Substance Info: (and synonyms)
White Bean / Cannellini Bean

Background Info:

Staple food in many countries.
These dried beans are the beans used as haricot beans in stews, or as canned baked beans. Aka white kidney beans.


Adverse Reactions:


[ 1 / 6 ]

A report of severe chicken and turkey meat allergy without sensitisation to egg proteins. There was also coexisting Leguminosae allergy. At the age of 21 and 23, he experienced generalised pruriginous erythema, laryngeal tightness and sialorrhoea immediately after ingestion of cooked red beans, white beans and black-eyed beans. At the age of 29, the patient developed generalised itch, palmar erythema, laryngeal tightness and dysphagia after ingestion of grilled chicken meat. One year later, he had a similar episode with ingestion of grilled turkey meat and oropharyngeal pruritus and sialorrhoea with ingestion of duck meat. He had never had any complaints after ingestion of other legumes (namely soy), tree nuts and cooked or fresh eggs and had not previously ingested goose, pheasant and/or grouse meat. (Sokolova 2009 ref.23972 5)

Sokolova A, Costa AC, Santos MC, Bartolome B, Barbosa MP. Severe allergy to poultry meat without sensitisation to egg proteins with concomitant Leguminosae allergy. Case report. Allergol Immunopathol (Madr) 2009 May;37(3):168-171

[ 2 / 6 ]

The objective of this study was to describe the clinical features of a Spanish pediatric population allergic to legumes (lentils, chickpeas, peas, white beans, and peanuts), to evaluate the clinical allergy to several legumes, and to determine which legume extract is most appropriate to use in the diagnosis of legume allergy by skin tests. Fifty-four children with allergic reactions after exposure to legumes were studied. The onset of allergic reactions was at approximately the age of 2 years (median, 22 months). Skin prick test results were positive for at least 3 legumes in 38 children (70%). Positive results were more frequent to boiled extracts than to raw extracts in children with a positive oral challenge. Allergy to lentil was the most frequently diagnosed legume allergy (43 children [80%]), followed by allergy to chickpea (32 children [59%]), pea (27 children [50%]), peanut (18 children [33%]) and white bean (6 children [11%]). Oral challenges with more than 1 legume (median, 3 legumes) were positive in 37 children (69%). The most frequent induced symptoms on challenge were respiratory (rhinitis and/or asthma) and cutaneous.
Clinical Manifestations During Oral Challenges
Symptom Total Lentil Chickpea Pea White bean Peanut
(n=105) (n=37) (n=29) (n = 24) (n=6) (n=9)
Cutaneous 45 (43) 14 (38) 15 (52) 13 (54) 2(33) 3 (33)
GITl 20 (19) 4 (11) 3 (10) 3 (13) 2(33) 2 (22)
Resp 60 (57) 12 (32) 17 (59) 11 (46) 0 4 (44)
OAS 28 (27) 16 (43) 5 (17) 3 (13) 2 (33) 2 (22)
Severe react 11(10) 3 (8) 4(14) 2 (8) 0 2 (22)
(Martínez 2008 ref.22238 3)

Martínez San Ireneo M, Ibáñez MD, Sánchez JJ, Carnés J, Fernández-Caldas E. Clinical features of legume allergy in children from a Mediterranean area. Ann Allergy Asthma Immunol 2008 Aug;101(2):179-84

[ 3 / 6 ]

Legume allergy, mainly to lentils and chickpeas, is the fifth most common cause of food allergy in Spanish children. Serological cross-reactivity among legumes is frequent, but its clinical relevance is controversial. The aim of this study was to investigate the cross-reactivity among lentils, chickpeas, peas, white beans and peanuts and its clinical relevance in pediatric patients. Fifty-four children with clinical allergy to legumes were included. Inhibition experiments demonstrated more than 80% inhibition with lentil, chickpea and pea extracts. Immunoblots performed with raw legume extracts (lentil, chickpea and pea) and individual sera revealed that more than 50% of the sera identified an allergen with approximately 50 kDa in all three legume extracts. In all three boiled extracts an intense band at approximately 50 kDa was visualized using a serum pool. The oral legume challenges demonstrated that 37 children (69%) were allergic to 2 or more legumes (median 3 legumes). The most frequent associations were allergy to lentils and chickpeas (57%), allergy to lentils and peas (54%) and allergy to lentils, chickpeas and peas (43%). Food challenges confirmed that clinical allergy to all three legumes is frequent in this cohort of Spanish children. (Martínez 2008 ref.21964 7)

