise 2013;1(4):418-421.e2
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Intolerance to sweet treats in a child.  
Phillip Lieberman, Scott H. Sicherer.
J Allergy Clin Immunol: In Practise 2013;1(4):422.
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Food allergy and increased asthma morbidity in a school-based inner-city asthma study  
James L. Friedlander, William J. Sheehan, Sachin N. Baxi, Lianne S. Kopel, et al.
J Allergy Clin Immunol: In Practise 2013;1(5):
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The relationship between a specific IgE level and asthma outcomes: results from the 2005-2006 national health and nutrition examination survey  
Whitney D. Arroyave, Felicia A. Rabito, John C. Carlson
J Allergy Clin Immunol: In Practise 2013;1(5):501-508
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IgE-mediated hypersensitivity to ondansetron and safe use of palonosetron  
John Leung, Autumn Guyer, Aleena Banerji
J Allergy Clin Immunol: In Practise 2013;1(5):
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Natural resolution of peanut allergy: A 12-year longitudinal follow-up study  
Philippe Bégin, Louis Paradis, Jean Paradis, Matthieu Picard, et al.
J Allergy Clin Immunol: In Practise 2013;1(5):528-530.e4
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Re: Integrated research on the association between climate change and Bjerkandera allergy  
Haruhiko Ogawa, Masaki Fujimura, Kazuo Satoh, Koichi Makimura
J Allergy Clin Immunol: In Practise 2013;1(5):543
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Cat, dog and house dust mite allergen levels on children's soft toys.  
Fu-Sheng WF, Wu MW, Ting MH, Crane J, Siebers R.
J Asthma 2013 Sep 12;
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Systematic review of the effects of domestic paints on asthma related symptoms in people with or without asthma.  
Canova C, Jarvis D, Walker S, Cullinan P.
J Asthma 2013 Sep 18;
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Allergic bronchopulmonary aspergillosis: a clinico-serological correlation with radiologic profile.  
Kumar RM, Goel NM.
J Asthma 2013 Sep;50(7):759-763
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Impact of Schizophyllum sensitization on decline of lung function in asthma.  
Ogawa H, Fujimura M, Takeuchi Y, Makimura K.
J Asthma 2013 Sep;50(7):764-768
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Food vibrations: Asian spice sets lips trembling  
Hagura N, Barber H, Haggard P.
Miscellaneous 592 2013;280 1770 20131680; 1471-2954
Abstract

Comprehensive research and evaluation of chlorogenic acid allergy. [Chinese]  
Wu X, Yang H, Lin D, Zhang J, Luo F, Xu X.
Miscellaneous 592 2010 Dec;35(24):3357-61.
Abstract

Analysis of the pollen allergen content of twelve olive cultivars grown in Portugal.  
Ribeiro H , Morales S, Salmerón C, Cruz A, Calado L, Rodríguez-García MI , Alché JD, Abreu I.
Miscellaneous Aerobiologia 2013;29(4):513-521.
Abstract