Martínez San Ireneo M, Ibáñez MD, Fernández-Caldas E, Carnés J. In vitro and in vivo cross-reactivity studies of legume allergy in a Mediterranean population. Int Arch Allergy Immunol 2008 Jul 2;147(3):222-230

[ 4 / 6 ]

A 7-year-old child who suffered two episodes of angioedema related to white bean: the first episode occurred after ingestion, and subsequently developed angioedema following inhalation of vapours from cooked white bean. Skin prick test with white bean and green bean were positive (8x8 mm). The prick-by-prick with cooked white bean was positive. Serum specific IgE assayed by CAP was positive for white bean (24.30 KU/I) and green bean (7.2 KU/I) and <0.35 KU/I to peanut, pea and soybean. An oral challenge test with several legumes were performed showing an immediate response alter ingestion of white bean, with symptoms of angioedema involving lips and tongue. The results indicate that he has type I hypersensitivity to white bean and green bean. The patient tolerated chickpeas, lentils, and soybean. (Martinez 2005 ref.12049 7)

Martinez AJ, Callejo MA, Fuentes Gonzalo MJ, Martin GC. Angioedema induced by inhalation of vapours from cooked white bean in a child. Allergol Immunopathol (Madr ) 2005 Jul;33(4):4-230

[ 5 / 6 ]

This study investigated the cross-reactivity to non-Rosaceae LTPs. IgE antibodies to Rosaceae LTPs reacted to a broad range of vegetable foods were evaluated in 498 subjects (age > 12 years) with Rosaccae allergy as judged by skin prick test with fresh fruits and (in most cases) clinical history. The majority had OAS (>97%), and only a minority (approximately 10%) showed urticaria/angioedema, gastrointestinal symptoms, food-induced rhinitis, asthma, or anaphylaxis. Sera from 37 patients were available for follow-up studies. Peach was identified most frequently as an offending Rosaceae food (in 30/37 patients), followed by apple (16/37), apricot (11/37), cherry (9/37), plum (8/37), almond (7/37) and pear (6/37). Four patients did not have any clinical symptoms related to Rosaccae fruits, despite a positive SPT with commercial plum extract and peach peel extract. All 37 patients were interviewed for allergies to other foods. Walnut and hazelnut were most frequently reported as offending foods (19/37 and 15/37, respectively), closely followed by peanut (9/37). For the other 33 different foods, the number of patients reporting symptoms ranged from 1 to 5. These foods were found among all major groups of vegetable foods, including cereals (corn, wheat), legumes (soybean, string bean, white bean, chick pea, lentils, lupine), Solanaceae (potato, tomato, eggplant) Brassicaceae (cabbage, mustard), Umbelliferae (celery, fennel), Rutaceae (lemon, orange), and several other plant families. This article contains a table of the 37 patients and the effecting foods and symptoms of each patient.
(Asero 2000 ref.3711 7)

Asero R, Mistrello G, Roncarolo D, de Vries SC, Gautier MF, Ciurana CL, Verbeek E, Mohammadi T, Knul-Brettlova V, Akkerdaas JH, Bulder I, Aalberse RC, van Ree R. Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int Arch Allergy Immunol 2000;122(1):20-32

[ 6 / 6 ]

This study reports on a 33 year old woman who developed tongue swelling and burning and mouth itching occurring minutes after eating baked beans. Similar symptoms occurred a day after ingesting pea soup, and on another occasion within 15 minutes after eating a bean burrito, and again 20 minutes after eating chilli containing kidney and pinto beans. In this instance she also developed chest tightness, wheezing, generalised erythema, urticaria, abdominal pain, feeling of impending doom and light headedness. Skin specific IgE was positive to red kidney and white beans but negative to pea, string and lima beans. Serum specific IgE was positive to red kidney, white, pinto , chick, garden and black-eyed peas. (Zacharisen 1998 ref.7310 2)

Zacharisen MC, Kurup V. Anaphylaxis to beans. J Allergy Clin Immunol 1998;101(4 Pt 1):556-7


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