Mortality Related to Honey-Bee stings in Mexico from 1988 to 2009. [Spanish]  
Becerril-Ngeles M, Zquez No, rias-Martinez MI.
Rev Alerg Mex 2013 Apr;60(2):58-62
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Allergy to ranitidine: one case report and literature review. [Spanish]  
Cuevas-Castillejos H, Cuevas-Castillejos JE, Garcia-Murray O, Larenas-Linnemann D.
Rev Alerg Mex 2013 Jan;60(1):41-48
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Sensitization to house dust and storage mites in allergic adults from the South of Mexico city. [Spanish]  
Ramirez-Heredia J, Oifarrill-Romanillos PM, Guidos-Fogelbach G, Miyagui-Nakamura RK, Segura-Mendez NH.
Rev Alerg Mex 2013 Jan;60(1):31-37
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Sensitization to three house dust mites in a children allergic population of Cuba. [Spanish]  
Reyes-Zamora MC, Labrada-Rosado A, Mateo-Morejun M, Lupez-Chacun A.
Rev Alerg Mex 2012 Jul;59(3):148-154
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Sensitization to aeroallergens in allergic patients from Medellin, Colombia. [Spanish]  
Nchez-Caraballo S, ez-Zuluaga S, Cardona-Villa R.
Rev Alerg Mex 2012 Jul;59(3):139-147
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Prevalence of sensitization to the most common allergens in elderly patients from the western of Mexico. [Spanish]  
Bedolla-Barajas M, Morales-Romero J, Hern Ndez-Colin DD, revalo-Cruz D.
Rev Alerg Mex 2012 Jul;59(3):131-138
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Frequency of food-sensitization by prick-to-prick skin tests and atopy patch tests in children with allergic diseases. [Spanish]  
Maya-Epelstein J, Rosas-Vargas MN, Del-Rio-Navarro B.
Rev Alerg Mex 2012 Jul;59(3):123-130
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Correlation of cutaneous reactivity between allergenic extracts of Dermatophagoides pteronyssinus and Dermatophagoides farinae with Blomis tropicalis in patients with allergic rinitis and asthma. [Spanish]  
Morales-de-Leun G, Lupez-Garcia A, rana-Muooz O, Carcaoo-Perez Y, Papaqui-Tapia S, Caballero-Lupez CG, Martinez-Villegas M, Rios-Lupez JJ.
Rev Alerg Mex 2012 Jul;59(3):107-112
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Latex Allergy in Patients Who Underwent Surgical Treatment. Case series. [Spanish]  
Campos-Romero FH, Mendoza-Reyna LD, Guillen-Rocha NL, Segura-Mendez NH.
Rev Alerg Mex 2012 Apr;59(2):79-85
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Anaphylaxis due to ingestion of ivy syrup (Hedera helix). Report of two cases. [Spanish]  
Morfin-Maciel BM, Rosas-Alvarado A, Vel Zquez-S Mano.
Rev Alerg Mex 2012 Jan;59(1):31-36
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Hypersensitivity reactions to insulin. [Spanish]  
Becerril-Ngeles M, Moctezuma-Trejo C, Espinosa-Larraoaga F.
Rev Alerg Mex 2012 Jan;59(1):25-30
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Sensitization to mites and occupational allergens in bakery workers of La Habana, Cuba. [Spanish]  
Lvarez-Castellu M, Leyva M, Vargas-Ortega RL, Labrada-Rosado A, Meli VR, Barata H.
Rev Alerg Mex 2012 Jan;59(1):9-15
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Relative potency of allergenic extracts from mites in patients with asthma and allergic rhinitis. [Spanish]  
Rodriguez-Santos O, Celio-Murillo R, bou-Khair F, Meli VR, Barata HJ, Labrada-Rosado A, Cruz-S MN, Cruz M.
Rev Alerg Mex 2011 Oct;58(4):200-204
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Survey of adverse reactions to drugs in hospitalized patients. [Spanish]  
Becerril-Ngeles M, randa-Jan A, Moreno-Quiruz J.
Rev Alerg Mex 2011 Oct;58(4):179-184
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Influenza vaccine and its use in patients with asthma and egg allergy. [Spanish]  
Becerril-Ngeles M.
Rev Alerg Mex 2011 Oct;58(4):177-178

Occupational asthma related to Wheat. Presentation of One Case. [Spanish]  
Galindo-Pacheco LV, Toral-Villanueva R, Segura-Mendez NH.
Rev Alerg Mex 2013 Apr;60(2):82-86
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Anaphylaxis by atracurium. One case report. [Spanish]  
Dominguez-Sansores L, Gonz Lez-Diaz S, rias-Cruz A, Palacios-Rios D, Lupez-Cabrera NG.
Rev Alerg Mex 2013 Apr;60(2):78-81
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Frequency and clinical features of the oral allergy syndrome in Mexican adults with nasal pollinosi. [Spanish]  
Bedolla-Barajas M, Morales-Romero J, Ortiz-Miramontes LR, RO JU.
Rev Alerg Mex 2013 Jan;60(1):17-25
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Sensitization and oral challenge with ovoalbumin in an animal model of food allergy. [Spanish]  
Vinuesa MN, Bassan ND, Chaparro S, Martinez A, Batle R, Giacomozzi F, Torres V.
Rev Alerg Mex 2012 Apr;59(2):65-71
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Evaluation of the efficacy of a soybean allergenic extract in the diagnosis of immediate hypersensitivity. [spanish]  
Figueroa-Garcia I, Estruch-Fajardo IM, Labrada-Rosado A, Leun-Rivero M.
Rev Alerg Mex 2012 Apr;59(2):47-55
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Anaphylaxis only to a home-made rose wine from a variety of grape.  
Vovolis V, Delyargiris C, Tsiougkos N.
Eur Ann Allergy Clin Immunol 2013 Aug;45(4):148-149
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Bovine Serum Albumin: a double allergy risk.  
Voltolini S, Spigno F, Cioe Et AA.
Eur Ann Allergy Clin Immunol 2013 Aug;45(4):144-147
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Mugwort-fennel-allergy-syndrome associated with sensitization to an allergen homologous to Api g 5.  
Borghesan F, Mistrello G, mato Et AS.
Eur Ann Allergy Clin Immunol 2013 Aug;45(4):130-137
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The relationship between pollen count levels and prevalence of Japanese cedar pollinosis in northeast Japan.  
Honda K, Saito H, Fukui N, Ito E, Ishikawa K.
Allergol Int 2013 Sep;62(3):375-380
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Gastrointestinal food allergy in infants.  
Morita H, Nomura I, Matsuda A, Saito H, Matsumoto K.
Allergol Int 2013 Sep;62(3):297-307
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Characterization of causative allergens for Wheat-Dependent Exercise-Induced anaphylaxis sensitized with hydrolyzed wheat proteins in facial soap.  
Yokooji T, Kurihara S, Murakami T, Chinuki Y, Takahashi H, Morita E, Harada S, Ishii K, Hiragun M, Hide M, Matsuo H.
Allergol Int 2013 Aug 25;
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Evaluation of latex subclinical sensitization by way of the basophil activation test and specific IgE to latex recombinant allergens.  
Rodriguez TA, Fernandez Pereira LM, Romero-Chala S, Garcia-Trujillo JA, Camara HC.
Allergol Int 2013 Sep;62(3):385-387

Is Bjerkandera allergy affected by the arrival of yellow sand dust?  
Ogawa H, Fujimura M, Satoh K, Makimura K.
Allergol Int 2013 Sep 25;

Characterization and gene cloning of an acidic Thaumatin-Like Protein (TLP 1), an allergen from Sapodilla Fruit (Manilkara zapota).  
shok Kumar HG, Hegde VL, Shetty SM, Venkatesh YP.
Allergol Int 2013 Sep 25;
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Serum allergen-specific IgA is not associated with natural or induced tolerance to egg in children.  
Vazquez-Ortiz M, Pascal M, Juan M, Alsina L, Martin-Mateos MA, Plaza AM.
Allergy 2013 Sep 4;
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Diagnosis of immediate hypersensitivity reactions to radiocontrast media.  
Salas M, Gomez F, Fernandez TD, Dona I, Aranda A, Ariza A, Blanca-Lopez N, Mayorga C, Blanca M, Torres MJ.
Allergy 2013 Sep;68(9):1203-1206
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Where to prick the apple for skin testing?  
Vlieg-Boerstra BJ, van de Weg WE, van der HS, Dubois AE.
Allergy 2013 Sep;68(9):1196-1198
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About the role and underlying mechanisms of cofactors in anaphylaxis.  
Wolbing F, Fischer J, Koberle M, Kaesler S, Biedermann T.
Allergy 2013 Sep;68(9):1085-1092
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Tolerance of a cow's milk-based hydrolyzed formula in patients with eosinophilic esophagitis triggered by milk.  
Lucendo AJ, Arias A, Gonzalez-Cervera J, Mota-Huertas T, Yague-Compadre JL.
Allergy 2013 Aug;68(8):1065-1072

Favorable trends in the frequency of U.S. emergency department visits for food allergy, 2001-2009.  
Clark S, Espinola JA, Rudders SA, Banerji A, Camargo CA.
Allergy Asthma Proc 2013 Sep;34(5):439-445
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A case of fixed drug eruption due to doxycycline and erythromycin present in food.  
Lim WS, Kim DH, Jin SY, Choi YS, Lee SH, Huh HJ, Chae SL, Lee AY.
Allergy Asthma Immunol Res 2013 Sep;5(5):337-339
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The allergenic potency of Japanese hop pollen is increasing with environmental changes in Korea.  
Jin HJ, Choi GS, Shin YS, Kim JH, Kim JE, Ye YM, Park HS.
Allergy Asthma Immunol Res 2013 Sep;5(5):309-314
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Seasonal variation in skin sensitivity to aeroallergens.  
Choi IS, Lee SS, Myeong E, Lee JW, Kim WJ, Jin J.
Allergy Asthma Immunol Res 2013 Sep;5(5):301-308
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Association between pet ownership and the sensitization to pet allergens in adults with various allergic diseases.  
Park YB, Mo EK, Lee JY, Kim JH, Kim CH, Hyun IG, Choi JH.
Allergy Asthma Immunol Res 2013 Sep;5(5):295-300
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Peanut Allergen Threshold Study (PATS): validation of eliciting doses using a novel single-dose challenge protocol.  
Zurzolo GA, Allen KJ, Taylor SL, Shreffler WG, Baumert JL, Tang ML, Gurrin LC, Mathai ML, Nordlee JA, Dunngalvin A, Hourihane JO.
Allergy Asthma Clin Immunol 2013 Sep 12;9(1):35
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Correction: Predictive value of IgE/IgG4 antibody ratio in children with egg allergy.  
Okamoto S, Taniuchi S, Sudo K, Hatano Y, Nakano K, Shimo T, Kaneko K.
Allergy Asthma Clin Immunol 2013 Sep 9;9(1):34
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A 5-year study of systemic reactions using both shared and patient-specific vaccines.  

Am J Rhinol Allergy 2013 Sep 6;
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Oral food challenge to wheat: a near-fatal anaphylaxis and review of 93 food challenges in children  
Fiedler J, Garrett JP, Naimi DR, Spergel JM
WAO Journal 2013, 6:14
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Recent 5-year trends of asthma severity and allergen sensitization among children in southern Thailand.  
Yuenyongviwat A, Koonrangsesomboon D, Sangsupawanich P.
Asian Pac J Allergy Immunol 2013 Sep;31(3):242-246
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Comparison of conjunctival and nasal provocation tests in allergic rhinitis children with Dermatophagoides pteronyssinus sensitization.  
Anantasit N, Vilaiyuk S, Kamchaisatian W, Supakornthanasarn W, Sasisakulporn C, Teawsomboonkit W, Benjaponpitak S.
Asian Pac J Allergy Immunol 2013 Sep;31(3):227-232
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